LeishMANIAdb
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IQ calmodulin-binding motif family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
IQ calmodulin-binding motif family protein
Gene product:
IQ calmodulin-binding motif containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IE66_LEIIN
TriTrypDb:
LINF_360049900
Length:
533

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IE66
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE66

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 256 260 PF00656 0.630
CLV_NRD_NRD_1 103 105 PF00675 0.278
CLV_NRD_NRD_1 140 142 PF00675 0.298
CLV_NRD_NRD_1 285 287 PF00675 0.551
CLV_NRD_NRD_1 414 416 PF00675 0.759
CLV_NRD_NRD_1 417 419 PF00675 0.722
CLV_NRD_NRD_1 463 465 PF00675 0.612
CLV_NRD_NRD_1 529 531 PF00675 0.606
CLV_NRD_NRD_1 80 82 PF00675 0.286
CLV_PCSK_KEX2_1 105 107 PF00082 0.263
CLV_PCSK_KEX2_1 184 186 PF00082 0.513
CLV_PCSK_KEX2_1 285 287 PF00082 0.498
CLV_PCSK_KEX2_1 463 465 PF00082 0.739
CLV_PCSK_KEX2_1 468 470 PF00082 0.698
CLV_PCSK_KEX2_1 529 531 PF00082 0.557
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.295
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.529
CLV_PCSK_PC1ET2_1 468 470 PF00082 0.628
CLV_PCSK_PC7_1 464 470 PF00082 0.635
CLV_PCSK_SKI1_1 115 119 PF00082 0.362
CLV_PCSK_SKI1_1 48 52 PF00082 0.508
CLV_PCSK_SKI1_1 81 85 PF00082 0.357
DEG_COP1_1 203 210 PF00400 0.588
DEG_Nend_UBRbox_3 1 3 PF02207 0.563
DEG_SPOP_SBC_1 404 408 PF00917 0.596
DOC_CKS1_1 222 227 PF01111 0.595
DOC_CKS1_1 37 42 PF01111 0.513
DOC_CYCLIN_yCln2_LP_2 243 249 PF00134 0.512
DOC_CYCLIN_yCln2_LP_2 309 315 PF00134 0.628
DOC_MAPK_gen_1 81 87 PF00069 0.486
DOC_PP2B_LxvP_1 309 312 PF13499 0.750
DOC_PP2B_LxvP_1 385 388 PF13499 0.543
DOC_PP4_FxxP_1 214 217 PF00568 0.508
DOC_SPAK_OSR1_1 464 468 PF12202 0.636
DOC_USP7_MATH_1 159 163 PF00917 0.473
DOC_USP7_MATH_1 215 219 PF00917 0.599
DOC_USP7_MATH_1 220 224 PF00917 0.522
DOC_USP7_MATH_1 225 229 PF00917 0.501
DOC_USP7_MATH_1 250 254 PF00917 0.593
DOC_USP7_MATH_1 273 277 PF00917 0.525
DOC_USP7_MATH_1 300 304 PF00917 0.542
DOC_USP7_MATH_1 313 317 PF00917 0.529
DOC_USP7_MATH_1 333 337 PF00917 0.572
DOC_USP7_MATH_1 355 359 PF00917 0.596
DOC_USP7_MATH_1 360 364 PF00917 0.712
DOC_USP7_MATH_1 404 408 PF00917 0.626
DOC_USP7_MATH_1 442 446 PF00917 0.689
DOC_USP7_MATH_1 451 455 PF00917 0.557
DOC_USP7_MATH_1 456 460 PF00917 0.682
DOC_USP7_MATH_1 492 496 PF00917 0.692
DOC_USP7_MATH_2 373 379 PF00917 0.666
DOC_WW_Pin1_4 221 226 PF00397 0.602
DOC_WW_Pin1_4 242 247 PF00397 0.652
DOC_WW_Pin1_4 314 319 PF00397 0.646
DOC_WW_Pin1_4 347 352 PF00397 0.650
DOC_WW_Pin1_4 36 41 PF00397 0.564
LIG_14-3-3_CanoR_1 111 115 PF00244 0.480
LIG_14-3-3_CanoR_1 235 244 PF00244 0.522
LIG_14-3-3_CanoR_1 295 299 PF00244 0.653
LIG_14-3-3_CanoR_1 455 465 PF00244 0.646
LIG_14-3-3_CanoR_1 491 498 PF00244 0.490
LIG_Actin_WH2_2 166 181 PF00022 0.487
LIG_CaM_IQ_9 128 144 PF13499 0.475
LIG_CaM_IQ_9 68 84 PF13499 0.475
LIG_CaM_IQ_9 91 107 PF13499 0.312
LIG_FHA_1 202 208 PF00498 0.511
LIG_FHA_1 367 373 PF00498 0.568
LIG_FHA_1 432 438 PF00498 0.567
LIG_FHA_1 66 72 PF00498 0.486
LIG_FHA_1 9 15 PF00498 0.515
LIG_FHA_2 120 126 PF00498 0.412
LIG_FHA_2 169 175 PF00498 0.445
LIG_FHA_2 228 234 PF00498 0.611
LIG_LIR_Gen_1 122 131 PF02991 0.413
LIG_LIR_Gen_1 21 31 PF02991 0.490
LIG_LIR_Gen_1 32 42 PF02991 0.478
LIG_LIR_Nem_3 122 127 PF02991 0.411
LIG_LIR_Nem_3 209 214 PF02991 0.473
LIG_LIR_Nem_3 21 26 PF02991 0.487
LIG_LIR_Nem_3 319 324 PF02991 0.548
LIG_LIR_Nem_3 32 38 PF02991 0.482
LIG_LIR_Nem_3 73 78 PF02991 0.508
LIG_MYND_1 347 351 PF01753 0.649
LIG_Pex14_2 461 465 PF04695 0.574
LIG_SH2_CRK 321 325 PF00017 0.557
LIG_SH2_CRK 35 39 PF00017 0.472
LIG_SH2_GRB2like 153 156 PF00017 0.388
LIG_SH2_NCK_1 35 39 PF00017 0.493
LIG_SH2_SRC 153 156 PF00017 0.437
LIG_SH2_STAP1 148 152 PF00017 0.418
LIG_SH2_STAT3 147 150 PF00017 0.466
LIG_SH2_STAT5 119 122 PF00017 0.395
LIG_SH2_STAT5 153 156 PF00017 0.433
LIG_SH3_3 207 213 PF00018 0.615
LIG_SH3_3 243 249 PF00018 0.641
LIG_SH3_3 348 354 PF00018 0.599
LIG_SH3_3 385 391 PF00018 0.635
LIG_SUMO_SIM_par_1 61 66 PF11976 0.442
LIG_WRC_WIRS_1 458 463 PF05994 0.571
MOD_CDC14_SPxK_1 319 322 PF00782 0.628
MOD_CDK_SPxK_1 316 322 PF00069 0.621
MOD_CK1_1 140 146 PF00069 0.424
MOD_CK1_1 203 209 PF00069 0.518
MOD_CK1_1 242 248 PF00069 0.552
MOD_CK1_1 316 322 PF00069 0.618
MOD_CK1_1 336 342 PF00069 0.476
MOD_CK1_1 36 42 PF00069 0.634
MOD_CK1_1 407 413 PF00069 0.615
MOD_CK1_1 445 451 PF00069 0.671
MOD_CK2_1 15 21 PF00069 0.548
MOD_CK2_1 168 174 PF00069 0.434
MOD_CK2_1 227 233 PF00069 0.612
MOD_CK2_1 250 256 PF00069 0.645
MOD_CK2_1 49 55 PF00069 0.475
MOD_CK2_1 496 502 PF00069 0.546
MOD_Cter_Amidation 413 416 PF01082 0.638
MOD_GlcNHglycan 179 182 PF01048 0.388
MOD_GlcNHglycan 252 255 PF01048 0.659
MOD_GlcNHglycan 275 278 PF01048 0.563
MOD_GlcNHglycan 31 34 PF01048 0.475
MOD_GlcNHglycan 335 338 PF01048 0.728
MOD_GlcNHglycan 341 344 PF01048 0.636
MOD_GlcNHglycan 377 380 PF01048 0.570
MOD_GlcNHglycan 444 447 PF01048 0.742
MOD_GlcNHglycan 494 497 PF01048 0.624
MOD_GlcNHglycan 498 501 PF01048 0.527
MOD_GlcNHglycan 51 54 PF01048 0.495
MOD_GlcNHglycan 526 529 PF01048 0.625
MOD_GSK3_1 115 122 PF00069 0.373
MOD_GSK3_1 216 223 PF00069 0.556
MOD_GSK3_1 235 242 PF00069 0.559
MOD_GSK3_1 29 36 PF00069 0.700
MOD_GSK3_1 307 314 PF00069 0.598
MOD_GSK3_1 327 334 PF00069 0.778
MOD_GSK3_1 335 342 PF00069 0.624
MOD_GSK3_1 394 401 PF00069 0.627
MOD_GSK3_1 403 410 PF00069 0.650
MOD_GSK3_1 445 452 PF00069 0.653
MOD_GSK3_1 487 494 PF00069 0.625
MOD_N-GLC_1 220 225 PF02516 0.595
MOD_N-GLC_1 33 38 PF02516 0.438
MOD_N-GLC_1 361 366 PF02516 0.633
MOD_N-GLC_1 487 492 PF02516 0.600
MOD_NEK2_1 126 131 PF00069 0.345
MOD_NEK2_1 15 20 PF00069 0.560
MOD_NEK2_1 201 206 PF00069 0.536
MOD_NEK2_1 398 403 PF00069 0.686
MOD_NEK2_1 524 529 PF00069 0.719
MOD_NEK2_2 119 124 PF00069 0.418
MOD_NEK2_2 457 462 PF00069 0.738
MOD_PIKK_1 168 174 PF00454 0.508
MOD_PIKK_1 336 342 PF00454 0.581
MOD_PIKK_1 349 355 PF00454 0.659
MOD_PIKK_1 396 402 PF00454 0.668
MOD_PKA_2 110 116 PF00069 0.395
MOD_PKA_2 140 146 PF00069 0.424
MOD_PKA_2 159 165 PF00069 0.481
MOD_PKA_2 294 300 PF00069 0.508
MOD_PKA_2 408 414 PF00069 0.711
MOD_PKB_1 185 193 PF00069 0.394
MOD_Plk_1 187 193 PF00069 0.543
MOD_Plk_1 239 245 PF00069 0.518
MOD_Plk_1 307 313 PF00069 0.568
MOD_Plk_1 33 39 PF00069 0.437
MOD_Plk_1 425 431 PF00069 0.544
MOD_Plk_1 65 71 PF00069 0.327
MOD_Plk_4 115 121 PF00069 0.414
MOD_Plk_4 206 212 PF00069 0.515
MOD_Plk_4 239 245 PF00069 0.518
MOD_Plk_4 33 39 PF00069 0.504
MOD_Plk_4 42 48 PF00069 0.330
MOD_ProDKin_1 221 227 PF00069 0.604
MOD_ProDKin_1 242 248 PF00069 0.646
MOD_ProDKin_1 314 320 PF00069 0.646
MOD_ProDKin_1 347 353 PF00069 0.651
MOD_ProDKin_1 36 42 PF00069 0.562
MOD_SUMO_rev_2 176 186 PF00179 0.538
MOD_SUMO_rev_2 509 515 PF00179 0.524
TRG_DiLeu_BaEn_1 239 244 PF01217 0.518
TRG_DiLeu_BaLyEn_6 89 94 PF01217 0.334
TRG_ENDOCYTIC_2 153 156 PF00928 0.485
TRG_ENDOCYTIC_2 211 214 PF00928 0.481
TRG_ENDOCYTIC_2 23 26 PF00928 0.555
TRG_ENDOCYTIC_2 321 324 PF00928 0.558
TRG_ENDOCYTIC_2 35 38 PF00928 0.450
TRG_ER_diArg_1 104 107 PF00400 0.340
TRG_ER_diArg_1 284 286 PF00400 0.483
TRG_ER_diArg_1 463 465 PF00400 0.745
TRG_NLS_MonoCore_2 414 419 PF00514 0.685
TRG_NLS_MonoExtC_3 414 419 PF00514 0.637
TRG_NLS_MonoExtN_4 412 419 PF00514 0.590

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I2 Leptomonas seymouri 39% 100%
A0A3S7XBK4 Leishmania donovani 99% 100%
A4HPS6 Leishmania braziliensis 68% 100%
E9ATJ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q107 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS