LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Galactose oxidase - central domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IE28_LEIIN
TriTrypDb:
LINF_360071700
Length:
485

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IE28
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE28

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 38 42 PF00656 0.479
CLV_NRD_NRD_1 123 125 PF00675 0.735
CLV_NRD_NRD_1 479 481 PF00675 0.697
CLV_PCSK_KEX2_1 123 125 PF00082 0.735
CLV_PCSK_KEX2_1 22 24 PF00082 0.779
CLV_PCSK_KEX2_1 478 480 PF00082 0.800
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.779
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.800
CLV_PCSK_SKI1_1 37 41 PF00082 0.508
CLV_PCSK_SKI1_1 442 446 PF00082 0.524
DOC_CKS1_1 263 268 PF01111 0.505
DOC_CYCLIN_RxL_1 439 449 PF00134 0.616
DOC_MAPK_DCC_7 134 142 PF00069 0.748
DOC_MAPK_MEF2A_6 134 142 PF00069 0.748
DOC_MAPK_MEF2A_6 461 469 PF00069 0.684
DOC_PP1_RVXF_1 440 447 PF00149 0.610
DOC_USP7_MATH_1 159 163 PF00917 0.680
DOC_USP7_MATH_1 16 20 PF00917 0.542
DOC_USP7_MATH_1 199 203 PF00917 0.783
DOC_USP7_MATH_1 211 215 PF00917 0.648
DOC_USP7_MATH_1 376 380 PF00917 0.712
DOC_USP7_MATH_1 4 8 PF00917 0.671
DOC_USP7_MATH_1 415 419 PF00917 0.750
DOC_USP7_MATH_1 434 438 PF00917 0.289
DOC_USP7_MATH_1 481 485 PF00917 0.735
DOC_USP7_MATH_1 89 93 PF00917 0.501
DOC_USP7_MATH_1 98 102 PF00917 0.525
DOC_USP7_UBL2_3 18 22 PF12436 0.763
DOC_WW_Pin1_4 133 138 PF00397 0.736
DOC_WW_Pin1_4 146 151 PF00397 0.807
DOC_WW_Pin1_4 203 208 PF00397 0.726
DOC_WW_Pin1_4 233 238 PF00397 0.697
DOC_WW_Pin1_4 262 267 PF00397 0.514
DOC_WW_Pin1_4 278 283 PF00397 0.402
DOC_WW_Pin1_4 332 337 PF00397 0.570
LIG_14-3-3_CanoR_1 158 168 PF00244 0.691
LIG_14-3-3_CanoR_1 178 184 PF00244 0.557
LIG_14-3-3_CanoR_1 23 33 PF00244 0.737
LIG_14-3-3_CanoR_1 392 401 PF00244 0.578
LIG_14-3-3_CanoR_1 414 420 PF00244 0.762
LIG_14-3-3_CanoR_1 433 443 PF00244 0.337
LIG_Actin_WH2_2 265 281 PF00022 0.588
LIG_BIR_II_1 1 5 PF00653 0.618
LIG_BIR_III_1 1 5 PF00653 0.715
LIG_BIR_III_3 1 5 PF00653 0.715
LIG_CSL_BTD_1 333 336 PF09270 0.581
LIG_CtBP_PxDLS_1 137 141 PF00389 0.798
LIG_deltaCOP1_diTrp_1 258 263 PF00928 0.555
LIG_FHA_1 251 257 PF00498 0.561
LIG_FHA_1 263 269 PF00498 0.295
LIG_FHA_1 279 285 PF00498 0.409
LIG_FHA_1 310 316 PF00498 0.580
LIG_FHA_1 34 40 PF00498 0.626
LIG_FHA_1 59 65 PF00498 0.633
LIG_FHA_2 128 134 PF00498 0.660
LIG_FHA_2 236 242 PF00498 0.673
LIG_FHA_2 449 455 PF00498 0.574
LIG_Integrin_isoDGR_2 385 387 PF01839 0.636
LIG_LIR_Gen_1 367 376 PF02991 0.596
LIG_LIR_Nem_3 333 337 PF02991 0.576
LIG_LIR_Nem_3 367 372 PF02991 0.472
LIG_LIR_Nem_3 430 435 PF02991 0.647
LIG_LYPXL_SIV_4 12 20 PF13949 0.682
LIG_NRP_CendR_1 483 485 PF00754 0.819
LIG_Pex14_1 334 338 PF04695 0.582
LIG_SH2_NCK_1 13 17 PF00017 0.734
LIG_SH2_SRC 13 16 PF00017 0.734
LIG_SH2_STAP1 13 17 PF00017 0.734
LIG_SH2_STAP1 67 71 PF00017 0.579
LIG_SH2_STAT5 245 248 PF00017 0.466
LIG_SH2_STAT5 369 372 PF00017 0.411
LIG_SH3_2 82 87 PF14604 0.604
LIG_SH3_3 132 138 PF00018 0.697
LIG_SH3_3 192 198 PF00018 0.577
LIG_SH3_3 204 210 PF00018 0.647
LIG_SH3_3 28 34 PF00018 0.657
LIG_SH3_3 333 339 PF00018 0.508
LIG_SH3_3 79 85 PF00018 0.498
LIG_TRAF2_1 406 409 PF00917 0.589
LIG_TYR_ITIM 65 70 PF00017 0.576
MOD_CK1_1 136 142 PF00069 0.799
MOD_CK1_1 206 212 PF00069 0.822
MOD_CK1_1 25 31 PF00069 0.582
MOD_CK1_1 309 315 PF00069 0.575
MOD_CK1_1 327 333 PF00069 0.600
MOD_CK1_1 413 419 PF00069 0.789
MOD_CK2_1 159 165 PF00069 0.713
MOD_CK2_1 235 241 PF00069 0.695
MOD_CK2_1 4 10 PF00069 0.712
MOD_CK2_1 401 407 PF00069 0.512
MOD_CK2_1 448 454 PF00069 0.616
MOD_CMANNOS 260 263 PF00535 0.555
MOD_GlcNHglycan 142 145 PF01048 0.726
MOD_GlcNHglycan 179 182 PF01048 0.589
MOD_GlcNHglycan 195 198 PF01048 0.383
MOD_GlcNHglycan 231 234 PF01048 0.632
MOD_GlcNHglycan 309 312 PF01048 0.530
MOD_GlcNHglycan 329 332 PF01048 0.607
MOD_GlcNHglycan 91 94 PF01048 0.557
MOD_GSK3_1 136 143 PF00069 0.782
MOD_GSK3_1 146 153 PF00069 0.681
MOD_GSK3_1 199 206 PF00069 0.686
MOD_GSK3_1 211 218 PF00069 0.730
MOD_GSK3_1 229 236 PF00069 0.526
MOD_GSK3_1 33 40 PF00069 0.677
MOD_GSK3_1 399 406 PF00069 0.563
MOD_GSK3_1 409 416 PF00069 0.698
MOD_GSK3_1 453 460 PF00069 0.692
MOD_N-GLC_1 249 254 PF02516 0.586
MOD_N-GLC_1 350 355 PF02516 0.698
MOD_NEK2_1 140 145 PF00069 0.755
MOD_NEK2_1 193 198 PF00069 0.616
MOD_NEK2_1 296 301 PF00069 0.413
MOD_NEK2_1 393 398 PF00069 0.481
MOD_NEK2_1 401 406 PF00069 0.583
MOD_NEK2_1 419 424 PF00069 0.541
MOD_NEK2_1 447 452 PF00069 0.636
MOD_NEK2_1 471 476 PF00069 0.721
MOD_NEK2_2 226 231 PF00069 0.748
MOD_NEK2_2 415 420 PF00069 0.793
MOD_PIKK_1 199 205 PF00454 0.736
MOD_PIKK_1 25 31 PF00454 0.633
MOD_PIKK_1 455 461 PF00454 0.773
MOD_PIKK_1 58 64 PF00454 0.545
MOD_PKA_1 22 28 PF00069 0.698
MOD_PKA_2 157 163 PF00069 0.731
MOD_PKA_2 177 183 PF00069 0.356
MOD_PKA_2 22 28 PF00069 0.698
MOD_PKA_2 413 419 PF00069 0.757
MOD_Plk_1 325 331 PF00069 0.529
MOD_Plk_1 40 46 PF00069 0.605
MOD_Plk_4 226 232 PF00069 0.766
MOD_Plk_4 319 325 PF00069 0.568
MOD_Plk_4 364 370 PF00069 0.480
MOD_Plk_4 98 104 PF00069 0.609
MOD_ProDKin_1 133 139 PF00069 0.735
MOD_ProDKin_1 146 152 PF00069 0.809
MOD_ProDKin_1 203 209 PF00069 0.726
MOD_ProDKin_1 233 239 PF00069 0.685
MOD_ProDKin_1 262 268 PF00069 0.514
MOD_ProDKin_1 278 284 PF00069 0.405
MOD_ProDKin_1 332 338 PF00069 0.579
MOD_SUMO_rev_2 42 52 PF00179 0.491
MOD_SUMO_rev_2 468 477 PF00179 0.649
TRG_DiLeu_BaEn_2 47 53 PF01217 0.611
TRG_ENDOCYTIC_2 369 372 PF00928 0.474
TRG_ENDOCYTIC_2 67 70 PF00928 0.580
TRG_ER_diArg_1 122 124 PF00400 0.694

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7XC07 Leishmania donovani 100% 100%
D0A3W0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AU52 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q0E3 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS