LeishMANIAdb
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Paraflagellar rod component

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Paraflagellar rod component
Gene product:
paraflagellar rod component - putative
Species:
Leishmania infantum
UniProt:
A4IE50_LEIIN
TriTrypDb:
LINF_360051600
Length:
1123

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod component Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:0031514 motile cilium 5 3

Expansion

Sequence features

A4IE50
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE50

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 287 289 PF00675 0.547
CLV_NRD_NRD_1 725 727 PF00675 0.469
CLV_PCSK_KEX2_1 333 335 PF00082 0.529
CLV_PCSK_KEX2_1 42 44 PF00082 0.494
CLV_PCSK_KEX2_1 651 653 PF00082 0.540
CLV_PCSK_KEX2_1 813 815 PF00082 0.490
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.529
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.494
CLV_PCSK_PC1ET2_1 651 653 PF00082 0.540
CLV_PCSK_PC1ET2_1 813 815 PF00082 0.490
CLV_PCSK_SKI1_1 1057 1061 PF00082 0.567
CLV_PCSK_SKI1_1 1081 1085 PF00082 0.606
CLV_PCSK_SKI1_1 112 116 PF00082 0.564
CLV_PCSK_SKI1_1 179 183 PF00082 0.417
CLV_PCSK_SKI1_1 202 206 PF00082 0.458
CLV_PCSK_SKI1_1 492 496 PF00082 0.510
CLV_PCSK_SKI1_1 513 517 PF00082 0.528
CLV_PCSK_SKI1_1 52 56 PF00082 0.555
CLV_PCSK_SKI1_1 561 565 PF00082 0.395
CLV_PCSK_SKI1_1 620 624 PF00082 0.491
CLV_PCSK_SKI1_1 727 731 PF00082 0.451
CLV_PCSK_SKI1_1 813 817 PF00082 0.371
CLV_Separin_Metazoa 1009 1013 PF03568 0.518
CLV_Separin_Metazoa 203 207 PF03568 0.531
DEG_APCC_DBOX_1 1056 1064 PF00400 0.565
DEG_APCC_DBOX_1 491 499 PF00400 0.538
DEG_Nend_Nbox_1 1 3 PF02207 0.497
DOC_CYCLIN_RxL_1 202 212 PF00134 0.493
DOC_CYCLIN_RxL_1 530 544 PF00134 0.455
DOC_CYCLIN_RxL_1 852 865 PF00134 0.458
DOC_CYCLIN_RxL_1 941 951 PF00134 0.477
DOC_CYCLIN_RxL_1 987 998 PF00134 0.437
DOC_MAPK_gen_1 143 149 PF00069 0.521
DOC_MAPK_gen_1 333 339 PF00069 0.517
DOC_MAPK_gen_1 458 466 PF00069 0.479
DOC_MAPK_gen_1 6 16 PF00069 0.460
DOC_MAPK_gen_1 749 758 PF00069 0.320
DOC_MAPK_gen_1 813 819 PF00069 0.453
DOC_MAPK_MEF2A_6 458 466 PF00069 0.529
DOC_MAPK_MEF2A_6 503 510 PF00069 0.557
DOC_MAPK_MEF2A_6 561 568 PF00069 0.398
DOC_MAPK_MEF2A_6 929 938 PF00069 0.551
DOC_MAPK_NFAT4_5 561 569 PF00069 0.359
DOC_PP1_RVXF_1 162 168 PF00149 0.317
DOC_PP1_RVXF_1 911 918 PF00149 0.464
DOC_USP7_MATH_1 1026 1030 PF00917 0.398
DOC_USP7_MATH_1 160 164 PF00917 0.482
DOC_USP7_MATH_1 369 373 PF00917 0.494
DOC_USP7_MATH_1 54 58 PF00917 0.484
DOC_USP7_MATH_1 590 594 PF00917 0.411
DOC_USP7_UBL2_3 144 148 PF12436 0.534
DOC_WW_Pin1_4 1069 1074 PF00397 0.501
DOC_WW_Pin1_4 309 314 PF00397 0.526
DOC_WW_Pin1_4 468 473 PF00397 0.557
DOC_WW_Pin1_4 668 673 PF00397 0.602
DOC_WW_Pin1_4 85 90 PF00397 0.465
LIG_14-3-3_CanoR_1 1095 1101 PF00244 0.640
LIG_14-3-3_CanoR_1 112 122 PF00244 0.558
LIG_14-3-3_CanoR_1 269 275 PF00244 0.550
LIG_14-3-3_CanoR_1 340 349 PF00244 0.503
LIG_14-3-3_CanoR_1 411 417 PF00244 0.416
LIG_14-3-3_CanoR_1 43 51 PF00244 0.589
LIG_14-3-3_CanoR_1 458 463 PF00244 0.512
LIG_14-3-3_CanoR_1 530 536 PF00244 0.430
LIG_14-3-3_CanoR_1 628 637 PF00244 0.517
LIG_14-3-3_CanoR_1 691 697 PF00244 0.463
LIG_14-3-3_CanoR_1 814 818 PF00244 0.460
LIG_14-3-3_CanoR_1 929 936 PF00244 0.509
LIG_14-3-3_CanoR_1 970 978 PF00244 0.519
LIG_Actin_WH2_2 389 405 PF00022 0.505
LIG_Actin_WH2_2 899 915 PF00022 0.495
LIG_APCC_ABBA_1 207 212 PF00400 0.490
LIG_APCC_ABBAyCdc20_2 206 212 PF00400 0.495
LIG_BRCT_BRCA1_1 215 219 PF00533 0.492
LIG_BRCT_BRCA1_1 272 276 PF00533 0.439
LIG_BRCT_BRCA1_1 291 295 PF00533 0.447
LIG_BRCT_BRCA1_1 913 917 PF00533 0.470
LIG_BRCT_BRCA1_1 995 999 PF00533 0.475
LIG_Clathr_ClatBox_1 208 212 PF01394 0.574
LIG_FHA_1 1102 1108 PF00498 0.616
LIG_FHA_1 114 120 PF00498 0.520
LIG_FHA_1 448 454 PF00498 0.433
LIG_FHA_1 459 465 PF00498 0.417
LIG_FHA_1 720 726 PF00498 0.583
LIG_FHA_1 814 820 PF00498 0.492
LIG_FHA_2 194 200 PF00498 0.567
LIG_FHA_2 291 297 PF00498 0.440
LIG_FHA_2 514 520 PF00498 0.418
LIG_FHA_2 560 566 PF00498 0.417
LIG_FHA_2 663 669 PF00498 0.494
LIG_FHA_2 692 698 PF00498 0.477
LIG_FHA_2 715 721 PF00498 0.483
LIG_FHA_2 750 756 PF00498 0.495
LIG_FHA_2 785 791 PF00498 0.591
LIG_FHA_2 81 87 PF00498 0.512
LIG_FHA_2 949 955 PF00498 0.536
LIG_FHA_2 970 976 PF00498 0.507
LIG_Integrin_RGD_1 952 954 PF01839 0.413
LIG_IRF3_LxIS_1 373 380 PF10401 0.482
LIG_LIR_Gen_1 22 30 PF02991 0.489
LIG_LIR_Gen_1 312 319 PF02991 0.552
LIG_LIR_Nem_3 1033 1039 PF02991 0.419
LIG_LIR_Nem_3 1072 1077 PF02991 0.600
LIG_LIR_Nem_3 136 141 PF02991 0.370
LIG_LIR_Nem_3 196 200 PF02991 0.514
LIG_LIR_Nem_3 22 27 PF02991 0.486
LIG_LIR_Nem_3 312 318 PF02991 0.524
LIG_LIR_Nem_3 780 786 PF02991 0.508
LIG_NRBOX 204 210 PF00104 0.532
LIG_NRBOX 978 984 PF00104 0.511
LIG_PCNA_yPIPBox_3 248 260 PF02747 0.498
LIG_Pex14_2 137 141 PF04695 0.370
LIG_PTB_Apo_2 264 271 PF02174 0.500
LIG_PTB_Phospho_1 264 270 PF10480 0.531
LIG_REV1ctd_RIR_1 13 22 PF16727 0.465
LIG_SH2_CRK 1074 1078 PF00017 0.636
LIG_SH2_PTP2 315 318 PF00017 0.391
LIG_SH2_STAT3 1100 1103 PF00017 0.692
LIG_SH2_STAT5 1036 1039 PF00017 0.467
LIG_SH2_STAT5 109 112 PF00017 0.467
LIG_SH2_STAT5 1100 1103 PF00017 0.654
LIG_SH2_STAT5 113 116 PF00017 0.452
LIG_SH2_STAT5 166 169 PF00017 0.432
LIG_SH2_STAT5 315 318 PF00017 0.548
LIG_SH2_STAT5 363 366 PF00017 0.407
LIG_SH2_STAT5 367 370 PF00017 0.398
LIG_SH2_STAT5 448 451 PF00017 0.445
LIG_SH2_STAT5 552 555 PF00017 0.384
LIG_SH2_STAT5 556 559 PF00017 0.442
LIG_SH2_STAT5 873 876 PF00017 0.501
LIG_SH2_STAT5 947 950 PF00017 0.558
LIG_SH3_3 848 854 PF00018 0.539
LIG_SH3_3 86 92 PF00018 0.508
LIG_SUMO_SIM_anti_2 504 509 PF11976 0.489
LIG_SUMO_SIM_anti_2 694 700 PF11976 0.449
LIG_SUMO_SIM_anti_2 793 800 PF11976 0.491
LIG_SUMO_SIM_anti_2 972 980 PF11976 0.513
LIG_SUMO_SIM_par_1 1103 1108 PF11976 0.649
LIG_SUMO_SIM_par_1 228 234 PF11976 0.490
LIG_SUMO_SIM_par_1 504 509 PF11976 0.562
LIG_SUMO_SIM_par_1 609 615 PF11976 0.438
LIG_SUMO_SIM_par_1 697 702 PF11976 0.475
LIG_SUMO_SIM_par_1 815 820 PF11976 0.460
LIG_SUMO_SIM_par_1 873 879 PF11976 0.485
LIG_SUMO_SIM_par_1 93 98 PF11976 0.560
LIG_TRAF2_1 474 477 PF00917 0.568
LIG_TRAF2_1 672 675 PF00917 0.685
LIG_TRAF2_1 972 975 PF00917 0.531
LIG_TYR_ITSM 1070 1077 PF00017 0.611
LIG_UBA3_1 1 9 PF00899 0.476
LIG_UBA3_1 420 426 PF00899 0.512
LIG_WRC_WIRS_1 232 237 PF05994 0.431
MOD_CDK_SPxK_1 1069 1075 PF00069 0.502
MOD_CK1_1 1062 1068 PF00069 0.485
MOD_CK1_1 158 164 PF00069 0.500
MOD_CK1_1 242 248 PF00069 0.461
MOD_CK1_1 28 34 PF00069 0.470
MOD_CK1_1 471 477 PF00069 0.533
MOD_CK1_1 541 547 PF00069 0.449
MOD_CK1_1 719 725 PF00069 0.556
MOD_CK1_1 883 889 PF00069 0.448
MOD_CK1_1 923 929 PF00069 0.533
MOD_CK1_1 98 104 PF00069 0.495
MOD_CK2_1 166 172 PF00069 0.514
MOD_CK2_1 193 199 PF00069 0.558
MOD_CK2_1 471 477 PF00069 0.512
MOD_CK2_1 559 565 PF00069 0.430
MOD_CK2_1 662 668 PF00069 0.514
MOD_CK2_1 691 697 PF00069 0.477
MOD_CK2_1 714 720 PF00069 0.462
MOD_CK2_1 749 755 PF00069 0.518
MOD_CK2_1 788 794 PF00069 0.631
MOD_CK2_1 80 86 PF00069 0.447
MOD_CK2_1 87 93 PF00069 0.483
MOD_CK2_1 969 975 PF00069 0.500
MOD_GlcNHglycan 103 106 PF01048 0.404
MOD_GlcNHglycan 157 160 PF01048 0.501
MOD_GlcNHglycan 179 182 PF01048 0.490
MOD_GlcNHglycan 218 222 PF01048 0.379
MOD_GlcNHglycan 241 244 PF01048 0.439
MOD_GlcNHglycan 36 39 PF01048 0.640
MOD_GlcNHglycan 46 49 PF01048 0.501
MOD_GlcNHglycan 509 513 PF01048 0.463
MOD_GlcNHglycan 606 609 PF01048 0.543
MOD_GlcNHglycan 700 704 PF01048 0.393
MOD_GlcNHglycan 711 714 PF01048 0.399
MOD_GlcNHglycan 867 870 PF01048 0.531
MOD_GlcNHglycan 888 892 PF01048 0.312
MOD_GlcNHglycan 895 899 PF01048 0.396
MOD_GlcNHglycan 922 925 PF01048 0.494
MOD_GSK3_1 1089 1096 PF00069 0.535
MOD_GSK3_1 168 175 PF00069 0.505
MOD_GSK3_1 177 184 PF00069 0.460
MOD_GSK3_1 213 220 PF00069 0.430
MOD_GSK3_1 25 32 PF00069 0.468
MOD_GSK3_1 270 277 PF00069 0.444
MOD_GSK3_1 291 298 PF00069 0.460
MOD_GSK3_1 307 314 PF00069 0.366
MOD_GSK3_1 541 548 PF00069 0.351
MOD_GSK3_1 590 597 PF00069 0.450
MOD_GSK3_1 624 631 PF00069 0.393
MOD_GSK3_1 681 688 PF00069 0.462
MOD_GSK3_1 716 723 PF00069 0.500
MOD_GSK3_1 784 791 PF00069 0.579
MOD_GSK3_1 834 841 PF00069 0.535
MOD_GSK3_1 883 890 PF00069 0.403
MOD_GSK3_1 907 914 PF00069 0.522
MOD_GSK3_1 965 972 PF00069 0.586
MOD_GSK3_1 984 991 PF00069 0.145
MOD_N-GLC_1 1013 1018 PF02516 0.393
MOD_N-GLC_1 1069 1074 PF02516 0.460
MOD_N-GLC_1 340 345 PF02516 0.559
MOD_N-GLC_1 377 382 PF02516 0.417
MOD_N-GLC_1 398 403 PF02516 0.382
MOD_N-GLC_1 499 504 PF02516 0.516
MOD_N-GLC_1 531 536 PF02516 0.406
MOD_N-GLC_1 538 543 PF02516 0.373
MOD_N-GLC_1 559 564 PF02516 0.339
MOD_N-GLC_1 691 696 PF02516 0.440
MOD_N-GLC_1 761 766 PF02516 0.476
MOD_N-GLC_1 777 782 PF02516 0.288
MOD_N-GLC_1 794 799 PF02516 0.429
MOD_N-GLC_1 962 967 PF02516 0.510
MOD_N-GLC_1 98 103 PF02516 0.459
MOD_N-GLC_1 984 989 PF02516 0.427
MOD_N-GLC_2 580 582 PF02516 0.300
MOD_N-GLC_2 709 711 PF02516 0.437
MOD_NEK2_1 1050 1055 PF00069 0.442
MOD_NEK2_1 274 279 PF00069 0.419
MOD_NEK2_1 290 295 PF00069 0.287
MOD_NEK2_1 304 309 PF00069 0.358
MOD_NEK2_1 377 382 PF00069 0.472
MOD_NEK2_1 508 513 PF00069 0.534
MOD_NEK2_1 531 536 PF00069 0.364
MOD_NEK2_1 538 543 PF00069 0.320
MOD_NEK2_1 545 550 PF00069 0.293
MOD_NEK2_1 569 574 PF00069 0.396
MOD_NEK2_1 594 599 PF00069 0.401
MOD_NEK2_1 624 629 PF00069 0.418
MOD_NEK2_1 639 644 PF00069 0.374
MOD_NEK2_1 714 719 PF00069 0.469
MOD_NEK2_1 758 763 PF00069 0.439
MOD_NEK2_1 80 85 PF00069 0.481
MOD_NEK2_1 838 843 PF00069 0.434
MOD_NEK2_1 846 851 PF00069 0.405
MOD_NEK2_1 887 892 PF00069 0.358
MOD_NEK2_1 946 951 PF00069 0.522
MOD_NEK2_1 962 967 PF00069 0.584
MOD_NEK2_1 983 988 PF00069 0.470
MOD_NEK2_2 133 138 PF00069 0.356
MOD_NEK2_2 19 24 PF00069 0.467
MOD_PIKK_1 1089 1095 PF00454 0.518
MOD_PIKK_1 236 242 PF00454 0.476
MOD_PIKK_1 928 934 PF00454 0.504
MOD_PK_1 143 149 PF00069 0.598
MOD_PKA_1 143 149 PF00069 0.520
MOD_PKA_1 41 47 PF00069 0.677
MOD_PKA_1 813 819 PF00069 0.453
MOD_PKA_2 1094 1100 PF00069 0.584
MOD_PKA_2 236 242 PF00069 0.433
MOD_PKA_2 410 416 PF00069 0.468
MOD_PKA_2 44 50 PF00069 0.424
MOD_PKA_2 813 819 PF00069 0.543
MOD_PKA_2 907 913 PF00069 0.519
MOD_PKA_2 928 934 PF00069 0.540
MOD_PKA_2 969 975 PF00069 0.542
MOD_PKB_1 626 634 PF00069 0.365
MOD_Plk_1 1013 1019 PF00069 0.364
MOD_Plk_1 1050 1056 PF00069 0.525
MOD_Plk_1 1089 1095 PF00069 0.518
