Conserved oligomeric Golgi complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG (conserved oligomeric Golgi) complex component - COG2/Domain of unknown function (DUF3510) - putative

Species:

Leishmania infantum

UniProt:

A4IE16_LEIIN

TriTrypDb:

LINF_360070300

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	10
GO:0016020	membrane	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0017119	Golgi transport complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4IE16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE16

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	11
GO:0007030	Golgi organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.476
CLV_NRD_NRD_1	562	564	PF00675	0.327
CLV_NRD_NRD_1	800	802	PF00675	0.355
CLV_NRD_NRD_1	874	876	PF00675	0.323
CLV_NRD_NRD_1	958	960	PF00675	0.445
CLV_PCSK_KEX2_1	123	125	PF00082	0.476
CLV_PCSK_KEX2_1	562	564	PF00082	0.327
CLV_PCSK_KEX2_1	873	875	PF00082	0.335
CLV_PCSK_KEX2_1	958	960	PF00082	0.445
CLV_PCSK_SKI1_1	198	202	PF00082	0.469
CLV_PCSK_SKI1_1	461	465	PF00082	0.486
CLV_PCSK_SKI1_1	478	482	PF00082	0.404
CLV_PCSK_SKI1_1	648	652	PF00082	0.476
CLV_PCSK_SKI1_1	928	932	PF00082	0.537
DEG_APCC_DBOX_1	189	197	PF00400	0.447
DEG_APCC_DBOX_1	450	458	PF00400	0.420
DEG_APCC_DBOX_1	927	935	PF00400	0.535
DEG_SCF_FBW7_1	887	892	PF00400	0.363
DEG_SPOP_SBC_1	394	398	PF00917	0.732
DOC_ANK_TNKS_1	466	473	PF00023	0.516
DOC_CDC14_PxL_1	489	497	PF14671	0.473
DOC_CKS1_1	633	638	PF01111	0.406
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.527
DOC_MAPK_gen_1	140	149	PF00069	0.480
DOC_MAPK_gen_1	562	569	PF00069	0.464
DOC_MAPK_gen_1	916	923	PF00069	0.335
DOC_MAPK_MEF2A_6	562	569	PF00069	0.503
DOC_MAPK_MEF2A_6	916	925	PF00069	0.335
DOC_MAPK_NFAT4_5	918	926	PF00069	0.361
DOC_PP2B_LxvP_1	450	453	PF13499	0.459
DOC_PP2B_LxvP_1	939	942	PF13499	0.534
DOC_USP7_MATH_1	148	152	PF00917	0.408
DOC_USP7_MATH_1	22	26	PF00917	0.779
DOC_USP7_MATH_1	285	289	PF00917	0.699
DOC_USP7_MATH_1	34	38	PF00917	0.756
DOC_USP7_MATH_1	365	369	PF00917	0.554
DOC_USP7_MATH_1	395	399	PF00917	0.773
DOC_USP7_MATH_1	466	470	PF00917	0.420
DOC_USP7_MATH_1	590	594	PF00917	0.488
DOC_USP7_MATH_1	604	608	PF00917	0.566
DOC_USP7_MATH_1	662	666	PF00917	0.680
DOC_USP7_MATH_1	721	725	PF00917	0.554
DOC_USP7_MATH_1	730	734	PF00917	0.633
DOC_USP7_MATH_1	744	748	PF00917	0.551
DOC_USP7_MATH_1	759	763	PF00917	0.441
DOC_USP7_MATH_1	826	830	PF00917	0.449
DOC_USP7_MATH_1	889	893	PF00917	0.442
DOC_USP7_MATH_1	93	97	PF00917	0.460
DOC_USP7_UBL2_3	220	224	PF12436	0.480
DOC_USP7_UBL2_3	69	73	PF12436	0.601
DOC_WW_Pin1_4	26	31	PF00397	0.518
DOC_WW_Pin1_4	396	401	PF00397	0.797
DOC_WW_Pin1_4	415	420	PF00397	0.406
DOC_WW_Pin1_4	561	566	PF00397	0.373
DOC_WW_Pin1_4	593	598	PF00397	0.478
DOC_WW_Pin1_4	632	637	PF00397	0.432
DOC_WW_Pin1_4	658	663	PF00397	0.638
DOC_WW_Pin1_4	682	687	PF00397	0.760
DOC_WW_Pin1_4	7	12	PF00397	0.822
DOC_WW_Pin1_4	738	743	PF00397	0.671
DOC_WW_Pin1_4	885	890	PF00397	0.410
DOC_WW_Pin1_4	98	103	PF00397	0.483
LIG_14-3-3_CanoR_1	198	207	PF00244	0.407
LIG_14-3-3_CanoR_1	413	417	PF00244	0.492
LIG_14-3-3_CanoR_1	467	471	PF00244	0.457
LIG_14-3-3_CanoR_1	583	591	PF00244	0.478
LIG_14-3-3_CanoR_1	640	644	PF00244	0.441
LIG_14-3-3_CanoR_1	746	752	PF00244	0.572
LIG_14-3-3_CanoR_1	770	776	PF00244	0.467
LIG_14-3-3_CanoR_1	794	804	PF00244	0.436
LIG_14-3-3_CanoR_1	845	854	PF00244	0.369
LIG_14-3-3_CanoR_1	907	911	PF00244	0.429
LIG_14-3-3_CanoR_1	97	102	PF00244	0.404
LIG_Actin_WH2_2	325	341	PF00022	0.492
LIG_Actin_WH2_2	625	642	PF00022	0.416
LIG_Actin_WH2_2	942	960	PF00022	0.383
LIG_APCC_ABBA_1	332	337	PF00400	0.507
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BRCT_BRCA1_1	108	112	PF00533	0.441
LIG_BRCT_BRCA1_1	626	630	PF00533	0.533
LIG_FHA_1	175	181	PF00498	0.440
LIG_FHA_1	378	384	PF00498	0.548
LIG_FHA_1	40	46	PF00498	0.787
LIG_FHA_1	471	477	PF00498	0.412
LIG_FHA_1	484	490	PF00498	0.430
LIG_FHA_1	504	510	PF00498	0.188
LIG_FHA_1	593	599	PF00498	0.562
LIG_FHA_1	691	697	PF00498	0.518
LIG_FHA_1	707	713	PF00498	0.513
LIG_FHA_1	746	752	PF00498	0.559
LIG_FHA_1	882	888	PF00498	0.440
LIG_FHA_1	918	924	PF00498	0.335
LIG_FHA_2	61	67	PF00498	0.519
LIG_FHA_2	676	682	PF00498	0.769
LIG_FHA_2	910	916	PF00498	0.335
LIG_GBD_Chelix_1	840	848	PF00786	0.305
LIG_LIR_Apic_2	13	17	PF02991	0.703
LIG_LIR_Gen_1	109	120	PF02991	0.478
LIG_LIR_Gen_1	177	187	PF02991	0.447
LIG_LIR_Gen_1	234	245	PF02991	0.350
LIG_LIR_Gen_1	340	349	PF02991	0.483
LIG_LIR_Gen_1	627	638	PF02991	0.432
LIG_LIR_Gen_1	849	859	PF02991	0.480
LIG_LIR_Nem_3	109	115	PF02991	0.468
LIG_LIR_Nem_3	177	182	PF02991	0.495
LIG_LIR_Nem_3	340	345	PF02991	0.461
LIG_LIR_Nem_3	486	491	PF02991	0.462
LIG_LIR_Nem_3	508	514	PF02991	0.457
LIG_LIR_Nem_3	627	633	PF02991	0.466
LIG_LIR_Nem_3	81	87	PF02991	0.408
LIG_LIR_Nem_3	849	854	PF02991	0.404
LIG_LIR_Nem_3	866	872	PF02991	0.263
LIG_NRBOX	257	263	PF00104	0.498
LIG_PCNA_yPIPBox_3	837	845	PF02747	0.480
LIG_PDZ_Class_2	971	976	PF00595	0.649
LIG_Pex14_2	950	954	PF04695	0.517
LIG_PTAP_UEV_1	52	57	PF05743	0.693
LIG_SH2_CRK	133	137	PF00017	0.447
LIG_SH2_CRK	14	18	PF00017	0.703
LIG_SH2_CRK	342	346	PF00017	0.503
LIG_SH2_CRK	579	583	PF00017	0.417
LIG_SH2_CRK	647	651	PF00017	0.494
LIG_SH2_NCK_1	248	252	PF00017	0.447
LIG_SH2_NCK_1	3	7	PF00017	0.716
LIG_SH2_NCK_1	432	436	PF00017	0.464
LIG_SH2_STAP1	159	163	PF00017	0.308
LIG_SH2_STAP1	248	252	PF00017	0.447
LIG_SH2_STAP1	3	7	PF00017	0.716
LIG_SH2_STAP1	542	546	PF00017	0.496
LIG_SH2_STAT5	162	165	PF00017	0.409
LIG_SH2_STAT5	241	244	PF00017	0.447
LIG_SH2_STAT5	361	364	PF00017	0.497
LIG_SH2_STAT5	615	618	PF00017	0.438
LIG_SH2_STAT5	811	814	PF00017	0.335
LIG_SH3_3	381	387	PF00018	0.548
LIG_SH3_3	413	419	PF00018	0.551
LIG_SH3_3	446	452	PF00018	0.505
LIG_SH3_3	487	493	PF00018	0.497
LIG_SH3_3	50	56	PF00018	0.728
LIG_SH3_3	525	531	PF00018	0.474
LIG_SH3_3	591	597	PF00018	0.533
LIG_SH3_3	931	937	PF00018	0.550
LIG_SH3_3	966	972	PF00018	0.534
LIG_SUMO_SIM_anti_2	374	381	PF11976	0.501
LIG_SUMO_SIM_anti_2	473	478	PF11976	0.436
LIG_SUMO_SIM_anti_2	543	551	PF11976	0.456
LIG_SUMO_SIM_par_1	374	381	PF11976	0.469
LIG_SUMO_SIM_par_1	543	551	PF11976	0.495
LIG_SUMO_SIM_par_1	693	700	PF11976	0.502
LIG_SUMO_SIM_par_1	937	943	PF11976	0.587
LIG_TRAF2_1	724	727	PF00917	0.445
LIG_TYR_ITIM	246	251	PF00017	0.356
LIG_UBA3_1	334	339	PF00899	0.501
LIG_WRC_WIRS_1	704	709	PF05994	0.464
MOD_CDK_SPxxK_3	593	600	PF00069	0.511
MOD_CK1_1	103	109	PF00069	0.449
MOD_CK1_1	111	117	PF00069	0.453
MOD_CK1_1	2	8	PF00069	0.719
MOD_CK1_1	215	221	PF00069	0.414
MOD_CK1_1	268	274	PF00069	0.633
MOD_CK1_1	275	281	PF00069	0.677
MOD_CK1_1	283	289	PF00069	0.634
MOD_CK1_1	300	306	PF00069	0.547
MOD_CK1_1	313	319	PF00069	0.456
MOD_CK1_1	347	353	PF00069	0.587
MOD_CK1_1	389	395	PF00069	0.723
MOD_CK1_1	396	402	PF00069	0.763
MOD_CK1_1	408	414	PF00069	0.574
MOD_CK1_1	593	599	PF00069	0.555
MOD_CK1_1	628	634	PF00069	0.424
MOD_CK1_1	706	712	PF00069	0.370
MOD_CK1_1	792	798	PF00069	0.334
MOD_CK1_1	806	812	PF00069	0.493
MOD_CK1_1	829	835	PF00069	0.344
MOD_CK1_1	940	946	PF00069	0.573
MOD_CK1_1	96	102	PF00069	0.446
MOD_CK2_1	191	197	PF00069	0.419
MOD_CK2_1	521	527	PF00069	0.434
MOD_CK2_1	60	66	PF00069	0.677
MOD_CK2_1	675	681	PF00069	0.750
MOD_CK2_1	721	727	PF00069	0.586
MOD_GlcNHglycan	182	185	PF01048	0.335
MOD_GlcNHglycan	267	270	PF01048	0.709
MOD_GlcNHglycan	274	277	PF01048	0.758
MOD_GlcNHglycan	282	285	PF01048	0.660
MOD_GlcNHglycan	301	305	PF01048	0.477
MOD_GlcNHglycan	32	35	PF01048	0.764
MOD_GlcNHglycan	390	394	PF01048	0.730
MOD_GlcNHglycan	4	7	PF01048	0.715
MOD_GlcNHglycan	407	410	PF01048	0.532
MOD_GlcNHglycan	48	51	PF01048	0.616
MOD_GlcNHglycan	664	667	PF01048	0.754
MOD_GlcNHglycan	668	671	PF01048	0.764
MOD_GlcNHglycan	723	726	PF01048	0.545
MOD_GlcNHglycan	759	762	PF01048	0.504
MOD_GlcNHglycan	794	797	PF01048	0.312
MOD_GlcNHglycan	805	808	PF01048	0.351
MOD_GlcNHglycan	813	816	PF01048	0.430
MOD_GlcNHglycan	828	831	PF01048	0.443
MOD_GlcNHglycan	893	898	PF01048	0.385
MOD_GSK3_1	100	107	PF00069	0.374
MOD_GSK3_1	170	177	PF00069	0.447
MOD_GSK3_1	22	29	PF00069	0.775
MOD_GSK3_1	265	272	PF00069	0.647
MOD_GSK3_1	275	282	PF00069	0.718
MOD_GSK3_1	293	300	PF00069	0.480
MOD_GSK3_1	30	37	PF00069	0.718
MOD_GSK3_1	385	392	PF00069	0.677
MOD_GSK3_1	408	415	PF00069	0.710
MOD_GSK3_1	466	473	PF00069	0.413
MOD_GSK3_1	51	58	PF00069	0.803
MOD_GSK3_1	624	631	PF00069	0.481
MOD_GSK3_1	658	665	PF00069	0.627
MOD_GSK3_1	673	680	PF00069	0.632
MOD_GSK3_1	702	709	PF00069	0.498
MOD_GSK3_1	730	737	PF00069	0.639
MOD_GSK3_1	858	865	PF00069	0.335
MOD_GSK3_1	877	884	PF00069	0.335
MOD_GSK3_1	885	892	PF00069	0.388
MOD_GSK3_1	91	98	PF00069	0.409
MOD_N-GLC_1	180	185	PF02516	0.421
MOD_N-GLC_1	34	39	PF02516	0.712
MOD_N-GLC_1	405	410	PF02516	0.738
MOD_N-GLC_1	681	686	PF02516	0.791
MOD_NEK2_1	1	6	PF00069	0.752
MOD_NEK2_1	214	219	PF00069	0.346
MOD_NEK2_1	262	267	PF00069	0.466
MOD_NEK2_1	310	315	PF00069	0.613
MOD_NEK2_1	338	343	PF00069	0.415
MOD_NEK2_1	377	382	PF00069	0.558
MOD_NEK2_1	46	51	PF00069	0.602
MOD_NEK2_1	514	519	PF00069	0.502
MOD_NEK2_1	624	629	PF00069	0.486
MOD_NEK2_1	639	644	PF00069	0.301
MOD_NEK2_1	836	841	PF00069	0.464
MOD_NEK2_1	843	848	PF00069	0.345
MOD_NEK2_2	285	290	PF00069	0.467
MOD_PIKK_1	150	156	PF00454	0.429
MOD_PIKK_1	378	384	PF00454	0.548
MOD_PIKK_1	39	45	PF00454	0.729
MOD_PIKK_1	461	467	PF00454	0.427
MOD_PIKK_1	604	610	PF00454	0.565
MOD_PK_1	206	212	PF00069	0.363
MOD_PKA_2	385	391	PF00069	0.733
MOD_PKA_2	412	418	PF00069	0.664
MOD_PKA_2	466	472	PF00069	0.443
MOD_PKA_2	582	588	PF00069	0.494
MOD_PKA_2	639	645	PF00069	0.411
MOD_PKA_2	672	678	PF00069	0.781
MOD_PKA_2	745	751	PF00069	0.619
MOD_PKA_2	771	777	PF00069	0.508
MOD_PKA_2	800	806	PF00069	0.447
MOD_PKA_2	855	861	PF00069	0.447
MOD_PKA_2	906	912	PF00069	0.364
MOD_PKA_2	96	102	PF00069	0.422
MOD_Plk_1	103	109	PF00069	0.480
MOD_Plk_1	191	197	PF00069	0.447
MOD_Plk_1	365	371	PF00069	0.542
MOD_Plk_1	865	871	PF00069	0.335
MOD_Plk_2-3	191	197	PF00069	0.434
MOD_Plk_2-3	911	917	PF00069	0.335
MOD_Plk_4	191	197	PF00069	0.417
MOD_Plk_4	206	212	PF00069	0.378
MOD_Plk_4	285	291	PF00069	0.552
MOD_Plk_4	315	321	PF00069	0.566
MOD_Plk_4	365	371	PF00069	0.518
MOD_Plk_4	484	490	PF00069	0.513
MOD_Plk_4	505	511	PF00069	0.415
MOD_Plk_4	514	520	PF00069	0.395
MOD_Plk_4	521	527	PF00069	0.317
MOD_Plk_4	625	631	PF00069	0.432
MOD_Plk_4	639	645	PF00069	0.387
MOD_Plk_4	690	696	PF00069	0.472
MOD_Plk_4	703	709	PF00069	0.384
MOD_Plk_4	771	777	PF00069	0.522
MOD_Plk_4	806	812	PF00069	0.335
MOD_Plk_4	855	861	PF00069	0.354
MOD_Plk_4	877	883	PF00069	0.437
MOD_Plk_4	940	946	PF00069	0.543
MOD_ProDKin_1	26	32	PF00069	0.518
MOD_ProDKin_1	396	402	PF00069	0.797
MOD_ProDKin_1	415	421	PF00069	0.391
MOD_ProDKin_1	561	567	PF00069	0.368
MOD_ProDKin_1	593	599	PF00069	0.480
MOD_ProDKin_1	632	638	PF00069	0.425
MOD_ProDKin_1	658	664	PF00069	0.651
MOD_ProDKin_1	682	688	PF00069	0.747
MOD_ProDKin_1	7	13	PF00069	0.823
MOD_ProDKin_1	738	744	PF00069	0.670
MOD_ProDKin_1	885	891	PF00069	0.410
MOD_ProDKin_1	98	104	PF00069	0.483
MOD_SUMO_rev_2	161	168	PF00179	0.433
TRG_DiLeu_BaEn_1	329	334	PF01217	0.505
TRG_DiLeu_BaEn_1	354	359	PF01217	0.540
TRG_DiLeu_BaEn_4	556	562	PF01217	0.537
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.457
TRG_ENDOCYTIC_2	133	136	PF00928	0.447
TRG_ENDOCYTIC_2	248	251	PF00928	0.378
TRG_ENDOCYTIC_2	342	345	PF00928	0.472
TRG_ENDOCYTIC_2	542	545	PF00928	0.480
TRG_ENDOCYTIC_2	579	582	PF00928	0.379
TRG_ENDOCYTIC_2	647	650	PF00928	0.453
TRG_ER_diArg_1	123	125	PF00400	0.476
TRG_ER_diArg_1	561	563	PF00400	0.323
TRG_ER_diArg_1	872	875	PF00400	0.335
TRG_ER_diArg_1	957	959	PF00400	0.433
TRG_NES_CRM1_1	842	857	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C0	Leptomonas seymouri	59%	100%
A0A1X0P3C4	Trypanosomatidae	32%	100%
A0A3Q8II01	Leishmania donovani	99%	100%
A0A3R7L6I8	Trypanosoma rangeli	34%	100%
A4HQC3	Leishmania braziliensis	75%	100%
D0A8R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0F6	Leishmania major	90%	100%
V5DND8	Trypanosoma cruzi	33%	100%