Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquinone biosynthesis protein-like protein, putative

Species:

Leishmania major

UniProt:

COQ4_LEIMA

TriTrypDb:

LmjF.09.1430 , LMJLV39_090021700 , LMJSD75_090021400

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0019898	extrinsic component of membrane	2	11
GO:0031312	extrinsic component of organelle membrane	3	11
GO:0031314	extrinsic component of mitochondrial inner membrane	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QHN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHN2

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	183	185	PF00082	0.396
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.370
CLV_PCSK_SKI1_1	12	16	PF00082	0.237
DEG_Nend_UBRbox_1	1	4	PF02207	0.292
DOC_CDC14_PxL_1	114	122	PF14671	0.350
DOC_MAPK_MEF2A_6	102	110	PF00069	0.255
DOC_MAPK_MEF2A_6	143	151	PF00069	0.382
DOC_PP1_RVXF_1	127	133	PF00149	0.398
DOC_PP2B_LxvP_1	153	156	PF13499	0.344
DOC_WW_Pin1_4	172	177	PF00397	0.255
LIG_14-3-3_CanoR_1	119	125	PF00244	0.377
LIG_APCC_ABBA_1	128	133	PF00400	0.279
LIG_LIR_Gen_1	164	171	PF02991	0.288
LIG_LIR_Gen_1	78	83	PF02991	0.422
LIG_LIR_Nem_3	164	168	PF02991	0.304
LIG_LIR_Nem_3	78	82	PF02991	0.422
LIG_NRBOX	109	115	PF00104	0.292
LIG_SH2_CRK	17	21	PF00017	0.149
LIG_SH2_CRK	171	175	PF00017	0.292
LIG_SH2_GRB2like	152	155	PF00017	0.333
LIG_SH2_SRC	152	155	PF00017	0.370
LIG_SH2_SRC	165	168	PF00017	0.370
LIG_SH2_SRC	17	20	PF00017	0.165
LIG_SH2_STAP1	165	169	PF00017	0.314
LIG_SH2_STAP1	41	45	PF00017	0.300
LIG_SH2_STAT5	152	155	PF00017	0.256
LIG_SH2_STAT5	171	174	PF00017	0.151
LIG_SH2_STAT5	68	71	PF00017	0.237
LIG_SH3_3	144	150	PF00018	0.413
LIG_TRAF2_1	89	92	PF00917	0.237
LIG_TYR_ITIM	15	20	PF00017	0.149
LIG_TYR_ITIM	169	174	PF00017	0.253
MOD_CK1_1	53	59	PF00069	0.243
MOD_CK2_1	86	92	PF00069	0.237
MOD_GlcNHglycan	120	123	PF01048	0.214
MOD_GlcNHglycan	52	55	PF01048	0.300
MOD_NEK2_1	26	31	PF00069	0.357
MOD_PK_1	10	16	PF00069	0.292
MOD_PKA_2	118	124	PF00069	0.358
MOD_Plk_4	109	115	PF00069	0.370
MOD_ProDKin_1	172	178	PF00069	0.255
TRG_ENDOCYTIC_2	152	155	PF00928	0.328
TRG_ENDOCYTIC_2	165	168	PF00928	0.215
TRG_ENDOCYTIC_2	17	20	PF00928	0.149
TRG_ENDOCYTIC_2	171	174	PF00928	0.150
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.149
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEX5	Leptomonas seymouri	69%	78%
A0A1X0NI19	Trypanosomatidae	58%	74%
A0A3R7M889	Trypanosoma rangeli	54%	77%
A0A3S7WQX8	Leishmania donovani	96%	100%
A0DUC3	Paramecium tetraurelia	32%	81%
A4H5X0	Leishmania braziliensis	87%	100%
A4HU65	Leishmania infantum	96%	100%
A6QW12	Ajellomyces capsulatus (strain NAm1 / WU24)	36%	68%
A6SS55	Botryotinia fuckeliana (strain B05.10)	34%	67%
A7F6D9	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	33%	66%
A7SNR3	Nematostella vectensis	35%	90%
A9JR86	Danio rerio	32%	69%
A9JS49	Xenopus laevis	31%	66%
B0WH96	Culex quinquefasciatus	32%	70%
B3M6C8	Drosophila ananassae	34%	70%
B3NHV5	Drosophila erecta	32%	70%
B4H6M2	Drosophila persimilis	33%	70%
B4HKS2	Drosophila sechellia	34%	70%
B4J252	Drosophila grimshawi	35%	71%
B4KZ16	Drosophila mojavensis	33%	71%
B4LE89	Drosophila virilis	36%	71%
B4N6G2	Drosophila willistoni	34%	71%
B4PJV6	Drosophila yakuba	34%	70%
B4QNU8	Drosophila simulans	34%	70%
B6JWE5	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	38%	78%
C0HL93	Caenorhabditis briggsae	26%	82%
C0NJU0	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	37%	68%
C4JE58	Uncinocarpus reesii (strain UAMH 1704)	34%	67%
C5FZH5	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	36%	70%
C5PIQ6	Coccidioides posadasii (strain C735)	34%	66%
D0A9P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	75%
E9AMZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O94453	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	69%
P91428	Caenorhabditis elegans	29%	81%
Q16FT5	Aedes aegypti	33%	68%
Q1EAH9	Coccidioides immitis (strain RS)	34%	66%
Q1HPV1	Bombyx mori	30%	72%
Q28CM7	Xenopus tropicalis	32%	67%
Q2H4H9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	36%	80%
Q2LZH7	Drosophila pseudoobscura pseudoobscura	33%	70%
Q382H9	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	56%	75%
Q4DBV7	Trypanosoma cruzi (strain CL Brener)	55%	74%
Q4DLX3	Trypanosoma cruzi (strain CL Brener)	54%	74%
Q4FZU1	Rattus norvegicus	30%	71%
Q4QHN2	Leishmania major	100%	100%
Q6C074	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	71%
Q7Q9J8	Anopheles gambiae	32%	66%
Q8BGB8	Mus musculus	30%	70%
Q9VVG6	Drosophila melanogaster	34%	70%
Q9Y3A0	Homo sapiens	30%	71%
Q9ZPR0	Arabidopsis thaliana	30%	83%
V5BI62	Trypanosoma cruzi	55%	74%