Bifunctional dihydrofolate reductase-thymidylate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrofolate reductase-thymidylate synthase

Species:

Leishmania major

UniProt:

DRTS_LEIMA

TriTrypDb:

LmjF.06.0860 , LMJSD75_060015000

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

P07382

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: P07382

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006220	pyrimidine nucleotide metabolic process	5	6
GO:0006221	pyrimidine nucleotide biosynthetic process	6	6
GO:0006231	dTMP biosynthetic process	8	6
GO:0006575	cellular modified amino acid metabolic process	3	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006730	one-carbon metabolic process	3	6
GO:0006753	nucleoside phosphate metabolic process	4	6
GO:0006760	folic acid-containing compound metabolic process	4	6
GO:0006793	phosphorus metabolic process	3	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004146	dihydrofolate reductase activity	5	6
GO:0004799	thymidylate synthase activity	6	6
GO:0008168	methyltransferase activity	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	6
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	5	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.598
CLV_C14_Caspase3-7	321	325	PF00656	0.598
CLV_C14_Caspase3-7	458	462	PF00656	0.598
CLV_NRD_NRD_1	212	214	PF00675	0.363
CLV_NRD_NRD_1	380	382	PF00675	0.311
CLV_NRD_NRD_1	80	82	PF00675	0.339
CLV_PCSK_KEX2_1	212	214	PF00082	0.339
CLV_PCSK_KEX2_1	282	284	PF00082	0.398
CLV_PCSK_KEX2_1	380	382	PF00082	0.398
CLV_PCSK_KEX2_1	73	75	PF00082	0.398

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX9	Leptomonas seymouri	77%	98%
A0A0S4JJI0	Bodo saltans	62%	100%
A0A1X0NKM2	Trypanosomatidae	68%	100%
A0A3R7P0P8	Trypanosoma rangeli	66%	100%
A0A3S5H5T0	Leishmania donovani	96%	100%
A4H4P8	Leishmania braziliensis	87%	100%
C9ZTK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AKW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O81395	Zea mays	46%	100%
P07382	Leishmania major	100%	100%

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