Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GINS complex protein - putative

Species:

Leishmania infantum

UniProt:

A4IE54_LEIIN

TriTrypDb:

LINF_360051100

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	9
GO:0005694	chromosome	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0016020	membrane	2	1

Phosphorylation

Promastigote: 313

Expansion

Sequence features

A4IE54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE54

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.688
CLV_NRD_NRD_1	336	338	PF00675	0.601
CLV_PCSK_KEX2_1	335	337	PF00082	0.614
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.599
CLV_PCSK_SKI1_1	130	134	PF00082	0.344
DEG_APCC_DBOX_1	222	230	PF00400	0.623
DEG_SPOP_SBC_1	256	260	PF00917	0.783
DOC_MAPK_gen_1	169	179	PF00069	0.464
DOC_MAPK_gen_1	221	229	PF00069	0.607
DOC_MAPK_RevD_3	323	337	PF00069	0.696
DOC_USP7_MATH_1	23	27	PF00917	0.625
DOC_USP7_MATH_1	301	305	PF00917	0.648
DOC_USP7_MATH_1	310	314	PF00917	0.796
DOC_WW_Pin1_4	182	187	PF00397	0.464
DOC_WW_Pin1_4	233	238	PF00397	0.574
DOC_WW_Pin1_4	264	269	PF00397	0.759
LIG_14-3-3_CanoR_1	206	210	PF00244	0.399
LIG_14-3-3_CanoR_1	239	245	PF00244	0.699
LIG_14-3-3_CanoR_1	246	250	PF00244	0.716
LIG_14-3-3_CanoR_1	257	263	PF00244	0.722
LIG_14-3-3_CanoR_1	336	340	PF00244	0.592
LIG_14-3-3_CanoR_1	86	96	PF00244	0.471
LIG_14-3-3_CterR_2	340	342	PF00244	0.621
LIG_Actin_WH2_2	190	208	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	119	123	PF00533	0.544
LIG_BRCT_BRCA1_1	184	188	PF00533	0.507
LIG_BRCT_BRCA1_1	282	286	PF00533	0.640
LIG_deltaCOP1_diTrp_1	29	33	PF00928	0.596
LIG_FHA_1	193	199	PF00498	0.482
LIG_FHA_1	257	263	PF00498	0.749
LIG_FHA_1	265	271	PF00498	0.582
LIG_FHA_1	320	326	PF00498	0.685
LIG_FHA_1	88	94	PF00498	0.464
LIG_FHA_2	176	182	PF00498	0.538
LIG_FHA_2	271	277	PF00498	0.690
LIG_LIR_Gen_1	115	126	PF02991	0.378
LIG_LIR_Gen_1	39	48	PF02991	0.374
LIG_LIR_Gen_1	97	104	PF02991	0.531
LIG_LIR_Nem_3	115	121	PF02991	0.378
LIG_LIR_Nem_3	208	212	PF02991	0.404
LIG_LIR_Nem_3	30	36	PF02991	0.442
LIG_LIR_Nem_3	65	69	PF02991	0.481
LIG_LIR_Nem_3	97	101	PF02991	0.531
LIG_PCNA_yPIPBox_3	169	177	PF02747	0.550
LIG_Pex14_1	80	84	PF04695	0.544
LIG_Pex14_2	27	31	PF04695	0.445
LIG_Rb_LxCxE_1	195	208	PF01857	0.587
LIG_SH2_STAT3	84	87	PF00017	0.544
LIG_SH2_STAT5	103	106	PF00017	0.368
LIG_SH2_STAT5	124	127	PF00017	0.464
LIG_SH2_STAT5	84	87	PF00017	0.527
LIG_SH2_STAT5	98	101	PF00017	0.417
LIG_SH3_3	65	71	PF00018	0.378
LIG_WRC_WIRS_1	24	29	PF05994	0.560
LIG_WRC_WIRS_1	38	43	PF05994	0.338
LIG_WW_1	95	98	PF00397	0.507
MOD_CDK_SPxK_1	233	239	PF00069	0.577
MOD_CK1_1	14	20	PF00069	0.683
MOD_CK1_1	233	239	PF00069	0.656
MOD_CK1_1	251	257	PF00069	0.656
MOD_CK1_1	264	270	PF00069	0.646
MOD_CK1_1	294	300	PF00069	0.679
MOD_CK1_1	304	310	PF00069	0.645
MOD_CK2_1	175	181	PF00069	0.474
MOD_GlcNHglycan	232	235	PF01048	0.709
MOD_GlcNHglycan	250	253	PF01048	0.616
MOD_GlcNHglycan	296	299	PF01048	0.658
MOD_GSK3_1	240	247	PF00069	0.616
MOD_GSK3_1	248	255	PF00069	0.575
MOD_GSK3_1	256	263	PF00069	0.519
MOD_GSK3_1	276	283	PF00069	0.454
MOD_GSK3_1	297	304	PF00069	0.622
MOD_GSK3_1	335	342	PF00069	0.646
MOD_N-GLC_2	89	91	PF02516	0.303
MOD_NEK2_1	205	210	PF00069	0.391
MOD_NEK2_1	262	267	PF00069	0.680
MOD_NEK2_1	275	280	PF00069	0.654
MOD_NEK2_1	62	67	PF00069	0.466
MOD_NEK2_1	85	90	PF00069	0.577
MOD_PIKK_1	291	297	PF00454	0.681
MOD_PKA_1	130	136	PF00069	0.544
MOD_PKA_1	335	341	PF00069	0.592
MOD_PKA_2	205	211	PF00069	0.398
MOD_PKA_2	245	251	PF00069	0.615
MOD_PKA_2	256	262	PF00069	0.755
MOD_PKA_2	335	341	PF00069	0.608
MOD_PKA_2	85	91	PF00069	0.476
MOD_Plk_4	175	181	PF00069	0.474
MOD_Plk_4	282	288	PF00069	0.696
MOD_Plk_4	37	43	PF00069	0.402
MOD_Plk_4	46	52	PF00069	0.346
MOD_ProDKin_1	182	188	PF00069	0.464
MOD_ProDKin_1	233	239	PF00069	0.577
MOD_ProDKin_1	264	270	PF00069	0.758
TRG_DiLeu_BaEn_1	157	162	PF01217	0.464
TRG_ENDOCYTIC_2	66	69	PF00928	0.367
TRG_ENDOCYTIC_2	98	101	PF00928	0.517
TRG_NES_CRM1_1	201	215	PF08389	0.456
TRG_NLS_MonoCore_2	333	338	PF00514	0.588
TRG_NLS_MonoExtN_4	331	338	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H9	Leptomonas seymouri	67%	100%
A0A3Q8IPD7	Leishmania donovani	100%	100%
A0A3R7KS72	Trypanosoma rangeli	45%	100%
A4HPT8	Leishmania braziliensis	83%	100%
D0A8Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0Z5	Leishmania major	91%	100%
V5BMD4	Trypanosoma cruzi	47%	83%