LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
eukaryotic translation initation factor 4 gamma - putative
Species:
Leishmania infantum
UniProt:
A4IE18_LEIIN
TriTrypDb:
LINF_360070500
Length:
758

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initation factor 4 gamma Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IE18
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE18

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0019538 protein metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043043 peptide biosynthetic process 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0003743 translation initiation factor activity 4 7
GO:0005488 binding 1 7
GO:0008135 translation factor activity, RNA binding 3 7
GO:0045182 translation regulator activity 1 7
GO:0090079 translation regulator activity, nucleic acid binding 2 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 216 218 PF00675 0.288
CLV_NRD_NRD_1 320 322 PF00675 0.288
CLV_NRD_NRD_1 507 509 PF00675 0.535
CLV_NRD_NRD_1 54 56 PF00675 0.518
CLV_NRD_NRD_1 85 87 PF00675 0.288
CLV_PCSK_KEX2_1 192 194 PF00082 0.291
CLV_PCSK_KEX2_1 218 220 PF00082 0.288
CLV_PCSK_KEX2_1 278 280 PF00082 0.361
CLV_PCSK_KEX2_1 320 322 PF00082 0.288
CLV_PCSK_KEX2_1 85 87 PF00082 0.288
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.361
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.288
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.361
CLV_PCSK_SKI1_1 187 191 PF00082 0.272
CLV_PCSK_SKI1_1 239 243 PF00082 0.288
CLV_PCSK_SKI1_1 258 262 PF00082 0.288
CLV_PCSK_SKI1_1 44 48 PF00082 0.474
CLV_PCSK_SKI1_1 570 574 PF00082 0.416
CLV_PCSK_SKI1_1 581 585 PF00082 0.445
CLV_PCSK_SKI1_1 596 600 PF00082 0.387
DEG_MDM2_SWIB_1 28 35 PF02201 0.520
DEG_MDM2_SWIB_1 670 678 PF02201 0.411
DEG_Nend_Nbox_1 1 3 PF02207 0.535
DOC_ANK_TNKS_1 445 452 PF00023 0.787
DOC_CKS1_1 513 518 PF01111 0.590
DOC_CYCLIN_RxL_1 41 48 PF00134 0.502
DOC_MAPK_DCC_7 55 64 PF00069 0.527
DOC_MAPK_gen_1 12 22 PF00069 0.575
DOC_MAPK_gen_1 217 226 PF00069 0.488
DOC_MAPK_MEF2A_6 119 126 PF00069 0.488
DOC_MAPK_MEF2A_6 55 64 PF00069 0.529
DOC_MAPK_RevD_3 264 279 PF00069 0.488
DOC_MAPK_RevD_3 60 75 PF00069 0.478
DOC_PP1_RVXF_1 318 325 PF00149 0.488
DOC_PP2B_LxvP_1 655 658 PF13499 0.467
DOC_PP4_FxxP_1 381 384 PF00568 0.696
DOC_PP4_MxPP_1 474 477 PF00568 0.682
DOC_PP4_MxPP_1 486 489 PF00568 0.602
DOC_SPAK_OSR1_1 323 327 PF12202 0.488
DOC_USP7_MATH_1 243 247 PF00917 0.488
DOC_USP7_MATH_1 308 312 PF00917 0.488
DOC_USP7_MATH_1 339 343 PF00917 0.723
DOC_USP7_MATH_1 344 348 PF00917 0.736
DOC_USP7_MATH_1 352 356 PF00917 0.634
DOC_USP7_MATH_1 457 461 PF00917 0.699
DOC_USP7_MATH_1 496 500 PF00917 0.745
DOC_USP7_MATH_1 631 635 PF00917 0.407
DOC_USP7_UBL2_3 93 97 PF12436 0.488
DOC_WW_Pin1_4 105 110 PF00397 0.458
DOC_WW_Pin1_4 253 258 PF00397 0.500
DOC_WW_Pin1_4 512 517 PF00397 0.592
LIG_14-3-3_CanoR_1 233 242 PF00244 0.560
LIG_14-3-3_CanoR_1 307 316 PF00244 0.488
LIG_14-3-3_CanoR_1 432 437 PF00244 0.596
LIG_14-3-3_CanoR_1 600 605 PF00244 0.380
LIG_AP2alpha_1 197 201 PF02296 0.488
LIG_APCC_ABBAyCdc20_2 742 748 PF00400 0.592
LIG_BRCT_BRCA1_1 589 593 PF00533 0.474
LIG_BRCT_BRCA1_1 633 637 PF00533 0.412
LIG_deltaCOP1_diTrp_1 331 337 PF00928 0.488
LIG_deltaCOP1_diTrp_1 665 670 PF00928 0.445
LIG_deltaCOP1_diTrp_1 672 681 PF00928 0.407
LIG_EH1_1 323 331 PF00400 0.488
LIG_EVH1_2 477 481 PF00568 0.664
LIG_FHA_1 160 166 PF00498 0.510
LIG_FHA_1 245 251 PF00498 0.488
LIG_FHA_1 46 52 PF00498 0.602
LIG_FHA_1 605 611 PF00498 0.385
LIG_FHA_1 673 679 PF00498 0.364
LIG_FHA_2 19 25 PF00498 0.523
LIG_FHA_2 260 266 PF00498 0.460
LIG_FHA_2 357 363 PF00498 0.693
LIG_FHA_2 535 541 PF00498 0.494
LIG_FHA_2 573 579 PF00498 0.456
LIG_FHA_2 689 695 PF00498 0.511
LIG_Integrin_isoDGR_2 183 185 PF01839 0.361
LIG_Integrin_RGD_1 439 441 PF01839 0.784
LIG_LIR_Apic_2 378 384 PF02991 0.656
LIG_LIR_Gen_1 136 146 PF02991 0.462
LIG_LIR_Gen_1 30 40 PF02991 0.526
LIG_LIR_Gen_1 459 469 PF02991 0.670
LIG_LIR_Gen_1 634 645 PF02991 0.409
LIG_LIR_Gen_1 667 678 PF02991 0.395
LIG_LIR_Gen_1 96 107 PF02991 0.488
LIG_LIR_Nem_3 132 138 PF02991 0.454
LIG_LIR_Nem_3 30 35 PF02991 0.525
LIG_LIR_Nem_3 303 309 PF02991 0.488
LIG_LIR_Nem_3 459 464 PF02991 0.670
LIG_LIR_Nem_3 616 621 PF02991 0.426
LIG_LIR_Nem_3 653 659 PF02991 0.400
LIG_LIR_Nem_3 667 673 PF02991 0.413
LIG_LIR_Nem_3 741 746 PF02991 0.502
LIG_LIR_Nem_3 96 102 PF02991 0.464
LIG_PCNA_yPIPBox_3 39 53 PF02747 0.507
LIG_PDZ_Class_3 753 758 PF00595 0.639
LIG_Pex14_1 666 670 PF04695 0.425
LIG_Pex14_2 197 201 PF04695 0.488
LIG_Pex14_2 28 32 PF04695 0.513
LIG_Pex14_2 670 674 PF04695 0.406
LIG_PTB_Apo_2 220 227 PF02174 0.446
LIG_SH2_CRK 139 143 PF00017 0.488
LIG_SH2_PTP2 656 659 PF00017 0.474
LIG_SH2_SRC 651 654 PF00017 0.401
LIG_SH2_STAP1 149 153 PF00017 0.488
LIG_SH2_STAP1 602 606 PF00017 0.375
LIG_SH2_STAP1 622 626 PF00017 0.162
LIG_SH2_STAT5 651 654 PF00017 0.401
LIG_SH2_STAT5 656 659 PF00017 0.474
LIG_SH2_STAT5 724 727 PF00017 0.570
LIG_SH3_3 109 115 PF00018 0.488
LIG_SH3_3 127 133 PF00018 0.488
LIG_SH3_3 199 205 PF00018 0.488
LIG_SH3_3 473 479 PF00018 0.679
LIG_SH3_3 487 493 PF00018 0.581
LIG_Sin3_3 99 106 PF02671 0.560
LIG_SUMO_SIM_par_1 240 247 PF11976 0.488
LIG_UBA3_1 272 278 PF00899 0.488
LIG_UBA3_1 510 518 PF00899 0.497
LIG_UBA3_1 592 596 PF00899 0.451
LIG_UBA3_1 695 703 PF00899 0.446
LIG_WRC_WIRS_1 458 463 PF05994 0.631
LIG_WW_3 205 209 PF00397 0.505
MOD_CDK_SPK_2 253 258 PF00069 0.560
MOD_CDK_SPxK_1 512 518 PF00069 0.498
MOD_CK1_1 234 240 PF00069 0.505
MOD_CK1_1 348 354 PF00069 0.748
MOD_CK1_1 355 361 PF00069 0.664
MOD_CK1_1 399 405 PF00069 0.722
MOD_CK1_1 501 507 PF00069 0.507
MOD_CK1_1 587 593 PF00069 0.422
MOD_CK1_1 639 645 PF00069 0.402
MOD_CK1_1 690 696 PF00069 0.514
MOD_CK2_1 356 362 PF00069 0.674
MOD_CK2_1 572 578 PF00069 0.442
MOD_CK2_1 77 83 PF00069 0.445
MOD_Cter_Amidation 276 279 PF01082 0.288
MOD_GlcNHglycan 135 138 PF01048 0.288
MOD_GlcNHglycan 341 345 PF01048 0.671
MOD_GlcNHglycan 347 350 PF01048 0.673
MOD_GlcNHglycan 381 384 PF01048 0.774
MOD_GlcNHglycan 398 401 PF01048 0.503
MOD_GlcNHglycan 411 414 PF01048 0.549
MOD_GlcNHglycan 498 501 PF01048 0.728
MOD_GlcNHglycan 523 527 PF01048 0.407
MOD_GlcNHglycan 589 592 PF01048 0.441
MOD_GSK3_1 340 347 PF00069 0.748
MOD_GSK3_1 348 355 PF00069 0.701
MOD_GSK3_1 371 378 PF00069 0.680
MOD_GSK3_1 428 435 PF00069 0.779
MOD_GSK3_1 494 501 PF00069 0.603
MOD_GSK3_1 570 577 PF00069 0.433
MOD_GSK3_1 583 590 PF00069 0.423
MOD_GSK3_1 596 603 PF00069 0.490
MOD_GSK3_1 627 634 PF00069 0.438
MOD_N-GLC_1 309 314 PF02516 0.361
MOD_N-GLC_1 355 360 PF02516 0.680
MOD_N-GLC_1 38 43 PF02516 0.519
MOD_N-GLC_1 736 741 PF02516 0.462
MOD_N-GLC_2 371 373 PF02516 0.650
MOD_NEK2_1 197 202 PF00069 0.560
MOD_NEK2_1 268 273 PF00069 0.479
MOD_NEK2_1 28 33 PF00069 0.514
MOD_NEK2_1 309 314 PF00069 0.560
MOD_NEK2_1 419 424 PF00069 0.608
MOD_NEK2_1 583 588 PF00069 0.417
MOD_NEK2_1 645 650 PF00069 0.394
MOD_NEK2_1 717 722 PF00069 0.554
MOD_NEK2_2 698 703 PF00069 0.426
MOD_PIKK_1 462 468 PF00454 0.662
MOD_PIKK_1 498 504 PF00454 0.662
MOD_PIKK_1 717 723 PF00454 0.560
MOD_PKA_1 570 576 PF00069 0.427
MOD_PKA_2 28 34 PF00069 0.512
MOD_PKA_2 316 322 PF00069 0.488
MOD_PKA_2 366 372 PF00069 0.687
MOD_PKA_2 431 437 PF00069 0.597
MOD_Plk_1 309 315 PF00069 0.560
MOD_Plk_1 38 44 PF00069 0.515
MOD_Plk_1 462 468 PF00069 0.662
MOD_Plk_2-3 534 540 PF00069 0.497
MOD_Plk_2-3 574 580 PF00069 0.464
MOD_Plk_4 197 203 PF00069 0.560
MOD_Plk_4 268 274 PF00069 0.505
MOD_Plk_4 301 307 PF00069 0.488
MOD_Plk_4 636 642 PF00069 0.414
MOD_Plk_4 673 679 PF00069 0.411
MOD_Plk_4 729 735 PF00069 0.426
MOD_ProDKin_1 105 111 PF00069 0.458
MOD_ProDKin_1 253 259 PF00069 0.500
MOD_ProDKin_1 512 518 PF00069 0.602
MOD_SUMO_rev_2 176 182 PF00179 0.505
MOD_SUMO_rev_2 501 511 PF00179 0.546
MOD_SUMO_rev_2 590 598 PF00179 0.503
TRG_DiLeu_BaEn_1 164 169 PF01217 0.560
TRG_DiLeu_BaEn_1 506 511 PF01217 0.523
TRG_DiLeu_BaEn_1 58 63 PF01217 0.557
TRG_ENDOCYTIC_2 139 142 PF00928 0.488
TRG_ENDOCYTIC_2 622 625 PF00928 0.393
TRG_ENDOCYTIC_2 656 659 PF00928 0.474
TRG_ENDOCYTIC_2 743 746 PF00928 0.484
TRG_ER_diArg_1 216 219 PF00400 0.488
TRG_ER_diArg_1 320 323 PF00400 0.488
TRG_ER_diArg_1 69 72 PF00400 0.484
TRG_ER_diArg_1 84 86 PF00400 0.488
TRG_Pf-PMV_PEXEL_1 323 327 PF00026 0.288

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDL6 Leptomonas seymouri 68% 100%
A0A3Q8IJA9 Leishmania donovani 100% 100%
A4HQC5 Leishmania braziliensis 83% 99%
E9AU41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q0F4 Leishmania major 95% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS