Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IE35_LEIIN

TriTrypDb:

LINF_360072400

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IE35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE35

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	577	581	PF00656	0.632
CLV_C14_Caspase3-7	670	674	PF00656	0.593
CLV_C14_Caspase3-7	711	715	PF00656	0.563
CLV_C14_Caspase3-7	726	730	PF00656	0.625
CLV_NRD_NRD_1	226	228	PF00675	0.377
CLV_NRD_NRD_1	667	669	PF00675	0.732
CLV_NRD_NRD_1	702	704	PF00675	0.613
CLV_NRD_NRD_1	705	707	PF00675	0.593
CLV_PCSK_FUR_1	224	228	PF00082	0.384
CLV_PCSK_KEX2_1	226	228	PF00082	0.377
CLV_PCSK_KEX2_1	482	484	PF00082	0.608
CLV_PCSK_KEX2_1	49	51	PF00082	0.544
CLV_PCSK_KEX2_1	667	669	PF00082	0.594
CLV_PCSK_KEX2_1	702	704	PF00082	0.624
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.608
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.513
CLV_PCSK_PC7_1	45	51	PF00082	0.507
CLV_PCSK_SKI1_1	226	230	PF00082	0.559
CLV_PCSK_SKI1_1	249	253	PF00082	0.373
CLV_PCSK_SKI1_1	445	449	PF00082	0.610
CLV_PCSK_SKI1_1	57	61	PF00082	0.376
CLV_PCSK_SKI1_1	645	649	PF00082	0.520
CLV_PCSK_SKI1_1	667	671	PF00082	0.566
DEG_APCC_DBOX_1	444	452	PF00400	0.507
DEG_SPOP_SBC_1	461	465	PF00917	0.676
DOC_ANK_TNKS_1	709	716	PF00023	0.543
DOC_CKS1_1	341	346	PF01111	0.606
DOC_CKS1_1	588	593	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.627
DOC_MAPK_gen_1	49	60	PF00069	0.424
DOC_MAPK_MEF2A_6	53	60	PF00069	0.441
DOC_PP2B_LxvP_1	101	104	PF13499	0.514
DOC_PP2B_LxvP_1	186	189	PF13499	0.388
DOC_PP2B_LxvP_1	524	527	PF13499	0.671
DOC_PP2B_LxvP_1	537	540	PF13499	0.548
DOC_USP7_MATH_1	356	360	PF00917	0.631
DOC_USP7_MATH_1	364	368	PF00917	0.634
DOC_USP7_MATH_1	372	376	PF00917	0.561
DOC_USP7_MATH_1	392	396	PF00917	0.647
DOC_USP7_MATH_1	461	465	PF00917	0.651
DOC_USP7_MATH_1	472	476	PF00917	0.559
DOC_USP7_MATH_1	519	523	PF00917	0.642
DOC_USP7_MATH_1	562	566	PF00917	0.525
DOC_USP7_MATH_1	616	620	PF00917	0.582
DOC_USP7_MATH_1	635	639	PF00917	0.521
DOC_USP7_MATH_1	685	689	PF00917	0.556
DOC_WW_Pin1_4	306	311	PF00397	0.598
DOC_WW_Pin1_4	340	345	PF00397	0.628
DOC_WW_Pin1_4	387	392	PF00397	0.688
DOC_WW_Pin1_4	457	462	PF00397	0.672
DOC_WW_Pin1_4	500	505	PF00397	0.616
DOC_WW_Pin1_4	522	527	PF00397	0.643
DOC_WW_Pin1_4	532	537	PF00397	0.610
DOC_WW_Pin1_4	587	592	PF00397	0.636
DOC_WW_Pin1_4	82	87	PF00397	0.446
LIG_14-3-3_CanoR_1	173	179	PF00244	0.386
LIG_14-3-3_CanoR_1	226	233	PF00244	0.533
LIG_14-3-3_CanoR_1	278	284	PF00244	0.458
LIG_14-3-3_CanoR_1	405	413	PF00244	0.613
LIG_14-3-3_CanoR_1	436	444	PF00244	0.550
LIG_14-3-3_CanoR_1	604	610	PF00244	0.668
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_BIR_III_4	454	458	PF00653	0.598
LIG_CtBP_PxDLS_1	526	530	PF00389	0.554
LIG_eIF4E_1	160	166	PF01652	0.415
LIG_FHA_1	139	145	PF00498	0.531
LIG_FHA_1	183	189	PF00498	0.391
LIG_FHA_1	227	233	PF00498	0.571
LIG_FHA_1	250	256	PF00498	0.382
LIG_FHA_1	388	394	PF00498	0.630
LIG_FHA_1	415	421	PF00498	0.643
LIG_FHA_1	492	498	PF00498	0.655
LIG_FHA_1	590	596	PF00498	0.561
LIG_FHA_1	609	615	PF00498	0.679
LIG_FHA_1	647	653	PF00498	0.613
LIG_FHA_1	86	92	PF00498	0.417
LIG_FHA_2	106	112	PF00498	0.376
LIG_FHA_2	278	284	PF00498	0.458
LIG_FHA_2	668	674	PF00498	0.725
LIG_GBD_Chelix_1	550	558	PF00786	0.553
LIG_LIR_Gen_1	111	118	PF02991	0.415
LIG_LIR_Gen_1	732	738	PF02991	0.575
LIG_LIR_Nem_3	111	116	PF02991	0.394
LIG_LIR_Nem_3	2	6	PF02991	0.460
LIG_LIR_Nem_3	732	736	PF02991	0.580
LIG_LIR_Nem_3	9	14	PF02991	0.452
LIG_MAD2	235	243	PF02301	0.508
LIG_MAD2	613	621	PF02301	0.635
LIG_NRBOX	288	294	PF00104	0.486
LIG_PDZ_Class_2	733	738	PF00595	0.629
LIG_PTB_Apo_2	727	734	PF02174	0.636
LIG_RPA_C_Fungi	471	483	PF08784	0.622
LIG_SH2_STAP1	196	200	PF00017	0.335
LIG_SH2_STAT3	180	183	PF00017	0.401
LIG_SH2_STAT5	6	9	PF00017	0.432
LIG_SH2_STAT5	84	87	PF00017	0.434
LIG_SH3_1	338	344	PF00018	0.617
LIG_SH3_3	338	344	PF00018	0.590
LIG_SH3_3	539	545	PF00018	0.627
LIG_SH3_3	585	591	PF00018	0.617
LIG_SUMO_SIM_anti_2	636	641	PF11976	0.539
LIG_TRAF2_1	181	184	PF00917	0.400
LIG_TRAF2_1	280	283	PF00917	0.454
LIG_TRAF2_1	675	678	PF00917	0.590
LIG_UBA3_1	640	645	PF00899	0.515
MOD_CDK_SPK_2	457	462	PF00069	0.629
MOD_CK1_1	123	129	PF00069	0.604
MOD_CK1_1	18	24	PF00069	0.546
MOD_CK1_1	2	8	PF00069	0.515
MOD_CK1_1	256	262	PF00069	0.392
MOD_CK1_1	26	32	PF00069	0.609
MOD_CK1_1	306	312	PF00069	0.650
MOD_CK1_1	355	361	PF00069	0.644
MOD_CK1_1	414	420	PF00069	0.634
MOD_CK1_1	456	462	PF00069	0.629
MOD_CK1_1	463	469	PF00069	0.659
MOD_CK1_1	522	528	PF00069	0.671
MOD_CK2_1	173	179	PF00069	0.451
MOD_CK2_1	198	204	PF00069	0.569
MOD_CK2_1	277	283	PF00069	0.452
MOD_CK2_1	436	442	PF00069	0.563
MOD_CK2_1	525	531	PF00069	0.608
MOD_GlcNHglycan	127	130	PF01048	0.643
MOD_GlcNHglycan	209	212	PF01048	0.598
MOD_GlcNHglycan	25	28	PF01048	0.679
MOD_GlcNHglycan	255	258	PF01048	0.371
MOD_GlcNHglycan	315	318	PF01048	0.634
MOD_GlcNHglycan	327	330	PF01048	0.546
MOD_GlcNHglycan	34	37	PF01048	0.553
MOD_GlcNHglycan	345	348	PF01048	0.686
MOD_GlcNHglycan	354	357	PF01048	0.635
MOD_GlcNHglycan	396	399	PF01048	0.679
MOD_GlcNHglycan	40	43	PF01048	0.374
MOD_GlcNHglycan	406	409	PF01048	0.785
MOD_GlcNHglycan	454	458	PF01048	0.620
MOD_GlcNHglycan	467	470	PF01048	0.723
MOD_GlcNHglycan	510	514	PF01048	0.802
MOD_GlcNHglycan	521	524	PF01048	0.590
MOD_GlcNHglycan	592	595	PF01048	0.736
MOD_GlcNHglycan	622	625	PF01048	0.691
MOD_GlcNHglycan	658	661	PF01048	0.623
MOD_GlcNHglycan	673	676	PF01048	0.582
MOD_GlcNHglycan	75	78	PF01048	0.439
MOD_GSK3_1	120	127	PF00069	0.595
MOD_GSK3_1	14	21	PF00069	0.514
MOD_GSK3_1	2	9	PF00069	0.535
MOD_GSK3_1	23	30	PF00069	0.736
MOD_GSK3_1	249	256	PF00069	0.437
MOD_GSK3_1	309	316	PF00069	0.775
MOD_GSK3_1	348	355	PF00069	0.654
MOD_GSK3_1	359	366	PF00069	0.551
MOD_GSK3_1	368	375	PF00069	0.539
MOD_GSK3_1	376	383	PF00069	0.602
MOD_GSK3_1	404	411	PF00069	0.753
MOD_GSK3_1	432	439	PF00069	0.626
MOD_GSK3_1	453	460	PF00069	0.749
MOD_GSK3_1	461	468	PF00069	0.648
MOD_GSK3_1	496	503	PF00069	0.616
MOD_GSK3_1	616	623	PF00069	0.579
MOD_GSK3_1	63	70	PF00069	0.397
MOD_GSK3_1	667	674	PF00069	0.587
MOD_N-GLC_1	198	203	PF02516	0.575
MOD_N-GLC_1	352	357	PF02516	0.666
MOD_N-GLC_1	414	419	PF02516	0.677
MOD_N-GLC_1	424	429	PF02516	0.601
MOD_N-GLC_1	500	505	PF02516	0.673
MOD_N-GLC_1	729	734	PF02516	0.606
MOD_NEK2_1	304	309	PF00069	0.613
MOD_NEK2_1	352	357	PF00069	0.664
MOD_NEK2_1	368	373	PF00069	0.683
MOD_NEK2_1	60	65	PF00069	0.384
MOD_NEK2_1	679	684	PF00069	0.621
MOD_NEK2_2	244	249	PF00069	0.487
MOD_NEK2_2	356	361	PF00069	0.619
MOD_NEK2_2	364	369	PF00069	0.584
MOD_PIKK_1	27	33	PF00454	0.607
MOD_PIKK_1	608	614	PF00454	0.623
MOD_PIKK_1	679	685	PF00454	0.549
MOD_PKA_1	226	232	PF00069	0.380
MOD_PKA_1	49	55	PF00069	0.437
MOD_PKA_1	667	673	PF00069	0.563
MOD_PKA_2	121	127	PF00069	0.561
MOD_PKA_2	174	180	PF00069	0.386
MOD_PKA_2	226	232	PF00069	0.384
MOD_PKA_2	277	283	PF00069	0.452
MOD_PKA_2	368	374	PF00069	0.571
MOD_PKA_2	404	410	PF00069	0.618
MOD_PKA_2	461	467	PF00069	0.597
MOD_PKA_2	49	55	PF00069	0.536
MOD_PKA_2	60	66	PF00069	0.340
MOD_PKA_2	616	622	PF00069	0.603
MOD_PKA_2	667	673	PF00069	0.563
MOD_PKA_2	679	685	PF00069	0.437
MOD_PKA_2	73	79	PF00069	0.402
MOD_PKB_1	120	128	PF00069	0.578
MOD_PKB_1	224	232	PF00069	0.383
MOD_Plk_1	18	24	PF00069	0.618
MOD_Plk_1	244	250	PF00069	0.415
MOD_Plk_1	509	515	PF00069	0.572
MOD_Plk_1	560	566	PF00069	0.645
MOD_Plk_1	635	641	PF00069	0.518
MOD_Plk_2-3	729	735	PF00069	0.572
MOD_Plk_4	272	278	PF00069	0.368
MOD_Plk_4	6	12	PF00069	0.452
MOD_Plk_4	635	641	PF00069	0.522
MOD_Plk_4	67	73	PF00069	0.427
MOD_ProDKin_1	306	312	PF00069	0.598
MOD_ProDKin_1	340	346	PF00069	0.627
MOD_ProDKin_1	387	393	PF00069	0.687
MOD_ProDKin_1	457	463	PF00069	0.672
MOD_ProDKin_1	500	506	PF00069	0.615
MOD_ProDKin_1	522	528	PF00069	0.644
MOD_ProDKin_1	532	538	PF00069	0.609
MOD_ProDKin_1	587	593	PF00069	0.637
MOD_ProDKin_1	82	88	PF00069	0.450
MOD_SUMO_for_1	181	184	PF00179	0.400
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.441
TRG_ER_diArg_1	172	175	PF00400	0.424
TRG_ER_diArg_1	224	227	PF00400	0.392
TRG_ER_diArg_1	666	668	PF00400	0.595
TRG_NLS_MonoExtC_3	705	710	PF00514	0.662
TRG_NLS_MonoExtN_4	684	690	PF00514	0.569
TRG_NLS_MonoExtN_4	703	710	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD4	Leptomonas seymouri	45%	99%
A0A3Q8IJC2	Leishmania donovani	99%	100%
A4HQE4	Leishmania braziliensis	68%	100%
E9AU59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0D6	Leishmania major	91%	100%