MOD_Plk_1 398 404 PF00069 0.376
MOD_Plk_1 518 524 PF00069 0.419
MOD_Plk_1 531 537 PF00069 0.309
MOD_Plk_1 559 565 PF00069 0.344
MOD_Plk_1 614 620 PF00069 0.477
MOD_Plk_1 624 630 PF00069 0.463
MOD_Plk_1 660 666 PF00069 0.489
MOD_Plk_1 679 685 PF00069 0.229
MOD_Plk_1 691 697 PF00069 0.330
MOD_Plk_1 777 783 PF00069 0.428
MOD_Plk_1 794 800 PF00069 0.427
MOD_Plk_1 834 840 PF00069 0.516
MOD_Plk_1 98 104 PF00069 0.495
MOD_Plk_1 984 990 PF00069 0.449
MOD_Plk_2-3 559 565 PF00069 0.463
MOD_Plk_4 1062 1068 PF00069 0.489
MOD_Plk_4 133 139 PF00069 0.457
MOD_Plk_4 19 25 PF00069 0.469
MOD_Plk_4 231 237 PF00069 0.462
MOD_Plk_4 311 317 PF00069 0.510
MOD_Plk_4 369 375 PF00069 0.437
MOD_Plk_4 379 385 PF00069 0.447
MOD_Plk_4 479 485 PF00069 0.462
MOD_Plk_4 518 524 PF00069 0.485
MOD_Plk_4 548 554 PF00069 0.385
MOD_Plk_4 685 691 PF00069 0.516
MOD_Plk_4 777 783 PF00069 0.476
MOD_Plk_4 794 800 PF00069 0.497
MOD_Plk_4 846 852 PF00069 0.398
MOD_ProDKin_1 1069 1075 PF00069 0.502
MOD_ProDKin_1 309 315 PF00069 0.525
MOD_ProDKin_1 468 474 PF00069 0.549
MOD_ProDKin_1 668 674 PF00069 0.610
MOD_ProDKin_1 85 91 PF00069 0.470
MOD_SUMO_for_1 622 625 PF00179 0.555
MOD_SUMO_rev_2 1112 1122 PF00179 0.634
MOD_SUMO_rev_2 615 624 PF00179 0.550
TRG_DiLeu_BaEn_1 794 799 PF01217 0.493
TRG_DiLeu_BaEn_2 202 208 PF01217 0.483
TRG_DiLeu_BaEn_3 776 782 PF01217 0.468
TRG_DiLeu_BaEn_4 974 980 PF01217 0.515
TRG_DiLeu_BaLyEn_6 493 498 PF01217 0.529
TRG_ENDOCYTIC_2 1036 1039 PF00928 0.431
TRG_ENDOCYTIC_2 1074 1077 PF00928 0.638
TRG_ENDOCYTIC_2 197 200 PF00928 0.490
TRG_ENDOCYTIC_2 315 318 PF00928 0.566
TRG_ENDOCYTIC_2 654 657 PF00928 0.476
TRG_ER_diArg_1 43 46 PF00400 0.466
TRG_ER_diArg_1 626 629 PF00400 0.554
TRG_NES_CRM1_1 1058 1071 PF08389 0.440
TRG_NES_CRM1_1 199 212 PF08389 0.531
TRG_NES_CRM1_1 879 893 PF08389 0.378
TRG_NLS_MonoCore_2 39 44 PF00514 0.469
TRG_NLS_MonoExtC_3 40 45 PF00514 0.478
TRG_NLS_MonoExtN_4 40 46 PF00514 0.483
TRG_Pf-PMV_PEXEL_1 676 680 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 751 755 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 773 777 PF00026 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFA2 Leptomonas seymouri 53% 100%
A0A0S4JML5 Bodo saltans 30% 100%
A0A1X0P080 Trypanosomatidae 36% 100%
A0A3Q8IWA4 Leishmania donovani 100% 100%
A0A422MVT9 Trypanosoma rangeli 35% 100%
A4HPU2 Leishmania braziliensis 73% 100%
D0A481 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ATK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q0Z1 Leishmania major 92% 100%
V5DLP2 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS