LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat/Utp21 specific WD40 associated putative domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IE52_LEIIN
TriTrypDb:
LINF_360051300
Length:
984

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 11
GO:0030684 preribosome 3 11
GO:0032040 small-subunit processome 4 11
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 12
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome 3 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0140513 nuclear protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IE52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE52

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006364 rRNA processing 8 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0016072 rRNA metabolic process 7 11
GO:0034470 ncRNA processing 7 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034660 ncRNA metabolic process 6 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 248 252 PF00656 0.300
CLV_C14_Caspase3-7 328 332 PF00656 0.334
CLV_C14_Caspase3-7 611 615 PF00656 0.423
CLV_MEL_PAP_1 939 945 PF00089 0.362
CLV_NRD_NRD_1 340 342 PF00675 0.264
CLV_NRD_NRD_1 756 758 PF00675 0.491
CLV_NRD_NRD_1 829 831 PF00675 0.349
CLV_NRD_NRD_1 917 919 PF00675 0.262
CLV_PCSK_FUR_1 338 342 PF00082 0.283
CLV_PCSK_KEX2_1 116 118 PF00082 0.281
CLV_PCSK_KEX2_1 340 342 PF00082 0.264
CLV_PCSK_KEX2_1 388 390 PF00082 0.356
CLV_PCSK_KEX2_1 755 757 PF00082 0.488
CLV_PCSK_KEX2_1 882 884 PF00082 0.240
CLV_PCSK_KEX2_1 917 919 PF00082 0.265
CLV_PCSK_PC1ET2_1 116 118 PF00082 0.281
CLV_PCSK_PC1ET2_1 388 390 PF00082 0.478
CLV_PCSK_PC1ET2_1 882 884 PF00082 0.240
CLV_PCSK_SKI1_1 152 156 PF00082 0.336
CLV_PCSK_SKI1_1 487 491 PF00082 0.304
CLV_PCSK_SKI1_1 906 910 PF00082 0.333
DEG_APCC_DBOX_1 283 291 PF00400 0.500
DEG_Nend_UBRbox_2 1 3 PF02207 0.353
DEG_SCF_FBW7_2 581 587 PF00400 0.295
DEG_SCF_FBW7_2 849 854 PF00400 0.233
DEG_SPOP_SBC_1 608 612 PF00917 0.423
DOC_ANK_TNKS_1 68 75 PF00023 0.250
DOC_CKS1_1 25 30 PF01111 0.418
DOC_CKS1_1 581 586 PF01111 0.217
DOC_CYCLIN_RxL_1 149 159 PF00134 0.403
DOC_CYCLIN_RxL_1 453 462 PF00134 0.404
DOC_CYCLIN_RxL_1 900 913 PF00134 0.332
DOC_CYCLIN_yClb1_LxF_4 780 785 PF00134 0.282
DOC_CYCLIN_yCln2_LP_2 800 803 PF00134 0.221
DOC_MAPK_DCC_7 667 676 PF00069 0.421
DOC_MAPK_gen_1 247 255 PF00069 0.349
DOC_MAPK_gen_1 804 810 PF00069 0.221
DOC_MAPK_gen_1 917 924 PF00069 0.261
DOC_MAPK_HePTP_8 869 881 PF00069 0.300
DOC_MAPK_JIP1_4 819 825 PF00069 0.265
DOC_MAPK_MEF2A_6 632 640 PF00069 0.294
DOC_MAPK_MEF2A_6 667 676 PF00069 0.503
DOC_MAPK_MEF2A_6 872 881 PF00069 0.300
DOC_MAPK_MEF2A_6 96 103 PF00069 0.349
DOC_MAPK_RevD_3 903 918 PF00069 0.149
DOC_PP1_RVXF_1 115 122 PF00149 0.398
DOC_PP1_RVXF_1 780 786 PF00149 0.304
DOC_PP1_RVXF_1 918 925 PF00149 0.386
DOC_PP2B_LxvP_1 800 803 PF13499 0.221
DOC_PP4_FxxP_1 304 307 PF00568 0.454
DOC_PP4_FxxP_1 633 636 PF00568 0.365
DOC_PP4_FxxP_1 810 813 PF00568 0.221
DOC_USP7_MATH_1 240 244 PF00917 0.300
DOC_USP7_MATH_1 499 503 PF00917 0.400
DOC_USP7_MATH_1 609 613 PF00917 0.445
DOC_USP7_MATH_1 702 706 PF00917 0.548
DOC_USP7_MATH_1 711 715 PF00917 0.593
DOC_WW_Pin1_4 24 29 PF00397 0.414
DOC_WW_Pin1_4 580 585 PF00397 0.353
DOC_WW_Pin1_4 590 595 PF00397 0.371
DOC_WW_Pin1_4 632 637 PF00397 0.263
DOC_WW_Pin1_4 674 679 PF00397 0.379
DOC_WW_Pin1_4 847 852 PF00397 0.251
LIG_14-3-3_CanoR_1 376 380 PF00244 0.302
LIG_14-3-3_CanoR_1 712 719 PF00244 0.590
LIG_14-3-3_CanoR_1 962 966 PF00244 0.267
LIG_Actin_WH2_2 520 538 PF00022 0.385
LIG_Actin_WH2_2 805 821 PF00022 0.221
LIG_Actin_WH2_2 947 964 PF00022 0.233
LIG_AP2alpha_2 5 7 PF02296 0.371
LIG_BRCT_BRCA1_1 242 246 PF00533 0.300
LIG_BRCT_BRCA1_1 553 557 PF00533 0.269
LIG_BRCT_BRCA1_1 638 642 PF00533 0.248
LIG_CaM_NSCaTE_8 531 538 PF13499 0.373
LIG_Clathr_ClatBox_1 301 305 PF01394 0.399
LIG_EH1_1 962 970 PF00400 0.217
LIG_eIF4E_1 149 155 PF01652 0.257
LIG_eIF4E_1 25 31 PF01652 0.267
LIG_eIF4E_1 353 359 PF01652 0.258
LIG_eIF4E_1 416 422 PF01652 0.352
LIG_FHA_1 123 129 PF00498 0.320
LIG_FHA_1 135 141 PF00498 0.279
LIG_FHA_1 159 165 PF00498 0.330
LIG_FHA_1 224 230 PF00498 0.339
LIG_FHA_1 240 246 PF00498 0.218
LIG_FHA_1 25 31 PF00498 0.313
LIG_FHA_1 308 314 PF00498 0.346
LIG_FHA_1 346 352 PF00498 0.296
LIG_FHA_1 35 41 PF00498 0.217
LIG_FHA_1 353 359 PF00498 0.274
LIG_FHA_1 512 518 PF00498 0.386
LIG_FHA_1 530 536 PF00498 0.238
LIG_FHA_1 562 568 PF00498 0.302
LIG_FHA_1 813 819 PF00498 0.221
LIG_FHA_1 911 917 PF00498 0.349
LIG_FHA_1 98 104 PF00498 0.404
LIG_FHA_2 229 235 PF00498 0.228
LIG_FHA_2 246 252 PF00498 0.273
LIG_FHA_2 52 58 PF00498 0.457
LIG_FHA_2 575 581 PF00498 0.473
LIG_FHA_2 609 615 PF00498 0.423
LIG_FHA_2 699 705 PF00498 0.649
LIG_FHA_2 718 724 PF00498 0.611
LIG_FHA_2 786 792 PF00498 0.221
LIG_FHA_2 812 818 PF00498 0.221
LIG_FHA_2 892 898 PF00498 0.253
LIG_LIR_Apic_2 22 28 PF02991 0.286
LIG_LIR_Apic_2 807 813 PF02991 0.221
LIG_LIR_Gen_1 308 314 PF02991 0.424
LIG_LIR_Gen_1 685 694 PF02991 0.464
LIG_LIR_Gen_1 821 826 PF02991 0.265
LIG_LIR_Gen_1 866 876 PF02991 0.335
LIG_LIR_Gen_1 910 916 PF02991 0.270
LIG_LIR_Nem_3 2 7 PF02991 0.282
LIG_LIR_Nem_3 204 209 PF02991 0.222
LIG_LIR_Nem_3 308 312 PF02991 0.441
LIG_LIR_Nem_3 37 41 PF02991 0.247
LIG_LIR_Nem_3 603 608 PF02991 0.393
LIG_LIR_Nem_3 685 691 PF02991 0.449
LIG_LIR_Nem_3 866 871 PF02991 0.294
LIG_LIR_Nem_3 910 914 PF02991 0.149
LIG_LRP6_Inhibitor_1 661 667 PF00058 0.332
LIG_MAD2 8 16 PF02301 0.386
LIG_MYND_1 799 803 PF01753 0.221
LIG_MYND_3 948 952 PF01753 0.289
LIG_PCNA_yPIPBox_3 900 909 PF02747 0.343
LIG_PCNA_yPIPBox_3 920 933 PF02747 0.077
LIG_PDZ_Class_1 979 984 PF00595 0.365
LIG_Pex14_2 911 915 PF04695 0.240
LIG_PTB_Apo_2 662 669 PF02174 0.425
LIG_PTB_Phospho_1 662 668 PF10480 0.418
LIG_Rb_pABgroove_1 484 492 PF01858 0.344
LIG_RPA_C_Fungi 184 196 PF08784 0.392
LIG_SH2_CRK 25 29 PF00017 0.299
LIG_SH2_CRK 309 313 PF00017 0.418
LIG_SH2_CRK 466 470 PF00017 0.370
LIG_SH2_CRK 605 609 PF00017 0.240
LIG_SH2_CRK 668 672 PF00017 0.322
LIG_SH2_CRK 68 72 PF00017 0.259
LIG_SH2_GRB2like 149 152 PF00017 0.314
LIG_SH2_GRB2like 887 890 PF00017 0.221
LIG_SH2_NCK_1 466 470 PF00017 0.370
LIG_SH2_NCK_1 893 897 PF00017 0.331
LIG_SH2_SRC 80 83 PF00017 0.367
LIG_SH2_SRC 887 890 PF00017 0.270
LIG_SH2_STAP1 149 153 PF00017 0.303
LIG_SH2_STAP1 309 313 PF00017 0.418
LIG_SH2_STAT5 149 152 PF00017 0.314
LIG_SH2_STAT5 309 312 PF00017 0.426
LIG_SH2_STAT5 607 610 PF00017 0.221
LIG_SH2_STAT5 660 663 PF00017 0.341
LIG_SH2_STAT5 670 673 PF00017 0.399
LIG_SH2_STAT5 80 83 PF00017 0.367
LIG_SH2_STAT5 867 870 PF00017 0.240
LIG_SH2_STAT5 887 890 PF00017 0.223
LIG_SH2_STAT5 893 896 PF00017 0.225
LIG_SH3_1 796 802 PF00018 0.221
LIG_SH3_2 799 804 PF14604 0.221
LIG_SH3_3 15 21 PF00018 0.339
LIG_SH3_3 397 403 PF00018 0.455
LIG_SH3_3 672 678 PF00018 0.329
LIG_SH3_3 796 802 PF00018 0.221
LIG_SH3_3 966 972 PF00018 0.265
LIG_SUMO_SIM_anti_2 141 147 PF11976 0.397
LIG_SUMO_SIM_anti_2 98 103 PF11976 0.292
LIG_SUMO_SIM_par_1 27 34 PF11976 0.258
LIG_SUMO_SIM_par_1 513 518 PF11976 0.300
LIG_SUMO_SIM_par_1 821 828 PF11976 0.282
LIG_TRAF2_1 577 580 PF00917 0.438
LIG_TRAF2_1 701 704 PF00917 0.651
LIG_TRAF2_1 722 725 PF00917 0.595
LIG_TRAF2_1 814 817 PF00917 0.240
LIG_TRAF2_1 851 854 PF00917 0.233
LIG_TRAF2_1 950 953 PF00917 0.349
LIG_TYR_ITIM 666 671 PF00017 0.320
LIG_WRC_WIRS_1 1 6 PF05994 0.328
LIG_WRC_WIRS_1 230 235 PF05994 0.240
LIG_WRC_WIRS_1 908 913 PF05994 0.265
MOD_CDK_SPK_2 674 679 PF00069 0.343
MOD_CDK_SPxK_1 580 586 PF00069 0.217
MOD_CK1_1 176 182 PF00069 0.526
MOD_CK1_1 188 194 PF00069 0.536
MOD_CK1_1 256 262 PF00069 0.202
MOD_CK1_1 420 426 PF00069 0.269
MOD_CK1_1 451 457 PF00069 0.382
MOD_CK1_1 593 599 PF00069 0.308
MOD_CK1_1 870 876 PF00069 0.294
MOD_CK1_1 891 897 PF00069 0.347
MOD_CK1_1 910 916 PF00069 0.412
MOD_CK1_1 970 976 PF00069 0.149
MOD_CK2_1 256 262 PF00069 0.206
MOD_CK2_1 282 288 PF00069 0.372
MOD_CK2_1 499 505 PF00069 0.231
MOD_CK2_1 574 580 PF00069 0.432
MOD_CK2_1 698 704 PF00069 0.643
MOD_CK2_1 717 723 PF00069 0.591
MOD_CK2_1 811 817 PF00069 0.221
MOD_CK2_1 86 92 PF00069 0.466
MOD_CK2_1 891 897 PF00069 0.245
MOD_CMANNOS 528 531 PF00535 0.396
MOD_Cter_Amidation 386 389 PF01082 0.329
MOD_GlcNHglycan 168 171 PF01048 0.349
MOD_GlcNHglycan 179 182 PF01048 0.547
MOD_GlcNHglycan 255 258 PF01048 0.233
MOD_GlcNHglycan 316 319 PF01048 0.273
MOD_GlcNHglycan 427 430 PF01048 0.317
MOD_GlcNHglycan 445 448 PF01048 0.263
MOD_GlcNHglycan 450 453 PF01048 0.344
MOD_GlcNHglycan 472 475 PF01048 0.265
MOD_GlcNHglycan 611 614 PF01048 0.215
MOD_GlcNHglycan 713 716 PF01048 0.617
MOD_GlcNHglycan 979 982 PF01048 0.345
MOD_GSK3_1 134 141 PF00069 0.341
MOD_GSK3_1 154 161 PF00069 0.268
MOD_GSK3_1 173 180 PF00069 0.253
MOD_GSK3_1 181 188 PF00069 0.510
MOD_GSK3_1 229 236 PF00069 0.344
MOD_GSK3_1 273 280 PF00069 0.429
MOD_GSK3_1 308 315 PF00069 0.353
MOD_GSK3_1 367 374 PF00069 0.298
MOD_GSK3_1 375 382 PF00069 0.338
MOD_GSK3_1 416 423 PF00069 0.260
MOD_GSK3_1 443 450 PF00069 0.317
MOD_GSK3_1 51 58 PF00069 0.446
MOD_GSK3_1 511 518 PF00069 0.236
MOD_GSK3_1 632 639 PF00069 0.262
MOD_GSK3_1 698 705 PF00069 0.682
MOD_GSK3_1 706 713 PF00069 0.675
MOD_GSK3_1 957 964 PF00069 0.242
MOD_GSK3_1 975 982 PF00069 0.320
MOD_N-GLC_1 482 487 PF02516 0.346
MOD_N-GLC_1 706 711 PF02516 0.538
MOD_N-GLC_1 785 790 PF02516 0.265
MOD_N-GLC_1 831 836 PF02516 0.267
MOD_N-GLC_1 888 893 PF02516 0.221
MOD_N-GLC_2 270 272 PF02516 0.206
MOD_NEK2_1 108 113 PF00069 0.373
MOD_NEK2_1 173 178 PF00069 0.446
MOD_NEK2_1 201 206 PF00069 0.324
MOD_NEK2_1 253 258 PF00069 0.300
MOD_NEK2_1 273 278 PF00069 0.314
MOD_NEK2_1 31 36 PF00069 0.254
MOD_NEK2_1 312 317 PF00069 0.337
MOD_NEK2_1 357 362 PF00069 0.236
MOD_NEK2_1 367 372 PF00069 0.264
MOD_NEK2_1 443 448 PF00069 0.427
MOD_NEK2_1 545 550 PF00069 0.322
MOD_NEK2_1 55 60 PF00069 0.347
MOD_NEK2_1 638 643 PF00069 0.307
MOD_NEK2_1 648 653 PF00069 0.279
MOD_NEK2_1 785 790 PF00069 0.280
MOD_NEK2_1 86 91 PF00069 0.371
MOD_NEK2_1 975 980 PF00069 0.395
MOD_NEK2_2 867 872 PF00069 0.352
MOD_PIKK_1 379 385 PF00454 0.302
MOD_PIKK_1 745 751 PF00454 0.576
MOD_PIKK_1 812 818 PF00454 0.274
MOD_PKA_1 756 762 PF00069 0.539
MOD_PKA_2 177 183 PF00069 0.494
MOD_PKA_2 188 194 PF00069 0.610
MOD_PKA_2 367 373 PF00069 0.270
MOD_PKA_2 375 381 PF00069 0.297
MOD_PKA_2 711 717 PF00069 0.593
MOD_PKA_2 756 762 PF00069 0.410
MOD_PKA_2 818 824 PF00069 0.249
MOD_PKA_2 961 967 PF00069 0.280
MOD_Plk_1 307 313 PF00069 0.440
MOD_Plk_1 482 488 PF00069 0.310
MOD_Plk_1 500 506 PF00069 0.147
MOD_Plk_1 551 557 PF00069 0.386
MOD_Plk_1 785 791 PF00069 0.221
MOD_Plk_2-3 375 381 PF00069 0.291
MOD_Plk_4 124 130 PF00069 0.366
MOD_Plk_4 19 25 PF00069 0.274
MOD_Plk_4 240 246 PF00069 0.300
MOD_Plk_4 297 303 PF00069 0.250
MOD_Plk_4 308 314 PF00069 0.278
MOD_Plk_4 417 423 PF00069 0.254
MOD_Plk_4 511 517 PF00069 0.213
MOD_Plk_4 552 558 PF00069 0.279
MOD_Plk_4 785 791 PF00069 0.226
MOD_Plk_4 818 824 PF00069 0.221
MOD_Plk_4 907 913 PF00069 0.300
MOD_ProDKin_1 24 30 PF00069 0.406
MOD_ProDKin_1 580 586 PF00069 0.217
MOD_ProDKin_1 590 596 PF00069 0.208
MOD_ProDKin_1 632 638 PF00069 0.266
MOD_ProDKin_1 674 680 PF00069 0.384
MOD_ProDKin_1 847 853 PF00069 0.251
MOD_SUMO_rev_2 111 118 PF00179 0.376
MOD_SUMO_rev_2 437 446 PF00179 0.284
MOD_SUMO_rev_2 878 884 PF00179 0.240
TRG_DiLeu_BaEn_1 308 313 PF01217 0.428
TRG_DiLeu_BaLyEn_6 796 801 PF01217 0.221
TRG_ENDOCYTIC_2 206 209 PF00928 0.221
TRG_ENDOCYTIC_2 309 312 PF00928 0.426
TRG_ENDOCYTIC_2 466 469 PF00928 0.371
TRG_ENDOCYTIC_2 605 608 PF00928 0.240
TRG_ENDOCYTIC_2 660 663 PF00928 0.282
TRG_ENDOCYTIC_2 668 671 PF00928 0.289
TRG_ENDOCYTIC_2 68 71 PF00928 0.261
TRG_ER_diArg_1 755 757 PF00400 0.539
TRG_ER_diArg_1 916 918 PF00400 0.300
TRG_NES_CRM1_1 847 859 PF08389 0.270
TRG_Pf-PMV_PEXEL_1 487 491 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7H8 Leptomonas seymouri 84% 100%
A0A0S4IK94 Bodo saltans 51% 100%
A0A1X0P3D2 Trypanosomatidae 63% 100%
A0A3R7KJ70 Trypanosoma rangeli 64% 100%
A0A3S7XBK1 Leishmania donovani 100% 100%
A4HPU0 Leishmania braziliensis 91% 100%
D0A8Q5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 89%
E9ATK5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O14053 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q06078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q4Q0Z3 Leishmania major 95% 99%
Q8NI36 Homo sapiens 24% 100%
V5BS01 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS