NAD-specific glutamate dehydrogenase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

E8NHC5_LEIIN

TriTrypDb:

Length:

1047

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_2	1	2	PF02207	0.509
DOC_CYCLIN_RxL_1	1007	1016	PF00134	0.369
DOC_CYCLIN_RxL_1	132	141	PF00134	0.337
DOC_CYCLIN_RxL_1	167	176	PF00134	0.334
DOC_CYCLIN_RxL_1	202	211	PF00134	0.331
DOC_CYCLIN_RxL_1	237	246	PF00134	0.329
DOC_CYCLIN_RxL_1	27	36	PF00134	0.386
DOC_CYCLIN_RxL_1	307	316	PF00134	0.329
DOC_CYCLIN_RxL_1	342	351	PF00134	0.329
DOC_CYCLIN_RxL_1	377	386	PF00134	0.330
DOC_CYCLIN_RxL_1	447	456	PF00134	0.325
DOC_CYCLIN_RxL_1	482	491	PF00134	0.327
DOC_CYCLIN_RxL_1	587	596	PF00134	0.334
DOC_CYCLIN_RxL_1	622	631	PF00134	0.336
DOC_CYCLIN_RxL_1	657	666	PF00134	0.339
DOC_CYCLIN_RxL_1	692	701	PF00134	0.338
DOC_CYCLIN_RxL_1	762	771	PF00134	0.338
DOC_CYCLIN_RxL_1	797	806	PF00134	0.339
DOC_CYCLIN_RxL_1	832	841	PF00134	0.342
DOC_CYCLIN_RxL_1	867	876	PF00134	0.344
DOC_CYCLIN_RxL_1	937	946	PF00134	0.341
DOC_CYCLIN_RxL_1	972	981	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	1008	1014	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.318
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	553	559	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	658	664	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	693	699	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	728	734	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	798	804	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	833	839	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	868	874	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	903	909	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	938	944	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	973	979	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.336
LIG_Actin_WH2_2	1020	1036	PF00022	0.369
LIG_Actin_WH2_2	110	126	PF00022	0.314
LIG_Actin_WH2_2	145	161	PF00022	0.310
LIG_Actin_WH2_2	17	35	PF00022	0.360
LIG_Actin_WH2_2	180	196	PF00022	0.308
LIG_Actin_WH2_2	215	231	PF00022	0.301
LIG_Actin_WH2_2	250	266	PF00022	0.301
LIG_Actin_WH2_2	285	301	PF00022	0.308
LIG_Actin_WH2_2	320	336	PF00022	0.302
LIG_Actin_WH2_2	355	371	PF00022	0.304
LIG_Actin_WH2_2	390	406	PF00022	0.305
LIG_Actin_WH2_2	40	56	PF00022	0.331
LIG_Actin_WH2_2	425	441	PF00022	0.312
LIG_Actin_WH2_2	460	476	PF00022	0.311
LIG_Actin_WH2_2	495	511	PF00022	0.309
LIG_Actin_WH2_2	530	546	PF00022	0.312
LIG_Actin_WH2_2	565	581	PF00022	0.320
LIG_Actin_WH2_2	600	616	PF00022	0.315
LIG_Actin_WH2_2	635	651	PF00022	0.318
LIG_Actin_WH2_2	670	686	PF00022	0.321
LIG_Actin_WH2_2	705	721	PF00022	0.328
LIG_Actin_WH2_2	740	756	PF00022	0.330
LIG_Actin_WH2_2	75	91	PF00022	0.320
LIG_Actin_WH2_2	775	791	PF00022	0.329
LIG_Actin_WH2_2	810	826	PF00022	0.330
LIG_Actin_WH2_2	845	861	PF00022	0.332
LIG_Actin_WH2_2	880	896	PF00022	0.332
LIG_Actin_WH2_2	915	931	PF00022	0.334
LIG_Actin_WH2_2	950	966	PF00022	0.330
LIG_Actin_WH2_2	985	1001	PF00022	0.336
LIG_EH1_1	17	25	PF00400	0.338
LIG_GBD_Chelix_1	1000	1008	PF00786	0.325
LIG_GBD_Chelix_1	1035	1043	PF00786	0.359
LIG_GBD_Chelix_1	125	133	PF00786	0.307
LIG_GBD_Chelix_1	160	168	PF00786	0.306
LIG_GBD_Chelix_1	195	203	PF00786	0.307
