Aminoalcohol phosphotransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase - putative

Species:

Leishmania infantum

UniProt:

E8NHC2_LEIIN

TriTrypDb:

LINF_030013300

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E8NHC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHC2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.474
CLV_C14_Caspase3-7	268	272	PF00656	0.693
CLV_C14_Caspase3-7	519	523	PF00656	0.723
CLV_NRD_NRD_1	129	131	PF00675	0.272
CLV_NRD_NRD_1	35	37	PF00675	0.371
CLV_NRD_NRD_1	371	373	PF00675	0.611
CLV_NRD_NRD_1	384	386	PF00675	0.638
CLV_NRD_NRD_1	422	424	PF00675	0.354
CLV_NRD_NRD_1	457	459	PF00675	0.489
CLV_NRD_NRD_1	482	484	PF00675	0.442
CLV_NRD_NRD_1	615	617	PF00675	0.548
CLV_PCSK_KEX2_1	129	131	PF00082	0.272
CLV_PCSK_KEX2_1	371	373	PF00082	0.611
CLV_PCSK_KEX2_1	384	386	PF00082	0.638
CLV_PCSK_KEX2_1	422	424	PF00082	0.354
CLV_PCSK_KEX2_1	457	459	PF00082	0.489
CLV_PCSK_KEX2_1	482	484	PF00082	0.442
CLV_PCSK_SKI1_1	12	16	PF00082	0.374
CLV_PCSK_SKI1_1	190	194	PF00082	0.547
CLV_PCSK_SKI1_1	297	301	PF00082	0.485
CLV_PCSK_SKI1_1	326	330	PF00082	0.341
CLV_PCSK_SKI1_1	336	340	PF00082	0.279
CLV_PCSK_SKI1_1	600	604	PF00082	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_ODPH_VHL_1	46	58	PF01847	0.381
DEG_ODPH_VHL_1	460	472	PF01847	0.442
DEG_SCF_FBW7_2	370	377	PF00400	0.413
DOC_CDC14_PxL_1	273	281	PF14671	0.612
DOC_CYCLIN_yClb3_PxF_3	99	105	PF00134	0.351
DOC_MAPK_gen_1	10	17	PF00069	0.621
DOC_MAPK_gen_1	36	44	PF00069	0.569
DOC_MAPK_gen_1	384	390	PF00069	0.431
DOC_MAPK_HePTP_8	34	46	PF00069	0.502
DOC_MAPK_MEF2A_6	10	17	PF00069	0.621
DOC_MAPK_MEF2A_6	190	197	PF00069	0.351
DOC_MAPK_MEF2A_6	342	350	PF00069	0.489
DOC_MAPK_MEF2A_6	37	46	PF00069	0.503
DOC_MAPK_MEF2A_6	398	407	PF00069	0.323
DOC_MAPK_MEF2A_6	438	445	PF00069	0.323
DOC_MAPK_MEF2A_6	457	466	PF00069	0.272
DOC_MAPK_NFAT4_5	10	18	PF00069	0.621
DOC_MAPK_NFAT4_5	190	198	PF00069	0.355
DOC_MAPK_NFAT4_5	438	446	PF00069	0.323
DOC_MAPK_RevD_3	443	458	PF00069	0.497
DOC_PP2B_LxvP_1	193	196	PF13499	0.301
DOC_PP2B_LxvP_1	577	580	PF13499	0.564
DOC_PP4_FxxP_1	582	585	PF00568	0.554
DOC_SPAK_OSR1_1	385	389	PF12202	0.429
DOC_USP7_MATH_1	163	167	PF00917	0.516
DOC_USP7_MATH_1	356	360	PF00917	0.347
DOC_USP7_MATH_1	493	497	PF00917	0.687
DOC_USP7_MATH_1	518	522	PF00917	0.752
DOC_USP7_MATH_1	523	527	PF00917	0.764
DOC_USP7_MATH_1	532	536	PF00917	0.587
DOC_WW_Pin1_4	132	137	PF00397	0.472
DOC_WW_Pin1_4	370	375	PF00397	0.407
DOC_WW_Pin1_4	608	613	PF00397	0.654
DOC_WW_Pin1_4	86	91	PF00397	0.546
LIG_14-3-3_CanoR_1	130	136	PF00244	0.490
LIG_14-3-3_CanoR_1	342	347	PF00244	0.492
LIG_14-3-3_CanoR_1	457	461	PF00244	0.289
LIG_Actin_WH2_2	577	595	PF00022	0.637
LIG_BIR_III_2	522	526	PF00653	0.661
LIG_BIR_III_4	269	273	PF00653	0.616
LIG_BRCT_BRCA1_1	386	390	PF00533	0.447
LIG_BRCT_BRCA1_1	449	453	PF00533	0.381
LIG_eIF4E_1	188	194	PF01652	0.272
LIG_EVH1_2	101	105	PF00568	0.309
LIG_FHA_1	167	173	PF00498	0.478
LIG_FHA_1	177	183	PF00498	0.313
LIG_FHA_1	213	219	PF00498	0.381
LIG_FHA_1	294	300	PF00498	0.620
LIG_FHA_1	343	349	PF00498	0.469
LIG_FHA_1	429	435	PF00498	0.309
LIG_FHA_1	571	577	PF00498	0.608
LIG_FHA_1	60	66	PF00498	0.373
LIG_FHA_1	603	609	PF00498	0.705
LIG_FHA_1	86	92	PF00498	0.530
LIG_FHA_2	182	188	PF00498	0.348
LIG_FHA_2	262	268	PF00498	0.646
LIG_FHA_2	413	419	PF00498	0.478
LIG_FHA_2	517	523	PF00498	0.761
LIG_FHA_2	535	541	PF00498	0.664
LIG_FHA_2	80	86	PF00498	0.499
LIG_GBD_Chelix_1	112	120	PF00786	0.442
LIG_LIR_Gen_1	169	178	PF02991	0.305
LIG_LIR_Gen_1	24	34	PF02991	0.622
LIG_LIR_Gen_1	271	280	PF02991	0.589
LIG_LIR_Gen_1	340	351	PF02991	0.538
LIG_LIR_Gen_1	506	514	PF02991	0.718
LIG_LIR_Gen_1	559	570	PF02991	0.555
LIG_LIR_Nem_3	169	173	PF02991	0.307
LIG_LIR_Nem_3	184	188	PF02991	0.305
LIG_LIR_Nem_3	271	276	PF02991	0.599
LIG_LIR_Nem_3	340	346	PF02991	0.546
LIG_LIR_Nem_3	387	393	PF02991	0.402
LIG_LIR_Nem_3	40	44	PF02991	0.563
LIG_LIR_Nem_3	450	456	PF02991	0.347
LIG_LIR_Nem_3	506	510	PF02991	0.720
LIG_LIR_Nem_3	559	565	PF02991	0.562
LIG_NRBOX	115	121	PF00104	0.395
LIG_PCNA_PIPBox_1	325	334	PF02747	0.586
LIG_PCNA_yPIPBox_3	325	336	PF02747	0.640
LIG_Pex14_1	185	189	PF04695	0.272
LIG_Pex14_2	181	185	PF04695	0.348
LIG_Pex14_2	386	390	PF04695	0.420
LIG_PROFILIN_1	97	103	PF00235	0.308
LIG_Rb_LxCxE_1	76	95	PF01857	0.402
LIG_SH2_CRK	189	193	PF00017	0.357
LIG_SH2_CRK	343	347	PF00017	0.489
LIG_SH2_CRK	367	371	PF00017	0.318
LIG_SH2_CRK	436	440	PF00017	0.381
LIG_SH2_SRC	4	7	PF00017	0.596
LIG_SH2_SRC	41	44	PF00017	0.551
LIG_SH2_STAP1	436	440	PF00017	0.426
LIG_SH2_STAP1	541	545	PF00017	0.664
LIG_SH2_STAP1	552	556	PF00017	0.601
LIG_SH2_STAT5	16	19	PF00017	0.529
LIG_SH2_STAT5	212	215	PF00017	0.304
LIG_SH2_STAT5	25	28	PF00017	0.510
LIG_SH2_STAT5	262	265	PF00017	0.599
LIG_SH2_STAT5	4	7	PF00017	0.522
LIG_SH2_STAT5	41	44	PF00017	0.471
LIG_SH2_STAT5	436	439	PF00017	0.348
LIG_SH2_STAT5	474	477	PF00017	0.451
LIG_SH2_STAT5	512	515	PF00017	0.756
LIG_SH2_STAT5	80	83	PF00017	0.463
LIG_SH3_1	289	295	PF00018	0.631
LIG_SH3_2	292	297	PF14604	0.624
LIG_SH3_3	215	221	PF00018	0.361
LIG_SH3_3	289	295	PF00018	0.587
LIG_SH3_3	91	97	PF00018	0.510
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.442
LIG_SUMO_SIM_par_1	169	176	PF11976	0.381
LIG_SUMO_SIM_par_1	400	406	PF11976	0.383
LIG_TRAF2_1	184	187	PF00917	0.348
LIG_TYR_ITIM	341	346	PF00017	0.522
LIG_TYR_ITIM	39	44	PF00017	0.598
LIG_TYR_ITIM	434	439	PF00017	0.381
LIG_UBA3_1	1	10	PF00899	0.625
LIG_WRC_WIRS_1	177	182	PF05994	0.442
LIG_WRC_WIRS_1	404	409	PF05994	0.442
MOD_CDC14_SPxK_1	611	614	PF00782	0.665
MOD_CDK_SPxK_1	608	614	PF00069	0.658
MOD_CK1_1	156	162	PF00069	0.487
MOD_CK1_1	166	172	PF00069	0.530
MOD_CK1_1	319	325	PF00069	0.610
MOD_CK1_1	531	537	PF00069	0.723
MOD_CK1_1	558	564	PF00069	0.530
MOD_CK2_1	181	187	PF00069	0.348
MOD_CK2_1	261	267	PF00069	0.674
MOD_CK2_1	79	85	PF00069	0.497
MOD_CMANNOS	167	170	PF00535	0.272
MOD_CMANNOS	214	217	PF00535	0.426
MOD_Cter_Amidation	382	385	PF01082	0.644
MOD_GlcNHglycan	161	164	PF01048	0.323
MOD_GlcNHglycan	318	321	PF01048	0.439
MOD_GlcNHglycan	333	336	PF01048	0.378
MOD_GlcNHglycan	358	361	PF01048	0.385
MOD_GlcNHglycan	409	412	PF01048	0.488
MOD_GlcNHglycan	449	452	PF01048	0.621
MOD_GlcNHglycan	489	492	PF01048	0.464
MOD_GlcNHglycan	495	498	PF01048	0.547
MOD_GlcNHglycan	514	517	PF01048	0.347
MOD_GlcNHglycan	530	533	PF01048	0.537
MOD_GlcNHglycan	75	78	PF01048	0.638
MOD_GSK3_1	128	135	PF00069	0.463
MOD_GSK3_1	159	166	PF00069	0.532
MOD_GSK3_1	17	24	PF00069	0.629
MOD_GSK3_1	403	410	PF00069	0.426
MOD_GSK3_1	510	517	PF00069	0.785
MOD_GSK3_1	528	535	PF00069	0.742
MOD_GSK3_1	604	611	PF00069	0.640
MOD_GSK3_1	79	86	PF00069	0.484
MOD_N-GLC_1	282	287	PF02516	0.354
MOD_N-GLC_1	476	481	PF02516	0.453
MOD_NEK2_1	282	287	PF00069	0.636
MOD_NEK2_1	331	336	PF00069	0.595
MOD_NEK2_1	407	412	PF00069	0.352
MOD_NEK2_1	428	433	PF00069	0.315
MOD_NEK2_1	434	439	PF00069	0.320
MOD_NEK2_1	456	461	PF00069	0.283
MOD_NEK2_1	555	560	PF00069	0.523
MOD_NEK2_1	565	570	PF00069	0.498
MOD_NEK2_1	58	63	PF00069	0.401
MOD_NEK2_1	596	601	PF00069	0.599
MOD_NEK2_2	337	342	PF00069	0.644
MOD_PIKK_1	476	482	PF00454	0.566
MOD_PK_1	384	390	PF00069	0.431
MOD_PKA_1	384	390	PF00069	0.431
MOD_PKA_2	128	134	PF00069	0.472
MOD_PKA_2	384	390	PF00069	0.419
MOD_PKA_2	456	462	PF00069	0.289
MOD_PKA_2	570	576	PF00069	0.533
MOD_Plk_1	21	27	PF00069	0.511
MOD_Plk_1	476	482	PF00069	0.625
MOD_Plk_4	166	172	PF00069	0.501
MOD_Plk_4	173	179	PF00069	0.375
MOD_Plk_4	319	325	PF00069	0.553
MOD_Plk_4	470	476	PF00069	0.358
MOD_ProDKin_1	132	138	PF00069	0.472
MOD_ProDKin_1	370	376	PF00069	0.411
MOD_ProDKin_1	608	614	PF00069	0.658
MOD_ProDKin_1	86	92	PF00069	0.549
TRG_DiLeu_BaEn_1	572	577	PF01217	0.601
TRG_ENDOCYTIC_2	117	120	PF00928	0.323
TRG_ENDOCYTIC_2	189	192	PF00928	0.345
TRG_ENDOCYTIC_2	27	30	PF00928	0.508
TRG_ENDOCYTIC_2	343	346	PF00928	0.491
TRG_ENDOCYTIC_2	367	370	PF00928	0.309
TRG_ENDOCYTIC_2	41	44	PF00928	0.488
TRG_ENDOCYTIC_2	436	439	PF00928	0.381
TRG_ENDOCYTIC_2	552	555	PF00928	0.556
TRG_ER_diArg_1	370	372	PF00400	0.404
TRG_ER_diArg_1	384	386	PF00400	0.438
TRG_ER_diArg_1	421	423	PF00400	0.553
TRG_ER_diArg_1	456	458	PF00400	0.370
TRG_ER_diArg_1	481	483	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y1	Leptomonas seymouri	64%	100%
A0A0S4J7L0	Bodo saltans	45%	100%
A0A1X0P8W0	Trypanosomatidae	43%	100%
A0A3S5H562	Leishmania donovani	100%	100%
E9AJW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
V5BXC7	Trypanosoma cruzi	45%	100%