Putative centrin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative centrin

Gene product:

centrin - putative

Species:

Leishmania infantum

UniProt:

A4IE23_LEIIN

TriTrypDb:

LINF_360071000

Length:

165

Annotations

Annotations by Jardim et al.

Metal Binding, centrin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4IE23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE23

Function

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Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.619
CLV_NRD_NRD_1	12	14	PF00675	0.709
CLV_NRD_NRD_1	62	64	PF00675	0.541
CLV_PCSK_KEX2_1	12	14	PF00082	0.714
CLV_PCSK_KEX2_1	121	123	PF00082	0.314
CLV_PCSK_KEX2_1	23	25	PF00082	0.353
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.314
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.411
CLV_PCSK_SKI1_1	159	163	PF00082	0.412
CLV_PCSK_SKI1_1	16	20	PF00082	0.559

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	33%	100%
A0A0N0P8Y6	Leptomonas seymouri	36%	91%
A0A0N1I2Q3	Leptomonas seymouri	36%	100%
A0A0N1IMR9	Leptomonas seymouri	85%	100%
A0A0N1PB14	Leptomonas seymouri	35%	78%
A0A0N1PB23	Leptomonas seymouri	27%	100%
A0A0S4ILD1	Bodo saltans	57%	94%
A0A0S4INC8	Bodo saltans	36%	88%
A0A0S4IS38	Bodo saltans	33%	100%
A0A0S4J2T4	Bodo saltans	31%	96%

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