TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IE46_LEIIN

TriTrypDb:

LINF_360052100

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0071007	U2-type catalytic step 2 spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4IE46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE46

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000245	spliceosomal complex assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.659
CLV_NRD_NRD_1	20	22	PF00675	0.579
CLV_NRD_NRD_1	207	209	PF00675	0.459
CLV_NRD_NRD_1	217	219	PF00675	0.355
CLV_NRD_NRD_1	341	343	PF00675	0.428
CLV_NRD_NRD_1	445	447	PF00675	0.512
CLV_NRD_NRD_1	483	485	PF00675	0.431
CLV_NRD_NRD_1	621	623	PF00675	0.413
CLV_NRD_NRD_1	632	634	PF00675	0.504
CLV_NRD_NRD_1	758	760	PF00675	0.552
CLV_NRD_NRD_1	76	78	PF00675	0.505
CLV_NRD_NRD_1	815	817	PF00675	0.538
CLV_NRD_NRD_1	85	87	PF00675	0.529
CLV_NRD_NRD_1	9	11	PF00675	0.552
CLV_PCSK_FUR_1	73	77	PF00082	0.432
CLV_PCSK_KEX2_1	19	21	PF00082	0.566
CLV_PCSK_KEX2_1	2	4	PF00082	0.568
CLV_PCSK_KEX2_1	207	209	PF00082	0.459
CLV_PCSK_KEX2_1	217	219	PF00082	0.355
CLV_PCSK_KEX2_1	445	447	PF00082	0.512
CLV_PCSK_KEX2_1	483	485	PF00082	0.497
CLV_PCSK_KEX2_1	621	623	PF00082	0.421
CLV_PCSK_KEX2_1	632	634	PF00082	0.522
CLV_PCSK_KEX2_1	75	77	PF00082	0.430
CLV_PCSK_KEX2_1	758	760	PF00082	0.544
CLV_PCSK_KEX2_1	814	816	PF00082	0.535
CLV_PCSK_KEX2_1	85	87	PF00082	0.356
CLV_PCSK_KEX2_1	9	11	PF00082	0.556
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.568
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.430
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.553
CLV_PCSK_PC7_1	213	219	PF00082	0.373
CLV_PCSK_PC7_1	5	11	PF00082	0.628
CLV_PCSK_PC7_1	628	634	PF00082	0.488
CLV_PCSK_PC7_1	754	760	PF00082	0.517
CLV_PCSK_SKI1_1	150	154	PF00082	0.377
CLV_PCSK_SKI1_1	179	183	PF00082	0.369
CLV_PCSK_SKI1_1	213	217	PF00082	0.410
CLV_PCSK_SKI1_1	245	249	PF00082	0.336
CLV_PCSK_SKI1_1	288	292	PF00082	0.501
CLV_PCSK_SKI1_1	404	408	PF00082	0.511
CLV_PCSK_SKI1_1	424	428	PF00082	0.200
CLV_PCSK_SKI1_1	483	487	PF00082	0.405
CLV_PCSK_SKI1_1	563	567	PF00082	0.454
CLV_PCSK_SKI1_1	743	747	PF00082	0.413
CLV_PCSK_SKI1_1	811	815	PF00082	0.619
CLV_PCSK_SKI1_1	818	822	PF00082	0.627
CLV_PCSK_SKI1_1	86	90	PF00082	0.480
CLV_Separin_Metazoa	573	577	PF03568	0.484
DEG_APCC_DBOX_1	643	651	PF00400	0.504
DEG_APCC_DBOX_1	742	750	PF00400	0.517
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DOC_ANK_TNKS_1	316	323	PF00023	0.490
DOC_CYCLIN_RxL_1	480	490	PF00134	0.508
DOC_MAPK_gen_1	775	784	PF00069	0.499
DOC_PP1_RVXF_1	757	764	PF00149	0.535
DOC_PP2B_LxvP_1	411	414	PF13499	0.548
DOC_PP4_FxxP_1	49	52	PF00568	0.634
DOC_USP7_MATH_1	154	158	PF00917	0.379
DOC_USP7_MATH_1	280	284	PF00917	0.445
DOC_USP7_MATH_1	369	373	PF00917	0.661
DOC_USP7_MATH_1	386	390	PF00917	0.488
DOC_USP7_MATH_1	400	404	PF00917	0.524
DOC_USP7_MATH_1	52	56	PF00917	0.650
DOC_WW_Pin1_4	392	397	PF00397	0.584
DOC_WW_Pin1_4	398	403	PF00397	0.580
DOC_WW_Pin1_4	48	53	PF00397	0.603
DOC_WW_Pin1_4	522	527	PF00397	0.556
DOC_WW_Pin1_4	702	707	PF00397	0.483
DOC_WW_Pin1_4	782	787	PF00397	0.375
LIG_14-3-3_CanoR_1	150	159	PF00244	0.482
LIG_14-3-3_CanoR_1	222	232	PF00244	0.281
LIG_14-3-3_CanoR_1	342	352	PF00244	0.503
LIG_14-3-3_CanoR_1	445	449	PF00244	0.508
LIG_14-3-3_CanoR_1	475	485	PF00244	0.426
LIG_14-3-3_CanoR_1	594	599	PF00244	0.404
LIG_14-3-3_CanoR_1	710	718	PF00244	0.495
LIG_14-3-3_CanoR_1	724	730	PF00244	0.584
LIG_14-3-3_CanoR_1	758	762	PF00244	0.542
LIG_APCC_ABBA_1	118	123	PF00400	0.510
LIG_APCC_ABBA_1	334	339	PF00400	0.498
LIG_APCC_ABBA_1	496	501	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	20	26	PF00400	0.533
LIG_BIR_III_2	189	193	PF00653	0.508
LIG_BRCT_BRCA1_1	136	140	PF00533	0.505
LIG_BRCT_BRCA1_1	677	681	PF00533	0.507
LIG_deltaCOP1_diTrp_1	789	794	PF00928	0.372
LIG_FHA_1	331	337	PF00498	0.460
LIG_FHA_1	388	394	PF00498	0.588
LIG_FHA_1	491	497	PF00498	0.453
LIG_FHA_1	640	646	PF00498	0.352
LIG_FHA_1	737	743	PF00498	0.470
LIG_FHA_2	585	591	PF00498	0.450
LIG_FHA_2	647	653	PF00498	0.401
LIG_FHA_2	766	772	PF00498	0.582
LIG_LIR_Gen_1	106	114	PF02991	0.385
LIG_LIR_Gen_1	130	136	PF02991	0.363
LIG_LIR_Gen_1	311	319	PF02991	0.399
LIG_LIR_Gen_1	349	358	PF02991	0.383
LIG_LIR_Gen_1	767	776	PF02991	0.490
LIG_LIR_Gen_1	789	796	PF02991	0.481
LIG_LIR_Nem_3	130	134	PF02991	0.361
LIG_LIR_Nem_3	160	165	PF02991	0.356
LIG_LIR_Nem_3	226	232	PF02991	0.355
LIG_LIR_Nem_3	311	315	PF02991	0.369
LIG_LIR_Nem_3	345	351	PF02991	0.387
LIG_LIR_Nem_3	353	358	PF02991	0.355
LIG_LIR_Nem_3	664	669	PF02991	0.329
LIG_LIR_Nem_3	767	773	PF02991	0.493
LIG_LIR_Nem_3	778	782	PF02991	0.375
LIG_LIR_Nem_3	789	794	PF02991	0.327
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.475
LIG_MLH1_MIPbox_1	677	681	PF16413	0.507
LIG_PCNA_PIPBox_1	33	42	PF02747	0.547
LIG_PCNA_PIPBox_1	651	660	PF02747	0.478
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.566
LIG_PCNA_yPIPBox_3	644	658	PF02747	0.472
LIG_Pex14_1	560	564	PF04695	0.449
LIG_Pex14_1	676	680	PF04695	0.511
LIG_Pex14_2	556	560	PF04695	0.367
LIG_Pex14_2	677	681	PF04695	0.507
LIG_PTB_Apo_2	451	458	PF02174	0.491
LIG_RPA_C_Fungi	617	629	PF08784	0.490
LIG_SH2_CRK	602	606	PF00017	0.473
LIG_SH2_CRK	658	662	PF00017	0.430
LIG_SH2_GRB2like	547	550	PF00017	0.465
LIG_SH2_NCK_1	196	200	PF00017	0.446
LIG_SH2_SRC	547	550	PF00017	0.465
LIG_SH2_STAP1	196	200	PF00017	0.452
LIG_SH2_STAP1	337	341	PF00017	0.430
LIG_SH2_STAP1	658	662	PF00017	0.424
LIG_SH2_STAT3	202	205	PF00017	0.474
LIG_SH2_STAT3	358	361	PF00017	0.450
LIG_SH2_STAT3	419	422	PF00017	0.505
LIG_SH2_STAT5	165	168	PF00017	0.349
LIG_SH2_STAT5	351	354	PF00017	0.348
LIG_SH2_STAT5	539	542	PF00017	0.495
LIG_SH2_STAT5	680	683	PF00017	0.517
LIG_SH3_3	390	396	PF00018	0.505
LIG_SUMO_SIM_par_1	270	276	PF11976	0.419
LIG_SUMO_SIM_par_1	300	306	PF11976	0.482
LIG_TRAF2_1	471	474	PF00917	0.489
LIG_TRAF2_1	528	531	PF00917	0.621
LIG_TRAF2_1	649	652	PF00917	0.494
LIG_TRAF2_1	65	68	PF00917	0.411
LIG_TYR_ITIM	562	567	PF00017	0.459
LIG_WRC_WIRS_1	585	590	PF05994	0.388
LIG_WRC_WIRS_1	595	600	PF05994	0.437
MOD_CDC14_SPxK_1	401	404	PF00782	0.519
MOD_CDK_SPxK_1	398	404	PF00069	0.570
MOD_CK1_1	490	496	PF00069	0.510
MOD_CK1_1	702	708	PF00069	0.440
MOD_CK2_1	310	316	PF00069	0.344
MOD_CK2_1	525	531	PF00069	0.643
MOD_CK2_1	62	68	PF00069	0.421
MOD_CK2_1	646	652	PF00069	0.405
MOD_CK2_1	745	751	PF00069	0.489
MOD_CK2_1	789	795	PF00069	0.492
MOD_GlcNHglycan	282	285	PF01048	0.404
MOD_GlcNHglycan	369	372	PF01048	0.680
MOD_GlcNHglycan	527	530	PF01048	0.549
MOD_GlcNHglycan	54	57	PF01048	0.640
MOD_GlcNHglycan	685	689	PF01048	0.557
MOD_GlcNHglycan	725	728	PF01048	0.503
MOD_GSK3_1	146	153	PF00069	0.389
MOD_GSK3_1	387	394	PF00069	0.629
MOD_GSK3_1	48	55	PF00069	0.593
MOD_GSK3_1	521	528	PF00069	0.595
MOD_GSK3_1	696	703	PF00069	0.566
MOD_GSK3_1	705	712	PF00069	0.534
MOD_GSK3_1	732	739	PF00069	0.654
MOD_GSK3_1	757	764	PF00069	0.554
MOD_GSK3_1	794	801	PF00069	0.539
MOD_N-GLC_1	223	228	PF02516	0.236
MOD_N-GLC_1	343	348	PF02516	0.506
MOD_N-GLC_1	52	57	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.702
MOD_NEK2_1	134	139	PF00069	0.543
MOD_NEK2_1	223	228	PF00069	0.348
MOD_NEK2_1	367	372	PF00069	0.594
MOD_NEK2_1	387	392	PF00069	0.544
MOD_NEK2_1	657	662	PF00069	0.321
MOD_NEK2_1	745	750	PF00069	0.435
MOD_NEK2_1	794	799	PF00069	0.427
MOD_NEK2_1	80	85	PF00069	0.496
MOD_NEK2_2	350	355	PF00069	0.459
MOD_PIKK_1	487	493	PF00454	0.530
MOD_PIKK_1	765	771	PF00454	0.588
MOD_PKA_1	342	348	PF00069	0.430
MOD_PKA_1	814	820	PF00069	0.562
MOD_PKA_2	362	368	PF00069	0.493
MOD_PKA_2	444	450	PF00069	0.522
MOD_PKA_2	709	715	PF00069	0.490
MOD_PKA_2	723	729	PF00069	0.564
MOD_PKA_2	757	763	PF00069	0.509
MOD_PKA_2	814	820	PF00069	0.542
MOD_PKB_1	340	348	PF00069	0.504
MOD_Plk_1	80	86	PF00069	0.503
MOD_Plk_2-3	646	652	PF00069	0.413
MOD_Plk_4	225	231	PF00069	0.391
MOD_Plk_4	350	356	PF00069	0.470
MOD_Plk_4	657	663	PF00069	0.330
MOD_Plk_4	745	751	PF00069	0.533
MOD_ProDKin_1	392	398	PF00069	0.585
MOD_ProDKin_1	48	54	PF00069	0.606
MOD_ProDKin_1	522	528	PF00069	0.548
MOD_ProDKin_1	702	708	PF00069	0.480
MOD_ProDKin_1	782	788	PF00069	0.376
MOD_SUMO_for_1	565	568	PF00179	0.328
TRG_DiLeu_BaEn_1	778	783	PF01217	0.489
TRG_DiLeu_BaEn_4	652	658	PF01217	0.471
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.505
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.512
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.462
TRG_ENDOCYTIC_2	131	134	PF00928	0.341
TRG_ENDOCYTIC_2	165	168	PF00928	0.336
TRG_ENDOCYTIC_2	312	315	PF00928	0.348
TRG_ENDOCYTIC_2	351	354	PF00928	0.378
TRG_ENDOCYTIC_2	564	567	PF00928	0.332
TRG_ENDOCYTIC_2	602	605	PF00928	0.343
TRG_ENDOCYTIC_2	658	661	PF00928	0.331
TRG_ER_diArg_1	18	21	PF00400	0.529
TRG_ER_diArg_1	216	218	PF00400	0.386
TRG_ER_diArg_1	483	485	PF00400	0.475
TRG_ER_diArg_1	621	624	PF00400	0.433
TRG_ER_diArg_1	757	759	PF00400	0.523
TRG_ER_diArg_1	815	818	PF00400	0.543
TRG_ER_diArg_1	84	86	PF00400	0.520
TRG_ER_diArg_1	9	11	PF00400	0.565
TRG_NES_CRM1_1	108	123	PF08389	0.493
TRG_NLS_MonoExtC_3	1	7	PF00514	0.603
TRG_NLS_MonoExtC_3	813	818	PF00514	0.554
TRG_NLS_MonoExtN_4	811	818	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P767	Leptomonas seymouri	75%	99%
A0A0S4JKT1	Bodo saltans	28%	95%
A0A1X0P0C5	Trypanosomatidae	43%	100%
A0A3Q8IHN6	Leishmania donovani	100%	100%
A0A3R7P515	Trypanosoma rangeli	43%	100%
A4HPU7	Leishmania braziliensis	88%	100%
D0A493	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P63154	Mus musculus	25%	100%
P63155	Rattus norvegicus	25%	100%
P87312	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4PB37	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4Q0Y6	Leishmania major	95%	100%
Q4WT84	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q5BDX1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5K654	Paracoccidioides brasiliensis	25%	100%
Q6CJK2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q7SGD2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9BZJ0	Homo sapiens	25%	97%
V5B545	Trypanosoma cruzi	43%	100%