Ribosome biogenesis protein BOP1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 89, putative

Species:

Leishmania braziliensis

UniProt:

BOP1_LEIBR

TriTrypDb:

LbrM.11.0090 , LBRM2903_110005800

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005730	nucleolus	5	12
GO:0030684	preribosome	3	11
GO:0030687	preribosome, large subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11
GO:0070545	PeBoW complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H6F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F7

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	11
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	11
GO:0000470	maturation of LSU-rRNA	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.709
CLV_C14_Caspase3-7	484	488	PF00656	0.697
CLV_C14_Caspase3-7	510	514	PF00656	0.435
CLV_C14_Caspase3-7	70	74	PF00656	0.565
CLV_C14_Caspase3-7	8	12	PF00656	0.625
CLV_NRD_NRD_1	209	211	PF00675	0.332
CLV_NRD_NRD_1	292	294	PF00675	0.335
CLV_NRD_NRD_1	566	568	PF00675	0.379
CLV_NRD_NRD_1	573	575	PF00675	0.409
CLV_NRD_NRD_1	612	614	PF00675	0.376
CLV_PCSK_FUR_1	505	509	PF00082	0.467
CLV_PCSK_KEX2_1	209	211	PF00082	0.280
CLV_PCSK_KEX2_1	292	294	PF00082	0.194
CLV_PCSK_KEX2_1	403	405	PF00082	0.396
CLV_PCSK_KEX2_1	507	509	PF00082	0.433
CLV_PCSK_KEX2_1	566	568	PF00082	0.379
CLV_PCSK_KEX2_1	612	614	PF00082	0.365
CLV_PCSK_KEX2_1	655	657	PF00082	0.374
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.396
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.433
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.394
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.374
CLV_PCSK_PC7_1	288	294	PF00082	0.194
CLV_PCSK_SKI1_1	106	110	PF00082	0.298
CLV_PCSK_SKI1_1	112	116	PF00082	0.302
CLV_PCSK_SKI1_1	191	195	PF00082	0.348
CLV_PCSK_SKI1_1	221	225	PF00082	0.408
CLV_PCSK_SKI1_1	400	404	PF00082	0.406
CLV_PCSK_SKI1_1	479	483	PF00082	0.724
CLV_PCSK_SKI1_1	567	571	PF00082	0.376
CLV_PCSK_SKI1_1	612	616	PF00082	0.493
CLV_PCSK_SKI1_1	701	705	PF00082	0.383
CLV_PCSK_SKI1_1	709	713	PF00082	0.228
DEG_APCC_DBOX_1	111	119	PF00400	0.315
DEG_APCC_DBOX_1	587	595	PF00400	0.239
DOC_CDC14_PxL_1	453	461	PF14671	0.586
DOC_CYCLIN_yClb1_LxF_4	356	361	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	704	710	PF00134	0.375
DOC_MAPK_DCC_7	701	710	PF00069	0.379
DOC_MAPK_gen_1	317	326	PF00069	0.299
DOC_MAPK_gen_1	329	337	PF00069	0.299
DOC_MAPK_gen_1	517	525	PF00069	0.428
DOC_MAPK_gen_1	555	564	PF00069	0.352
DOC_MAPK_HePTP_8	314	326	PF00069	0.299
DOC_MAPK_MEF2A_6	317	326	PF00069	0.293
DOC_MAPK_MEF2A_6	519	527	PF00069	0.375
DOC_MAPK_MEF2A_6	555	564	PF00069	0.352
DOC_MAPK_MEF2A_6	701	710	PF00069	0.379
DOC_MAPK_NFAT4_5	557	565	PF00069	0.466
DOC_PP1_RVXF_1	356	362	PF00149	0.299
DOC_PP2B_LxvP_1	454	457	PF13499	0.431
DOC_PP2B_LxvP_1	704	707	PF13499	0.369
DOC_PP4_FxxP_1	435	438	PF00568	0.318
DOC_USP7_MATH_1	110	114	PF00917	0.194
DOC_USP7_MATH_1	184	188	PF00917	0.325
DOC_USP7_MATH_1	418	422	PF00917	0.495
DOC_USP7_UBL2_3	105	109	PF12436	0.381
DOC_USP7_UBL2_3	202	206	PF12436	0.299
DOC_USP7_UBL2_3	551	555	PF12436	0.398
DOC_WW_Pin1_4	373	378	PF00397	0.472
LIG_14-3-3_CanoR_1	155	163	PF00244	0.384
LIG_14-3-3_CanoR_1	371	376	PF00244	0.493
LIG_14-3-3_CanoR_1	479	486	PF00244	0.739
LIG_14-3-3_CanoR_1	656	664	PF00244	0.381
LIG_APCC_ABBA_1	352	357	PF00400	0.299
LIG_APCC_ABBA_1	37	42	PF00400	0.542
LIG_APCC_ABBA_1	624	629	PF00400	0.343
LIG_BIR_III_4	28	32	PF00653	0.705
LIG_BRCT_BRCA1_1	431	435	PF00533	0.336
LIG_CSL_BTD_1	721	724	PF09270	0.458
LIG_eIF4E_1	699	705	PF01652	0.400
LIG_EVH1_2	261	265	PF00568	0.420
LIG_FHA_1	199	205	PF00498	0.374
LIG_FHA_1	331	337	PF00498	0.299
LIG_FHA_1	365	371	PF00498	0.447
LIG_FHA_1	396	402	PF00498	0.383
LIG_FHA_1	494	500	PF00498	0.656
LIG_FHA_1	557	563	PF00498	0.345
LIG_FHA_1	595	601	PF00498	0.332
LIG_FHA_1	619	625	PF00498	0.353
LIG_FHA_1	64	70	PF00498	0.569
LIG_FHA_2	128	134	PF00498	0.313
LIG_FHA_2	311	317	PF00498	0.299
LIG_FHA_2	382	388	PF00498	0.443
LIG_FHA_2	482	488	PF00498	0.599
LIG_FHA_2	489	495	PF00498	0.612
LIG_FHA_2	729	735	PF00498	0.452
LIG_Integrin_isoDGR_2	57	59	PF01839	0.656
LIG_LIR_Apic_2	266	271	PF02991	0.299
LIG_LIR_Apic_2	432	438	PF02991	0.321
LIG_LIR_Gen_1	130	138	PF02991	0.315
LIG_LIR_Gen_1	300	309	PF02991	0.371
LIG_LIR_Gen_1	430	438	PF02991	0.335
LIG_LIR_LC3C_4	333	337	PF02991	0.299
LIG_LIR_Nem_3	130	135	PF02991	0.315
LIG_LIR_Nem_3	161	166	PF02991	0.378
LIG_LIR_Nem_3	173	179	PF02991	0.301
LIG_LIR_Nem_3	246	251	PF02991	0.398
LIG_LIR_Nem_3	264	268	PF02991	0.150
LIG_LIR_Nem_3	300	304	PF02991	0.371
LIG_LIR_Nem_3	430	434	PF02991	0.406
LIG_LIR_Nem_3	673	679	PF02991	0.383
LIG_NRBOX	114	120	PF00104	0.299
LIG_Pex14_2	645	649	PF04695	0.496
LIG_SH2_CRK	132	136	PF00017	0.315
LIG_SH2_CRK	166	170	PF00017	0.194
LIG_SH2_CRK	268	272	PF00017	0.314
LIG_SH2_CRK	431	435	PF00017	0.336
LIG_SH2_GRB2like	250	253	PF00017	0.356
LIG_SH2_NCK_1	431	435	PF00017	0.336
LIG_SH2_SRC	274	277	PF00017	0.299
LIG_SH2_STAP1	431	435	PF00017	0.336
LIG_SH2_STAP1	718	722	PF00017	0.458
LIG_SH2_STAT3	394	397	PF00017	0.260
LIG_SH2_STAT5	250	253	PF00017	0.420
LIG_SH2_STAT5	274	277	PF00017	0.314
LIG_SH2_STAT5	381	384	PF00017	0.488
LIG_SH2_STAT5	5	8	PF00017	0.716
LIG_SH2_STAT5	544	547	PF00017	0.344
LIG_SH3_1	341	347	PF00018	0.315
LIG_SH3_1	584	590	PF00018	0.367
LIG_SH3_3	172	178	PF00018	0.420
LIG_SH3_3	251	257	PF00018	0.304
LIG_SH3_3	333	339	PF00018	0.299
LIG_SH3_3	341	347	PF00018	0.299
LIG_SH3_3	566	572	PF00018	0.375
LIG_SH3_3	584	590	PF00018	0.183
LIG_TRAF2_1	223	226	PF00917	0.359
LIG_TYR_ITIM	429	434	PF00017	0.359
LIG_UBA3_1	342	350	PF00899	0.334
LIG_UBA3_1	560	568	PF00899	0.357
LIG_WRC_WIRS_1	437	442	PF05994	0.409
LIG_WW_1	271	274	PF00397	0.315
MOD_CK1_1	187	193	PF00069	0.278
MOD_CK1_1	640	646	PF00069	0.458
MOD_CK1_1	72	78	PF00069	0.555
MOD_CK2_1	110	116	PF00069	0.315
MOD_CK2_1	488	494	PF00069	0.695
MOD_CK2_1	512	518	PF00069	0.414
MOD_CK2_1	72	78	PF00069	0.555
MOD_CK2_1	728	734	PF00069	0.307
MOD_Cter_Amidation	103	106	PF01082	0.294
MOD_GlcNHglycan	111	115	PF01048	0.316
MOD_GlcNHglycan	166	169	PF01048	0.294
MOD_GlcNHglycan	186	189	PF01048	0.383
MOD_GlcNHglycan	459	462	PF01048	0.614
MOD_GlcNHglycan	513	517	PF01048	0.439
MOD_GlcNHglycan	616	619	PF01048	0.526
MOD_GSK3_1	183	190	PF00069	0.420
MOD_GSK3_1	369	376	PF00069	0.321
MOD_GSK3_1	574	581	PF00069	0.415
MOD_GSK3_1	614	621	PF00069	0.393
MOD_GSK3_1	635	642	PF00069	0.349
MOD_LATS_1	362	368	PF00433	0.420
MOD_N-GLC_1	155	160	PF02516	0.299
MOD_NEK2_1	183	188	PF00069	0.420
MOD_NEK2_1	198	203	PF00069	0.356
MOD_NEK2_1	512	517	PF00069	0.450
MOD_NEK2_1	562	567	PF00069	0.352
MOD_NEK2_1	593	598	PF00069	0.352
MOD_NEK2_1	614	619	PF00069	0.493
MOD_NEK2_1	63	68	PF00069	0.569
MOD_NEK2_1	678	683	PF00069	0.345
MOD_NEK2_2	127	132	PF00069	0.299
MOD_PIKK_1	479	485	PF00454	0.592
MOD_PIKK_1	63	69	PF00454	0.533
MOD_PK_1	371	377	PF00069	0.334
MOD_PKA_1	574	580	PF00069	0.421
MOD_PKA_2	156	162	PF00069	0.420
MOD_PKA_2	184	190	PF00069	0.329
MOD_PKA_2	556	562	PF00069	0.351
MOD_Plk_1	110	116	PF00069	0.375
MOD_Plk_1	170	176	PF00069	0.420
MOD_Plk_1	429	435	PF00069	0.339
MOD_Plk_1	447	453	PF00069	0.379
MOD_Plk_1	77	83	PF00069	0.432
MOD_Plk_4	170	176	PF00069	0.420
MOD_Plk_4	429	435	PF00069	0.327
MOD_Plk_4	556	562	PF00069	0.351
MOD_Plk_4	640	646	PF00069	0.434
MOD_ProDKin_1	373	379	PF00069	0.334
MOD_SUMO_for_1	108	111	PF00179	0.315
MOD_SUMO_rev_2	101	107	PF00179	0.370
MOD_SUMO_rev_2	133	142	PF00179	0.299
MOD_SUMO_rev_2	214	220	PF00179	0.341
MOD_SUMO_rev_2	90	98	PF00179	0.400
TRG_DiLeu_BaEn_1	103	108	PF01217	0.294
TRG_DiLeu_BaEn_2	588	594	PF01217	0.354
TRG_DiLeu_BaEn_2	628	634	PF01217	0.368
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.315
TRG_ENDOCYTIC_2	132	135	PF00928	0.315
TRG_ENDOCYTIC_2	16	19	PF00928	0.705
TRG_ENDOCYTIC_2	166	169	PF00928	0.305
TRG_ENDOCYTIC_2	431	434	PF00928	0.342
TRG_ENDOCYTIC_2	603	606	PF00928	0.360
TRG_ENDOCYTIC_2	654	657	PF00928	0.381
TRG_ENDOCYTIC_2	676	679	PF00928	0.363
TRG_ER_diArg_1	208	210	PF00400	0.301
TRG_ER_diArg_1	332	335	PF00400	0.299
TRG_ER_diArg_1	612	614	PF00400	0.380
TRG_NLS_MonoExtN_4	652	659	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I232	Leptomonas seymouri	90%	90%
A0A0S4IU17	Bodo saltans	69%	93%
A0A1X0NV50	Trypanosomatidae	77%	91%
A0A3S5H6I3	Leishmania donovani	94%	92%
A0A422NYV3	Trypanosoma rangeli	78%	95%
A0JMQ0	Danio rerio	34%	96%
A1CQI9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	33%	94%
A1D3F5	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	33%	94%
A2QPZ4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	33%	94%
A3LXF0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	92%
A4H6F7	Leishmania braziliensis	100%	100%
A4HUV2	Leishmania infantum	93%	92%
A4IHS2	Xenopus tropicalis	35%	100%
A4R0Q1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	96%
A5DBG1	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	34%	94%
A5DWF4	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	85%
A6QX61	Ajellomyces capsulatus (strain NAm1 / WU24)	32%	94%
A6RRD4	Botryotinia fuckeliana (strain B05.10)	32%	97%
A6ZMA9	Saccharomyces cerevisiae (strain YJM789)	32%	92%
A8NWR2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	31%	99%
A8PWB6	Brugia malayi	29%	100%
A8QD31	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	33%	86%
A8XYW9	Caenorhabditis briggsae	31%	100%
A9UZS7	Monosiga brevicollis	35%	93%
B0WC36	Culex quinquefasciatus	32%	86%
B0XQ42	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	33%	93%
B2AY28	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	32%	95%
B2VR76	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	33%	95%
B3MHX6	Drosophila ananassae	33%	94%
B3NLK7	Drosophila erecta	34%	95%
B4GIU9	Drosophila persimilis	34%	95%
B4HN85	Drosophila sechellia	34%	95%
B4J9K1	Drosophila grimshawi	32%	95%
B4KQU8	Drosophila mojavensis	33%	94%
B4LKS9	Drosophila virilis	33%	95%
B4MYI5	Drosophila willistoni	33%	96%
B4P528	Drosophila yakuba	34%	95%
D0A7K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	95%
E9ANI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	88%
F4IH25	Arabidopsis thaliana	32%	99%
G0SCK6	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	31%	93%
O74399	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P0CS34	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	90%
P0CS35	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	90%
P97452	Mus musculus	34%	100%
Q04660	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
Q0CCP0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	34%	95%
Q0D6V7	Oryza sativa subsp. japonica	35%	100%
Q0UN56	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	33%	95%
Q14137	Homo sapiens	34%	100%
Q17LZ2	Aedes aegypti	33%	86%
Q1DRB6	Coccidioides immitis (strain RS)	32%	88%
Q28XF0	Drosophila pseudoobscura pseudoobscura	34%	95%
Q2HDW0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	32%	95%
Q2UPK0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	32%	95%
Q4P2E9	Ustilago maydis (strain 521 / FGSC 9021)	31%	80%
Q4QH39	Leishmania major	93%	100%
Q4WTI3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	93%
Q54TD8	Dictyostelium discoideum	33%	89%
Q562C2	Rattus norvegicus	34%	100%
Q59VP7	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	88%
Q5BDL3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	94%
Q6BRG6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	92%
Q6C4I9	Yarrowia lipolytica (strain CLIB 122 / E 150)	34%	91%
Q6CIH3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	94%
Q6FLA4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	92%
Q75DC5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	90%
Q7K0Y1	Drosophila melanogaster	34%	95%
Q7PTC5	Anopheles gambiae	32%	86%
Q7SEM3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	95%
Q7T0W1	Xenopus laevis	35%	100%
Q7ZXX9	Xenopus laevis	34%	100%
Q9U2A9	Caenorhabditis elegans	30%	100%
V5BRK9	Trypanosoma cruzi	77%	93%