LeishMANIAdb
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CCR4-NOT transcription complex subunit 10

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CCR4-NOT transcription complex subunit 10
Gene product:
CCR4-NOT transcription complex subunit 10 - putative
Species:
Leishmania infantum
UniProt:
A4IE22_LEIIN
TriTrypDb:
LINF_360070900
Length:
557

Annotations

Annotations by Jardim et al.

Transcription, CCR4-NOT transcription complex subunit 10 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0030014 CCR4-NOT complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IE22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE22

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006401 RNA catabolic process 5 1
GO:0006402 mRNA catabolic process 6 1
GO:0006417 regulation of translation 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009890 negative regulation of biosynthetic process 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010558 negative regulation of macromolecule biosynthetic process 6 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010629 negative regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0017148 negative regulation of translation 7 1
GO:0019222 regulation of metabolic process 3 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031327 negative regulation of cellular biosynthetic process 6 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034249 negative regulation of amide metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051248 negative regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
GO:2000113 obsolete negative regulation of cellular macromolecule biosynthetic process 7 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 111 113 PF00675 0.497
CLV_NRD_NRD_1 139 141 PF00675 0.652
CLV_NRD_NRD_1 294 296 PF00675 0.518
CLV_NRD_NRD_1 298 300 PF00675 0.553
CLV_NRD_NRD_1 401 403 PF00675 0.414
CLV_NRD_NRD_1 453 455 PF00675 0.415
CLV_NRD_NRD_1 505 507 PF00675 0.536
CLV_PCSK_KEX2_1 111 113 PF00082 0.497
CLV_PCSK_KEX2_1 298 300 PF00082 0.504
CLV_PCSK_KEX2_1 401 403 PF00082 0.511
CLV_PCSK_KEX2_1 453 455 PF00082 0.415
CLV_PCSK_SKI1_1 111 115 PF00082 0.350
CLV_PCSK_SKI1_1 13 17 PF00082 0.423
CLV_PCSK_SKI1_1 140 144 PF00082 0.497
CLV_PCSK_SKI1_1 348 352 PF00082 0.454
CLV_PCSK_SKI1_1 447 451 PF00082 0.382
DEG_APCC_DBOX_1 453 461 PF00400 0.411
DEG_SPOP_SBC_1 158 162 PF00917 0.341
DOC_ANK_TNKS_1 61 68 PF00023 0.641
DOC_CDC14_PxL_1 166 174 PF14671 0.450
DOC_MAPK_gen_1 474 482 PF00069 0.521
DOC_MAPK_MEF2A_6 476 484 PF00069 0.379
DOC_PP1_RVXF_1 550 556 PF00149 0.457
DOC_PP2B_LxvP_1 365 368 PF13499 0.372
DOC_USP7_MATH_1 181 185 PF00917 0.407
DOC_USP7_MATH_1 285 289 PF00917 0.399
DOC_USP7_MATH_1 338 342 PF00917 0.631
DOC_USP7_MATH_1 422 426 PF00917 0.428
DOC_USP7_MATH_1 472 476 PF00917 0.487
DOC_USP7_UBL2_3 137 141 PF12436 0.542
DOC_WW_Pin1_4 517 522 PF00397 0.623
LIG_14-3-3_CanoR_1 304 310 PF00244 0.626
LIG_14-3-3_CanoR_1 453 458 PF00244 0.417
LIG_Actin_WH2_2 151 169 PF00022 0.454
LIG_APCC_ABBA_1 532 537 PF00400 0.373
LIG_BRCT_BRCA1_1 220 224 PF00533 0.370
LIG_BRCT_BRCA1_1 274 278 PF00533 0.340
LIG_BRCT_BRCA1_2 220 226 PF00533 0.366
LIG_deltaCOP1_diTrp_1 548 555 PF00928 0.571
LIG_DLG_GKlike_1 453 460 PF00625 0.414
LIG_EH1_1 433 441 PF00400 0.347
LIG_eIF4E_1 434 440 PF01652 0.343
LIG_FHA_1 134 140 PF00498 0.519
LIG_FHA_1 344 350 PF00498 0.432
LIG_FHA_1 354 360 PF00498 0.549
LIG_FHA_1 428 434 PF00498 0.442
LIG_FHA_2 66 72 PF00498 0.719
LIG_GBD_Chelix_1 44 52 PF00786 0.385
LIG_IRF3_LxIS_1 480 487 PF10401 0.426
LIG_LIR_Gen_1 264 272 PF02991 0.388
LIG_LIR_Gen_1 308 313 PF02991 0.532
LIG_LIR_Gen_1 320 330 PF02991 0.483
LIG_LIR_Gen_1 372 381 PF02991 0.503
LIG_LIR_Gen_1 478 489 PF02991 0.376
LIG_LIR_Gen_1 533 539 PF02991 0.514
LIG_LIR_Nem_3 264 268 PF02991 0.388
LIG_LIR_Nem_3 323 327 PF02991 0.500
LIG_LIR_Nem_3 372 376 PF02991 0.483
LIG_LIR_Nem_3 478 484 PF02991 0.422
LIG_LIR_Nem_3 533 538 PF02991 0.530
LIG_NRBOX 249 255 PF00104 0.387
LIG_PCNA_yPIPBox_3 199 213 PF02747 0.439
LIG_PCNA_yPIPBox_3 242 254 PF02747 0.364
LIG_PCNA_yPIPBox_3 37 48 PF02747 0.498
LIG_PTB_Apo_2 318 325 PF02174 0.491
LIG_PTB_Apo_2 358 365 PF02174 0.437
LIG_SH2_CRK 389 393 PF00017 0.395
LIG_SH2_GRB2like 203 206 PF00017 0.337
LIG_SH2_GRB2like 319 322 PF00017 0.635
LIG_SH2_NCK_1 21 25 PF00017 0.503
LIG_SH2_NCK_1 509 513 PF00017 0.592
LIG_SH2_SRC 21 24 PF00017 0.428
LIG_SH2_STAP1 127 131 PF00017 0.472
LIG_SH2_STAP1 389 393 PF00017 0.387
LIG_SH2_STAT3 302 305 PF00017 0.597
LIG_SH2_STAT5 203 206 PF00017 0.337
LIG_SH2_STAT5 434 437 PF00017 0.420
LIG_SH2_STAT5 47 50 PF00017 0.515
LIG_SH2_STAT5 519 522 PF00017 0.651
LIG_SH2_STAT5 529 532 PF00017 0.480
LIG_SH3_3 330 336 PF00018 0.612
LIG_SH3_4 137 144 PF00018 0.515
LIG_SH3_4 234 241 PF00018 0.494
LIG_TRAF2_1 381 384 PF00917 0.523
LIG_TRAF2_1 410 413 PF00917 0.518
LIG_TRFH_1 324 328 PF08558 0.550
LIG_TRFH_1 364 368 PF08558 0.458
LIG_TYR_ITIM 387 392 PF00017 0.412
LIG_UBA3_1 131 137 PF00899 0.452
LIG_UBA3_1 363 369 PF00899 0.435
LIG_UBA3_1 500 507 PF00899 0.520
MOD_CDK_SPxK_1 517 523 PF00069 0.618
MOD_CK1_1 144 150 PF00069 0.707
MOD_CK1_1 157 163 PF00069 0.407
MOD_CK1_1 329 335 PF00069 0.562
MOD_CK1_1 456 462 PF00069 0.421
MOD_CK2_1 158 164 PF00069 0.476
MOD_CK2_1 208 214 PF00069 0.448
MOD_CK2_1 317 323 PF00069 0.610
MOD_CK2_1 338 344 PF00069 0.624
MOD_CK2_1 372 378 PF00069 0.413
MOD_CK2_1 472 478 PF00069 0.465
MOD_CK2_1 496 502 PF00069 0.400
MOD_GlcNHglycan 182 186 PF01048 0.499
MOD_GlcNHglycan 274 277 PF01048 0.420
MOD_GlcNHglycan 309 312 PF01048 0.529
MOD_GlcNHglycan 314 317 PF01048 0.530
MOD_GlcNHglycan 328 331 PF01048 0.423
MOD_GlcNHglycan 63 66 PF01048 0.687
MOD_GlcNHglycan 99 102 PF01048 0.374
MOD_GSK3_1 121 128 PF00069 0.479
MOD_GSK3_1 140 147 PF00069 0.567
MOD_GSK3_1 154 161 PF00069 0.498
MOD_GSK3_1 268 275 PF00069 0.421
MOD_GSK3_1 339 346 PF00069 0.575
MOD_GSK3_1 455 462 PF00069 0.406
MOD_GSK3_1 484 491 PF00069 0.516
MOD_GSK3_1 496 503 PF00069 0.411
MOD_GSK3_1 513 520 PF00069 0.550
MOD_GSK3_1 61 68 PF00069 0.642
MOD_N-GLC_1 482 487 PF02516 0.485
MOD_NEK2_1 125 130 PF00069 0.412
MOD_NEK2_1 131 136 PF00069 0.294
MOD_NEK2_1 154 159 PF00069 0.444
MOD_NEK2_1 175 180 PF00069 0.411
MOD_NEK2_1 272 277 PF00069 0.444
MOD_NEK2_1 312 317 PF00069 0.587
MOD_NEK2_1 397 402 PF00069 0.484
MOD_NEK2_1 427 432 PF00069 0.487
MOD_NEK2_1 484 489 PF00069 0.375
MOD_NEK2_1 490 495 PF00069 0.425
MOD_NEK2_1 551 556 PF00069 0.538
MOD_OFUCOSY 282 289 PF10250 0.383
MOD_PKA_1 140 146 PF00069 0.561
MOD_PKA_1 453 459 PF00069 0.418
MOD_PKA_2 144 150 PF00069 0.553
MOD_PKA_2 453 459 PF00069 0.420
MOD_PKA_2 522 528 PF00069 0.567
MOD_PKA_2 61 67 PF00069 0.630
MOD_Plk_1 482 488 PF00069 0.506
MOD_Plk_4 121 127 PF00069 0.459
MOD_Plk_4 154 160 PF00069 0.450
MOD_Plk_4 372 378 PF00069 0.506
MOD_Plk_4 427 433 PF00069 0.497
MOD_Plk_4 456 462 PF00069 0.465
MOD_Plk_4 496 502 PF00069 0.418
MOD_Plk_4 522 528 PF00069 0.567
MOD_ProDKin_1 517 523 PF00069 0.618
MOD_SUMO_for_1 225 228 PF00179 0.361
MOD_SUMO_rev_2 211 217 PF00179 0.507
MOD_SUMO_rev_2 34 38 PF00179 0.484
TRG_DiLeu_BaEn_1 105 110 PF01217 0.494
TRG_DiLeu_BaEn_1 171 176 PF01217 0.471
TRG_ENDOCYTIC_2 319 322 PF00928 0.687
TRG_ENDOCYTIC_2 389 392 PF00928 0.388
TRG_ENDOCYTIC_2 529 532 PF00928 0.430
TRG_ER_diArg_1 110 112 PF00400 0.499
TRG_ER_diArg_1 452 454 PF00400 0.408
TRG_ER_diArg_1 474 477 PF00400 0.566
TRG_NLS_MonoExtC_3 294 299 PF00514 0.563
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 46 51 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 506 510 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Z8 Leptomonas seymouri 79% 100%
A0A0S4ILH8 Bodo saltans 28% 100%
A0A1X0NLF6 Trypanosomatidae 47% 99%
A0A3Q8IJX9 Leishmania donovani 100% 100%
A0A422NJ69 Trypanosoma rangeli 47% 99%
A4HQC9 Leishmania braziliensis 90% 100%
D0A3X0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AU45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q0F0 Leishmania major 97% 100%
V5BT61 Trypanosoma cruzi 48% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS