LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2 - putative
Species:
Leishmania infantum
UniProt:
D1GJ51_LEIIN
TriTrypDb:
LINF_120014700
Length:
463

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Annotations by Jardim et al.

Plasma membrane, surface antigen 2 PSA-50S

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 160
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 61, no: 7
NetGPI no yes: 0, no: 68
Cellular components
Term Name Level Count
GO:0005929 cilium 4 69
GO:0042995 cell projection 2 69
GO:0043226 organelle 2 69
GO:0043227 membrane-bounded organelle 3 69
GO:0110165 cellular anatomical entity 1 69
GO:0120025 plasma membrane bounded cell projection 3 69
GO:0016020 membrane 2 30
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

D1GJ51
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: D1GJ51

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.298
CLV_NRD_NRD_1 6 8 PF00675 0.742
CLV_PCSK_KEX2_1 6 8 PF00082 0.742
CLV_PCSK_SKI1_1 154 158 PF00082 0.640
CLV_PCSK_SKI1_1 206 210 PF00082 0.452
CLV_PCSK_SKI1_1 230 234 PF00082 0.542
CLV_PCSK_SKI1_1 299 303 PF00082 0.624
CLV_PCSK_SKI1_1 7 11 PF00082 0.706
DEG_SPOP_SBC_1 372 376 PF00917 0.569
DOC_CYCLIN_RxL_1 107 115 PF00134 0.267
DOC_CYCLIN_RxL_1 203 212 PF00134 0.236
DOC_CYCLIN_RxL_1 3 13 PF00134 0.551
DOC_MAPK_gen_1 154 164 PF00069 0.234
DOC_MAPK_HePTP_8 431 443 PF00069 0.325
DOC_MAPK_MEF2A_6 157 164 PF00069 0.211
DOC_MAPK_MEF2A_6 349 356 PF00069 0.391
DOC_MAPK_MEF2A_6 434 443 PF00069 0.179
DOC_PP1_RVXF_1 108 115 PF00149 0.296
DOC_USP7_MATH_1 192 196 PF00917 0.347
DOC_USP7_MATH_1 240 244 PF00917 0.369
DOC_USP7_MATH_2 175 181 PF00917 0.303
DOC_USP7_MATH_2 223 229 PF00917 0.361
DOC_WW_Pin1_4 383 388 PF00397 0.626
LIG_14-3-3_CanoR_1 154 160 PF00244 0.430
LIG_14-3-3_CanoR_1 43 48 PF00244 0.420
LIG_BIR_II_1 1 5 PF00653 0.694
LIG_Clathr_ClatBox_1 258 262 PF01394 0.216
LIG_FHA_1 169 175 PF00498 0.355
LIG_FHA_1 217 223 PF00498 0.368
LIG_FHA_1 276 282 PF00498 0.282
LIG_FHA_1 42 48 PF00498 0.444
LIG_FHA_1 427 433 PF00498 0.455
LIG_FHA_1 90 96 PF00498 0.312
LIG_FHA_2 122 128 PF00498 0.458
LIG_FHA_2 207 213 PF00498 0.309
LIG_FHA_2 375 381 PF00498 0.595
LIG_FHA_2 395 401 PF00498 0.548
LIG_FHA_2 92 98 PF00498 0.400
LIG_LIR_Gen_1 101 112 PF02991 0.457
LIG_LIR_Gen_1 113 121 PF02991 0.420
LIG_LIR_Gen_1 127 135 PF02991 0.380
LIG_LIR_Gen_1 177 184 PF02991 0.350
LIG_LIR_Gen_1 201 210 PF02991 0.314
LIG_LIR_Gen_1 225 234 PF02991 0.269
LIG_LIR_Gen_1 305 314 PF02991 0.357
LIG_LIR_Gen_1 321 328 PF02991 0.392
LIG_LIR_Nem_3 101 107 PF02991 0.455
LIG_LIR_Nem_3 127 132 PF02991 0.377
LIG_LIR_Nem_3 305 309 PF02991 0.397
LIG_PCNA_PIPBox_1 156 165 PF02747 0.326
LIG_PCNA_PIPBox_1 277 286 PF02747 0.218
LIG_PDZ_Class_2 458 463 PF00595 0.516
LIG_PTB_Apo_2 300 307 PF02174 0.225
LIG_SH2_CRK 104 108 PF00017 0.453
LIG_SH2_STAP1 104 108 PF00017 0.273
LIG_SH2_STAT5 104 107 PF00017 0.415
LIG_SH2_STAT5 422 425 PF00017 0.319
LIG_SH2_STAT5 83 86 PF00017 0.383
LIG_SH2_STAT5 91 94 PF00017 0.385
LIG_SH3_3 93 99 PF00018 0.413
LIG_Sin3_3 447 454 PF02671 0.272
LIG_SUMO_SIM_anti_2 207 212 PF11976 0.247
LIG_SUMO_SIM_anti_2 254 260 PF11976 0.281
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.345
LIG_SUMO_SIM_par_1 209 216 PF11976 0.224
LIG_SUMO_SIM_par_1 257 262 PF11976 0.337
LIG_SUMO_SIM_par_1 352 358 PF11976 0.310
LIG_SUMO_SIM_par_1 437 442 PF11976 0.180
LIG_SUMO_SIM_par_1 44 51 PF11976 0.209
LIG_SUMO_SIM_par_1 97 103 PF11976 0.413
LIG_TYR_ITIM 102 107 PF00017 0.461
LIG_UBA3_1 234 241 PF00899 0.280
MOD_CK1_1 152 158 PF00069 0.368
MOD_CK1_1 166 172 PF00069 0.330
MOD_CK1_1 180 186 PF00069 0.357
MOD_CK1_1 228 234 PF00069 0.310
MOD_CK1_1 251 257 PF00069 0.363
MOD_CK1_1 275 281 PF00069 0.350
MOD_CK1_1 383 389 PF00069 0.427
MOD_CK2_1 374 380 PF00069 0.409
MOD_CK2_1 390 396 PF00069 0.618
MOD_CK2_1 91 97 PF00069 0.407
MOD_GlcNHglycan 121 124 PF01048 0.592
MOD_GlcNHglycan 140 143 PF01048 0.495
MOD_GlcNHglycan 145 148 PF01048 0.549
MOD_GlcNHglycan 194 197 PF01048 0.597
MOD_GlcNHglycan 242 245 PF01048 0.518
MOD_GlcNHglycan 25 28 PF01048 0.688
MOD_GlcNHglycan 266 269 PF01048 0.575
MOD_GlcNHglycan 274 277 PF01048 0.548
MOD_GlcNHglycan 290 293 PF01048 0.590
MOD_GlcNHglycan 313 317 PF01048 0.593
MOD_GlcNHglycan 392 395 PF01048 0.626
MOD_GlcNHglycan 410 413 PF01048 0.646
MOD_GSK3_1 121 128 PF00069 0.379
MOD_GSK3_1 134 141 PF00069 0.296
MOD_GSK3_1 145 152 PF00069 0.324
MOD_GSK3_1 176 183 PF00069 0.338
MOD_GSK3_1 200 207 PF00069 0.361
MOD_GSK3_1 224 231 PF00069 0.324
MOD_GSK3_1 248 255 PF00069 0.360
MOD_GSK3_1 257 264 PF00069 0.269
MOD_GSK3_1 272 279 PF00069 0.329
MOD_GSK3_1 370 377 PF00069 0.515
MOD_GSK3_1 379 386 PF00069 0.586
MOD_GSK3_1 390 397 PF00069 0.552
MOD_GSK3_1 422 429 PF00069 0.480
MOD_GSK3_1 87 94 PF00069 0.363
MOD_N-GLC_2 363 365 PF02516 0.665
MOD_NEK2_1 10 15 PF00069 0.549
MOD_NEK2_1 112 117 PF00069 0.310
MOD_NEK2_1 119 124 PF00069 0.335
MOD_NEK2_1 138 143 PF00069 0.314
MOD_NEK2_1 21 26 PF00069 0.542
MOD_NEK2_1 213 218 PF00069 0.333
MOD_NEK2_1 261 266 PF00069 0.305
MOD_NEK2_1 285 290 PF00069 0.418
MOD_NEK2_1 71 76 PF00069 0.375
MOD_PIKK_1 112 118 PF00454 0.279
MOD_PIKK_1 213 219 PF00454 0.387
MOD_PIKK_1 261 267 PF00454 0.444
MOD_PIKK_1 285 291 PF00454 0.417
MOD_Plk_1 102 108 PF00069 0.386
MOD_Plk_1 112 118 PF00069 0.320
MOD_Plk_1 176 182 PF00069 0.355
MOD_Plk_1 200 206 PF00069 0.344
MOD_Plk_1 224 230 PF00069 0.328
MOD_Plk_1 426 432 PF00069 0.337
MOD_Plk_4 155 161 PF00069 0.365
MOD_Plk_4 206 212 PF00069 0.353
MOD_Plk_4 230 236 PF00069 0.376
MOD_Plk_4 254 260 PF00069 0.395
MOD_Plk_4 276 282 PF00069 0.263
MOD_Plk_4 71 77 PF00069 0.295
MOD_ProDKin_1 383 389 PF00069 0.625
MOD_SUMO_rev_2 355 361 PF00179 0.288
TRG_DiLeu_BaEn_1 427 432 PF01217 0.296
TRG_ENDOCYTIC_2 104 107 PF00928 0.459
TRG_ER_diArg_1 5 7 PF00400 0.679
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 35% 73%
A0A0N1I661 Leptomonas seymouri 40% 81%
A0A0N1I7S5 Leptomonas seymouri 33% 91%
A0A0N1II82 Leptomonas seymouri 36% 67%
A0A0S4ISU4 Bodo saltans 36% 70%
A0A0S4IVN7 Bodo saltans 34% 100%
A0A0S4IVQ8 Bodo saltans 36% 77%
A0A0S4IZC7 Bodo saltans 27% 100%
A0A0S4J3T7 Bodo saltans 30% 100%
A0A0S4J7Q5 Bodo saltans 28% 100%
A0A0S4JAQ6 Bodo saltans 25% 90%
A0A0S4JAS1 Bodo saltans 28% 73%
A0A0S4JB95 Bodo saltans 26% 76%
A0A0S4JD35 Bodo saltans 29% 77%
A0A0S4JDT0 Bodo saltans 28% 70%
A0A0S4JEK1 Bodo saltans 26% 100%
A0A0S4JMF9 Bodo saltans 34% 100%
A0A0S4JP43 Bodo saltans 35% 100%
A0A0S4KGV4 Bodo saltans 24% 85%
A0A0S4KH41 Bodo saltans 28% 67%
A0A0S4KJA7 Bodo saltans 25% 69%
A0A0S4KK37 Bodo saltans 27% 79%
A0A0S4KMV2 Bodo saltans 27% 100%
A0A3Q8I9A6 Leishmania donovani 51% 100%
A0A3Q8IC27 Leishmania donovani 34% 97%
A0A3Q8IFC2 Leishmania donovani 32% 100%
A0A3S5H6M3 Leishmania donovani 59% 67%
A0A3S5H6M4 Leishmania donovani 55% 70%
A0A3S7WS66 Leishmania donovani 55% 70%
A4HBX3 Leishmania braziliensis 38% 100%
A4HJX1 Leishmania braziliensis 31% 100%
A4HVB0 Leishmania infantum 47% 85%
A4HZ93 Leishmania infantum 34% 100%
A4I6S3 Leishmania infantum 32% 100%
E9AEF4 Leishmania major 32% 100%
E9AGG2 Leishmania infantum 60% 70%
E9AGG5 Leishmania infantum 53% 85%
E9AGG7 Leishmania infantum 57% 74%
E9AGG9 Leishmania infantum 63% 86%
E9AGH0 Leishmania infantum 56% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 78%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 84%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 66%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 79%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 85%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q25331 Leishmania major 49% 76%
Q4QC79 Leishmania major 34% 100%
Q4QGI0 Leishmania major 62% 100%
Q4QGI2 Leishmania major 54% 83%
Q4QGI4 Leishmania major 54% 86%
Q4QGI6 Leishmania major 61% 100%
Q4QGJ0 Leishmania major 50% 74%
Q4QGJ2 Leishmania major 51% 100%
Q4QGJ4 Leishmania major 49% 76%
Q4QGJ6 Leishmania major 61% 81%
Q4QGJ7 Leishmania major 50% 76%
Q4QGJ9 Leishmania major 55% 100%
Q4QGK0 Leishmania major 55% 100%
Q4QGK2 Leishmania major 54% 83%
Q4QGK4 Leishmania major 51% 69%
Q4QGK6 Leishmania major 49% 76%
Q4QGK8 Leishmania major 55% 100%
Q4QGL2 Leishmania major 55% 100%
Q4QGL4 Leishmania major 60% 85%
Q4QGL5 Leishmania major 58% 100%
Q4QGL8 Leishmania major 63% 76%
Q8W3M4 Arabidopsis thaliana 23% 100%
Q9SSD1 Arabidopsis thaliana 26% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS