Alpha-tubulin N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha-tubulin N-acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

ATAT_LEIBR

TriTrypDb:

LbrM.25.1130 , LBRM2903_250020800

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HE59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE59

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	11
GO:0006475	internal protein amino acid acetylation	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018205	peptidyl-lysine modification	6	11
GO:0018393	internal peptidyl-lysine acetylation	8	11
GO:0018394	peptidyl-lysine acetylation	7	11
GO:0019538	protein metabolic process	3	11
GO:0032886	regulation of microtubule-based process	4	11
GO:0033043	regulation of organelle organization	5	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043543	protein acylation	5	11
GO:0044238	primary metabolic process	2	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051128	regulation of cellular component organization	4	11
GO:0051493	regulation of cytoskeleton organization	6	11
GO:0065007	biological regulation	1	11
GO:0070507	regulation of microtubule cytoskeleton organization	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0071929	alpha-tubulin acetylation	9	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019799	tubulin N-acetyltransferase activity	4	11
GO:0034212	peptide N-acetyltransferase activity	7	11
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.371
CLV_NRD_NRD_1	43	45	PF00675	0.528
CLV_PCSK_KEX2_1	43	45	PF00082	0.528
CLV_PCSK_PC7_1	39	45	PF00082	0.492
CLV_PCSK_SKI1_1	111	115	PF00082	0.255
DEG_APCC_DBOX_1	160	168	PF00400	0.378
DEG_COP1_1	14	27	PF00400	0.534
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DOC_MAPK_JIP1_4	161	167	PF00069	0.535
DOC_PP1_RVXF_1	171	178	PF00149	0.455
DOC_PP1_RVXF_1	191	198	PF00149	0.322
DOC_PP1_SILK_1	103	108	PF00149	0.455
DOC_USP7_UBL2_3	107	111	PF12436	0.455
DOC_WW_Pin1_4	185	190	PF00397	0.466
DOC_WW_Pin1_4	214	219	PF00397	0.595
LIG_14-3-3_CanoR_1	214	218	PF00244	0.537
LIG_14-3-3_CanoR_1	68	78	PF00244	0.378
LIG_Actin_WH2_2	71	88	PF00022	0.378
LIG_BRCT_BRCA1_1	87	91	PF00533	0.378
LIG_Clathr_ClatBox_1	123	127	PF01394	0.455
LIG_Clathr_ClatBox_1	164	168	PF01394	0.378
LIG_FHA_1	114	120	PF00498	0.524
LIG_FHA_1	186	192	PF00498	0.558
LIG_FHA_1	59	65	PF00498	0.483
LIG_FHA_1	70	76	PF00498	0.469
LIG_FHA_1	88	94	PF00498	0.508
LIG_FHA_2	203	209	PF00498	0.559
LIG_FHA_2	29	35	PF00498	0.527
LIG_KLC1_Yacidic_2	133	137	PF13176	0.535
LIG_LIR_Nem_3	88	94	PF02991	0.536
LIG_OCRL_FandH_1	176	188	PF00620	0.507
LIG_Pex14_2	197	201	PF04695	0.443
LIG_SH2_STAP1	150	154	PF00017	0.535
LIG_SH2_STAT3	145	148	PF00017	0.378
LIG_SH2_STAT3	187	190	PF00017	0.469
LIG_SH2_STAT5	135	138	PF00017	0.535
LIG_SH2_STAT5	187	190	PF00017	0.469
LIG_SH2_STAT5	94	97	PF00017	0.449
LIG_SH3_3	112	118	PF00018	0.469
LIG_SH3_3	156	162	PF00018	0.558
LIG_SUMO_SIM_anti_2	61	66	PF11976	0.507
LIG_SUMO_SIM_par_1	122	127	PF11976	0.486
LIG_SUMO_SIM_par_1	163	168	PF11976	0.535
LIG_TRAF2_1	13	16	PF00917	0.570
LIG_UBA3_1	105	112	PF00899	0.385
LIG_UBA3_1	174	180	PF00899	0.535
MOD_CK1_1	28	34	PF00069	0.493
MOD_CK1_1	69	75	PF00069	0.424
MOD_CK2_1	157	163	PF00069	0.530
MOD_CK2_1	202	208	PF00069	0.486
MOD_GlcNHglycan	3	6	PF01048	0.553
MOD_GlcNHglycan	39	42	PF01048	0.302
MOD_GSK3_1	1	8	PF00069	0.417
MOD_GSK3_1	113	120	PF00069	0.510
MOD_GSK3_1	212	219	PF00069	0.582
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	113	118	PF00069	0.468
MOD_NEK2_1	201	206	PF00069	0.479
MOD_NEK2_1	212	217	PF00069	0.573
MOD_NEK2_1	7	12	PF00069	0.538
MOD_NEK2_1	85	90	PF00069	0.499
MOD_PIKK_1	66	72	PF00454	0.510
MOD_PIKK_1	94	100	PF00454	0.558
MOD_PKA_2	1	7	PF00069	0.420
MOD_PKA_2	168	174	PF00069	0.460
MOD_PKA_2	213	219	PF00069	0.536
MOD_PKA_2	28	34	PF00069	0.483
MOD_PKA_2	85	91	PF00069	0.563
MOD_Plk_2-3	19	25	PF00069	0.407
MOD_ProDKin_1	185	191	PF00069	0.466
MOD_ProDKin_1	214	220	PF00069	0.604
MOD_SUMO_for_1	230	233	PF00179	0.466
MOD_SUMO_rev_2	50	58	PF00179	0.534
TRG_DiLeu_BaEn_1	208	213	PF01217	0.544
TRG_DiLeu_BaEn_4	15	21	PF01217	0.560
TRG_ENDOCYTIC_2	150	153	PF00928	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K7	Leptomonas seymouri	63%	97%
A0A0S4IKU1	Bodo saltans	46%	72%
A0A1X0NLY3	Trypanosomatidae	53%	70%
A0A3Q8IBQ9	Leishmania donovani	81%	96%
A0A422P1Z8	Trypanosoma rangeli	52%	74%
A4HE59	Leishmania braziliensis	100%	100%
A4I1F7	Leishmania infantum	81%	96%
B2RZF9	Xenopus tropicalis	41%	79%
B3L2R5	Plasmodium knowlesi (strain H)	33%	100%
B3RNE8	Trichoplax adhaerens	43%	99%
C0H559	Plasmodium falciparum (isolate 3D7)	27%	100%
C9ZK12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	71%
E9AXJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	96%
Q16Y34	Aedes aegypti	44%	87%
Q23192	Caenorhabditis elegans	29%	90%
Q4CQJ5	Trypanosoma cruzi (strain CL Brener)	55%	72%
Q4DTX9	Trypanosoma cruzi (strain CL Brener)	54%	72%
Q4Q9X8	Leishmania major	85%	100%
Q57XX3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	51%	71%
Q58CX6	Bos taurus	46%	100%
Q5DD96	Schistosoma japonicum	35%	88%
Q5TM63	Macaca mulatta	42%	73%
Q767K7	Sus scrofa	47%	79%
Q9W5X9	Drosophila melanogaster	34%	82%
V5BCX4	Trypanosoma cruzi	54%	72%