LeishMANIAdb
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Probable citrate synthase, mitochondrial

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable citrate synthase, mitochondrial
Gene product:
citrate synthase - putative
Species:
Leishmania infantum
UniProt:
CISY_LEIIN
TriTrypDb:
LINF_180012100 *
Length:
470

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, citrate synthase, mitochondrial LinJ18.0690

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 1
Forrest at al. (procyclic) no yes: 1
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 5
GO:0031974 membrane-enclosed lumen 2 5
GO:0043233 organelle lumen 3 5
GO:0070013 intracellular organelle lumen 4 5
GO:0110165 cellular anatomical entity 1 5
GO:0005739 mitochondrion 5 2
GO:0020023 kinetoplast 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A4HXU4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXU4

Function

Biological processes
Term Name Level Count
GO:0006099 tricarboxylic acid cycle 3 5
GO:0008152 metabolic process 1 5
GO:0044238 primary metabolic process 2 5
GO:0005975 carbohydrate metabolic process 3 2
GO:0006082 organic acid metabolic process 3 1
GO:0006101 citrate metabolic process 7 1
GO:0009987 cellular process 1 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
GO:0071704 organic substance metabolic process 2 2
GO:0072350 tricarboxylic acid metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016740 transferase activity 2 16
GO:0016746 acyltransferase activity 3 16
GO:0036440 citrate synthase activity 5 5
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer 4 16
GO:0004108 citrate (Si)-synthase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 75 79 PF00656 0.550
CLV_NRD_NRD_1 135 137 PF00675 0.313
CLV_NRD_NRD_1 31 33 PF00675 0.587
CLV_NRD_NRD_1 354 356 PF00675 0.380
CLV_NRD_NRD_1 43 45 PF00675 0.497
CLV_PCSK_KEX2_1 135 137 PF00082 0.313
CLV_PCSK_KEX2_1 31 33 PF00082 0.550
CLV_PCSK_SKI1_1 306 310 PF00082 0.293
CLV_PCSK_SKI1_1 330 334 PF00082 0.279
CLV_PCSK_SKI1_1 454 458 PF00082 0.457
CLV_PCSK_SKI1_1 65 69 PF00082 0.300
CLV_PCSK_SKI1_1 86 90 PF00082 0.300
DEG_Nend_UBRbox_1 1 4 PF02207 0.600
DEG_SPOP_SBC_1 268 272 PF00917 0.580
DOC_ANK_TNKS_1 313 320 PF00023 0.577
DOC_CYCLIN_RxL_1 235 246 PF00134 0.424
DOC_CYCLIN_RxL_1 303 313 PF00134 0.535
DOC_CYCLIN_yCln2_LP_2 278 284 PF00134 0.552
DOC_MAPK_gen_1 214 222 PF00069 0.572
DOC_MAPK_gen_1 314 322 PF00069 0.500
DOC_MAPK_MEF2A_6 248 257 PF00069 0.537
DOC_MAPK_NFAT4_5 248 256 PF00069 0.479
DOC_PP1_RVXF_1 236 243 PF00149 0.550
DOC_PP2B_LxvP_1 222 225 PF13499 0.572
DOC_USP7_MATH_1 181 185 PF00917 0.509
DOC_USP7_MATH_1 223 227 PF00917 0.552
DOC_USP7_UBL2_3 183 187 PF12436 0.553
DOC_USP7_UBL2_3 330 334 PF12436 0.528
DOC_USP7_UBL2_3 34 38 PF12436 0.524
DOC_USP7_UBL2_3 393 397 PF12436 0.504
DOC_WW_Pin1_4 201 206 PF00397 0.513
LIG_14-3-3_CanoR_1 16 22 PF00244 0.533
LIG_14-3-3_CanoR_1 252 258 PF00244 0.540
LIG_14-3-3_CanoR_1 360 367 PF00244 0.508
LIG_Actin_WH2_2 1 18 PF00022 0.502
LIG_APCC_ABBA_1 255 260 PF00400 0.500
LIG_APCC_ABBA_1 320 325 PF00400 0.544
LIG_deltaCOP1_diTrp_1 229 236 PF00928 0.490
LIG_FHA_1 115 121 PF00498 0.510
LIG_FHA_1 202 208 PF00498 0.530
LIG_FHA_1 268 274 PF00498 0.501
LIG_FHA_1 334 340 PF00498 0.545
LIG_FHA_1 456 462 PF00498 0.548
LIG_FHA_1 66 72 PF00498 0.500
LIG_FHA_2 186 192 PF00498 0.580
LIG_FHA_2 87 93 PF00498 0.500
LIG_GBD_Chelix_1 380 388 PF00786 0.282
LIG_IBAR_NPY_1 400 402 PF08397 0.580
LIG_LIR_Gen_1 171 180 PF02991 0.552
LIG_LIR_Gen_1 279 289 PF02991 0.513
LIG_LIR_Gen_1 336 345 PF02991 0.500
LIG_LIR_Gen_1 383 392 PF02991 0.498
LIG_LIR_Nem_3 109 115 PF02991 0.546
LIG_LIR_Nem_3 171 175 PF02991 0.543
LIG_LIR_Nem_3 188 192 PF02991 0.437
LIG_LIR_Nem_3 279 285 PF02991 0.500
LIG_LIR_Nem_3 336 340 PF02991 0.489
LIG_LIR_Nem_3 375 381 PF02991 0.530
LIG_LIR_Nem_3 420 426 PF02991 0.467
LIG_LYPXL_yS_3 402 405 PF13949 0.552
LIG_PCNA_yPIPBox_3 301 314 PF02747 0.520
LIG_PCNA_yPIPBox_3 370 381 PF02747 0.442
LIG_Pex14_1 232 236 PF04695 0.488
LIG_PTB_Apo_2 379 386 PF02174 0.580
LIG_PTB_Phospho_1 379 385 PF10480 0.580
LIG_Rb_LxCxE_1 89 109 PF01857 0.553
LIG_SH2_CRK 424 428 PF00017 0.460
LIG_SH2_SRC 72 75 PF00017 0.552
LIG_SH2_STAP1 172 176 PF00017 0.580
LIG_SH2_STAP1 335 339 PF00017 0.550
LIG_SH2_STAP1 424 428 PF00017 0.460
LIG_SH2_STAT3 361 364 PF00017 0.540
LIG_SH2_STAT5 254 257 PF00017 0.500
LIG_SH2_STAT5 282 285 PF00017 0.500
LIG_SH2_STAT5 307 310 PF00017 0.500
LIG_SH2_STAT5 335 338 PF00017 0.550
LIG_SH2_STAT5 361 364 PF00017 0.500
LIG_SH2_STAT5 424 427 PF00017 0.460
LIG_SH2_STAT5 465 468 PF00017 0.611
LIG_SH3_3 68 74 PF00018 0.528
LIG_SH3_3 95 101 PF00018 0.540
LIG_SUMO_SIM_par_1 165 171 PF11976 0.580
LIG_TRAF2_1 121 124 PF00917 0.607
LIG_TRAF2_1 300 303 PF00917 0.500
LIG_TRAF2_1 310 313 PF00917 0.500
LIG_UBA3_1 308 316 PF00899 0.352
LIG_UBA3_1 387 393 PF00899 0.326
MOD_CK1_1 267 273 PF00069 0.363
MOD_CK1_1 276 282 PF00069 0.311
MOD_CK1_1 455 461 PF00069 0.458
MOD_CK2_1 185 191 PF00069 0.454
MOD_CK2_1 307 313 PF00069 0.486
MOD_CK2_1 86 92 PF00069 0.352
MOD_GlcNHglycan 266 269 PF01048 0.360
MOD_GlcNHglycan 275 278 PF01048 0.339
MOD_GlcNHglycan 285 288 PF01048 0.268
MOD_GlcNHglycan 341 344 PF01048 0.465
MOD_GlcNHglycan 408 411 PF01048 0.352
MOD_GlcNHglycan 78 81 PF01048 0.499
MOD_GSK3_1 181 188 PF00069 0.380
MOD_GSK3_1 264 271 PF00069 0.357
MOD_GSK3_1 72 79 PF00069 0.324
MOD_N-GLC_1 264 269 PF02516 0.352
MOD_N-GLC_2 366 368 PF02516 0.492
MOD_NEK2_1 17 22 PF00069 0.537
MOD_NEK2_1 253 258 PF00069 0.395
MOD_NEK2_1 273 278 PF00069 0.168
MOD_NEK2_1 283 288 PF00069 0.352
MOD_NEK2_1 339 344 PF00069 0.438
MOD_NEK2_1 380 385 PF00069 0.377
MOD_NEK2_1 4 9 PF00069 0.698
MOD_NEK2_1 428 433 PF00069 0.358
MOD_PK_1 452 458 PF00069 0.486
MOD_PKA_2 213 219 PF00069 0.377
MOD_PKA_2 30 36 PF00069 0.374
MOD_PKA_2 359 365 PF00069 0.383
MOD_PKA_2 4 10 PF00069 0.633
MOD_PKB_1 84 92 PF00069 0.372
MOD_Plk_1 194 200 PF00069 0.374
MOD_Plk_1 53 59 PF00069 0.477
MOD_Plk_2-3 119 125 PF00069 0.427
MOD_Plk_4 17 23 PF00069 0.432
MOD_Plk_4 185 191 PF00069 0.454
MOD_Plk_4 269 275 PF00069 0.341
MOD_Plk_4 380 386 PF00069 0.355
MOD_Plk_4 4 10 PF00069 0.570
MOD_Plk_4 422 428 PF00069 0.296
MOD_Plk_4 72 78 PF00069 0.367
MOD_Plk_4 86 92 PF00069 0.352
MOD_ProDKin_1 201 207 PF00069 0.372
MOD_SUMO_rev_2 33 40 PF00179 0.539
TRG_ENDOCYTIC_2 172 175 PF00928 0.465
TRG_ENDOCYTIC_2 254 257 PF00928 0.341
TRG_ENDOCYTIC_2 282 285 PF00928 0.372
TRG_ENDOCYTIC_2 385 388 PF00928 0.339
TRG_ENDOCYTIC_2 402 405 PF00928 0.414
TRG_ENDOCYTIC_2 423 426 PF00928 0.360
TRG_ENDOCYTIC_2 61 64 PF00928 0.445
TRG_ER_diArg_1 135 137 PF00400 0.272
TRG_ER_diArg_1 30 32 PF00400 0.568
TRG_NES_CRM1_1 105 119 PF08389 0.465
TRG_NLS_Bipartite_1 31 48 PF00514 0.593
TRG_Pf-PMV_PEXEL_1 127 132 PF00026 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I014 Leptomonas seymouri 83% 100%
A0A0S3QTD0 Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6) 50% 100%
A0A1X0P7W7 Trypanosomatidae 65% 100%
A0A3Q8IB05 Leishmania donovani 97% 100%
A0A3Q8IB38 Leishmania donovani 99% 100%
A0A422P1U5 Trypanosoma rangeli 65% 100%
A4H9H8 Leishmania braziliensis 87% 100%
A4H9H9 Leishmania braziliensis 85% 100%
A4HXU4 Leishmania infantum 100% 100%
A4HXU5 Leishmania infantum 97% 100%
B0YD89 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 48% 100%
C7C435 Fusarium solani 47% 100%
C7C436 Gibberella moniliformis 47% 100%
C9ZZW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 97%
D4GS06 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 28% 100%
E9ARK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9ARK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
H8F0D7 Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) 26% 100%
I6Y9Q3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
O00098 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 56% 99%
O33915 Rhizobium meliloti (strain 1021) 29% 100%
O34002 Antarctic bacterium DS2-3R 26% 100%
O68883 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 29% 100%
O75390 Homo sapiens 55% 100%
O80433 Daucus carota 55% 100%
P00889 Sus scrofa 54% 100%
P00890 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 54% 98%
P08679 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 52% 100%
P09948 Rickettsia prowazekii (strain Madrid E) 26% 100%
P0ABH7 Escherichia coli (strain K12) 29% 100%
P0ABH8 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 29% 100%
P0C1Z2 Macaca fascicularis 55% 100%
P14165 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 26% 100%
P18789 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 30% 100%
P20115 Arabidopsis thaliana 52% 99%
P20901 Acetobacter aceti 27% 100%
P20902 Acinetobacter calcoaceticus subsp. anitratus 27% 100%
P21553 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 27% 100%
P23007 Gallus gallus 52% 100%
P24118 Tetrahymena thermophila 47% 100%
P27660 Weizmannia coagulans 26% 100%
P31660 Escherichia coli (strain K12) 25% 100%
P34085 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 55% 100%
P34575 Caenorhabditis elegans 52% 100%
P39119 Bacillus subtilis (strain 168) 24% 100%
P39120 Bacillus subtilis (strain 168) 25% 100%
P42457 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 26% 100%
P43635 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 97%
P45858 Bacillus subtilis (strain 168) 24% 100%
P49298 Citrus maxima 53% 100%
P49299 Cucurbita maxima 25% 91%
P51031 Bartonella bacilliformis 28% 100%
P51032 Bartonella elizabethae 29% 100%
P51033 Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) 29% 100%
P51034 Bartonella quintana (strain Toulouse) 28% 100%
P51036 Bartonella vinsonii 29% 100%
P51037 Rhizobium tropici 28% 100%
P51038 Rhizobium tropici 28% 100%
P51039 Rickettsia australis 27% 100%
P51040 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 26% 100%
P51041 Rickettsia canadensis 25% 100%
P51042 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 26% 100%
P51043 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 26% 100%
P51044 Aspergillus niger 57% 99%
P51045 Acidithiobacillus ferridurans 24% 100%
P56062 Helicobacter pylori (strain ATCC 700392 / 26695) 28% 100%
P79024 Candida tropicalis 52% 100%
P80148 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 26% 100%
P83372 Fragaria ananassa 51% 100%
P94325 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 26% 100%
P9WPD4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 100%
P9WPD5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 100%
Q0GNE0 Iguana iguana 53% 100%
Q0GNE1 Amblyrhynchus cristatus 53% 100%
Q0QHL3 Glossina morsitans morsitans 53% 100%
Q10306 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 53% 97%
Q16P20 Aedes aegypti 54% 100%
Q17GM7 Aedes aegypti 54% 100%
Q1RGV8 Rickettsia bellii (strain RML369-C) 26% 100%
Q28DK1 Xenopus tropicalis 53% 100%
Q29RK1 Bos taurus 54% 100%
Q2TXF1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 24% 100%
Q43175 Solanum tuberosum 49% 100%
Q4QDX2 Leishmania major 94% 100%
Q4QDX3 Leishmania major 95% 100%
Q4S5X1 Tetraodon nigroviridis 54% 100%
Q50I20 Neosartorya fumigata 48% 100%
Q53554 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 25% 100%
Q553V1 Dictyostelium discoideum 55% 100%
Q56063 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 100%
Q59136 Rickettsia conorii subsp. caspia (strain A-167) 27% 100%
Q59198 Bartonella doshiae 29% 100%
Q59258 Bartonella taylorii 29% 100%
Q59730 Rickettsia akari 25% 100%
Q59732 Rickettsia africae (strain ESF-5) 27% 100%
Q59734 Rickettsia bellii 27% 100%
Q59741 Rickettsia helvetica 27% 100%
Q59742 Rickettsia japonica 27% 100%
Q59748 Rickettsia massiliae 27% 100%
Q59759 Rickettsia parkeri 27% 100%
Q59768 Rickettsia rhipicephali 27% 100%
Q59776 Rickettsia slovaca (strain 13-B) 27% 100%
Q59778 Rickettsia sibirica (strain ATCC VR-151 / 246) 27% 100%
Q59939 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 27% 100%
Q59977 Synechocystis sp. (strain PCC 6803 / Kazusa) 27% 100%
Q61JF9 Caenorhabditis briggsae 52% 100%
Q6C793 Yarrowia lipolytica (strain CLIB 122 / E 150) 54% 100%
Q6S9V5 Kajikia audax 53% 100%
Q6S9V6 Xiphias gladius 54% 100%
Q6S9V7 Katsuwonus pelamis 54% 100%
Q6S9V8 Thunnus obesus 54% 100%
Q6S9V9 Thunnus albacares 54% 100%
Q7ZVY5 Danio rerio 54% 100%
Q7ZWZ5 Xenopus laevis 54% 100%
Q86AV6 Dictyostelium discoideum 27% 92%
Q8EJW2 Shewanella oneidensis (strain MR-1) 23% 100%
Q8MQU6 Dictyostelium discoideum 24% 96%
Q8NSH7 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 26% 100%
Q8NSL1 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 27% 100%
Q8VHF5 Rattus norvegicus 53% 100%
Q937N9 Cupriavidus necator 24% 100%
Q9CZU6 Mus musculus 54% 100%
Q9LXS6 Arabidopsis thaliana 27% 91%
Q9LXS7 Arabidopsis thaliana 23% 98%
Q9M1D3 Arabidopsis thaliana 53% 100%
Q9RWB2 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 29% 100%
Q9SJH7 Arabidopsis thaliana 26% 92%
Q9TEM3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 48% 100%
Q9W401 Drosophila melanogaster 55% 100%
Q9ZN37 Helicobacter pylori (strain J99 / ATCC 700824) 29% 100%
V5BWC7 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS