LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE65_LEIIN
TriTrypDb:
LINF_360050000
Length:
432

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE65

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.668
CLV_NRD_NRD_1 133 135 PF00675 0.534
CLV_NRD_NRD_1 237 239 PF00675 0.675
CLV_NRD_NRD_1 333 335 PF00675 0.639
CLV_NRD_NRD_1 390 392 PF00675 0.557
CLV_NRD_NRD_1 396 398 PF00675 0.549
CLV_NRD_NRD_1 85 87 PF00675 0.498
CLV_PCSK_FUR_1 278 282 PF00082 0.672
CLV_PCSK_KEX2_1 133 135 PF00082 0.510
CLV_PCSK_KEX2_1 280 282 PF00082 0.716
CLV_PCSK_KEX2_1 396 398 PF00082 0.578
CLV_PCSK_KEX2_1 85 87 PF00082 0.498
CLV_PCSK_PC1ET2_1 280 282 PF00082 0.716
CLV_PCSK_SKI1_1 113 117 PF00082 0.482
CLV_PCSK_SKI1_1 2 6 PF00082 0.463
CLV_PCSK_SKI1_1 255 259 PF00082 0.654
CLV_PCSK_SKI1_1 29 33 PF00082 0.592
CLV_PCSK_SKI1_1 419 423 PF00082 0.707
DEG_MDM2_SWIB_1 158 165 PF02201 0.479
DEG_Nend_UBRbox_1 1 4 PF02207 0.643
DEG_SPOP_SBC_1 191 195 PF00917 0.604
DEG_SPOP_SBC_1 51 55 PF00917 0.653
DOC_CYCLIN_RxL_1 252 261 PF00134 0.630
DOC_CYCLIN_yCln2_LP_2 135 141 PF00134 0.518
DOC_CYCLIN_yCln2_LP_2 31 34 PF00134 0.583
DOC_MAPK_DCC_7 293 303 PF00069 0.619
DOC_PP2B_LxvP_1 135 138 PF13499 0.520
DOC_PP2B_LxvP_1 265 268 PF13499 0.695
DOC_PP2B_LxvP_1 31 34 PF13499 0.680
DOC_USP7_MATH_1 120 124 PF00917 0.540
DOC_USP7_MATH_1 126 130 PF00917 0.472
DOC_USP7_MATH_1 139 143 PF00917 0.318
DOC_USP7_MATH_1 197 201 PF00917 0.658
DOC_USP7_MATH_1 289 293 PF00917 0.712
DOC_USP7_MATH_1 351 355 PF00917 0.657
DOC_USP7_MATH_1 356 360 PF00917 0.591
DOC_USP7_MATH_1 364 368 PF00917 0.513
DOC_USP7_MATH_1 51 55 PF00917 0.658
DOC_WW_Pin1_4 205 210 PF00397 0.655
DOC_WW_Pin1_4 258 263 PF00397 0.656
DOC_WW_Pin1_4 32 37 PF00397 0.586
LIG_14-3-3_CanoR_1 113 122 PF00244 0.495
LIG_14-3-3_CanoR_1 255 261 PF00244 0.630
LIG_14-3-3_CanoR_1 373 378 PF00244 0.525
LIG_14-3-3_CanoR_1 86 92 PF00244 0.513
LIG_BRCT_BRCA1_1 154 158 PF00533 0.491
LIG_eIF4E_1 9 15 PF01652 0.545
LIG_EVH1_2 68 72 PF00568 0.580
LIG_FHA_1 10 16 PF00498 0.556
LIG_FHA_1 114 120 PF00498 0.574
LIG_FHA_1 17 23 PF00498 0.488
LIG_FHA_1 298 304 PF00498 0.593
LIG_FHA_2 184 190 PF00498 0.543
LIG_FHA_2 35 41 PF00498 0.527
LIG_FHA_2 54 60 PF00498 0.520
LIG_LIR_Gen_1 155 166 PF02991 0.464
LIG_LIR_Nem_3 155 161 PF02991 0.485
LIG_NRBOX 40 46 PF00104 0.566
LIG_PCNA_yPIPBox_3 408 422 PF02747 0.561
LIG_Pex14_2 127 131 PF04695 0.491
LIG_Pex14_2 154 158 PF04695 0.585
LIG_SH2_STAT3 149 152 PF00017 0.490
LIG_SH2_STAT5 160 163 PF00017 0.440
LIG_SH2_STAT5 276 279 PF00017 0.653
LIG_SH2_STAT5 410 413 PF00017 0.617
LIG_SH3_3 116 122 PF00018 0.515
LIG_SH3_3 213 219 PF00018 0.644
LIG_SH3_3 30 36 PF00018 0.586
LIG_SH3_3 314 320 PF00018 0.801
LIG_SH3_3 333 339 PF00018 0.670
LIG_SUMO_SIM_anti_2 300 305 PF11976 0.585
LIG_SUMO_SIM_par_1 256 261 PF11976 0.629
LIG_SUMO_SIM_par_1 373 378 PF11976 0.597
LIG_WW_3 214 218 PF00397 0.567
MOD_CK1_1 192 198 PF00069 0.595
MOD_CK1_1 205 211 PF00069 0.568
MOD_CK1_1 354 360 PF00069 0.667
MOD_CK1_1 362 368 PF00069 0.559
MOD_CK1_1 73 79 PF00069 0.508
MOD_CK1_1 8 14 PF00069 0.594
MOD_CK2_1 34 40 PF00069 0.531
MOD_CK2_1 417 423 PF00069 0.516
MOD_Cter_Amidation 278 281 PF01082 0.721
MOD_GlcNHglycan 204 207 PF01048 0.723
MOD_GlcNHglycan 220 223 PF01048 0.611
MOD_GlcNHglycan 241 244 PF01048 0.712
MOD_GlcNHglycan 248 251 PF01048 0.630
MOD_GlcNHglycan 287 290 PF01048 0.660
MOD_GlcNHglycan 293 296 PF01048 0.602
MOD_GlcNHglycan 330 333 PF01048 0.698
MOD_GlcNHglycan 370 373 PF01048 0.580
MOD_GlcNHglycan 47 50 PF01048 0.577
MOD_GlcNHglycan 72 75 PF01048 0.557
MOD_GSK3_1 109 116 PF00069 0.456
MOD_GSK3_1 152 159 PF00069 0.517
MOD_GSK3_1 197 204 PF00069 0.671
MOD_GSK3_1 244 251 PF00069 0.684
MOD_GSK3_1 285 292 PF00069 0.659
MOD_GSK3_1 364 371 PF00069 0.593
MOD_GSK3_1 5 12 PF00069 0.621
MOD_GSK3_1 53 60 PF00069 0.742
MOD_GSK3_1 68 75 PF00069 0.420
MOD_N-GLC_1 239 244 PF02516 0.687
MOD_N-GLC_1 362 367 PF02516 0.581
MOD_NEK2_1 114 119 PF00069 0.514
MOD_NEK2_1 198 203 PF00069 0.622
MOD_NEK2_1 220 225 PF00069 0.743
MOD_NEK2_1 25 30 PF00069 0.531
MOD_NEK2_1 45 50 PF00069 0.697
MOD_NEK2_1 72 77 PF00069 0.446
MOD_NEK2_2 139 144 PF00069 0.515
MOD_NEK2_2 153 158 PF00069 0.444
MOD_PK_1 373 379 PF00069 0.461
MOD_PKA_2 198 204 PF00069 0.578
MOD_Plk_1 16 22 PF00069 0.496
MOD_Plk_4 153 159 PF00069 0.451
MOD_Plk_4 95 101 PF00069 0.495
MOD_ProDKin_1 205 211 PF00069 0.655
MOD_ProDKin_1 258 264 PF00069 0.654
MOD_ProDKin_1 32 38 PF00069 0.584
MOD_SUMO_rev_2 174 182 PF00179 0.592
TRG_DiLeu_BaEn_1 10 15 PF01217 0.544
TRG_DiLeu_BaEn_1 178 183 PF01217 0.538
TRG_DiLeu_BaEn_1 40 45 PF01217 0.515
TRG_DiLeu_BaLyEn_6 167 172 PF01217 0.568
TRG_DiLeu_BaLyEn_6 253 258 PF01217 0.657
TRG_ER_diArg_1 133 135 PF00400 0.510
TRG_ER_diArg_1 395 397 PF00400 0.589
TRG_ER_diArg_1 85 87 PF00400 0.498
TRG_Pf-PMV_PEXEL_1 180 184 PF00026 0.653
TRG_Pf-PMV_PEXEL_1 373 378 PF00026 0.539

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILA1 Leishmania donovani 99% 100%
A4HPS7 Leishmania braziliensis 70% 100%
E9ATJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q106 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS