LeishMANIAdb
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Ubiquitin thioesterase OTU1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin thioesterase OTU1
Gene product:
OTU-like cysteine protease - putative
Species:
Leishmania infantum
UniProt:
A4IE15_LEIIN
TriTrypDb:
LINF_360070100 *
Length:
385

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4IE15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE15

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006511 ubiquitin-dependent protein catabolic process 7 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009057 macromolecule catabolic process 4 12
GO:0009987 cellular process 1 12
GO:0010033 response to organic substance 3 12
GO:0010243 response to organonitrogen compound 4 12
GO:0010498 proteasomal protein catabolic process 5 12
GO:0016579 protein deubiquitination 6 12
GO:0019538 protein metabolic process 3 12
GO:0019941 modification-dependent protein catabolic process 6 12
GO:0030163 protein catabolic process 4 12
GO:0030433 ubiquitin-dependent ERAD pathway 6 12
GO:0033554 cellular response to stress 3 12
GO:0034976 response to endoplasmic reticulum stress 4 12
GO:0036211 protein modification process 4 12
GO:0036503 ERAD pathway 5 12
GO:0042221 response to chemical 2 12
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043632 modification-dependent macromolecule catabolic process 5 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044265 obsolete cellular macromolecule catabolic process 4 12
GO:0050896 response to stimulus 1 12
GO:0051603 proteolysis involved in protein catabolic process 5 12
GO:0051716 cellular response to stimulus 2 12
GO:0070646 protein modification by small protein removal 5 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
GO:1901698 response to nitrogen compound 3 12
GO:0007165 signal transduction 2 1
GO:0030968 endoplasmic reticulum unfolded protein response 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004843 cysteine-type deubiquitinase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0008234 cysteine-type peptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0019783 ubiquitin-like protein peptidase activity 4 12
GO:0101005 deubiquitinase activity 5 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 88 94 PF00089 0.406
CLV_NRD_NRD_1 151 153 PF00675 0.439
CLV_NRD_NRD_1 222 224 PF00675 0.320
CLV_NRD_NRD_1 67 69 PF00675 0.426
CLV_PCSK_FUR_1 367 371 PF00082 0.412
CLV_PCSK_KEX2_1 221 223 PF00082 0.327
CLV_PCSK_KEX2_1 369 371 PF00082 0.447
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.478
CLV_PCSK_SKI1_1 326 330 PF00082 0.398
CLV_PCSK_SKI1_1 54 58 PF00082 0.422
CLV_Separin_Metazoa 49 53 PF03568 0.393
DEG_SCF_FBW7_1 124 130 PF00400 0.427
DEG_SPOP_SBC_1 127 131 PF00917 0.460
DOC_CKS1_1 124 129 PF01111 0.560
DOC_CYCLIN_RxL_1 6 18 PF00134 0.365
DOC_CYCLIN_yCln2_LP_2 22 28 PF00134 0.364
DOC_MAPK_gen_1 152 158 PF00069 0.346
DOC_MAPK_gen_1 184 193 PF00069 0.413
DOC_SPAK_OSR1_1 91 95 PF12202 0.420
DOC_USP7_MATH_1 127 131 PF00917 0.457
DOC_USP7_MATH_1 226 230 PF00917 0.448
DOC_USP7_MATH_1 276 280 PF00917 0.408
DOC_WW_Pin1_4 123 128 PF00397 0.497
DOC_WW_Pin1_4 175 180 PF00397 0.497
LIG_14-3-3_CanoR_1 125 135 PF00244 0.411
LIG_14-3-3_CanoR_1 152 158 PF00244 0.547
LIG_14-3-3_CanoR_1 42 51 PF00244 0.381
LIG_14-3-3_CanoR_1 54 64 PF00244 0.350
LIG_14-3-3_CanoR_1 68 73 PF00244 0.361
LIG_14-3-3_CanoR_1 91 95 PF00244 0.432
LIG_BRCT_BRCA1_1 228 232 PF00533 0.267
LIG_EVH1_1 210 214 PF00568 0.324
LIG_FHA_1 16 22 PF00498 0.383
LIG_FHA_1 30 36 PF00498 0.349
LIG_FHA_1 45 51 PF00498 0.347
LIG_FHA_1 9 15 PF00498 0.392
LIG_FHA_2 106 112 PF00498 0.437
LIG_FHA_2 140 146 PF00498 0.440
LIG_LIR_Apic_2 207 212 PF02991 0.425
LIG_LIR_Gen_1 17 26 PF02991 0.376
LIG_LIR_Gen_1 58 66 PF02991 0.559
LIG_LIR_Gen_1 89 100 PF02991 0.478
LIG_LIR_Nem_3 17 22 PF02991 0.397
LIG_LIR_Nem_3 58 63 PF02991 0.599
LIG_LIR_Nem_3 89 95 PF02991 0.570
LIG_PCNA_yPIPBox_3 251 259 PF02747 0.374
LIG_Pex14_2 60 64 PF04695 0.382
LIG_PTB_Apo_2 339 346 PF02174 0.360
LIG_PTB_Phospho_1 339 345 PF10480 0.378
LIG_SH2_CRK 336 340 PF00017 0.263
LIG_SH2_NCK_1 336 340 PF00017 0.263
LIG_SH2_SRC 209 212 PF00017 0.395
LIG_SH2_STAP1 277 281 PF00017 0.386
LIG_SH2_STAP1 323 327 PF00017 0.293
LIG_SH2_STAP1 336 340 PF00017 0.278
LIG_SH2_STAT5 209 212 PF00017 0.413
LIG_SH2_STAT5 237 240 PF00017 0.276
LIG_SH2_STAT5 323 326 PF00017 0.348
LIG_SH2_STAT5 331 334 PF00017 0.325
LIG_SH3_1 208 214 PF00018 0.454
LIG_SH3_2 211 216 PF14604 0.463
LIG_SH3_3 208 214 PF00018 0.454
LIG_SH3_3 341 347 PF00018 0.476
LIG_SH3_3 69 75 PF00018 0.612
LIG_SUMO_SIM_anti_2 292 297 PF11976 0.271
LIG_SUMO_SIM_par_1 189 195 PF11976 0.369
LIG_UBA3_1 295 301 PF00899 0.403
LIG_UBA3_1 63 69 PF00899 0.378
LIG_WRC_WIRS_1 16 21 PF05994 0.373
LIG_WRC_WIRS_1 295 300 PF05994 0.285
LIG_WRC_WIRS_1 57 62 PF05994 0.483
MOD_CDK_SPK_2 123 128 PF00069 0.413
MOD_CK1_1 139 145 PF00069 0.436
MOD_CK1_1 151 157 PF00069 0.312
MOD_CK1_1 178 184 PF00069 0.568
MOD_CK1_1 279 285 PF00069 0.366
MOD_CK1_1 93 99 PF00069 0.428
MOD_CK2_1 105 111 PF00069 0.441
MOD_CK2_1 127 133 PF00069 0.579
MOD_CK2_1 139 145 PF00069 0.441
MOD_CK2_1 240 246 PF00069 0.390
MOD_CK2_1 346 352 PF00069 0.403
MOD_CK2_1 356 362 PF00069 0.408
MOD_CK2_1 43 49 PF00069 0.372
MOD_GlcNHglycan 139 142 PF01048 0.494
MOD_GlcNHglycan 180 183 PF01048 0.441
MOD_GSK3_1 123 130 PF00069 0.446
MOD_GSK3_1 279 286 PF00069 0.475
MOD_GSK3_1 352 359 PF00069 0.459
MOD_GSK3_1 4 11 PF00069 0.376
MOD_GSK3_1 99 106 PF00069 0.547
MOD_N-GLC_1 137 142 PF02516 0.447
MOD_N-GLC_2 228 230 PF02516 0.278
MOD_NEK2_1 1 6 PF00069 0.407
MOD_NEK2_1 118 123 PF00069 0.460
MOD_NEK2_1 137 142 PF00069 0.420
MOD_NEK2_1 14 19 PF00069 0.373
MOD_NEK2_1 321 326 PF00069 0.357
MOD_NEK2_1 329 334 PF00069 0.336
MOD_NEK2_1 43 48 PF00069 0.375
MOD_NEK2_2 90 95 PF00069 0.419
MOD_OFUCOSY 224 230 PF10250 0.320
MOD_PIKK_1 29 35 PF00454 0.399
MOD_PIKK_1 4 10 PF00454 0.366
MOD_PIKK_1 99 105 PF00454 0.437
MOD_PK_1 68 74 PF00069 0.390
MOD_PKA_1 68 74 PF00069 0.390
MOD_PKA_2 151 157 PF00069 0.353
MOD_PKA_2 90 96 PF00069 0.425
MOD_Plk_1 226 232 PF00069 0.287
MOD_Plk_1 352 358 PF00069 0.456
MOD_Plk_4 276 282 PF00069 0.497
MOD_Plk_4 294 300 PF00069 0.287
MOD_Plk_4 352 358 PF00069 0.450
MOD_Plk_4 56 62 PF00069 0.513
MOD_ProDKin_1 123 129 PF00069 0.500
MOD_ProDKin_1 175 181 PF00069 0.499
MOD_SUMO_rev_2 195 200 PF00179 0.533
MOD_SUMO_rev_2 375 385 PF00179 0.426
TRG_DiLeu_BaEn_1 145 150 PF01217 0.514
TRG_DiLeu_BaEn_2 293 299 PF01217 0.413
TRG_ENDOCYTIC_2 336 339 PF00928 0.265
TRG_ER_diArg_1 122 125 PF00400 0.330
TRG_ER_diArg_1 160 163 PF00400 0.366
TRG_ER_diArg_1 221 223 PF00400 0.348
TRG_ER_diArg_1 51 54 PF00400 0.394
TRG_NES_CRM1_1 263 273 PF08389 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P901 Leptomonas seymouri 76% 100%
A0A0S4IPY5 Bodo saltans 47% 100%
A0A1X0NNB5 Trypanosomatidae 50% 100%
A0A3R7LXZ2 Trypanosoma rangeli 54% 100%
A0A3S7XC16 Leishmania donovani 100% 100%
A4HQC1 Leishmania braziliensis 76% 100%
D0A3Y1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AU37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O13974 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q4Q0F8 Leishmania major 81% 97%
Q55BI3 Dictyostelium discoideum 32% 100%
Q9VRJ9 Drosophila melanogaster 29% 100%
V5B3J2 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS