Putative homocysteine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homocysteine S-methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4IE37_LEIIN

TriTrypDb:

LINF_360073700

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE37

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	136	140	PF00082	0.199
CLV_PCSK_SKI1_1	160	164	PF00082	0.199
CLV_PCSK_SKI1_1	96	100	PF00082	0.199
DEG_Nend_UBRbox_2	1	3	PF02207	0.442
DOC_CKS1_1	126	131	PF01111	0.400
DOC_USP7_MATH_1	185	189	PF00917	0.400
DOC_WW_Pin1_4	125	130	PF00397	0.400
DOC_WW_Pin1_4	98	103	PF00397	0.400
LIG_14-3-3_CanoR_1	118	127	PF00244	0.400
LIG_14-3-3_CanoR_1	136	144	PF00244	0.400
LIG_14-3-3_CanoR_1	152	158	PF00244	0.400
LIG_14-3-3_CanoR_1	33	41	PF00244	0.476
LIG_Actin_WH2_2	101	116	PF00022	0.400
LIG_BRCT_BRCA1_1	3	7	PF00533	0.358
LIG_FHA_2	37	43	PF00498	0.461
LIG_FHA_2	77	83	PF00498	0.400
LIG_Integrin_RGD_1	191	193	PF01839	0.327
LIG_LIR_Gen_1	36	46	PF02991	0.459
LIG_PTB_Apo_2	40	47	PF02174	0.449
LIG_SH2_STAT5	112	115	PF00017	0.400
LIG_SH2_STAT5	183	186	PF00017	0.400
LIG_SH2_STAT5	194	197	PF00017	0.366
LIG_SH2_STAT5	63	66	PF00017	0.304
LIG_SUMO_SIM_par_1	69	74	PF11976	0.296
LIG_TRAF2_1	146	149	PF00917	0.400
LIG_UBA3_1	88	96	PF00899	0.400
MOD_CDC14_SPxK_1	101	104	PF00782	0.400
MOD_CDK_SPxK_1	98	104	PF00069	0.400
MOD_CK2_1	128	134	PF00069	0.400
MOD_CK2_1	153	159	PF00069	0.400
MOD_CK2_1	36	42	PF00069	0.468
MOD_CK2_1	76	82	PF00069	0.400
MOD_GlcNHglycan	196	199	PF01048	0.389
MOD_GlcNHglycan	93	96	PF01048	0.199
MOD_GSK3_1	121	128	PF00069	0.400
MOD_GSK3_1	2	9	PF00069	0.361
MOD_GSK3_1	76	83	PF00069	0.400
MOD_NEK2_1	1	6	PF00069	0.391
MOD_Plk_1	1	7	PF00069	0.384
MOD_Plk_1	147	153	PF00069	0.400
MOD_Plk_4	128	134	PF00069	0.400
MOD_Plk_4	2	8	PF00069	0.362
MOD_Plk_4	21	27	PF00069	0.400
MOD_ProDKin_1	125	131	PF00069	0.400
MOD_ProDKin_1	98	104	PF00069	0.400
TRG_DiLeu_BaEn_2	41	47	PF01217	0.448
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4ZGQ8	BRAOT	41%	61%
O31463	BACSU	49%	63%
P56707	ASTBI	42%	59%
Q08985	YEAST	30%	61%
Q12525	YEAST	30%	61%
Q47690	ECOLI	60%	64%
Q4VNK0	BRAOT	45%	58%
Q8LAX0	ARATH	43%	57%
Q9FUM7	MAIZE	44%	58%
Q9FUM8	MAIZE	54%	59%
Q9FUM9	MAIZE	56%	59%
Q9FUN0	MAIZE	41%	62%
Q9M1W4	ARATH	43%	60%
Q9SDL7	ARATH	41%	61%