LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE48_LEIIN
TriTrypDb:
LINF_360051900
Length:
431

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE48
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE48

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 225 229 PF00656 0.533
CLV_C14_Caspase3-7 9 13 PF00656 0.486
CLV_NRD_NRD_1 124 126 PF00675 0.434
CLV_NRD_NRD_1 197 199 PF00675 0.495
CLV_NRD_NRD_1 309 311 PF00675 0.409
CLV_NRD_NRD_1 332 334 PF00675 0.380
CLV_NRD_NRD_1 339 341 PF00675 0.353
CLV_NRD_NRD_1 355 357 PF00675 0.398
CLV_NRD_NRD_1 405 407 PF00675 0.541
CLV_NRD_NRD_1 90 92 PF00675 0.655
CLV_PCSK_KEX2_1 124 126 PF00082 0.466
CLV_PCSK_KEX2_1 197 199 PF00082 0.495
CLV_PCSK_KEX2_1 309 311 PF00082 0.424
CLV_PCSK_KEX2_1 332 334 PF00082 0.419
CLV_PCSK_KEX2_1 35 37 PF00082 0.686
CLV_PCSK_KEX2_1 355 357 PF00082 0.398
CLV_PCSK_KEX2_1 405 407 PF00082 0.542
CLV_PCSK_KEX2_1 90 92 PF00082 0.607
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.664
CLV_PCSK_SKI1_1 127 131 PF00082 0.435
CLV_PCSK_SKI1_1 187 191 PF00082 0.431
CLV_PCSK_SKI1_1 197 201 PF00082 0.455
CLV_PCSK_SKI1_1 260 264 PF00082 0.403
DEG_APCC_DBOX_1 126 134 PF00400 0.412
DEG_MDM2_SWIB_1 211 219 PF02201 0.357
DEG_Nend_UBRbox_3 1 3 PF02207 0.566
DOC_CKS1_1 22 27 PF01111 0.575
DOC_CYCLIN_RxL_1 172 183 PF00134 0.391
DOC_CYCLIN_RxL_1 254 265 PF00134 0.430
DOC_MAPK_gen_1 124 130 PF00069 0.525
DOC_MAPK_gen_1 338 348 PF00069 0.398
DOC_MAPK_gen_1 366 374 PF00069 0.424
DOC_MAPK_MEF2A_6 340 348 PF00069 0.389
DOC_USP7_MATH_1 11 15 PF00917 0.678
DOC_USP7_MATH_1 129 133 PF00917 0.460
DOC_USP7_MATH_1 302 306 PF00917 0.454
DOC_USP7_MATH_1 354 358 PF00917 0.411
DOC_USP7_MATH_1 421 425 PF00917 0.642
DOC_USP7_MATH_1 60 64 PF00917 0.744
DOC_WW_Pin1_4 21 26 PF00397 0.693
LIG_14-3-3_CanoR_1 187 194 PF00244 0.507
LIG_14-3-3_CanoR_1 21 25 PF00244 0.746
LIG_14-3-3_CanoR_1 257 263 PF00244 0.452
LIG_14-3-3_CanoR_1 303 307 PF00244 0.443
LIG_14-3-3_CanoR_1 355 359 PF00244 0.535
LIG_14-3-3_CanoR_1 412 418 PF00244 0.655
LIG_14-3-3_CanoR_1 65 75 PF00244 0.495
LIG_Actin_WH2_2 241 259 PF00022 0.428
LIG_Actin_WH2_2 396 414 PF00022 0.454
LIG_AP_GAE_1 116 122 PF02883 0.575
LIG_BRCT_BRCA1_1 395 399 PF00533 0.496
LIG_eIF4E_1 164 170 PF01652 0.376
LIG_FHA_1 2 8 PF00498 0.617
LIG_FHA_1 25 31 PF00498 0.570
LIG_FHA_1 367 373 PF00498 0.400
LIG_FHA_1 385 391 PF00498 0.480
LIG_FHA_2 133 139 PF00498 0.625
LIG_FHA_2 154 160 PF00498 0.495
LIG_FHA_2 325 331 PF00498 0.470
LIG_FHA_2 7 13 PF00498 0.481
LIG_Integrin_RGD_1 85 87 PF01839 0.665
LIG_LIR_Gen_1 116 126 PF02991 0.421
LIG_LIR_Nem_3 116 122 PF02991 0.434
LIG_LIR_Nem_3 207 211 PF02991 0.381
LIG_NRBOX 343 349 PF00104 0.388
LIG_Pex14_2 211 215 PF04695 0.351
LIG_SH2_CRK 34 38 PF00017 0.485
LIG_SH2_GRB2like 351 354 PF00017 0.386
LIG_SH2_SRC 351 354 PF00017 0.405
LIG_SH2_STAP1 258 262 PF00017 0.433
LIG_SH2_STAP1 409 413 PF00017 0.505
LIG_SH2_STAT3 168 171 PF00017 0.510
LIG_SH2_STAT3 339 342 PF00017 0.499
LIG_SH2_STAT5 168 171 PF00017 0.398
LIG_SH2_STAT5 278 281 PF00017 0.549
LIG_SH2_STAT5 335 338 PF00017 0.510
LIG_SH2_STAT5 351 354 PF00017 0.412
LIG_SH3_3 104 110 PF00018 0.682
LIG_SH3_3 19 25 PF00018 0.588
LIG_SH3_3 27 33 PF00018 0.572
LIG_SUMO_SIM_anti_2 146 153 PF11976 0.513
LIG_SUMO_SIM_anti_2 230 235 PF11976 0.515
LIG_SUMO_SIM_anti_2 343 348 PF11976 0.383
LIG_TRAF2_1 221 224 PF00917 0.426
MOD_CK1_1 102 108 PF00069 0.714
MOD_CK1_1 132 138 PF00069 0.499
MOD_CK1_1 153 159 PF00069 0.491
MOD_CK1_1 20 26 PF00069 0.715
MOD_CK1_1 3 9 PF00069 0.697
MOD_CK1_1 357 363 PF00069 0.529
MOD_CK1_1 393 399 PF00069 0.538
MOD_CK1_1 54 60 PF00069 0.768
MOD_CK1_1 63 69 PF00069 0.644
MOD_CK2_1 132 138 PF00069 0.530
MOD_CK2_1 153 159 PF00069 0.484
MOD_CK2_1 258 264 PF00069 0.497
MOD_CK2_1 302 308 PF00069 0.451
MOD_CK2_1 324 330 PF00069 0.496
MOD_DYRK1A_RPxSP_1 21 25 PF00069 0.490
MOD_GlcNHglycan 383 387 PF01048 0.495
MOD_GlcNHglycan 392 395 PF01048 0.531
MOD_GlcNHglycan 421 424 PF01048 0.764
MOD_GlcNHglycan 56 59 PF01048 0.729
MOD_GlcNHglycan 66 69 PF01048 0.650
MOD_GSK3_1 1 8 PF00069 0.718
MOD_GSK3_1 13 20 PF00069 0.719
MOD_GSK3_1 258 265 PF00069 0.453
MOD_GSK3_1 324 331 PF00069 0.531
MOD_GSK3_1 60 67 PF00069 0.660
MOD_LATS_1 185 191 PF00433 0.428
MOD_N-GLC_1 1 6 PF02516 0.558
MOD_N-GLC_1 366 371 PF02516 0.495
MOD_NEK2_1 1 6 PF00069 0.589
MOD_NEK2_1 211 216 PF00069 0.497
MOD_NEK2_1 256 261 PF00069 0.507
MOD_NEK2_1 262 267 PF00069 0.431
MOD_NEK2_1 390 395 PF00069 0.518
MOD_NEK2_1 411 416 PF00069 0.515
MOD_NEK2_1 71 76 PF00069 0.688
MOD_NEK2_2 302 307 PF00069 0.446
MOD_NEK2_2 421 426 PF00069 0.562
MOD_NEK2_2 60 65 PF00069 0.491
MOD_PIKK_1 357 363 PF00454 0.467
MOD_PIKK_1 411 417 PF00454 0.679
MOD_PIKK_1 46 52 PF00454 0.732
MOD_PKA_2 20 26 PF00069 0.740
MOD_PKA_2 256 262 PF00069 0.506
MOD_PKA_2 302 308 PF00069 0.451
MOD_PKA_2 354 360 PF00069 0.528
MOD_PKA_2 411 417 PF00069 0.651
MOD_PKA_2 64 70 PF00069 0.514
MOD_Plk_1 11 17 PF00069 0.506
MOD_Plk_4 26 32 PF00069 0.718
MOD_Plk_4 302 308 PF00069 0.451
MOD_Plk_4 368 374 PF00069 0.415
MOD_Plk_4 398 404 PF00069 0.666
MOD_ProDKin_1 21 27 PF00069 0.696
TRG_DiLeu_BaEn_1 343 348 PF01217 0.383
TRG_DiLeu_BaEn_4 195 201 PF01217 0.503
TRG_DiLeu_BaLyEn_6 251 256 PF01217 0.568
TRG_ER_diArg_1 124 127 PF00400 0.500
TRG_ER_diArg_1 197 199 PF00400 0.543
TRG_ER_diArg_1 332 334 PF00400 0.398
TRG_Pf-PMV_PEXEL_1 175 180 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 197 201 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 332 337 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J8 Leptomonas seymouri 65% 100%
A0A0S4JG62 Bodo saltans 51% 100%
A0A1X0P1T1 Trypanosomatidae 54% 100%
A0A3Q8ILB9 Leishmania donovani 100% 100%
A0A422P583 Trypanosoma rangeli 56% 100%
A4HPU5 Leishmania braziliensis 79% 100%
D0A491 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ATL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q0Y8 Leishmania major 94% 100%
V5BQ98 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS