LeishMANIAdb
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Histone acetyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histone acetyltransferase
Gene product:
histone acetyltransferase, putative
Species:
Leishmania donovani
UniProt:
D7RTH9_LEIDO
TriTrypDb:
LdBPK_140140.1 , LdCL_140006300 , LDHU3_14.0180
Length:
525

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, histone acetyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

D7RTH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 11
GO:0009889 regulation of biosynthetic process 4 11
GO:0010468 regulation of gene expression 5 11
GO:0010556 regulation of macromolecule biosynthetic process 5 11
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 11
GO:0019222 regulation of metabolic process 3 11
GO:0031323 regulation of cellular metabolic process 4 11
GO:0031326 regulation of cellular biosynthetic process 5 11
GO:0050789 regulation of biological process 2 11
GO:0050794 regulation of cellular process 3 11
GO:0051171 regulation of nitrogen compound metabolic process 4 11
GO:0051252 regulation of RNA metabolic process 5 11
GO:0060255 regulation of macromolecule metabolic process 4 11
GO:0065007 biological regulation 1 11
GO:0080090 regulation of primary metabolic process 4 11
GO:1903506 regulation of nucleic acid-templated transcription 7 11
GO:2001141 regulation of RNA biosynthetic process 6 11
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009890 negative regulation of biosynthetic process 5 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010558 negative regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031327 negative regulation of cellular biosynthetic process 6 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0045892 negative regulation of DNA-templated transcription 7 1
GO:0045893 positive regulation of DNA-templated transcription 7 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 1
GO:0045944 positive regulation of transcription by RNA polymerase II 8 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048523 negative regulation of cellular process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0051254 positive regulation of RNA metabolic process 6 1
GO:1902679 negative regulation of RNA biosynthetic process 7 1
GO:1902680 positive regulation of RNA biosynthetic process 7 1
GO:1903507 negative regulation of nucleic acid-templated transcription 8 1
GO:1903508 positive regulation of nucleic acid-templated transcription 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004402 histone acetyltransferase activity 4 11
GO:0008080 N-acetyltransferase activity 6 11
GO:0016407 acetyltransferase activity 5 11
GO:0016410 N-acyltransferase activity 5 11
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 11
GO:0034212 peptide N-acetyltransferase activity 7 11
GO:0061733 peptide-lysine-N-acetyltransferase activity 3 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0003712 transcription coregulator activity 2 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 138 140 PF00675 0.503
CLV_NRD_NRD_1 290 292 PF00675 0.402
CLV_NRD_NRD_1 387 389 PF00675 0.307
CLV_NRD_NRD_1 89 91 PF00675 0.728
CLV_PCSK_FUR_1 136 140 PF00082 0.631
CLV_PCSK_KEX2_1 138 140 PF00082 0.587
CLV_PCSK_KEX2_1 290 292 PF00082 0.426
CLV_PCSK_KEX2_1 387 389 PF00082 0.307
CLV_PCSK_KEX2_1 473 475 PF00082 0.460
CLV_PCSK_KEX2_1 89 91 PF00082 0.728
CLV_PCSK_PC1ET2_1 473 475 PF00082 0.473
CLV_PCSK_PC7_1 286 292 PF00082 0.402
CLV_PCSK_PC7_1 469 475 PF00082 0.437
CLV_PCSK_SKI1_1 259 263 PF00082 0.469
CLV_PCSK_SKI1_1 314 318 PF00082 0.307
CLV_PCSK_SKI1_1 473 477 PF00082 0.556
CLV_PCSK_SKI1_1 479 483 PF00082 0.525
DEG_SPOP_SBC_1 195 199 PF00917 0.615
DOC_CKS1_1 392 397 PF01111 0.602
DOC_CKS1_1 80 85 PF01111 0.617
DOC_MAPK_gen_1 290 297 PF00069 0.602
DOC_MAPK_MEF2A_6 290 297 PF00069 0.520
DOC_PP2B_LxvP_1 364 367 PF13499 0.507
DOC_SPAK_OSR1_1 376 380 PF12202 0.507
DOC_USP7_MATH_1 218 222 PF00917 0.631
DOC_USP7_MATH_1 245 249 PF00917 0.379
DOC_USP7_UBL2_3 473 477 PF12436 0.537
DOC_WW_Pin1_4 163 168 PF00397 0.481
DOC_WW_Pin1_4 196 201 PF00397 0.543
DOC_WW_Pin1_4 324 329 PF00397 0.507
DOC_WW_Pin1_4 351 356 PF00397 0.507
DOC_WW_Pin1_4 391 396 PF00397 0.507
DOC_WW_Pin1_4 79 84 PF00397 0.781
LIG_14-3-3_CanoR_1 247 252 PF00244 0.459
LIG_APCC_ABBA_1 258 263 PF00400 0.469
LIG_BIR_II_1 1 5 PF00653 0.565
LIG_BRCT_BRCA1_1 140 144 PF00533 0.487
LIG_BRCT_BRCA1_1 312 316 PF00533 0.507
LIG_BRCT_BRCA1_1 482 486 PF00533 0.518
LIG_Clathr_ClatBox_1 292 296 PF01394 0.520
LIG_deltaCOP1_diTrp_1 161 165 PF00928 0.474
LIG_FHA_1 100 106 PF00498 0.570
LIG_FHA_1 145 151 PF00498 0.596
LIG_FHA_1 202 208 PF00498 0.600
LIG_FHA_1 325 331 PF00498 0.507
LIG_FHA_1 337 343 PF00498 0.507
LIG_FHA_1 414 420 PF00498 0.624
LIG_FHA_1 436 442 PF00498 0.553
LIG_FHA_1 470 476 PF00498 0.483
LIG_FHA_1 486 492 PF00498 0.538
LIG_FHA_2 302 308 PF00498 0.563
LIG_FHA_2 459 465 PF00498 0.507
LIG_GBD_Chelix_1 293 301 PF00786 0.402
LIG_LIR_Apic_2 161 167 PF02991 0.566
LIG_LIR_Apic_2 283 288 PF02991 0.507
LIG_LIR_Gen_1 485 495 PF02991 0.497
LIG_LIR_Nem_3 162 168 PF02991 0.471
LIG_LIR_Nem_3 327 332 PF02991 0.528
LIG_LIR_Nem_3 37 43 PF02991 0.521
LIG_LIR_Nem_3 404 410 PF02991 0.529
LIG_LIR_Nem_3 482 487 PF02991 0.516
LIG_LIR_Nem_3 499 504 PF02991 0.523
LIG_MLH1_MIPbox_1 140 144 PF16413 0.487
LIG_Pex14_1 493 497 PF04695 0.479
LIG_Pex14_2 497 501 PF04695 0.538
LIG_PTB_Apo_2 17 24 PF02174 0.602
LIG_REV1ctd_RIR_1 141 150 PF16727 0.472
LIG_SH2_CRK 16 20 PF00017 0.507
LIG_SH2_STAP1 151 155 PF00017 0.516
LIG_SH2_STAP1 471 475 PF00017 0.454
LIG_SH2_STAP1 487 491 PF00017 0.381
LIG_SH2_STAT3 433 436 PF00017 0.507
LIG_SH2_STAT3 46 49 PF00017 0.507
LIG_SH2_STAT5 164 167 PF00017 0.485
LIG_SH2_STAT5 256 259 PF00017 0.486
LIG_SH2_STAT5 332 335 PF00017 0.507
LIG_SH2_STAT5 347 350 PF00017 0.507
LIG_SH2_STAT5 407 410 PF00017 0.507
LIG_SH2_STAT5 43 46 PF00017 0.512
LIG_SH2_STAT5 433 436 PF00017 0.541
LIG_SH2_STAT5 471 474 PF00017 0.556
LIG_SH2_STAT5 484 487 PF00017 0.331
LIG_SH2_STAT5 81 84 PF00017 0.617
LIG_SH3_1 502 508 PF00018 0.545
LIG_SH3_3 389 395 PF00018 0.514
LIG_SH3_3 502 508 PF00018 0.435
LIG_SH3_3 513 519 PF00018 0.541
LIG_SUMO_SIM_anti_2 307 313 PF11976 0.538
LIG_SUMO_SIM_anti_2 361 367 PF11976 0.507
LIG_SUMO_SIM_par_1 27 34 PF11976 0.602
LIG_SUMO_SIM_par_1 291 296 PF11976 0.508
LIG_SUMO_SIM_par_1 377 382 PF11976 0.515
LIG_TRAF2_1 422 425 PF00917 0.507
LIG_TRAF2_1 8 11 PF00917 0.557
LIG_TRFH_1 256 260 PF08558 0.354
LIG_UBA3_1 311 320 PF00899 0.507
MOD_CDK_SPxK_1 391 397 PF00069 0.507
MOD_CK1_1 201 207 PF00069 0.676
MOD_CK1_1 336 342 PF00069 0.553
MOD_CK1_1 74 80 PF00069 0.734
MOD_CK1_1 92 98 PF00069 0.641
MOD_CK2_1 301 307 PF00069 0.582
MOD_CK2_1 383 389 PF00069 0.507
MOD_CK2_1 458 464 PF00069 0.560
MOD_GlcNHglycan 115 119 PF01048 0.553
MOD_GlcNHglycan 140 143 PF01048 0.695
MOD_GlcNHglycan 200 203 PF01048 0.596
MOD_GlcNHglycan 204 207 PF01048 0.627
MOD_GlcNHglycan 208 211 PF01048 0.607
MOD_GlcNHglycan 220 223 PF01048 0.417
MOD_GlcNHglycan 230 233 PF01048 0.526
MOD_GlcNHglycan 3 6 PF01048 0.657
MOD_GlcNHglycan 83 86 PF01048 0.627
MOD_GSK3_1 110 117 PF00069 0.475
MOD_GSK3_1 138 145 PF00069 0.515
MOD_GSK3_1 159 166 PF00069 0.448
MOD_GSK3_1 180 187 PF00069 0.667
MOD_GSK3_1 194 201 PF00069 0.506
MOD_GSK3_1 202 209 PF00069 0.569
MOD_GSK3_1 218 225 PF00069 0.666
MOD_GSK3_1 243 250 PF00069 0.445
MOD_GSK3_1 297 304 PF00069 0.602
MOD_GSK3_1 379 386 PF00069 0.513
MOD_GSK3_1 469 476 PF00069 0.645
MOD_GSK3_1 485 492 PF00069 0.428
MOD_GSK3_1 81 88 PF00069 0.613
MOD_GSK3_1 99 106 PF00069 0.482
MOD_N-GLC_1 19 24 PF02516 0.402
MOD_N-GLC_1 358 363 PF02516 0.307
MOD_NEK2_1 1 6 PF00069 0.696
MOD_NEK2_1 144 149 PF00069 0.598
MOD_NEK2_1 19 24 PF00069 0.433
MOD_NEK2_1 194 199 PF00069 0.741
MOD_NEK2_1 406 411 PF00069 0.598
MOD_PIKK_1 180 186 PF00454 0.629
MOD_PKA_1 138 144 PF00069 0.491
MOD_PKA_1 473 479 PF00069 0.415
MOD_PKA_1 89 95 PF00069 0.719
MOD_PKA_2 138 144 PF00069 0.624
MOD_PKA_2 473 479 PF00069 0.415
MOD_PKA_2 89 95 PF00069 0.719
MOD_PKB_1 136 144 PF00069 0.492
MOD_Plk_1 358 364 PF00069 0.507
MOD_Plk_1 379 385 PF00069 0.507
MOD_Plk_1 479 485 PF00069 0.487
MOD_Plk_4 159 165 PF00069 0.558
MOD_Plk_4 406 412 PF00069 0.564
MOD_Plk_4 482 488 PF00069 0.514
MOD_ProDKin_1 163 169 PF00069 0.481
MOD_ProDKin_1 196 202 PF00069 0.541
MOD_ProDKin_1 324 330 PF00069 0.507
MOD_ProDKin_1 351 357 PF00069 0.507
MOD_ProDKin_1 391 397 PF00069 0.507
MOD_ProDKin_1 79 85 PF00069 0.780
MOD_SUMO_rev_2 313 322 PF00179 0.507
MOD_SUMO_rev_2 384 392 PF00179 0.520
TRG_DiLeu_BaEn_1 307 312 PF01217 0.507
TRG_ENDOCYTIC_2 16 19 PF00928 0.507
TRG_ENDOCYTIC_2 487 490 PF00928 0.365
TRG_ENDOCYTIC_2 498 501 PF00928 0.386
TRG_ER_diArg_1 136 139 PF00400 0.630
TRG_ER_diArg_1 289 291 PF00400 0.602
TRG_NES_CRM1_1 307 318 PF08389 0.507
TRG_Pf-PMV_PEXEL_1 269 273 PF00026 0.576
TRG_Pf-PMV_PEXEL_1 376 380 PF00026 0.307
TRG_Pf-PMV_PEXEL_1 447 452 PF00026 0.402

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5B0 Leptomonas seymouri 80% 100%
A0A1X0NNT9 Trypanosomatidae 58% 100%
A0A3R7M6T2 Trypanosoma rangeli 57% 100%
A4H7H5 Leishmania braziliensis 87% 100%
A4HVV6 Leishmania infantum 100% 100%
C9ZT70 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9APK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B048 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 68%
O94446 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q4QFX1 Leishmania major 97% 100%
V5BHR3 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS