Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen) - N-terminal domain/Arrestin N terminal like - putative

Species:

Leishmania infantum

UniProt:

A4IE53_LEIIN

TriTrypDb:

LINF_360051200

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IE53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE53

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.582
CLV_C14_Caspase3-7	348	352	PF00656	0.641
CLV_C14_Caspase3-7	426	430	PF00656	0.665
CLV_C14_Caspase3-7	546	550	PF00656	0.477
CLV_C14_Caspase3-7	89	93	PF00656	0.561
CLV_NRD_NRD_1	101	103	PF00675	0.580
CLV_NRD_NRD_1	2	4	PF00675	0.623
CLV_NRD_NRD_1	270	272	PF00675	0.453
CLV_NRD_NRD_1	299	301	PF00675	0.717
CLV_NRD_NRD_1	303	305	PF00675	0.678
CLV_NRD_NRD_1	407	409	PF00675	0.694
CLV_NRD_NRD_1	493	495	PF00675	0.654
CLV_NRD_NRD_1	657	659	PF00675	0.470
CLV_NRD_NRD_1	668	670	PF00675	0.612
CLV_NRD_NRD_1	71	73	PF00675	0.412
CLV_PCSK_FUR_1	300	304	PF00082	0.669
CLV_PCSK_KEX2_1	101	103	PF00082	0.543
CLV_PCSK_KEX2_1	270	272	PF00082	0.453
CLV_PCSK_KEX2_1	302	304	PF00082	0.716
CLV_PCSK_KEX2_1	4	6	PF00082	0.617
CLV_PCSK_KEX2_1	406	408	PF00082	0.695
CLV_PCSK_KEX2_1	417	419	PF00082	0.658
CLV_PCSK_KEX2_1	493	495	PF00082	0.660
CLV_PCSK_KEX2_1	657	659	PF00082	0.470
CLV_PCSK_KEX2_1	667	669	PF00082	0.551
CLV_PCSK_KEX2_1	94	96	PF00082	0.489
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.596
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.673
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.643
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.554
CLV_PCSK_PC7_1	413	419	PF00082	0.644
CLV_PCSK_SKI1_1	176	180	PF00082	0.431
CLV_PCSK_SKI1_1	407	411	PF00082	0.704
CLV_PCSK_SKI1_1	522	526	PF00082	0.466
CLV_PCSK_SKI1_1	56	60	PF00082	0.437
CLV_PCSK_SKI1_1	593	597	PF00082	0.455
CLV_PCSK_SKI1_1	657	661	PF00082	0.480
CLV_PCSK_SKI1_1	675	679	PF00082	0.590
DEG_APCC_DBOX_1	527	535	PF00400	0.388
DEG_APCC_DBOX_1	55	63	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	581	585	PF00917	0.459
DOC_CYCLIN_RxL_1	517	529	PF00134	0.436
DOC_CYCLIN_RxL_1	654	663	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.666
DOC_MAPK_DCC_7	200	210	PF00069	0.424
DOC_MAPK_DCC_7	593	602	PF00069	0.452
DOC_MAPK_gen_1	200	208	PF00069	0.422
DOC_MAPK_gen_1	308	318	PF00069	0.564
DOC_MAPK_gen_1	517	527	PF00069	0.414
DOC_MAPK_gen_1	593	602	PF00069	0.452
DOC_MAPK_gen_1	739	749	PF00069	0.623
DOC_MAPK_MEF2A_6	202	210	PF00069	0.414
DOC_MAPK_MEF2A_6	517	525	PF00069	0.442
DOC_MAPK_MEF2A_6	528	536	PF00069	0.510
DOC_MAPK_MEF2A_6	593	602	PF00069	0.452
DOC_MAPK_MEF2A_6	742	751	PF00069	0.575
DOC_MAPK_MEF2A_6	9	17	PF00069	0.465
DOC_MAPK_RevD_3	81	95	PF00069	0.416
DOC_PP1_RVXF_1	441	447	PF00149	0.670
DOC_PP1_RVXF_1	656	663	PF00149	0.440
DOC_PP2B_LxvP_1	157	160	PF13499	0.400
DOC_PP2B_LxvP_1	453	456	PF13499	0.663
DOC_PP2B_LxvP_1	602	605	PF13499	0.465
DOC_PP2B_LxvP_1	679	682	PF13499	0.519
DOC_PP2B_LxvP_1	762	765	PF13499	0.477
DOC_PP4_FxxP_1	446	449	PF00568	0.616
DOC_PP4_FxxP_1	498	501	PF00568	0.575
DOC_PP4_FxxP_1	787	790	PF00568	0.588
DOC_SPAK_OSR1_1	394	398	PF12202	0.538
DOC_USP7_MATH_1	183	187	PF00917	0.410
DOC_USP7_MATH_1	357	361	PF00917	0.582
DOC_USP7_MATH_1	380	384	PF00917	0.593
DOC_USP7_MATH_1	39	43	PF00917	0.472
DOC_USP7_MATH_1	473	477	PF00917	0.648
DOC_WW_Pin1_4	374	379	PF00397	0.646
DOC_WW_Pin1_4	427	432	PF00397	0.790
DOC_WW_Pin1_4	444	449	PF00397	0.562
DOC_WW_Pin1_4	526	531	PF00397	0.436
DOC_WW_Pin1_4	605	610	PF00397	0.438
LIG_14-3-3_CanoR_1	119	123	PF00244	0.627
LIG_14-3-3_CanoR_1	247	255	PF00244	0.620
LIG_14-3-3_CanoR_1	418	428	PF00244	0.616
LIG_14-3-3_CanoR_1	493	501	PF00244	0.510
LIG_14-3-3_CanoR_1	522	528	PF00244	0.445
LIG_14-3-3_CanoR_1	556	562	PF00244	0.462
LIG_14-3-3_CanoR_1	568	577	PF00244	0.373
LIG_14-3-3_CanoR_1	626	636	PF00244	0.384
LIG_14-3-3_CanoR_1	638	647	PF00244	0.434
LIG_14-3-3_CanoR_1	72	77	PF00244	0.400
LIG_14-3-3_CanoR_1	732	740	PF00244	0.599
LIG_Actin_WH2_2	504	519	PF00022	0.452
LIG_BRCT_BRCA1_1	151	155	PF00533	0.380
LIG_BRCT_BRCA1_1	494	498	PF00533	0.536
LIG_EH_1	784	788	PF12763	0.579
LIG_EH1_1	181	189	PF00400	0.336
LIG_FHA_1	320	326	PF00498	0.607
LIG_FHA_1	363	369	PF00498	0.560
LIG_FHA_1	432	438	PF00498	0.759
LIG_FHA_1	463	469	PF00498	0.763
LIG_FHA_1	516	522	PF00498	0.514
LIG_FHA_1	531	537	PF00498	0.287
LIG_FHA_1	540	546	PF00498	0.437
LIG_FHA_1	640	646	PF00498	0.371
LIG_FHA_1	681	687	PF00498	0.504
LIG_FHA_2	291	297	PF00498	0.495
LIG_FHA_2	567	573	PF00498	0.441
LIG_FHA_2	581	587	PF00498	0.506
LIG_FHA_2	73	79	PF00498	0.433
LIG_Integrin_isoDGR_2	392	394	PF01839	0.645
LIG_LIR_Apic_2	150	154	PF02991	0.364
LIG_LIR_Apic_2	445	449	PF02991	0.593
LIG_LIR_Apic_2	495	501	PF02991	0.525
LIG_LIR_Apic_2	571	577	PF02991	0.438
LIG_LIR_Gen_1	152	163	PF02991	0.399
LIG_LIR_Gen_1	619	629	PF02991	0.365
LIG_LIR_Gen_1	74	83	PF02991	0.391
LIG_LIR_Nem_3	152	158	PF02991	0.394
LIG_LIR_Nem_3	619	625	PF02991	0.363
LIG_LIR_Nem_3	74	80	PF02991	0.415
LIG_LIR_Nem_3	802	807	PF02991	0.606
LIG_MAD2	522	530	PF02301	0.463
LIG_Pex14_1	503	507	PF04695	0.432
LIG_Pex14_1	662	666	PF04695	0.396
LIG_PTB_Apo_2	389	396	PF02174	0.660
LIG_REV1ctd_RIR_1	663	673	PF16727	0.548
LIG_SH2_CRK	151	155	PF00017	0.380
LIG_SH2_CRK	181	185	PF00017	0.338
LIG_SH2_CRK	559	563	PF00017	0.420
LIG_SH2_CRK	574	578	PF00017	0.492
LIG_SH2_GRB2like	234	237	PF00017	0.561
LIG_SH2_NCK_1	559	563	PF00017	0.372
LIG_SH2_SRC	758	761	PF00017	0.534
LIG_SH2_STAP1	290	294	PF00017	0.526
LIG_SH2_STAP1	758	762	PF00017	0.530
LIG_SH2_STAP1	77	81	PF00017	0.386
LIG_SH2_STAT3	76	79	PF00017	0.394
LIG_SH2_STAT5	566	569	PF00017	0.419
LIG_SH2_STAT5	628	631	PF00017	0.397
LIG_SH3_3	33	39	PF00018	0.426
LIG_SH3_3	370	376	PF00018	0.617
LIG_SH3_3	592	598	PF00018	0.462
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.487
LIG_SUMO_SIM_anti_2	642	648	PF11976	0.381
LIG_SUMO_SIM_par_1	32	37	PF11976	0.408
LIG_SUMO_SIM_par_1	42	48	PF11976	0.335
LIG_SUMO_SIM_par_1	523	529	PF11976	0.459
LIG_SUMO_SIM_par_1	541	546	PF11976	0.416
LIG_SUMO_SIM_par_1	642	648	PF11976	0.443
LIG_TRAF2_1	476	479	PF00917	0.727
LIG_TRFH_1	677	681	PF08558	0.531
LIG_TYR_ITIM	179	184	PF00017	0.345
LIG_TYR_ITIM	557	562	PF00017	0.425
LIG_UBA3_1	58	67	PF00899	0.574
LIG_WRC_WIRS_1	633	638	PF05994	0.433
MOD_CK1_1	251	257	PF00069	0.760
MOD_CK1_1	346	352	PF00069	0.691
MOD_CK1_1	399	405	PF00069	0.635
MOD_CK1_1	469	475	PF00069	0.636
MOD_CK1_1	510	516	PF00069	0.465
MOD_CK1_1	526	532	PF00069	0.330
MOD_CK1_1	548	554	PF00069	0.494
MOD_CK1_1	560	566	PF00069	0.316
MOD_CK1_1	585	591	PF00069	0.443
MOD_CK1_1	639	645	PF00069	0.372
MOD_CK1_1	717	723	PF00069	0.643
MOD_CK1_1	725	731	PF00069	0.631
MOD_CK1_1	93	99	PF00069	0.559
MOD_CK2_1	290	296	PF00069	0.485
MOD_CK2_1	4	10	PF00069	0.599
MOD_CK2_1	473	479	PF00069	0.790
MOD_CK2_1	566	572	PF00069	0.414
MOD_CK2_1	72	78	PF00069	0.438
MOD_Cter_Amidation	404	407	PF01082	0.657
MOD_Cter_Amidation	413	416	PF01082	0.599
MOD_GlcNHglycan	114	117	PF01048	0.600
MOD_GlcNHglycan	130	134	PF01048	0.462
MOD_GlcNHglycan	190	193	PF01048	0.457
MOD_GlcNHglycan	250	253	PF01048	0.762
MOD_GlcNHglycan	328	331	PF01048	0.517
MOD_GlcNHglycan	398	401	PF01048	0.792
MOD_GlcNHglycan	487	490	PF01048	0.601
MOD_GlcNHglycan	512	515	PF01048	0.541
MOD_GlcNHglycan	549	553	PF01048	0.401
MOD_GlcNHglycan	647	650	PF01048	0.514
MOD_GlcNHglycan	724	727	PF01048	0.559
MOD_GSK3_1	108	115	PF00069	0.747
MOD_GSK3_1	149	156	PF00069	0.397
MOD_GSK3_1	183	190	PF00069	0.450
MOD_GSK3_1	243	250	PF00069	0.588
MOD_GSK3_1	319	326	PF00069	0.614
MOD_GSK3_1	376	383	PF00069	0.774
MOD_GSK3_1	427	434	PF00069	0.712
MOD_GSK3_1	462	469	PF00069	0.643
MOD_GSK3_1	526	533	PF00069	0.434
MOD_GSK3_1	548	555	PF00069	0.416
MOD_GSK3_1	577	584	PF00069	0.591
MOD_GSK3_1	604	611	PF00069	0.431
MOD_GSK3_1	628	635	PF00069	0.432
MOD_GSK3_1	680	687	PF00069	0.510
MOD_GSK3_1	714	721	PF00069	0.562
MOD_GSK3_1	734	741	PF00069	0.641
MOD_GSK3_1	789	796	PF00069	0.637
MOD_N-GLC_1	137	142	PF02516	0.571
MOD_N-GLC_1	235	240	PF02516	0.589
MOD_N-GLC_1	326	331	PF02516	0.544
MOD_N-GLC_1	343	348	PF02516	0.568
MOD_N-GLC_1	357	362	PF02516	0.637
MOD_N-GLC_1	462	467	PF02516	0.690
MOD_N-GLC_1	653	658	PF02516	0.465
MOD_N-GLC_1	684	689	PF02516	0.547
MOD_NEK2_1	131	136	PF00069	0.583
MOD_NEK2_1	187	192	PF00069	0.476
MOD_NEK2_1	248	253	PF00069	0.720
MOD_NEK2_1	507	512	PF00069	0.425
MOD_NEK2_1	515	520	PF00069	0.491
MOD_NEK2_1	627	632	PF00069	0.434
MOD_NEK2_1	636	641	PF00069	0.468
MOD_NEK2_1	653	658	PF00069	0.458
MOD_NEK2_1	660	665	PF00069	0.415
MOD_NEK2_1	722	727	PF00069	0.633
MOD_NEK2_1	734	739	PF00069	0.563
MOD_NEK2_1	752	757	PF00069	0.488
MOD_NEK2_1	90	95	PF00069	0.537
MOD_NEK2_2	380	385	PF00069	0.620
MOD_PIKK_1	560	566	PF00454	0.397
MOD_PIKK_1	734	740	PF00454	0.633
MOD_PKA_1	4	10	PF00069	0.645
MOD_PKA_1	493	499	PF00069	0.595
MOD_PKA_1	72	78	PF00069	0.438
MOD_PKA_2	118	124	PF00069	0.609
MOD_PKA_2	312	318	PF00069	0.583
MOD_PKA_2	4	10	PF00069	0.645
MOD_PKA_2	483	489	PF00069	0.693
MOD_PKA_2	492	498	PF00069	0.617
MOD_PKA_2	660	666	PF00069	0.401
MOD_PKA_2	71	77	PF00069	0.552
MOD_PKA_2	734	740	PF00069	0.590
MOD_PKB_1	3	11	PF00069	0.618
MOD_Plk_1	320	326	PF00069	0.560
MOD_Plk_1	343	349	PF00069	0.573
MOD_Plk_1	54	60	PF00069	0.467
MOD_Plk_1	585	591	PF00069	0.443
MOD_Plk_1	675	681	PF00069	0.527
MOD_Plk_1	717	723	PF00069	0.615
MOD_Plk_2-3	343	349	PF00069	0.627
MOD_Plk_4	131	137	PF00069	0.551
MOD_Plk_4	183	189	PF00069	0.428
MOD_Plk_4	312	318	PF00069	0.627
MOD_Plk_4	539	545	PF00069	0.562
MOD_Plk_4	557	563	PF00069	0.272
MOD_Plk_4	608	614	PF00069	0.389
MOD_Plk_4	618	624	PF00069	0.409
MOD_Plk_4	72	78	PF00069	0.420
MOD_ProDKin_1	374	380	PF00069	0.648
MOD_ProDKin_1	427	433	PF00069	0.791
MOD_ProDKin_1	444	450	PF00069	0.563
MOD_ProDKin_1	526	532	PF00069	0.434
MOD_ProDKin_1	605	611	PF00069	0.432
MOD_SUMO_rev_2	87	96	PF00179	0.514
TRG_DiLeu_BaEn_1	14	19	PF01217	0.417
TRG_DiLeu_BaEn_1	312	317	PF01217	0.627
TRG_DiLeu_BaEn_2	758	764	PF01217	0.525
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.441
TRG_DiLeu_BaLyEn_6	747	752	PF01217	0.541
TRG_ENDOCYTIC_2	181	184	PF00928	0.339
TRG_ENDOCYTIC_2	275	278	PF00928	0.521
TRG_ENDOCYTIC_2	559	562	PF00928	0.383
TRG_ENDOCYTIC_2	77	80	PF00928	0.391
TRG_ENDOCYTIC_2	804	807	PF00928	0.612
TRG_ER_diArg_1	101	103	PF00400	0.564
TRG_ER_diArg_1	170	173	PF00400	0.474
TRG_ER_diArg_1	2	5	PF00400	0.610
TRG_ER_diArg_1	200	203	PF00400	0.434
TRG_ER_diArg_1	270	273	PF00400	0.459
TRG_ER_diArg_1	406	408	PF00400	0.657
TRG_ER_diArg_1	657	659	PF00400	0.472
TRG_ER_diArg_1	666	669	PF00400	0.525
TRG_NLS_Bipartite_1	406	420	PF00514	0.645
TRG_NLS_MonoCore_2	300	305	PF00514	0.546
TRG_NLS_MonoCore_2	414	419	PF00514	0.588
TRG_NLS_MonoExtC_3	301	307	PF00514	0.589
TRG_NLS_MonoExtN_4	300	306	PF00514	0.587
TRG_NLS_MonoExtN_4	413	420	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I967	Leptomonas seymouri	46%	95%
A0A3S7XBE9	Leishmania donovani	99%	100%
A4HPT9	Leishmania braziliensis	67%	100%
E9ATK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0Z4	Leishmania major	91%	100%