LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE24_LEIIN
TriTrypDb:
LINF_360071300
Length:
323

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 162 164 PF00675 0.654
CLV_NRD_NRD_1 232 234 PF00675 0.782
CLV_NRD_NRD_1 307 309 PF00675 0.651
CLV_NRD_NRD_1 4 6 PF00675 0.729
CLV_PCSK_KEX2_1 162 164 PF00082 0.654
CLV_PCSK_KEX2_1 27 29 PF00082 0.785
CLV_PCSK_KEX2_1 4 6 PF00082 0.792
CLV_PCSK_PC1ET2_1 27 29 PF00082 0.785
CLV_PCSK_SKI1_1 127 131 PF00082 0.566
DEG_COP1_1 53 63 PF00400 0.803
DEG_SCF_FBW7_1 29 34 PF00400 0.767
DOC_CKS1_1 7 12 PF01111 0.660
DOC_MAPK_gen_1 308 315 PF00069 0.721
DOC_MAPK_MEF2A_6 308 315 PF00069 0.601
DOC_MAPK_RevD_3 218 234 PF00069 0.767
DOC_PP1_RVXF_1 314 321 PF00149 0.625
DOC_PP4_FxxP_1 252 255 PF00568 0.648
DOC_USP7_MATH_1 12 16 PF00917 0.782
DOC_USP7_MATH_1 19 23 PF00917 0.683
DOC_USP7_MATH_1 221 225 PF00917 0.641
DOC_USP7_MATH_1 241 245 PF00917 0.533
DOC_USP7_MATH_1 271 275 PF00917 0.723
DOC_USP7_MATH_1 83 87 PF00917 0.728
DOC_WW_Pin1_4 27 32 PF00397 0.779
DOC_WW_Pin1_4 6 11 PF00397 0.723
LIG_14-3-3_CanoR_1 127 132 PF00244 0.652
LIG_14-3-3_CanoR_1 142 150 PF00244 0.423
LIG_14-3-3_CanoR_1 201 209 PF00244 0.611
LIG_14-3-3_CanoR_1 88 97 PF00244 0.552
LIG_BIR_II_1 1 5 PF00653 0.802
LIG_BIR_III_4 69 73 PF00653 0.730
LIG_CaM_IQ_9 101 116 PF13499 0.640
LIG_FHA_1 28 34 PF00498 0.771
LIG_FHA_1 310 316 PF00498 0.736
LIG_FHA_1 76 82 PF00498 0.590
LIG_GBD_Chelix_1 178 186 PF00786 0.581
LIG_Integrin_isoDGR_2 189 191 PF01839 0.609
LIG_LIR_Gen_1 206 216 PF02991 0.612
LIG_LIR_Nem_3 206 212 PF02991 0.614
LIG_NRBOX 114 120 PF00104 0.638
LIG_PCNA_PIPBox_1 169 178 PF02747 0.623
LIG_PCNA_yPIPBox_3 106 119 PF02747 0.638
LIG_PCNA_yPIPBox_3 162 176 PF02747 0.628
LIG_Pex14_2 248 252 PF04695 0.656
LIG_PTAP_UEV_1 254 259 PF05743 0.702
LIG_SH2_NCK_1 209 213 PF00017 0.726
LIG_SH2_STAP1 209 213 PF00017 0.726
LIG_SH2_STAP1 283 287 PF00017 0.719
LIG_SH2_STAT5 283 286 PF00017 0.651
LIG_SH3_1 234 240 PF00018 0.649
LIG_SH3_3 217 223 PF00018 0.749
LIG_SH3_3 234 240 PF00018 0.506
LIG_SH3_3 252 258 PF00018 0.597
LIG_SUMO_SIM_par_1 8 15 PF11976 0.660
LIG_TRAF2_1 167 170 PF00917 0.630
LIG_WRC_WIRS_1 212 217 PF05994 0.724
LIG_WRC_WIRS_1 33 38 PF05994 0.764
MOD_CK1_1 15 21 PF00069 0.787
MOD_CK1_1 200 206 PF00069 0.614
MOD_CK1_1 22 28 PF00069 0.683
MOD_CK1_1 224 230 PF00069 0.583
MOD_CK1_1 256 262 PF00069 0.742
MOD_CK1_1 43 49 PF00069 0.728
MOD_CK1_1 86 92 PF00069 0.702
MOD_GlcNHglycan 115 118 PF01048 0.634
MOD_GlcNHglycan 14 17 PF01048 0.784
MOD_GlcNHglycan 204 208 PF01048 0.715
MOD_GlcNHglycan 226 229 PF01048 0.613
MOD_GlcNHglycan 245 248 PF01048 0.640
MOD_GlcNHglycan 255 258 PF01048 0.581
MOD_GlcNHglycan 259 262 PF01048 0.537
MOD_GlcNHglycan 267 270 PF01048 0.629
MOD_GlcNHglycan 273 276 PF01048 0.543
MOD_GlcNHglycan 88 91 PF01048 0.698
MOD_GSK3_1 11 18 PF00069 0.772
MOD_GSK3_1 19 26 PF00069 0.653
MOD_GSK3_1 203 210 PF00069 0.734
MOD_GSK3_1 253 260 PF00069 0.698
MOD_GSK3_1 27 34 PF00069 0.506
MOD_GSK3_1 40 47 PF00069 0.557
MOD_GSK3_1 55 62 PF00069 0.642
MOD_GSK3_1 71 78 PF00069 0.527
MOD_GSK3_1 82 89 PF00069 0.644
MOD_GSK3_1 92 99 PF00069 0.505
MOD_NEK2_1 168 173 PF00069 0.618
MOD_NEK2_1 197 202 PF00069 0.752
MOD_NEK2_1 40 45 PF00069 0.652
MOD_NEK2_1 97 102 PF00069 0.650
MOD_NEK2_2 83 88 PF00069 0.602
MOD_PIKK_1 142 148 PF00454 0.659
MOD_PIKK_1 71 77 PF00454 0.776
MOD_PIKK_1 92 98 PF00454 0.666
MOD_PIKK_1 99 105 PF00454 0.534
MOD_PKA_1 309 315 PF00069 0.729
MOD_PKA_2 200 206 PF00069 0.614
MOD_PKA_2 253 259 PF00069 0.704
MOD_PKA_2 295 301 PF00069 0.738
MOD_PKA_2 40 46 PF00069 0.711
MOD_Plk_1 203 209 PF00069 0.734
MOD_Plk_4 211 217 PF00069 0.725
MOD_Plk_4 221 227 PF00069 0.602
MOD_Plk_4 309 315 PF00069 0.729
MOD_ProDKin_1 27 33 PF00069 0.778
MOD_ProDKin_1 6 12 PF00069 0.721
TRG_DiLeu_BaLyEn_6 234 239 PF01217 0.649
TRG_ENDOCYTIC_2 136 139 PF00928 0.652
TRG_ENDOCYTIC_2 209 212 PF00928 0.726
TRG_ER_diArg_1 161 163 PF00400 0.656
TRG_ER_diArg_1 38 41 PF00400 0.764

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IK47 Leishmania donovani 100% 100%
E9AU48 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4Q0E7 Leishmania major 86% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS