LeishMANIAdb
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Arrestin_N domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Arrestin_N domain-containing protein
Gene product:
bilobe protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE12_LEIIN
TriTrypDb:
LINF_360069800
Length:
657

Annotations

Annotations by Jardim et al.

Membrane associated proteins, bilobe Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE12

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 603 607 PF00656 0.693
CLV_NRD_NRD_1 237 239 PF00675 0.663
CLV_NRD_NRD_1 252 254 PF00675 0.323
CLV_NRD_NRD_1 390 392 PF00675 0.733
CLV_NRD_NRD_1 539 541 PF00675 0.527
CLV_NRD_NRD_1 554 556 PF00675 0.466
CLV_NRD_NRD_1 614 616 PF00675 0.730
CLV_NRD_NRD_1 643 645 PF00675 0.716
CLV_NRD_NRD_1 647 649 PF00675 0.717
CLV_PCSK_KEX2_1 237 239 PF00082 0.663
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IMS1 Leptomonas seymouri 46% 94%
A0A1X0NLG6 Trypanosomatidae 33% 74%
A0A3R7KCV9 Trypanosoma rangeli 38% 83%
A0A3S7XBZ6 Leishmania donovani 99% 100%
A4HQB8 Leishmania braziliensis 62% 100%
E9AU34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 97%
Q4Q0G1 Leishmania major 92% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS