Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine kinase - putative

Species:

Leishmania infantum

UniProt:

A4IE49_LEIIN

TriTrypDb:

LINF_360051800

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IE49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE49

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.557
CLV_C14_Caspase3-7	372	376	PF00656	0.389
CLV_C14_Caspase3-7	503	507	PF00656	0.397
CLV_NRD_NRD_1	155	157	PF00675	0.436
CLV_NRD_NRD_1	344	346	PF00675	0.460
CLV_NRD_NRD_1	438	440	PF00675	0.369
CLV_NRD_NRD_1	457	459	PF00675	0.411
CLV_NRD_NRD_1	63	65	PF00675	0.411
CLV_PCSK_KEX2_1	155	157	PF00082	0.436
CLV_PCSK_KEX2_1	344	346	PF00082	0.460
CLV_PCSK_KEX2_1	438	440	PF00082	0.369
CLV_PCSK_KEX2_1	63	65	PF00082	0.411
CLV_PCSK_SKI1_1	104	108	PF00082	0.411
CLV_PCSK_SKI1_1	390	394	PF00082	0.411
CLV_PCSK_SKI1_1	64	68	PF00082	0.411
CLV_PCSK_SKI1_1	735	739	PF00082	0.571
CLV_Separin_Metazoa	108	112	PF03568	0.411
DEG_APCC_DBOX_1	63	71	PF00400	0.411
DEG_APCC_KENBOX_2	76	80	PF00400	0.513
DEG_Nend_Nbox_1	1	2	PF02207	0.428
DEG_SCF_FBW7_2	495	502	PF00400	0.436
DEG_SIAH_1	760	768	PF03145	0.706
DEG_SPOP_SBC_1	579	583	PF00917	0.689
DOC_CYCLIN_RxL_1	387	397	PF00134	0.424
DOC_CYCLIN_yClb5_NLxxxL_5	101	110	PF00134	0.411
DOC_MAPK_gen_1	111	120	PF00069	0.411
DOC_MAPK_gen_1	121	130	PF00069	0.411
DOC_MAPK_HePTP_8	118	130	PF00069	0.436
DOC_MAPK_MEF2A_6	121	130	PF00069	0.436
DOC_PP2B_LxvP_1	594	597	PF13499	0.781
DOC_PP4_FxxP_1	285	288	PF00568	0.666
DOC_PP4_FxxP_1	426	429	PF00568	0.513
DOC_PP4_FxxP_1	804	807	PF00568	0.528
DOC_USP7_MATH_1	133	137	PF00917	0.513
DOC_USP7_MATH_1	159	163	PF00917	0.784
DOC_USP7_MATH_1	171	175	PF00917	0.612
DOC_USP7_MATH_1	266	270	PF00917	0.660
DOC_USP7_MATH_1	373	377	PF00917	0.411
DOC_USP7_MATH_1	394	398	PF00917	0.436
DOC_USP7_MATH_1	525	529	PF00917	0.513
DOC_USP7_MATH_1	565	569	PF00917	0.679
DOC_USP7_MATH_1	610	614	PF00917	0.642
DOC_USP7_MATH_1	625	629	PF00917	0.614
DOC_USP7_MATH_1	761	765	PF00917	0.705
DOC_WW_Pin1_4	155	160	PF00397	0.640
DOC_WW_Pin1_4	163	168	PF00397	0.661
DOC_WW_Pin1_4	240	245	PF00397	0.685
DOC_WW_Pin1_4	495	500	PF00397	0.513
DOC_WW_Pin1_4	556	561	PF00397	0.684
DOC_WW_Pin1_4	589	594	PF00397	0.684
DOC_WW_Pin1_4	598	603	PF00397	0.677
DOC_WW_Pin1_4	708	713	PF00397	0.703
DOC_WW_Pin1_4	726	731	PF00397	0.698
DOC_WW_Pin1_4	745	750	PF00397	0.540
DOC_WW_Pin1_4	794	799	PF00397	0.623
LIG_14-3-3_CanoR_1	129	137	PF00244	0.430
LIG_14-3-3_CanoR_1	15	21	PF00244	0.482
LIG_14-3-3_CanoR_1	155	159	PF00244	0.694
LIG_14-3-3_CanoR_1	216	225	PF00244	0.611
LIG_14-3-3_CanoR_1	309	313	PF00244	0.615
LIG_14-3-3_CanoR_1	530	540	PF00244	0.513
LIG_14-3-3_CanoR_1	63	70	PF00244	0.411
LIG_Actin_WH2_2	140	157	PF00022	0.411
LIG_BIR_III_2	328	332	PF00653	0.573
LIG_BRCT_BRCA1_1	229	233	PF00533	0.687
LIG_BRCT_BRCA1_1	728	732	PF00533	0.692
LIG_CtBP_PxDLS_1	117	121	PF00389	0.411
LIG_deltaCOP1_diTrp_1	375	384	PF00928	0.411
LIG_eIF4E_1	332	338	PF01652	0.459
LIG_EVH1_2	16	20	PF00568	0.533
LIG_EVH1_2	647	651	PF00568	0.602
LIG_FHA_1	216	222	PF00498	0.672
LIG_FHA_1	265	271	PF00498	0.830
LIG_FHA_1	333	339	PF00498	0.460
LIG_FHA_1	369	375	PF00498	0.411
LIG_FHA_1	479	485	PF00498	0.436
LIG_FHA_1	532	538	PF00498	0.418
LIG_FHA_1	579	585	PF00498	0.717
LIG_FHA_1	636	642	PF00498	0.725
LIG_FHA_1	666	672	PF00498	0.764
LIG_FHA_1	673	679	PF00498	0.662
LIG_FHA_1	681	687	PF00498	0.533
LIG_FHA_2	299	305	PF00498	0.698
LIG_FHA_2	348	354	PF00498	0.411
LIG_FHA_2	370	376	PF00498	0.389
LIG_FHA_2	485	491	PF00498	0.380
LIG_IBAR_NPY_1	330	332	PF08397	0.599
LIG_LIR_Apic_2	13	17	PF02991	0.533
LIG_LIR_Apic_2	282	288	PF02991	0.663
LIG_LIR_Apic_2	356	362	PF02991	0.411
LIG_LIR_Apic_2	424	429	PF02991	0.436
LIG_LIR_Apic_2	708	712	PF02991	0.697
LIG_LIR_Gen_1	6	16	PF02991	0.369
LIG_LIR_Nem_3	33	39	PF02991	0.411
LIG_LIR_Nem_3	339	343	PF02991	0.381
LIG_LIR_Nem_3	348	354	PF02991	0.329
LIG_LIR_Nem_3	652	657	PF02991	0.779
LIG_LYPXL_yS_3	654	657	PF13949	0.791
LIG_MYND_1	167	171	PF01753	0.667
LIG_PTB_Apo_2	109	116	PF02174	0.367
LIG_PTB_Apo_2	136	143	PF02174	0.513
LIG_PTB_Phospho_1	136	142	PF10480	0.513
LIG_SH2_CRK	14	18	PF00017	0.529
LIG_SH2_CRK	36	40	PF00017	0.411
LIG_SH2_CRK	43	47	PF00017	0.411
LIG_SH2_CRK	709	713	PF00017	0.711
LIG_SH2_STAP1	370	374	PF00017	0.411
LIG_SH2_STAP1	43	47	PF00017	0.299
LIG_SH2_STAT3	253	256	PF00017	0.826
LIG_SH2_STAT3	352	355	PF00017	0.411
LIG_SH2_STAT5	142	145	PF00017	0.436
LIG_SH2_STAT5	25	28	PF00017	0.493
LIG_SH2_STAT5	332	335	PF00017	0.437
LIG_SH2_STAT5	370	373	PF00017	0.408
LIG_SH2_STAT5	663	666	PF00017	0.770
LIG_SH2_STAT5	709	712	PF00017	0.814
LIG_SH2_STAT5	773	776	PF00017	0.724
LIG_SH2_STAT5	799	802	PF00017	0.744
LIG_SH3_3	388	394	PF00018	0.411
LIG_SH3_3	406	412	PF00018	0.411
LIG_SH3_3	599	605	PF00018	0.674
LIG_SH3_3	755	761	PF00018	0.709
LIG_SH3_3	810	816	PF00018	0.654
LIG_SUMO_SIM_anti_2	509	517	PF11976	0.397
LIG_SUMO_SIM_par_1	116	122	PF11976	0.411
LIG_TRAF2_1	197	200	PF00917	0.654
LIG_TRAF2_1	508	511	PF00917	0.411
LIG_UBA3_1	383	390	PF00899	0.411
LIG_UBA3_1	73	77	PF00899	0.411
LIG_WRC_WIRS_1	86	91	PF05994	0.411
MOD_CDK_SPK_2	240	245	PF00069	0.685
MOD_CDK_SPK_2	730	735	PF00069	0.573
MOD_CK1_1	161	167	PF00069	0.648
MOD_CK1_1	178	184	PF00069	0.544
MOD_CK1_1	220	226	PF00069	0.767
MOD_CK1_1	227	233	PF00069	0.693
MOD_CK1_1	243	249	PF00069	0.676
MOD_CK1_1	478	484	PF00069	0.383
MOD_CK1_1	486	492	PF00069	0.383
MOD_CK1_1	592	598	PF00069	0.622
MOD_CK1_1	601	607	PF00069	0.619
MOD_CK1_1	711	717	PF00069	0.742
MOD_CK1_1	724	730	PF00069	0.679
MOD_CK1_1	777	783	PF00069	0.755
MOD_CK2_1	116	122	PF00069	0.411
MOD_CK2_1	445	451	PF00069	0.459
MOD_CK2_1	484	490	PF00069	0.380
MOD_GlcNHglycan	131	134	PF01048	0.399
MOD_GlcNHglycan	139	142	PF01048	0.428
MOD_GlcNHglycan	184	187	PF01048	0.668
MOD_GlcNHglycan	229	232	PF01048	0.685
MOD_GlcNHglycan	262	265	PF01048	0.820
MOD_GlcNHglycan	270	273	PF01048	0.707
MOD_GlcNHglycan	277	280	PF01048	0.640
MOD_GlcNHglycan	294	297	PF01048	0.650
MOD_GlcNHglycan	549	552	PF01048	0.675
MOD_GlcNHglycan	567	570	PF01048	0.533
MOD_GlcNHglycan	612	615	PF01048	0.688
MOD_GlcNHglycan	64	67	PF01048	0.411
MOD_GlcNHglycan	69	73	PF01048	0.411
MOD_GlcNHglycan	723	726	PF01048	0.773
MOD_GlcNHglycan	776	779	PF01048	0.754
MOD_GlcNHglycan	792	795	PF01048	0.500
MOD_GSK3_1	129	136	PF00069	0.490
MOD_GSK3_1	154	161	PF00069	0.552
MOD_GSK3_1	171	178	PF00069	0.607
MOD_GSK3_1	216	223	PF00069	0.638
MOD_GSK3_1	260	267	PF00069	0.704
MOD_GSK3_1	294	301	PF00069	0.730
MOD_GSK3_1	316	323	PF00069	0.739
MOD_GSK3_1	369	376	PF00069	0.389
MOD_GSK3_1	525	532	PF00069	0.362
MOD_GSK3_1	543	550	PF00069	0.707
MOD_GSK3_1	615	622	PF00069	0.683
MOD_GSK3_1	635	642	PF00069	0.771
MOD_GSK3_1	657	664	PF00069	0.701
MOD_GSK3_1	708	715	PF00069	0.791
MOD_GSK3_1	724	731	PF00069	0.700
MOD_GSK3_1	786	793	PF00069	0.787
MOD_N-GLC_1	175	180	PF02516	0.713
MOD_N-GLC_1	182	187	PF02516	0.708
MOD_N-GLC_1	216	221	PF02516	0.522
MOD_N-GLC_1	298	303	PF02516	0.724
MOD_N-GLC_1	543	548	PF02516	0.603
MOD_N-GLC_1	665	670	PF02516	0.678
MOD_NEK2_1	10	15	PF00069	0.629
MOD_NEK2_1	137	142	PF00069	0.513
MOD_NEK2_1	154	159	PF00069	0.395
MOD_NEK2_1	224	229	PF00069	0.678
MOD_NEK2_1	275	280	PF00069	0.687
MOD_NEK2_1	531	536	PF00069	0.389
MOD_NEK2_1	578	583	PF00069	0.643
MOD_NEK2_1	634	639	PF00069	0.727
MOD_NEK2_1	672	677	PF00069	0.711
MOD_NEK2_1	697	702	PF00069	0.788
MOD_NEK2_1	768	773	PF00069	0.683
MOD_NEK2_2	133	138	PF00069	0.513
MOD_NEK2_2	658	663	PF00069	0.669
MOD_PIKK_1	316	322	PF00454	0.755
MOD_PIKK_1	410	416	PF00454	0.389
MOD_PIKK_1	421	427	PF00454	0.389
MOD_PIKK_1	525	531	PF00454	0.411
MOD_PIKK_1	640	646	PF00454	0.744
MOD_PIKK_1	677	683	PF00454	0.787
MOD_PIKK_1	714	720	PF00454	0.739
MOD_PKA_2	154	160	PF00069	0.591
MOD_PKA_2	179	185	PF00069	0.606
MOD_PKA_2	215	221	PF00069	0.565
MOD_PKA_2	260	266	PF00069	0.763
MOD_PKA_2	275	281	PF00069	0.546
MOD_PKA_2	308	314	PF00069	0.753
MOD_PKA_2	529	535	PF00069	0.411
MOD_PKA_2	62	68	PF00069	0.513
MOD_Plk_1	216	222	PF00069	0.617
MOD_Plk_1	320	326	PF00069	0.740
MOD_Plk_1	347	353	PF00069	0.411
MOD_Plk_1	634	640	PF00069	0.725
MOD_Plk_1	68	74	PF00069	0.411
MOD_Plk_1	79	85	PF00069	0.411
MOD_Plk_2-3	506	512	PF00069	0.411
MOD_Plk_4	220	226	PF00069	0.690
MOD_Plk_4	347	353	PF00069	0.411
MOD_Plk_4	400	406	PF00069	0.411
MOD_Plk_4	42	48	PF00069	0.299
MOD_Plk_4	625	631	PF00069	0.776
MOD_Plk_4	658	664	PF00069	0.786
MOD_Plk_4	769	775	PF00069	0.665
MOD_Plk_4	809	815	PF00069	0.665
MOD_ProDKin_1	155	161	PF00069	0.650
MOD_ProDKin_1	163	169	PF00069	0.664
MOD_ProDKin_1	240	246	PF00069	0.685
MOD_ProDKin_1	495	501	PF00069	0.513
MOD_ProDKin_1	556	562	PF00069	0.684
MOD_ProDKin_1	589	595	PF00069	0.683
MOD_ProDKin_1	598	604	PF00069	0.676
MOD_ProDKin_1	708	714	PF00069	0.703
MOD_ProDKin_1	726	732	PF00069	0.697
MOD_ProDKin_1	745	751	PF00069	0.541
MOD_ProDKin_1	794	800	PF00069	0.623
MOD_SUMO_for_1	147	150	PF00179	0.411
MOD_SUMO_rev_2	140	149	PF00179	0.513
TRG_DiLeu_BaEn_1	490	495	PF01217	0.513
TRG_DiLeu_BaEn_1	510	515	PF01217	0.411
TRG_DiLeu_BaEn_1	69	74	PF01217	0.411
TRG_DiLeu_BaEn_4	490	496	PF01217	0.513
TRG_ENDOCYTIC_2	351	354	PF00928	0.353
TRG_ENDOCYTIC_2	36	39	PF00928	0.465
TRG_ENDOCYTIC_2	43	46	PF00928	0.506
TRG_ENDOCYTIC_2	654	657	PF00928	0.791
TRG_ER_diArg_1	110	113	PF00400	0.411
TRG_ER_diArg_1	154	156	PF00400	0.436
TRG_ER_diArg_1	343	345	PF00400	0.397
TRG_ER_diArg_1	62	64	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR0	Leptomonas seymouri	57%	100%
A0A3S7XBF4	Leishmania donovani	100%	100%
A4HPU4	Leishmania braziliensis	78%	100%
E9ATK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0Y9	Leishmania major	94%	100%