Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4IE60_LEIIN

TriTrypDb:

LINF_360050500

Length:

199

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4IE60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	5	9	PF00082	0.352
DEG_APCC_DBOX_1	4	12	PF00400	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DOC_CKS1_1	186	191	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.402
DOC_MAPK_gen_1	112	121	PF00069	0.482
DOC_MAPK_HePTP_8	113	125	PF00069	0.482
DOC_MAPK_HePTP_8	2	14	PF00069	0.466
DOC_MAPK_MEF2A_6	112	121	PF00069	0.482
DOC_MAPK_MEF2A_6	5	14	PF00069	0.482
DOC_MAPK_NFAT4_5	112	120	PF00069	0.482
DOC_PP2B_LxvP_1	115	118	PF13499	0.402
DOC_USP7_UBL2_3	143	147	PF12436	0.308
DOC_WW_Pin1_4	185	190	PF00397	0.411
LIG_14-3-3_CanoR_1	32	37	PF00244	0.304
LIG_14-3-3_CanoR_1	81	85	PF00244	0.276
LIG_BRCT_BRCA1_1	141	145	PF00533	0.349
LIG_BRCT_BRCA1_2	141	147	PF00533	0.308
LIG_DCNL_PONY_1	1	4	PF03556	0.571
LIG_EH1_1	14	22	PF00400	0.349
LIG_EH1_1	180	188	PF00400	0.411
LIG_FHA_1	154	160	PF00498	0.277
LIG_FHA_1	167	173	PF00498	0.297
LIG_FHA_1	189	195	PF00498	0.527
LIG_FHA_1	21	27	PF00498	0.321
LIG_LIR_Gen_1	45	54	PF02991	0.262
LIG_LIR_Nem_3	45	50	PF02991	0.282
LIG_LIR_Nem_3	95	100	PF02991	0.321
LIG_Pex14_2	120	124	PF04695	0.411
LIG_Pex14_2	80	84	PF04695	0.282
LIG_SH2_CRK	100	104	PF00017	0.321
LIG_SH2_GRB2like	29	32	PF00017	0.346
LIG_SH2_STAP1	100	104	PF00017	0.411
LIG_SH2_STAP1	141	145	PF00017	0.266
LIG_SH2_STAP1	29	33	PF00017	0.282
LIG_SH3_3	21	27	PF00018	0.358
MOD_GSK3_1	27	34	PF00069	0.397
MOD_GSK3_1	54	61	PF00069	0.296
MOD_N-GLC_1	153	158	PF02516	0.481
MOD_N-GLC_1	59	64	PF02516	0.482
MOD_NEK2_1	102	107	PF00069	0.319
MOD_NEK2_1	20	25	PF00069	0.335
MOD_NEK2_1	80	85	PF00069	0.266
MOD_PIKK_1	188	194	PF00454	0.411
MOD_PKA_2	31	37	PF00069	0.304
MOD_PKA_2	80	86	PF00069	0.268
MOD_Plk_1	153	159	PF00069	0.287
MOD_Plk_1	42	48	PF00069	0.386
MOD_Plk_4	154	160	PF00069	0.281
MOD_Plk_4	182	188	PF00069	0.358
MOD_Plk_4	42	48	PF00069	0.282
MOD_Plk_4	92	98	PF00069	0.321
MOD_ProDKin_1	185	191	PF00069	0.411
MOD_SUMO_rev_2	35	42	PF00179	0.257
TRG_ENDOCYTIC_2	100	103	PF00928	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C3	Leptomonas seymouri	65%	100%
A0A3S7XBF7	Leishmania donovani	99%	100%
A4HPT2	Leishmania braziliensis	79%	100%
E9ATJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q101	Leishmania major	97%	100%