LIG_GBD_Chelix_1	20	28	PF00786	0.345
LIG_GBD_Chelix_1	230	238	PF00786	0.304
LIG_GBD_Chelix_1	265	273	PF00786	0.303
LIG_GBD_Chelix_1	300	308	PF00786	0.305
LIG_GBD_Chelix_1	335	343	PF00786	0.304
LIG_GBD_Chelix_1	370	378	PF00786	0.303
LIG_GBD_Chelix_1	405	413	PF00786	0.301
LIG_GBD_Chelix_1	440	448	PF00786	0.303
LIG_GBD_Chelix_1	475	483	PF00786	0.303
LIG_GBD_Chelix_1	510	518	PF00786	0.306
LIG_GBD_Chelix_1	545	553	PF00786	0.308
LIG_GBD_Chelix_1	55	63	PF00786	0.312
LIG_GBD_Chelix_1	580	588	PF00786	0.310
LIG_GBD_Chelix_1	615	623	PF00786	0.308
LIG_GBD_Chelix_1	650	658	PF00786	0.307
LIG_GBD_Chelix_1	685	693	PF00786	0.308
LIG_GBD_Chelix_1	720	728	PF00786	0.313
LIG_GBD_Chelix_1	755	763	PF00786	0.314
LIG_GBD_Chelix_1	790	798	PF00786	0.313
LIG_GBD_Chelix_1	825	833	PF00786	0.314
LIG_GBD_Chelix_1	860	868	PF00786	0.317
LIG_GBD_Chelix_1	895	903	PF00786	0.317
LIG_GBD_Chelix_1	90	98	PF00786	0.309
LIG_GBD_Chelix_1	930	938	PF00786	0.318
LIG_GBD_Chelix_1	965	973	PF00786	0.318
MOD_GlcNHglycan	1005	1008	PF01048	0.334
MOD_GlcNHglycan	1040	1043	PF01048	0.365
MOD_GlcNHglycan	130	133	PF01048	0.313
MOD_GlcNHglycan	165	168	PF01048	0.311
MOD_GlcNHglycan	200	203	PF01048	0.311
MOD_GlcNHglycan	235	238	PF01048	0.309
MOD_GlcNHglycan	25	28	PF01048	0.356
MOD_GlcNHglycan	270	273	PF01048	0.309
MOD_GlcNHglycan	305	308	PF01048	0.309
MOD_GlcNHglycan	340	343	PF01048	0.311
MOD_GlcNHglycan	375	378	PF01048	0.314
MOD_GlcNHglycan	410	413	PF01048	0.309
MOD_GlcNHglycan	445	448	PF01048	0.310
MOD_GlcNHglycan	480	483	PF01048	0.311
MOD_GlcNHglycan	515	518	PF01048	0.315
MOD_GlcNHglycan	550	553	PF01048	0.319
MOD_GlcNHglycan	585	588	PF01048	0.320
MOD_GlcNHglycan	60	63	PF01048	0.319
MOD_GlcNHglycan	620	623	PF01048	0.320
MOD_GlcNHglycan	655	658	PF01048	0.317
MOD_GlcNHglycan	690	693	PF01048	0.320
MOD_GlcNHglycan	725	728	PF01048	0.321
MOD_GlcNHglycan	760	763	PF01048	0.323
MOD_GlcNHglycan	795	798	PF01048	0.321
MOD_GlcNHglycan	830	833	PF01048	0.320
MOD_GlcNHglycan	865	868	PF01048	0.324
MOD_GlcNHglycan	900	903	PF01048	0.325
MOD_GlcNHglycan	935	938	PF01048	0.324
MOD_GlcNHglycan	95	98	PF01048	0.315
MOD_GlcNHglycan	970	973	PF01048	0.324
MOD_NEK2_1	1003	1008	PF00069	0.334
MOD_NEK2_1	1038	1043	PF00069	0.367
MOD_NEK2_1	128	133	PF00069	0.313
MOD_NEK2_1	163	168	PF00069	0.311
MOD_NEK2_1	198	203	PF00069	0.313
MOD_NEK2_1	23	28	PF00069	0.355
MOD_NEK2_1	233	238	PF00069	0.311
MOD_NEK2_1	268	273	PF00069	0.310
MOD_NEK2_1	303	308	PF00069	0.311
MOD_NEK2_1	338	343	PF00069	0.312
MOD_NEK2_1	373	378	PF00069	0.312
MOD_NEK2_1	408	413	PF00069	0.308
MOD_NEK2_1	443	448	PF00069	0.309
MOD_NEK2_1	478	483	PF00069	0.309
MOD_NEK2_1	513	518	PF00069	0.314
MOD_NEK2_1	548	553	PF00069	0.316
MOD_NEK2_1	58	63	PF00069	0.320
MOD_NEK2_1	583	588	PF00069	0.318
MOD_NEK2_1	618	623	PF00069	0.316
MOD_NEK2_1	653	658	PF00069	0.314
MOD_NEK2_1	688	693	PF00069	0.315
MOD_NEK2_1	723	728	PF00069	0.320
MOD_NEK2_1	758	763	PF00069	0.320
MOD_NEK2_1	793	798	PF00069	0.319
MOD_NEK2_1	828	833	PF00069	0.320
MOD_NEK2_1	863	868	PF00069	0.323
MOD_NEK2_1	898	903	PF00069	0.324
MOD_NEK2_1	93	98	PF00069	0.316
MOD_NEK2_1	933	938	PF00069	0.325
MOD_NEK2_1	968	973	PF00069	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O60732	HUMAN	23%	92%