LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE26_LEIIN
TriTrypDb:
LINF_360071500
Length:
362

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4IE26
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE26

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.655
CLV_C14_Caspase3-7 283 287 PF00656 0.630
CLV_NRD_NRD_1 308 310 PF00675 0.401
CLV_NRD_NRD_1 335 337 PF00675 0.416
CLV_PCSK_KEX2_1 185 187 PF00082 0.466
CLV_PCSK_KEX2_1 335 337 PF00082 0.323
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.466
CLV_PCSK_SKI1_1 279 283 PF00082 0.534
CLV_PCSK_SKI1_1 293 297 PF00082 0.408
CLV_PCSK_SKI1_1 313 317 PF00082 0.344
CLV_PCSK_SKI1_1 335 339 PF00082 0.300
CLV_PCSK_SKI1_1 345 349 PF00082 0.312
CLV_TASPASE1 58 64 PF01112 0.613
DEG_Nend_Nbox_1 1 3 PF02207 0.676
DEG_SPOP_SBC_1 281 285 PF00917 0.734
DOC_CDC14_PxL_1 349 357 PF14671 0.364
DOC_CYCLIN_RxL_1 50 60 PF00134 0.511
DOC_MAPK_gen_1 293 303 PF00069 0.520
DOC_MAPK_MEF2A_6 70 79 PF00069 0.498
DOC_MAPK_RevD_3 322 336 PF00069 0.506
DOC_PP4_FxxP_1 153 156 PF00568 0.690
DOC_PP4_FxxP_1 350 353 PF00568 0.431
DOC_USP7_MATH_1 110 114 PF00917 0.710
DOC_USP7_MATH_1 129 133 PF00917 0.739
DOC_USP7_MATH_1 162 166 PF00917 0.752
DOC_USP7_MATH_1 187 191 PF00917 0.705
DOC_USP7_MATH_1 273 277 PF00917 0.801
DOC_USP7_MATH_1 281 285 PF00917 0.696
DOC_WW_Pin1_4 152 157 PF00397 0.692
DOC_WW_Pin1_4 322 327 PF00397 0.549
LIG_14-3-3_CanoR_1 178 184 PF00244 0.752
LIG_CaM_IQ_9 253 269 PF13499 0.619
LIG_CtBP_PxDLS_1 218 222 PF00389 0.655
LIG_deltaCOP1_diTrp_1 101 107 PF00928 0.607
LIG_deltaCOP1_diTrp_1 146 153 PF00928 0.664
LIG_EH1_1 315 323 PF00400 0.531
LIG_FHA_1 190 196 PF00498 0.702
LIG_FHA_1 40 46 PF00498 0.601
LIG_FHA_1 83 89 PF00498 0.510
LIG_FHA_2 230 236 PF00498 0.717
LIG_FHA_2 266 272 PF00498 0.713
LIG_FHA_2 69 75 PF00498 0.557
LIG_LIR_Apic_2 151 156 PF02991 0.688
LIG_LIR_Gen_1 146 157 PF02991 0.689
LIG_LIR_Gen_1 18 27 PF02991 0.549
LIG_LIR_Gen_1 289 299 PF02991 0.525
LIG_LIR_Gen_1 31 40 PF02991 0.527
LIG_LIR_Nem_3 101 106 PF02991 0.566
LIG_LIR_Nem_3 146 152 PF02991 0.724
LIG_LIR_Nem_3 18 24 PF02991 0.554
LIG_LIR_Nem_3 289 294 PF02991 0.564
LIG_LIR_Nem_3 31 37 PF02991 0.521
LIG_LYPXL_SIV_4 72 80 PF13949 0.501
LIG_NRBOX 333 339 PF00104 0.499
LIG_PDZ_Class_2 357 362 PF00595 0.312
LIG_Pex14_1 149 153 PF04695 0.684
LIG_SH2_CRK 305 309 PF00017 0.505
LIG_SH2_GRB2like 298 301 PF00017 0.509
LIG_SH2_GRB2like 47 50 PF00017 0.551
LIG_SH2_SRC 47 50 PF00017 0.551
LIG_SH2_STAP1 291 295 PF00017 0.582
LIG_SH2_STAP1 73 77 PF00017 0.506
LIG_SH2_STAT3 343 346 PF00017 0.324
LIG_SH2_STAT5 305 308 PF00017 0.495
LIG_SH2_STAT5 317 320 PF00017 0.507
LIG_SH2_STAT5 34 37 PF00017 0.525
LIG_SH2_STAT5 343 346 PF00017 0.315
LIG_SH2_STAT5 47 50 PF00017 0.506
LIG_SH2_STAT5 97 100 PF00017 0.512
LIG_SH3_3 167 173 PF00018 0.703
LIG_SH3_3 204 210 PF00018 0.654
LIG_SUMO_SIM_par_1 83 90 PF11976 0.499
LIG_TYR_ITIM 303 308 PF00017 0.326
LIG_UBA3_1 94 100 PF00899 0.433
LIG_WRC_WIRS_1 263 268 PF05994 0.616
MOD_CDK_SPK_2 322 327 PF00069 0.405
MOD_CK1_1 113 119 PF00069 0.648
MOD_CK1_1 236 242 PF00069 0.637
MOD_CK1_1 262 268 PF00069 0.655
MOD_CK1_1 325 331 PF00069 0.365
MOD_CK2_1 152 158 PF00069 0.610
MOD_CK2_1 286 292 PF00069 0.483
MOD_CK2_1 68 74 PF00069 0.416
MOD_GlcNHglycan 115 118 PF01048 0.596
MOD_GlcNHglycan 174 177 PF01048 0.719
MOD_GlcNHglycan 189 192 PF01048 0.560
MOD_GlcNHglycan 198 201 PF01048 0.635
MOD_GlcNHglycan 227 230 PF01048 0.696
MOD_GlcNHglycan 235 238 PF01048 0.623
MOD_GlcNHglycan 4 7 PF01048 0.599
MOD_GSK3_1 106 113 PF00069 0.524
MOD_GSK3_1 172 179 PF00069 0.681
MOD_GSK3_1 209 216 PF00069 0.623
MOD_GSK3_1 225 232 PF00069 0.631
MOD_GSK3_1 235 242 PF00069 0.572
MOD_GSK3_1 244 251 PF00069 0.634
MOD_GSK3_1 265 272 PF00069 0.716
MOD_GSK3_1 282 289 PF00069 0.496
MOD_GSK3_1 35 42 PF00069 0.510
MOD_GSK3_1 64 71 PF00069 0.584
MOD_N-GLC_1 162 167 PF02516 0.630
MOD_NEK2_1 196 201 PF00069 0.607
MOD_NEK2_1 2 7 PF00069 0.591
MOD_NEK2_1 259 264 PF00069 0.622
MOD_NEK2_1 316 321 PF00069 0.383
MOD_NEK2_1 348 353 PF00069 0.362
MOD_NEK2_1 35 40 PF00069 0.490
MOD_OFUCOSY 161 166 PF10250 0.603
MOD_PIKK_1 129 135 PF00454 0.659
MOD_PIKK_1 189 195 PF00454 0.580
MOD_PIKK_1 253 259 PF00454 0.583
MOD_PKA_2 113 119 PF00069 0.672
MOD_PKA_2 196 202 PF00069 0.683
MOD_PKB_1 223 231 PF00069 0.645
MOD_Plk_1 68 74 PF00069 0.463
MOD_Plk_4 16 22 PF00069 0.407
MOD_Plk_4 217 223 PF00069 0.564
MOD_Plk_4 82 88 PF00069 0.445
MOD_ProDKin_1 152 158 PF00069 0.619
MOD_ProDKin_1 322 328 PF00069 0.408
TRG_DiLeu_BaEn_1 90 95 PF01217 0.426
TRG_DiLeu_BaEn_4 329 335 PF01217 0.437
TRG_DiLeu_BaLyEn_6 333 338 PF01217 0.330
TRG_DiLeu_BaLyEn_6 350 355 PF01217 0.312
TRG_ENDOCYTIC_2 291 294 PF00928 0.439
TRG_ENDOCYTIC_2 298 301 PF00928 0.294
TRG_ENDOCYTIC_2 305 308 PF00928 0.211
TRG_ENDOCYTIC_2 34 37 PF00928 0.394
TRG_ER_diArg_1 111 114 PF00400 0.533
TRG_ER_diArg_1 334 336 PF00400 0.509
TRG_NES_CRM1_1 46 60 PF08389 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I247 Leptomonas seymouri 40% 100%
A0A3S7XC14 Leishmania donovani 99% 100%
A4HQD4 Leishmania braziliensis 62% 100%
E9AU50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q0E5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS