Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IE63_LEIIN

TriTrypDb:

LINF_360050200

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	593	597	PF00656	0.666
CLV_C14_Caspase3-7	788	792	PF00656	0.603
CLV_C14_Caspase3-7	839	843	PF00656	0.633
CLV_MEL_PAP_1	858	864	PF00089	0.530
CLV_NRD_NRD_1	1015	1017	PF00675	0.548
CLV_NRD_NRD_1	251	253	PF00675	0.623
CLV_NRD_NRD_1	334	336	PF00675	0.611
CLV_NRD_NRD_1	384	386	PF00675	0.791
CLV_NRD_NRD_1	695	697	PF00675	0.524
CLV_NRD_NRD_1	760	762	PF00675	0.551
CLV_NRD_NRD_1	8	10	PF00675	0.678
CLV_NRD_NRD_1	805	807	PF00675	0.657
CLV_NRD_NRD_1	85	87	PF00675	0.691
CLV_NRD_NRD_1	950	952	PF00675	0.479
CLV_PCSK_FUR_1	1013	1017	PF00082	0.548
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.548
CLV_PCSK_KEX2_1	185	187	PF00082	0.651
CLV_PCSK_KEX2_1	251	253	PF00082	0.623
CLV_PCSK_KEX2_1	334	336	PF00082	0.611
CLV_PCSK_KEX2_1	384	386	PF00082	0.732
CLV_PCSK_KEX2_1	565	567	PF00082	0.730
CLV_PCSK_KEX2_1	695	697	PF00082	0.524
CLV_PCSK_KEX2_1	760	762	PF00082	0.551
CLV_PCSK_KEX2_1	8	10	PF00082	0.745
CLV_PCSK_KEX2_1	805	807	PF00082	0.657
CLV_PCSK_KEX2_1	85	87	PF00082	0.691
CLV_PCSK_KEX2_1	950	952	PF00082	0.479
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.651
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.746
CLV_PCSK_PC7_1	4	10	PF00082	0.720
CLV_PCSK_SKI1_1	252	256	PF00082	0.544
CLV_PCSK_SKI1_1	356	360	PF00082	0.525
CLV_PCSK_SKI1_1	421	425	PF00082	0.473
CLV_PCSK_SKI1_1	444	448	PF00082	0.564
CLV_PCSK_SKI1_1	600	604	PF00082	0.602
CLV_PCSK_SKI1_1	696	700	PF00082	0.603
DEG_APCC_DBOX_1	355	363	PF00400	0.513
DEG_SCF_FBW7_1	360	367	PF00400	0.564
DEG_SPOP_SBC_1	23	27	PF00917	0.729
DEG_SPOP_SBC_1	877	881	PF00917	0.686
DEG_SPOP_SBC_1	930	934	PF00917	0.643
DEG_SPOP_SBC_1	976	980	PF00917	0.697
DOC_CKS1_1	124	129	PF01111	0.566
DOC_CYCLIN_RxL_1	248	257	PF00134	0.491
DOC_CYCLIN_RxL_1	418	426	PF00134	0.473
DOC_CYCLIN_RxL_1	438	449	PF00134	0.248
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.754
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	884	890	PF00134	0.630
DOC_MAPK_DCC_7	185	194	PF00069	0.517
DOC_MAPK_gen_1	1013	1021	PF00069	0.558
DOC_MAPK_gen_1	577	586	PF00069	0.661
DOC_MAPK_gen_1	803	811	PF00069	0.691
DOC_MAPK_gen_1	907	916	PF00069	0.580
DOC_PP2B_LxvP_1	601	604	PF13499	0.595
DOC_PP4_FxxP_1	1011	1014	PF00568	0.507
DOC_PP4_FxxP_1	368	371	PF00568	0.773
DOC_USP7_MATH_1	218	222	PF00917	0.602
DOC_USP7_MATH_1	23	27	PF00917	0.734
DOC_USP7_MATH_1	354	358	PF00917	0.515
DOC_USP7_MATH_1	376	380	PF00917	0.768
DOC_USP7_MATH_1	587	591	PF00917	0.614
DOC_USP7_MATH_1	606	610	PF00917	0.486
DOC_USP7_MATH_1	782	786	PF00917	0.607
DOC_USP7_MATH_1	837	841	PF00917	0.660
DOC_USP7_MATH_1	843	847	PF00917	0.578
DOC_USP7_MATH_1	875	879	PF00917	0.649
DOC_USP7_MATH_1	90	94	PF00917	0.531
DOC_USP7_MATH_1	930	934	PF00917	0.645
DOC_USP7_MATH_1	976	980	PF00917	0.697
DOC_WW_Pin1_4	108	113	PF00397	0.692
DOC_WW_Pin1_4	123	128	PF00397	0.470
DOC_WW_Pin1_4	360	365	PF00397	0.510
DOC_WW_Pin1_4	846	851	PF00397	0.510
DOC_WW_Pin1_4	920	925	PF00397	0.613
LIG_14-3-3_CanoR_1	203	207	PF00244	0.623
LIG_14-3-3_CanoR_1	275	281	PF00244	0.402
LIG_14-3-3_CanoR_1	569	578	PF00244	0.735
LIG_14-3-3_CanoR_1	580	586	PF00244	0.559
LIG_14-3-3_CanoR_1	917	924	PF00244	0.633
LIG_14-3-3_CanoR_1	95	104	PF00244	0.654
LIG_14-3-3_CanoR_1	950	960	PF00244	0.515
LIG_Actin_WH2_2	187	205	PF00022	0.598
LIG_Actin_WH2_2	901	919	PF00022	0.592
LIG_APCC_ABBA_1	862	867	PF00400	0.506
LIG_APCC_ABBAyCdc20_2	861	867	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	235	239	PF00533	0.729
LIG_Clathr_ClatBox_1	192	196	PF01394	0.484
LIG_CSL_BTD_1	343	346	PF09270	0.539
LIG_CtBP_PxDLS_1	850	854	PF00389	0.523
LIG_deltaCOP1_diTrp_1	283	289	PF00928	0.543
LIG_deltaCOP1_diTrp_1	714	721	PF00928	0.699
LIG_FHA_1	135	141	PF00498	0.608
LIG_FHA_1	150	156	PF00498	0.319
LIG_FHA_1	265	271	PF00498	0.697
LIG_FHA_1	275	281	PF00498	0.513
LIG_FHA_1	350	356	PF00498	0.509
LIG_FHA_1	411	417	PF00498	0.580
LIG_FHA_1	424	430	PF00498	0.387
LIG_FHA_1	447	453	PF00498	0.438
LIG_FHA_1	543	549	PF00498	0.519
LIG_FHA_1	720	726	PF00498	0.655
LIG_FHA_1	753	759	PF00498	0.536
LIG_FHA_1	853	859	PF00498	0.545
LIG_FHA_1	930	936	PF00498	0.594
LIG_FHA_1	95	101	PF00498	0.744
LIG_FHA_1	952	958	PF00498	0.460
LIG_FHA_2	296	302	PF00498	0.560
LIG_FHA_2	460	466	PF00498	0.758
LIG_FHA_2	489	495	PF00498	0.668
LIG_FHA_2	658	664	PF00498	0.633
LIG_FHA_2	701	707	PF00498	0.616
LIG_FHA_2	786	792	PF00498	0.716
LIG_FHA_2	877	883	PF00498	0.765
LIG_FHA_2	984	990	PF00498	0.610
LIG_GBD_Chelix_1	198	206	PF00786	0.493
LIG_Integrin_RGD_1	69	71	PF01839	0.515
LIG_IRF3_LxIS_1	893	900	PF10401	0.574
LIG_LIR_Apic_2	367	371	PF02991	0.768
LIG_LIR_Gen_1	298	307	PF02991	0.644
LIG_LIR_Gen_1	425	435	PF02991	0.462
LIG_LIR_Gen_1	52	62	PF02991	0.615
LIG_LIR_Gen_1	544	554	PF02991	0.569
LIG_LIR_Gen_1	63	73	PF02991	0.533
LIG_LIR_Gen_1	810	821	PF02991	0.619
LIG_LIR_Gen_1	991	1001	PF02991	0.599
LIG_LIR_Nem_3	154	160	PF02991	0.435
LIG_LIR_Nem_3	2	6	PF02991	0.620
LIG_LIR_Nem_3	298	302	PF02991	0.605
LIG_LIR_Nem_3	425	430	PF02991	0.461
LIG_LIR_Nem_3	484	490	PF02991	0.522
LIG_LIR_Nem_3	52	57	PF02991	0.632
LIG_LIR_Nem_3	544	549	PF02991	0.559
LIG_LIR_Nem_3	63	68	PF02991	0.511
LIG_LIR_Nem_3	810	816	PF02991	0.632
LIG_LIR_Nem_3	991	996	PF02991	0.601
LIG_LYPXL_SIV_4	693	701	PF13949	0.570
LIG_NRBOX	442	448	PF00104	0.562
LIG_OCRL_FandH_1	248	260	PF00620	0.539
LIG_PCNA_yPIPBox_3	170	179	PF02747	0.509
LIG_PCNA_yPIPBox_3	941	951	PF02747	0.466
LIG_PDZ_Class_2	1016	1021	PF00595	0.571
LIG_Pex14_1	813	817	PF04695	0.637
LIG_RPA_C_Fungi	575	587	PF08784	0.751
LIG_RPA_C_Fungi	755	767	PF08784	0.600
LIG_SH2_CRK	528	532	PF00017	0.482
LIG_SH2_CRK	65	69	PF00017	0.536
LIG_SH2_NCK_1	490	494	PF00017	0.565
LIG_SH2_NCK_1	649	653	PF00017	0.620
LIG_SH2_PTP2	655	658	PF00017	0.485
LIG_SH2_SRC	649	652	PF00017	0.624
LIG_SH2_STAP1	341	345	PF00017	0.537
LIG_SH2_STAP1	366	370	PF00017	0.753
LIG_SH2_STAP1	997	1001	PF00017	0.598
LIG_SH2_STAT5	490	493	PF00017	0.615
LIG_SH2_STAT5	65	68	PF00017	0.539
LIG_SH2_STAT5	655	658	PF00017	0.485
LIG_SH2_STAT5	769	772	PF00017	0.542
LIG_SH3_1	185	191	PF00018	0.630
LIG_SH3_3	118	124	PF00018	0.669
LIG_SH3_3	185	191	PF00018	0.495
LIG_SH3_3	205	211	PF00018	0.302
LIG_SH3_3	404	410	PF00018	0.662
LIG_SH3_3	472	478	PF00018	0.636
LIG_SH3_3	887	893	PF00018	0.689
LIG_SH3_3	97	103	PF00018	0.669
LIG_Sin3_3	681	688	PF02671	0.568
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.526
LIG_SUMO_SIM_anti_2	522	527	PF11976	0.447
LIG_SUMO_SIM_anti_2	748	755	PF11976	0.583
LIG_SUMO_SIM_anti_2	854	860	PF11976	0.477
LIG_SUMO_SIM_anti_2	954	961	PF11976	0.580
LIG_SUMO_SIM_par_1	131	137	PF11976	0.526
LIG_SUMO_SIM_par_1	351	357	PF11976	0.509
LIG_SUMO_SIM_par_1	849	855	PF11976	0.572
LIG_SUMO_SIM_par_1	895	900	PF11976	0.550
LIG_TRAF2_1	533	536	PF00917	0.480
LIG_TRAF2_1	591	594	PF00917	0.730
LIG_TRAF2_1	781	784	PF00917	0.684
LIG_TRAF2_1	866	869	PF00917	0.591
LIG_TRFH_1	123	127	PF08558	0.486
LIG_TYR_ITIM	526	531	PF00017	0.474
LIG_UBA3_1	133	139	PF00899	0.518
LIG_WRC_WIRS_1	365	370	PF05994	0.646
LIG_WW_2	893	896	PF00397	0.579
MOD_CK1_1	213	219	PF00069	0.560
MOD_CK1_1	227	233	PF00069	0.669
MOD_CK1_1	387	393	PF00069	0.795
MOD_CK1_1	56	62	PF00069	0.696
MOD_CK1_1	570	576	PF00069	0.677
MOD_CK1_1	625	631	PF00069	0.455
MOD_CK1_1	730	736	PF00069	0.697
MOD_CK1_1	785	791	PF00069	0.773
MOD_CK1_1	846	852	PF00069	0.530
MOD_CK1_1	876	882	PF00069	0.714
MOD_CK1_1	920	926	PF00069	0.688
MOD_CK1_1	968	974	PF00069	0.672
MOD_CK2_1	376	382	PF00069	0.828
MOD_CK2_1	459	465	PF00069	0.734
MOD_CK2_1	587	593	PF00069	0.644
MOD_CK2_1	657	663	PF00069	0.597
MOD_CK2_1	700	706	PF00069	0.700
MOD_CK2_1	777	783	PF00069	0.667
MOD_CK2_1	876	882	PF00069	0.687
MOD_CMANNOS	286	289	PF00535	0.467
MOD_CMANNOS	718	721	PF00535	0.676
MOD_CMANNOS	939	942	PF00535	0.473
MOD_Cter_Amidation	382	385	PF01082	0.737
MOD_GlcNHglycan	116	119	PF01048	0.660
MOD_GlcNHglycan	212	215	PF01048	0.544
MOD_GlcNHglycan	220	223	PF01048	0.619
MOD_GlcNHglycan	226	229	PF01048	0.652
MOD_GlcNHglycan	256	259	PF01048	0.712
MOD_GlcNHglycan	26	29	PF01048	0.622
MOD_GlcNHglycan	356	359	PF01048	0.616
MOD_GlcNHglycan	373	376	PF01048	0.663
MOD_GlcNHglycan	389	392	PF01048	0.691
MOD_GlcNHglycan	549	552	PF01048	0.628
MOD_GlcNHglycan	569	572	PF01048	0.517
MOD_GlcNHglycan	581	584	PF01048	0.707
MOD_GlcNHglycan	590	593	PF01048	0.593
MOD_GlcNHglycan	624	627	PF01048	0.584
MOD_GlcNHglycan	678	681	PF01048	0.522
MOD_GlcNHglycan	733	736	PF01048	0.716
MOD_GlcNHglycan	779	782	PF01048	0.716
MOD_GlcNHglycan	839	842	PF01048	0.664
MOD_GlcNHglycan	875	878	PF01048	0.691
MOD_GlcNHglycan	919	922	PF01048	0.643
MOD_GlcNHglycan	92	95	PF01048	0.603
MOD_GlcNHglycan	966	970	PF01048	0.753
MOD_GSK3_1	198	205	PF00069	0.571
MOD_GSK3_1	213	220	PF00069	0.456
MOD_GSK3_1	223	230	PF00069	0.627
MOD_GSK3_1	254	261	PF00069	0.690
MOD_GSK3_1	354	361	PF00069	0.548
MOD_GSK3_1	488	495	PF00069	0.537
MOD_GSK3_1	696	703	PF00069	0.663
MOD_GSK3_1	727	734	PF00069	0.633
MOD_GSK3_1	817	824	PF00069	0.451
MOD_GSK3_1	837	844	PF00069	0.679
MOD_GSK3_1	871	878	PF00069	0.589
MOD_GSK3_1	90	97	PF00069	0.732
MOD_GSK3_1	978	985	PF00069	0.655
MOD_N-GLC_1	233	238	PF02516	0.689
MOD_N-GLC_1	295	300	PF02516	0.604
MOD_N-GLC_1	519	524	PF02516	0.569
MOD_N-GLC_1	676	681	PF02516	0.594
MOD_NEK2_1	134	139	PF00069	0.623
MOD_NEK2_1	198	203	PF00069	0.589
MOD_NEK2_1	217	222	PF00069	0.402
MOD_NEK2_1	24	29	PF00069	0.625
MOD_NEK2_1	254	259	PF00069	0.583
MOD_NEK2_1	295	300	PF00069	0.604
MOD_NEK2_1	423	428	PF00069	0.473
MOD_NEK2_1	446	451	PF00069	0.492
MOD_NEK2_1	542	547	PF00069	0.514
MOD_NEK2_1	607	612	PF00069	0.599
MOD_NEK2_1	676	681	PF00069	0.574
MOD_NEK2_1	746	751	PF00069	0.583
MOD_NEK2_1	776	781	PF00069	0.556
MOD_NEK2_1	835	840	PF00069	0.600
MOD_NEK2_1	851	856	PF00069	0.299
MOD_NEK2_1	982	987	PF00069	0.569
MOD_NEK2_2	364	369	PF00069	0.626
MOD_NEK2_2	721	726	PF00069	0.649
MOD_OFUCOSY	605	611	PF10250	0.459
MOD_PIKK_1	727	733	PF00454	0.661
MOD_PIKK_1	785	791	PF00454	0.754
MOD_PIKK_1	821	827	PF00454	0.469
MOD_PK_1	53	59	PF00069	0.625
MOD_PKA_1	384	390	PF00069	0.785
MOD_PKA_1	565	571	PF00069	0.808
MOD_PKA_2	202	208	PF00069	0.620
MOD_PKA_2	274	280	PF00069	0.417
MOD_PKA_2	327	333	PF00069	0.770
MOD_PKA_2	384	390	PF00069	0.765
MOD_PKA_2	565	571	PF00069	0.698
MOD_PKA_2	579	585	PF00069	0.684
MOD_PKA_2	909	915	PF00069	0.480
MOD_PKA_2	94	100	PF00069	0.802
MOD_PKB_1	915	923	PF00069	0.558
MOD_Plk_1	233	239	PF00069	0.681
MOD_Plk_1	295	301	PF00069	0.616
MOD_Plk_1	841	847	PF00069	0.488
MOD_Plk_4	202	208	PF00069	0.541
MOD_Plk_4	423	429	PF00069	0.560
MOD_Plk_4	521	527	PF00069	0.445
MOD_Plk_4	749	755	PF00069	0.581
MOD_Plk_4	931	937	PF00069	0.569
MOD_Plk_4	943	949	PF00069	0.457
MOD_Plk_4	978	984	PF00069	0.607
MOD_Plk_4	988	994	PF00069	0.512
MOD_ProDKin_1	108	114	PF00069	0.692
MOD_ProDKin_1	123	129	PF00069	0.457
MOD_ProDKin_1	360	366	PF00069	0.519
MOD_ProDKin_1	846	852	PF00069	0.503
MOD_ProDKin_1	920	926	PF00069	0.619
TRG_DiLeu_BaEn_1	131	136	PF01217	0.534
TRG_DiLeu_BaEn_1	594	599	PF01217	0.686
TRG_DiLeu_BaEn_4	131	137	PF01217	0.526
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.705
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.490
TRG_ENDOCYTIC_2	146	149	PF00928	0.551
TRG_ENDOCYTIC_2	528	531	PF00928	0.481
TRG_ENDOCYTIC_2	65	68	PF00928	0.539
TRG_ENDOCYTIC_2	655	658	PF00928	0.496
TRG_ER_diArg_1	1012	1015	PF00400	0.515
TRG_ER_diArg_1	250	252	PF00400	0.616
TRG_ER_diArg_1	333	335	PF00400	0.626
TRG_ER_diArg_1	694	696	PF00400	0.516
TRG_ER_diArg_1	7	9	PF00400	0.741
TRG_ER_diArg_1	914	917	PF00400	0.515
TRG_NES_CRM1_1	153	165	PF08389	0.479
TRG_NLS_MonoExtN_4	562	568	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	961	966	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV3	Leptomonas seymouri	45%	99%
A0A3S7XBE1	Leishmania donovani	99%	100%
A4HPS9	Leishmania braziliensis	76%	100%
E9ATJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q104	Leishmania major	91%	100%