LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE40_LEIIN
TriTrypDb:
LINF_360052700
Length:
551

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 143, 443
Promastigote: 75

Expansion

Sequence features

A4IE40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE40

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 62 66 PF00656 0.601
CLV_NRD_NRD_1 119 121 PF00675 0.730
CLV_NRD_NRD_1 242 244 PF00675 0.658
CLV_NRD_NRD_1 253 255 PF00675 0.614
CLV_NRD_NRD_1 330 332 PF00675 0.515
CLV_NRD_NRD_1 346 348 PF00675 0.563
CLV_NRD_NRD_1 362 364 PF00675 0.401
CLV_NRD_NRD_1 502 504 PF00675 0.644
CLV_NRD_NRD_1 513 515 PF00675 0.653
CLV_NRD_NRD_1 516 518 PF00675 0.647
CLV_PCSK_KEX2_1 119 121 PF00082 0.730
CLV_PCSK_KEX2_1 242 244 PF00082 0.658
CLV_PCSK_KEX2_1 253 255 PF00082 0.614
CLV_PCSK_KEX2_1 330 332 PF00082 0.646
CLV_PCSK_KEX2_1 346 348 PF00082 0.443
CLV_PCSK_KEX2_1 361 363 PF00082 0.498
CLV_PCSK_KEX2_1 494 496 PF00082 0.711
CLV_PCSK_KEX2_1 502 504 PF00082 0.613
CLV_PCSK_PC1ET2_1 494 496 PF00082 0.704
CLV_PCSK_PC7_1 249 255 PF00082 0.607
CLV_PCSK_SKI1_1 25 29 PF00082 0.608
CLV_PCSK_SKI1_1 283 287 PF00082 0.565
CLV_PCSK_SKI1_1 350 354 PF00082 0.626
CLV_PCSK_SKI1_1 495 499 PF00082 0.531
CLV_PCSK_SKI1_1 538 542 PF00082 0.592
CLV_PCSK_SKI1_1 99 103 PF00082 0.691
DEG_COP1_1 317 328 PF00400 0.622
DOC_CYCLIN_RxL_1 535 542 PF00134 0.583
DOC_CYCLIN_yClb5_NLxxxL_5 17 26 PF00134 0.658
DOC_PP1_RVXF_1 536 542 PF00149 0.583
DOC_PP2B_LxvP_1 286 289 PF13499 0.538
DOC_PP4_FxxP_1 113 116 PF00568 0.689
DOC_USP7_MATH_1 154 158 PF00917 0.674
DOC_USP7_MATH_1 163 167 PF00917 0.649
DOC_USP7_MATH_1 311 315 PF00917 0.640
DOC_USP7_MATH_1 409 413 PF00917 0.773
DOC_USP7_MATH_1 415 419 PF00917 0.608
DOC_USP7_MATH_1 44 48 PF00917 0.809
DOC_USP7_MATH_1 546 550 PF00917 0.640
DOC_USP7_MATH_1 9 13 PF00917 0.638
DOC_USP7_UBL2_3 457 461 PF12436 0.613
DOC_WW_Pin1_4 122 127 PF00397 0.673
DOC_WW_Pin1_4 168 173 PF00397 0.629
DOC_WW_Pin1_4 225 230 PF00397 0.791
DOC_WW_Pin1_4 263 268 PF00397 0.653
DOC_WW_Pin1_4 40 45 PF00397 0.802
DOC_WW_Pin1_4 450 455 PF00397 0.660
DOC_WW_Pin1_4 495 500 PF00397 0.586
DOC_WW_Pin1_4 516 521 PF00397 0.654
LIG_14-3-3_CanoR_1 140 147 PF00244 0.721
LIG_14-3-3_CanoR_1 162 172 PF00244 0.758
LIG_14-3-3_CanoR_1 196 204 PF00244 0.593
LIG_14-3-3_CanoR_1 205 215 PF00244 0.671
LIG_14-3-3_CanoR_1 222 229 PF00244 0.721
LIG_14-3-3_CanoR_1 235 244 PF00244 0.588
LIG_14-3-3_CanoR_1 25 30 PF00244 0.572
LIG_14-3-3_CanoR_1 487 493 PF00244 0.713
LIG_14-3-3_CanoR_1 99 107 PF00244 0.636
LIG_Actin_WH2_2 265 280 PF00022 0.677
LIG_BIR_II_1 1 5 PF00653 0.587
LIG_BRCT_BRCA1_1 440 444 PF00533 0.694
LIG_deltaCOP1_diTrp_1 358 365 PF00928 0.471
LIG_FHA_1 137 143 PF00498 0.687
LIG_FHA_1 169 175 PF00498 0.651
LIG_FHA_1 184 190 PF00498 0.484
LIG_FHA_1 320 326 PF00498 0.594
LIG_FHA_1 545 551 PF00498 0.595
LIG_FHA_2 123 129 PF00498 0.805
LIG_FHA_2 318 324 PF00498 0.483
LIG_FHA_2 340 346 PF00498 0.649
LIG_FHA_2 50 56 PF00498 0.577
LIG_FHA_2 60 66 PF00498 0.594
LIG_LIR_Apic_2 176 181 PF02991 0.532
LIG_LIR_Gen_1 180 189 PF02991 0.654
LIG_LIR_Gen_1 2 10 PF02991 0.633
LIG_LIR_Gen_1 484 492 PF02991 0.570
LIG_LIR_Nem_3 180 185 PF02991 0.541
LIG_LIR_Nem_3 201 207 PF02991 0.495
LIG_LIR_Nem_3 334 339 PF02991 0.548
LIG_LIR_Nem_3 484 488 PF02991 0.573
LIG_LIR_Nem_3 55 61 PF02991 0.628
LIG_PDZ_Class_1 546 551 PF00595 0.630
LIG_SH2_CRK 204 208 PF00017 0.551
LIG_SH2_CRK 58 62 PF00017 0.639
LIG_SH2_NCK_1 178 182 PF00017 0.664
LIG_SH2_PTP2 338 341 PF00017 0.541
LIG_SH2_SRC 182 185 PF00017 0.683
LIG_SH2_SRC 293 296 PF00017 0.525
LIG_SH2_SRC 338 341 PF00017 0.541
LIG_SH2_STAP1 293 297 PF00017 0.521
LIG_SH2_STAP1 303 307 PF00017 0.574
LIG_SH2_STAP1 36 40 PF00017 0.639
LIG_SH2_STAT5 276 279 PF00017 0.592
LIG_SH2_STAT5 324 327 PF00017 0.671
LIG_SH2_STAT5 338 341 PF00017 0.480
LIG_SH2_STAT5 36 39 PF00017 0.747
LIG_SH3_2 160 165 PF14604 0.655
LIG_SH3_2 172 177 PF14604 0.628
LIG_SH3_3 157 163 PF00018 0.661
LIG_SH3_3 169 175 PF00018 0.641
LIG_SH3_CIN85_PxpxPR_1 244 249 PF14604 0.609
LIG_TRAF2_1 271 274 PF00917 0.671
LIG_TRAF2_1 341 344 PF00917 0.598
LIG_TRAF2_1 356 359 PF00917 0.443
LIG_TYR_ITIM 56 61 PF00017 0.629
LIG_WRC_WIRS_1 532 537 PF05994 0.646
MOD_CDK_SPK_2 122 127 PF00069 0.655
MOD_CDK_SPK_2 168 173 PF00069 0.707
MOD_CDK_SPK_2 225 230 PF00069 0.791
MOD_CDK_SPK_2 40 45 PF00069 0.693
MOD_CDK_SPxK_1 450 456 PF00069 0.702
MOD_CDK_SPxxK_3 263 270 PF00069 0.612
MOD_CDK_SPxxK_3 450 457 PF00069 0.761
MOD_CDK_SPxxK_3 495 502 PF00069 0.625
MOD_CK1_1 136 142 PF00069 0.739
MOD_CK1_1 166 172 PF00069 0.820
MOD_CK1_1 195 201 PF00069 0.504
MOD_CK1_1 211 217 PF00069 0.763
MOD_CK1_1 228 234 PF00069 0.555
MOD_CK1_1 256 262 PF00069 0.792
MOD_CK1_1 314 320 PF00069 0.675
MOD_CK1_1 35 41 PF00069 0.655
MOD_CK1_1 445 451 PF00069 0.740
MOD_CK1_1 509 515 PF00069 0.692
MOD_CK1_1 72 78 PF00069 0.742
MOD_CK1_1 8 14 PF00069 0.690
MOD_CK1_1 88 94 PF00069 0.629
MOD_CK2_1 122 128 PF00069 0.805
MOD_CK2_1 153 159 PF00069 0.731
MOD_CK2_1 195 201 PF00069 0.456
MOD_CK2_1 317 323 PF00069 0.526
MOD_CK2_1 339 345 PF00069 0.528
MOD_CK2_1 368 374 PF00069 0.537
MOD_CK2_1 474 480 PF00069 0.645
MOD_CK2_1 49 55 PF00069 0.587
MOD_CK2_1 516 522 PF00069 0.752
MOD_CK2_1 70 76 PF00069 0.674
MOD_Cter_Amidation 492 495 PF01082 0.689
MOD_Cter_Amidation 515 518 PF01082 0.729
MOD_DYRK1A_RPxSP_1 168 172 PF00069 0.623
MOD_DYRK1A_RPxSP_1 495 499 PF00069 0.621
MOD_GlcNHglycan 197 200 PF01048 0.434
MOD_GlcNHglycan 225 228 PF01048 0.750
MOD_GlcNHglycan 230 233 PF01048 0.701
MOD_GlcNHglycan 238 241 PF01048 0.643
MOD_GlcNHglycan 244 247 PF01048 0.744
MOD_GlcNHglycan 256 259 PF01048 0.612
MOD_GlcNHglycan 305 308 PF01048 0.666
MOD_GlcNHglycan 38 41 PF01048 0.801
MOD_GlcNHglycan 409 412 PF01048 0.636
MOD_GlcNHglycan 444 447 PF01048 0.783
MOD_GlcNHglycan 458 461 PF01048 0.592
MOD_GlcNHglycan 522 525 PF01048 0.749
MOD_GlcNHglycan 7 10 PF01048 0.615
MOD_GlcNHglycan 86 90 PF01048 0.753
MOD_GlcNHglycan 92 95 PF01048 0.654
MOD_GSK3_1 136 143 PF00069 0.734
MOD_GSK3_1 145 152 PF00069 0.645
MOD_GSK3_1 163 170 PF00069 0.718
MOD_GSK3_1 206 213 PF00069 0.659
MOD_GSK3_1 221 228 PF00069 0.721
MOD_GSK3_1 249 256 PF00069 0.790
MOD_GSK3_1 259 266 PF00069 0.667
MOD_GSK3_1 30 37 PF00069 0.654
MOD_GSK3_1 311 318 PF00069 0.786
MOD_GSK3_1 40 47 PF00069 0.528
MOD_GSK3_1 438 445 PF00069 0.773
MOD_GSK3_1 448 455 PF00069 0.662
MOD_GSK3_1 5 12 PF00069 0.635
MOD_GSK3_1 506 513 PF00069 0.791
MOD_GSK3_1 516 523 PF00069 0.624
MOD_LATS_1 23 29 PF00433 0.607
MOD_LATS_1 348 354 PF00433 0.448
MOD_N-GLC_1 140 145 PF02516 0.622
MOD_N-GLC_1 211 216 PF02516 0.770
MOD_N-GLC_1 236 241 PF02516 0.702
MOD_N-GLC_1 301 306 PF02516 0.660
MOD_N-GLC_1 318 323 PF02516 0.729
MOD_N-GLC_1 368 373 PF02516 0.608
MOD_N-GLC_1 438 443 PF02516 0.693
MOD_NEK2_1 111 116 PF00069 0.640
MOD_NEK2_1 488 493 PF00069 0.563
MOD_PIKK_1 111 117 PF00454 0.589
MOD_PIKK_1 133 139 PF00454 0.781
MOD_PIKK_1 213 219 PF00454 0.725
MOD_PIKK_1 221 227 PF00454 0.640
MOD_PIKK_1 396 402 PF00454 0.672
MOD_PIKK_1 415 421 PF00454 0.599
MOD_PKA_1 242 248 PF00069 0.644
MOD_PKA_1 253 259 PF00069 0.613
MOD_PKA_1 456 462 PF00069 0.699
MOD_PKA_2 164 170 PF00069 0.785
MOD_PKA_2 192 198 PF00069 0.633
MOD_PKA_2 221 227 PF00069 0.720
MOD_PKA_2 242 248 PF00069 0.734
MOD_PKA_2 253 259 PF00069 0.722
MOD_PKA_2 415 421 PF00069 0.619
MOD_PKA_2 44 50 PF00069 0.676
MOD_PKA_2 448 454 PF00069 0.744
MOD_PKA_2 509 515 PF00069 0.664
MOD_PKA_2 77 83 PF00069 0.777
MOD_PKB_1 247 255 PF00069 0.792
MOD_Plk_1 211 217 PF00069 0.728
MOD_Plk_1 350 356 PF00069 0.498
MOD_Plk_4 184 190 PF00069 0.521
MOD_ProDKin_1 122 128 PF00069 0.673
MOD_ProDKin_1 168 174 PF00069 0.628
MOD_ProDKin_1 225 231 PF00069 0.792
MOD_ProDKin_1 263 269 PF00069 0.649
MOD_ProDKin_1 40 46 PF00069 0.800
MOD_ProDKin_1 450 456 PF00069 0.659
MOD_ProDKin_1 495 501 PF00069 0.587
MOD_ProDKin_1 516 522 PF00069 0.656
TRG_DiLeu_BaEn_4 76 82 PF01217 0.709
TRG_ENDOCYTIC_2 182 185 PF00928 0.536
TRG_ENDOCYTIC_2 204 207 PF00928 0.545
TRG_ENDOCYTIC_2 4 7 PF00928 0.637
TRG_ENDOCYTIC_2 58 61 PF00928 0.638
TRG_ER_diArg_1 242 244 PF00400 0.670
TRG_ER_diArg_1 253 255 PF00400 0.657
TRG_ER_diArg_1 330 332 PF00400 0.515
TRG_ER_diArg_1 360 363 PF00400 0.493
TRG_ER_diArg_1 385 388 PF00400 0.679
TRG_NLS_Bipartite_1 502 518 PF00514 0.611
TRG_NLS_MonoExtC_3 513 518 PF00514 0.609
TRG_Pf-PMV_PEXEL_1 330 334 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 355 359 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U4 Leptomonas seymouri 38% 100%
A0A3Q8IPF2 Leishmania donovani 99% 100%
A4HPV1 Leishmania braziliensis 57% 99%
E9ATL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 97%
Q4Q0Y0 Leishmania major 83% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS