LeishMANIAdb
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Trypanothione synthetase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Trypanothione synthetase-like protein
Gene product:
trypanothione synthetase-like protein
Species:
Leishmania infantum
UniProt:
A4IE44_LEIIN
TriTrypDb:
LINF_360052300
Length:
749

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IE44
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE44

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016874 ligase activity 2 5
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 5
GO:0016880 acid-ammonia (or amide) ligase activity 4 5
GO:0047479 trypanothione synthase activity 5 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 158 162 PF00656 0.485
CLV_C14_Caspase3-7 197 201 PF00656 0.527
CLV_C14_Caspase3-7 680 684 PF00656 0.410
CLV_NRD_NRD_1 283 285 PF00675 0.376
CLV_NRD_NRD_1 392 394 PF00675 0.586
CLV_NRD_NRD_1 59 61 PF00675 0.478
CLV_NRD_NRD_1 659 661 PF00675 0.424
CLV_NRD_NRD_1 686 688 PF00675 0.414
CLV_PCSK_KEX2_1 283 285 PF00082 0.376
CLV_PCSK_KEX2_1 394 396 PF00082 0.582
CLV_PCSK_KEX2_1 59 61 PF00082 0.495
CLV_PCSK_KEX2_1 659 661 PF00082 0.424
CLV_PCSK_KEX2_1 686 688 PF00082 0.414
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.582
CLV_PCSK_PC7_1 390 396 PF00082 0.555
CLV_PCSK_SKI1_1 455 459 PF00082 0.529
CLV_PCSK_SKI1_1 548 552 PF00082 0.559
CLV_PCSK_SKI1_1 59 63 PF00082 0.495
CLV_PCSK_SKI1_1 599 603 PF00082 0.586
DEG_APCC_DBOX_1 274 282 PF00400 0.412
DEG_SPOP_SBC_1 647 651 PF00917 0.473
DOC_CKS1_1 210 215 PF01111 0.594
DOC_CKS1_1 476 481 PF01111 0.528
DOC_CYCLIN_RxL_1 269 277 PF00134 0.468
DOC_CYCLIN_RxL_1 57 66 PF00134 0.295
DOC_CYCLIN_RxL_1 653 666 PF00134 0.473
DOC_MAPK_FxFP_2 744 747 PF00069 0.632
DOC_MAPK_gen_1 272 282 PF00069 0.368
DOC_MAPK_MEF2A_6 275 282 PF00069 0.425
DOC_MAPK_NFAT4_5 275 283 PF00069 0.516
DOC_PP1_RVXF_1 270 277 PF00149 0.467
DOC_PP1_RVXF_1 446 452 PF00149 0.470
DOC_PP1_RVXF_1 523 530 PF00149 0.379
DOC_PP1_RVXF_1 546 553 PF00149 0.532
DOC_PP4_FxxP_1 152 155 PF00568 0.425
DOC_PP4_FxxP_1 242 245 PF00568 0.537
DOC_PP4_FxxP_1 348 351 PF00568 0.445
DOC_PP4_FxxP_1 619 622 PF00568 0.376
DOC_PP4_FxxP_1 744 747 PF00568 0.632
DOC_USP7_MATH_1 155 159 PF00917 0.515
DOC_USP7_MATH_1 307 311 PF00917 0.646
DOC_USP7_MATH_1 371 375 PF00917 0.536
DOC_USP7_MATH_1 412 416 PF00917 0.767
DOC_USP7_MATH_1 506 510 PF00917 0.478
DOC_USP7_MATH_1 559 563 PF00917 0.626
DOC_USP7_MATH_1 641 645 PF00917 0.559
DOC_USP7_UBL2_3 668 672 PF12436 0.505
DOC_WW_Pin1_4 121 126 PF00397 0.316
DOC_WW_Pin1_4 151 156 PF00397 0.433
DOC_WW_Pin1_4 209 214 PF00397 0.541
DOC_WW_Pin1_4 220 225 PF00397 0.446
DOC_WW_Pin1_4 333 338 PF00397 0.568
DOC_WW_Pin1_4 413 418 PF00397 0.784
DOC_WW_Pin1_4 475 480 PF00397 0.494
DOC_WW_Pin1_4 557 562 PF00397 0.541
DOC_WW_Pin1_4 643 648 PF00397 0.706
DOC_WW_Pin1_4 663 668 PF00397 0.476
DOC_WW_Pin1_4 696 701 PF00397 0.691
DOC_WW_Pin1_4 7 12 PF00397 0.540
LIG_14-3-3_CanoR_1 275 279 PF00244 0.383
LIG_14-3-3_CanoR_1 409 417 PF00244 0.612
LIG_14-3-3_CanoR_1 455 463 PF00244 0.537
LIG_14-3-3_CanoR_1 482 491 PF00244 0.639
LIG_14-3-3_CanoR_1 507 511 PF00244 0.555
LIG_14-3-3_CanoR_1 648 653 PF00244 0.495
LIG_14-3-3_CanoR_1 75 82 PF00244 0.314
LIG_BRCT_BRCA1_1 221 225 PF00533 0.548
LIG_BRCT_BRCA1_1 650 654 PF00533 0.398
LIG_BRCT_BRCA1_1 740 744 PF00533 0.576
LIG_deltaCOP1_diTrp_1 441 451 PF00928 0.428
LIG_eIF4E_1 57 63 PF01652 0.319
LIG_FHA_1 178 184 PF00498 0.486
LIG_FHA_1 275 281 PF00498 0.526
LIG_FHA_1 294 300 PF00498 0.298
LIG_FHA_1 469 475 PF00498 0.562
LIG_FHA_1 570 576 PF00498 0.599
LIG_FHA_1 64 70 PF00498 0.295
LIG_FHA_1 671 677 PF00498 0.641
LIG_FHA_1 722 728 PF00498 0.708
LIG_FHA_2 171 177 PF00498 0.546
LIG_FHA_2 221 227 PF00498 0.461
LIG_FHA_2 300 306 PF00498 0.594
LIG_FHA_2 333 339 PF00498 0.546
LIG_FHA_2 344 350 PF00498 0.392
LIG_FHA_2 428 434 PF00498 0.630
LIG_FHA_2 84 90 PF00498 0.319
LIG_LIR_Apic_2 346 351 PF02991 0.496
LIG_LIR_Apic_2 396 402 PF02991 0.626
LIG_LIR_Apic_2 616 622 PF02991 0.417
LIG_LIR_Apic_2 741 747 PF02991 0.593
LIG_LIR_Gen_1 508 514 PF02991 0.444
LIG_LIR_Nem_3 124 129 PF02991 0.353
LIG_LIR_Nem_3 20 24 PF02991 0.422
LIG_LIR_Nem_3 318 324 PF02991 0.496
LIG_LIR_Nem_3 346 350 PF02991 0.488
LIG_LIR_Nem_3 374 379 PF02991 0.489
LIG_LIR_Nem_3 44 50 PF02991 0.364
LIG_LIR_Nem_3 492 496 PF02991 0.447
LIG_LIR_Nem_3 508 513 PF02991 0.443
LIG_LIR_Nem_3 591 595 PF02991 0.411
LIG_LIR_Nem_3 651 657 PF02991 0.384
LIG_LYPXL_S_1 375 379 PF13949 0.513
LIG_LYPXL_yS_3 376 379 PF13949 0.515
LIG_MAD2 498 506 PF02301 0.519
LIG_MYND_1 121 125 PF01753 0.353
LIG_PCNA_PIPBox_1 369 378 PF02747 0.561
LIG_SH2_CRK 169 173 PF00017 0.488
LIG_SH2_SRC 159 162 PF00017 0.478
LIG_SH2_STAP1 57 61 PF00017 0.319
LIG_SH2_STAP1 581 585 PF00017 0.468
LIG_SH2_STAT5 148 151 PF00017 0.531
LIG_SH2_STAT5 159 162 PF00017 0.417
LIG_SH2_STAT5 34 37 PF00017 0.463
LIG_SH2_STAT5 347 350 PF00017 0.486
LIG_SH2_STAT5 41 44 PF00017 0.412
LIG_SH2_STAT5 47 50 PF00017 0.263
LIG_SH2_STAT5 496 499 PF00017 0.433
LIG_SH2_STAT5 607 610 PF00017 0.550
LIG_SH2_STAT5 662 665 PF00017 0.481
LIG_SH2_STAT5 94 97 PF00017 0.334
LIG_SH3_1 292 298 PF00018 0.526
LIG_SH3_2 199 204 PF14604 0.455
LIG_SH3_3 115 121 PF00018 0.319
LIG_SH3_3 196 202 PF00018 0.440
LIG_SH3_3 207 213 PF00018 0.456
LIG_SH3_3 292 298 PF00018 0.478
LIG_SH3_3 422 428 PF00018 0.677
LIG_SH3_3 433 439 PF00018 0.584
LIG_SH3_3 500 506 PF00018 0.463
LIG_SH3_3 535 541 PF00018 0.555
LIG_SUMO_SIM_anti_2 473 478 PF11976 0.578
LIG_SUMO_SIM_par_1 420 426 PF11976 0.739
LIG_SUMO_SIM_par_1 471 478 PF11976 0.559
LIG_SUMO_SIM_par_1 723 728 PF11976 0.731
LIG_TRAF2_1 430 433 PF00917 0.558
LIG_UBA3_1 320 327 PF00899 0.378
LIG_WRC_WIRS_1 131 136 PF05994 0.389
LIG_WRC_WIRS_1 171 176 PF05994 0.383
LIG_WRC_WIRS_1 372 377 PF05994 0.562
MOD_CDK_SPK_2 643 648 PF00069 0.706
MOD_CDK_SPK_2 663 668 PF00069 0.435
MOD_CDK_SPxK_1 333 339 PF00069 0.562
MOD_CDK_SPxxK_3 475 482 PF00069 0.582
MOD_CK1_1 188 194 PF00069 0.451
MOD_CK1_1 45 51 PF00069 0.461
MOD_CK1_1 562 568 PF00069 0.629
MOD_CK1_1 570 576 PF00069 0.657
MOD_CK1_1 646 652 PF00069 0.553
MOD_CK1_1 7 13 PF00069 0.672
MOD_CK2_1 151 157 PF00069 0.525
MOD_CK2_1 170 176 PF00069 0.502
MOD_CK2_1 299 305 PF00069 0.612
MOD_CK2_1 427 433 PF00069 0.646
MOD_CK2_1 83 89 PF00069 0.319
MOD_GlcNHglycan 190 193 PF01048 0.514
MOD_GlcNHglycan 245 248 PF01048 0.597
MOD_GlcNHglycan 267 270 PF01048 0.481
MOD_GlcNHglycan 309 312 PF01048 0.504
MOD_GlcNHglycan 35 38 PF01048 0.436
MOD_GlcNHglycan 382 385 PF01048 0.540
MOD_GlcNHglycan 395 398 PF01048 0.437
MOD_GlcNHglycan 561 564 PF01048 0.685
MOD_GlcNHglycan 577 580 PF01048 0.647
MOD_GlcNHglycan 628 631 PF01048 0.397
MOD_GSK3_1 151 158 PF00069 0.489
MOD_GSK3_1 403 410 PF00069 0.730
MOD_GSK3_1 41 48 PF00069 0.502
MOD_GSK3_1 423 430 PF00069 0.662
MOD_GSK3_1 508 515 PF00069 0.446
MOD_GSK3_1 622 629 PF00069 0.379
MOD_GSK3_1 643 650 PF00069 0.626
MOD_GSK3_1 83 90 PF00069 0.316
MOD_N-GLC_1 155 160 PF02516 0.481
MOD_N-GLC_1 256 261 PF02516 0.533
MOD_N-GLC_1 299 304 PF02516 0.633
MOD_N-GLC_1 330 335 PF02516 0.615
MOD_N-GLC_1 412 417 PF02516 0.659
MOD_N-GLC_1 632 637 PF02516 0.595
MOD_N-GLC_2 533 535 PF02516 0.539
MOD_NEK2_1 274 279 PF00069 0.464
MOD_NEK2_1 299 304 PF00069 0.616
MOD_NEK2_1 423 428 PF00069 0.717
MOD_NEK2_1 470 475 PF00069 0.503
MOD_NEK2_1 484 489 PF00069 0.617
MOD_NEK2_1 527 532 PF00069 0.508
MOD_NEK2_1 62 67 PF00069 0.295
MOD_NEK2_1 712 717 PF00069 0.491
MOD_NEK2_2 371 376 PF00069 0.509
MOD_NEK2_2 681 686 PF00069 0.489
MOD_NEK2_2 92 97 PF00069 0.389
MOD_PIKK_1 103 109 PF00454 0.391
MOD_PIKK_1 458 464 PF00454 0.600
MOD_PIKK_1 484 490 PF00454 0.608
MOD_PK_1 648 654 PF00069 0.501
MOD_PKA_1 393 399 PF00069 0.583
MOD_PKA_2 274 280 PF00069 0.381
MOD_PKA_2 408 414 PF00069 0.615
MOD_PKA_2 506 512 PF00069 0.457
MOD_PKA_2 570 576 PF00069 0.549
MOD_PKA_2 647 653 PF00069 0.580
MOD_PKA_2 74 80 PF00069 0.319
MOD_PKB_1 393 401 PF00069 0.599
MOD_Plk_1 155 161 PF00069 0.487
MOD_Plk_1 299 305 PF00069 0.632
MOD_Plk_1 42 48 PF00069 0.501
MOD_Plk_1 458 464 PF00069 0.529
MOD_Plk_1 548 554 PF00069 0.453
MOD_Plk_4 155 161 PF00069 0.538
MOD_Plk_4 259 265 PF00069 0.528
MOD_Plk_4 343 349 PF00069 0.489
MOD_Plk_4 371 377 PF00069 0.511
MOD_Plk_4 42 48 PF00069 0.505
MOD_Plk_4 548 554 PF00069 0.520
MOD_Plk_4 704 710 PF00069 0.435
MOD_Plk_4 738 744 PF00069 0.588
MOD_ProDKin_1 121 127 PF00069 0.316
MOD_ProDKin_1 151 157 PF00069 0.443
MOD_ProDKin_1 209 215 PF00069 0.547
MOD_ProDKin_1 220 226 PF00069 0.444
MOD_ProDKin_1 333 339 PF00069 0.562
MOD_ProDKin_1 413 419 PF00069 0.780
MOD_ProDKin_1 475 481 PF00069 0.491
MOD_ProDKin_1 557 563 PF00069 0.561
MOD_ProDKin_1 643 649 PF00069 0.688
MOD_ProDKin_1 663 669 PF00069 0.488
MOD_ProDKin_1 696 702 PF00069 0.687
MOD_ProDKin_1 7 13 PF00069 0.534
MOD_SUMO_for_1 363 366 PF00179 0.598
MOD_SUMO_rev_2 675 684 PF00179 0.469
TRG_ENDOCYTIC_2 169 172 PF00928 0.403
TRG_ENDOCYTIC_2 347 350 PF00928 0.486
TRG_ENDOCYTIC_2 376 379 PF00928 0.515
TRG_ENDOCYTIC_2 47 50 PF00928 0.305
TRG_ENDOCYTIC_2 496 499 PF00928 0.515
TRG_ENDOCYTIC_2 52 55 PF00928 0.293
TRG_ER_diArg_1 282 284 PF00400 0.434
TRG_ER_diArg_1 59 61 PF00400 0.295
TRG_ER_diArg_1 659 661 PF00400 0.451
TRG_ER_diArg_1 686 688 PF00400 0.495
TRG_NES_CRM1_1 338 353 PF08389 0.552
TRG_NLS_MonoExtN_4 390 397 PF00514 0.564
TRG_Pf-PMV_PEXEL_1 322 326 PF00026 0.556
TRG_Pf-PMV_PEXEL_1 594 598 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCF5 Leptomonas seymouri 64% 99%
A0A1X0P094 Trypanosomatidae 41% 100%
A0A3Q8IRG9 Leishmania donovani 99% 100%
E9ATL4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q0Y4 Leishmania major 94% 100%
V5BQ93 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS