WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IE11_LEIIN

TriTrypDb:

LINF_360069700

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.525
CLV_C14_Caspase3-7	325	329	PF00656	0.546
CLV_NRD_NRD_1	250	252	PF00675	0.455
CLV_NRD_NRD_1	400	402	PF00675	0.500
CLV_NRD_NRD_1	85	87	PF00675	0.492
CLV_PCSK_FUR_1	248	252	PF00082	0.372
CLV_PCSK_KEX2_1	225	227	PF00082	0.602
CLV_PCSK_KEX2_1	250	252	PF00082	0.451
CLV_PCSK_KEX2_1	400	402	PF00082	0.490
CLV_PCSK_KEX2_1	85	87	PF00082	0.492
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.500
CLV_PCSK_SKI1_1	13	17	PF00082	0.517
CLV_PCSK_SKI1_1	38	42	PF00082	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.420
DEG_SPOP_SBC_1	340	344	PF00917	0.644
DOC_CDC14_PxL_1	50	58	PF14671	0.422
DOC_CYCLIN_RxL_1	35	43	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	217	220	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.432
DOC_MAPK_DCC_7	215	223	PF00069	0.539
DOC_MAPK_gen_1	248	257	PF00069	0.402
DOC_MAPK_gen_1	85	94	PF00069	0.496
DOC_MAPK_MEF2A_6	215	223	PF00069	0.494
DOC_MAPK_MEF2A_6	4	11	PF00069	0.461
DOC_MAPK_NFAT4_5	4	12	PF00069	0.486
DOC_PP2B_LxvP_1	216	219	PF13499	0.388
DOC_PP2B_LxvP_1	256	259	PF13499	0.473
DOC_USP7_MATH_1	241	245	PF00917	0.500
DOC_USP7_MATH_1	339	343	PF00917	0.703
DOC_USP7_MATH_1	346	350	PF00917	0.609
DOC_USP7_MATH_1	355	359	PF00917	0.688
DOC_USP7_MATH_1	361	365	PF00917	0.618
DOC_USP7_MATH_1	90	94	PF00917	0.581
DOC_USP7_MATH_1	98	102	PF00917	0.560
DOC_WW_Pin1_4	230	235	PF00397	0.678
DOC_WW_Pin1_4	237	242	PF00397	0.576
DOC_WW_Pin1_4	335	340	PF00397	0.674
DOC_WW_Pin1_4	40	45	PF00397	0.602
LIG_14-3-3_CanoR_1	281	286	PF00244	0.482
LIG_14-3-3_CanoR_1	31	40	PF00244	0.418
LIG_14-3-3_CanoR_1	400	404	PF00244	0.525
LIG_deltaCOP1_diTrp_1	59	67	PF00928	0.442
LIG_EVH1_1	387	391	PF00568	0.434
LIG_FHA_1	156	162	PF00498	0.427
LIG_FHA_1	231	237	PF00498	0.699
LIG_FHA_1	252	258	PF00498	0.371
LIG_FHA_1	31	37	PF00498	0.421
LIG_FHA_1	330	336	PF00498	0.593
LIG_FHA_2	106	112	PF00498	0.565
LIG_FHA_2	128	134	PF00498	0.530
LIG_FHA_2	178	184	PF00498	0.492
LIG_FHA_2	323	329	PF00498	0.591
LIG_LIR_Apic_2	414	420	PF02991	0.438
LIG_LIR_Gen_1	266	273	PF02991	0.460
LIG_LIR_Gen_1	59	70	PF02991	0.394
LIG_LIR_Gen_1	87	97	PF02991	0.489
LIG_LIR_Nem_3	212	217	PF02991	0.464
LIG_LIR_Nem_3	384	390	PF02991	0.642
LIG_LIR_Nem_3	402	408	PF02991	0.268
LIG_LIR_Nem_3	59	65	PF02991	0.405
LIG_LIR_Nem_3	87	92	PF02991	0.507
LIG_MYND_2	219	223	PF01753	0.532
LIG_MYND_3	53	57	PF01753	0.397
LIG_NRP_CendR_1	427	430	PF00754	0.579
LIG_Pex14_1	275	279	PF04695	0.407
LIG_Pex14_1	62	66	PF04695	0.427
LIG_Pex14_2	269	273	PF04695	0.430
LIG_SH2_CRK	293	297	PF00017	0.444
LIG_SH2_STAT3	406	409	PF00017	0.506
LIG_SH2_STAT5	170	173	PF00017	0.472
LIG_SH2_STAT5	406	409	PF00017	0.431
LIG_SH3_3	256	262	PF00018	0.474
LIG_SH3_3	380	386	PF00018	0.539
LIG_SH3_3	48	54	PF00018	0.482
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.459
LIG_SUMO_SIM_par_1	219	224	PF11976	0.496
LIG_SUMO_SIM_par_1	233	240	PF11976	0.484
LIG_TRAF2_1	108	111	PF00917	0.537
LIG_TYR_ITIM	291	296	PF00017	0.425
LIG_ULM_U2AF65_1	85	90	PF00076	0.500
LIG_WW_2	388	391	PF00397	0.437
MOD_CK1_1	101	107	PF00069	0.753
MOD_CK1_1	331	337	PF00069	0.574
MOD_CK1_1	372	378	PF00069	0.702
MOD_CK1_1	399	405	PF00069	0.443
MOD_CK2_1	221	227	PF00069	0.640
MOD_CK2_1	237	243	PF00069	0.496
MOD_CK2_1	31	37	PF00069	0.452
MOD_CK2_1	339	345	PF00069	0.709
MOD_CK2_1	65	71	PF00069	0.468
MOD_CK2_1	99	105	PF00069	0.616
MOD_Cter_Amidation	410	413	PF01082	0.552
MOD_Cter_Amidation	83	86	PF01082	0.520
MOD_GlcNHglycan	148	151	PF01048	0.474
MOD_GlcNHglycan	164	167	PF01048	0.327
MOD_GlcNHglycan	243	246	PF01048	0.528
MOD_GlcNHglycan	302	305	PF01048	0.379
MOD_GlcNHglycan	348	351	PF01048	0.699
MOD_GlcNHglycan	363	366	PF01048	0.718
MOD_GlcNHglycan	371	374	PF01048	0.588
MOD_GlcNHglycan	409	412	PF01048	0.505
MOD_GlcNHglycan	68	71	PF01048	0.440
MOD_GSK3_1	101	108	PF00069	0.615
MOD_GSK3_1	221	228	PF00069	0.542
MOD_GSK3_1	232	239	PF00069	0.752
MOD_GSK3_1	26	33	PF00069	0.465
MOD_GSK3_1	331	338	PF00069	0.671
MOD_GSK3_1	340	347	PF00069	0.741
MOD_GSK3_1	357	364	PF00069	0.808
MOD_GSK3_1	369	376	PF00069	0.711
MOD_GSK3_1	407	414	PF00069	0.489
MOD_GSK3_1	61	68	PF00069	0.570
MOD_N-GLC_1	177	182	PF02516	0.449
MOD_N-GLC_1	329	334	PF02516	0.624
MOD_N-GLC_1	355	360	PF02516	0.666
MOD_NEK2_1	146	151	PF00069	0.427
MOD_NEK2_1	236	241	PF00069	0.577
MOD_NEK2_1	407	412	PF00069	0.537
MOD_NEK2_2	61	66	PF00069	0.409
MOD_PIKK_1	419	425	PF00454	0.541
MOD_PIKK_1	99	105	PF00454	0.593
MOD_PKA_1	225	231	PF00069	0.656
MOD_PKA_1	251	257	PF00069	0.387
MOD_PKA_1	412	418	PF00069	0.521
MOD_PKA_2	127	133	PF00069	0.538
MOD_PKA_2	16	22	PF00069	0.461
MOD_PKA_2	225	231	PF00069	0.642
MOD_PKA_2	30	36	PF00069	0.413
MOD_PKA_2	399	405	PF00069	0.448
MOD_PKA_2	84	90	PF00069	0.447
MOD_Plk_4	141	147	PF00069	0.391
MOD_Plk_4	232	238	PF00069	0.516
MOD_Plk_4	251	257	PF00069	0.471
MOD_Plk_4	61	67	PF00069	0.433
MOD_ProDKin_1	230	236	PF00069	0.678
MOD_ProDKin_1	237	243	PF00069	0.563
MOD_ProDKin_1	335	341	PF00069	0.673
MOD_ProDKin_1	40	46	PF00069	0.608
MOD_SUMO_rev_2	189	198	PF00179	0.347
TRG_DiLeu_BaEn_1	212	217	PF01217	0.427
TRG_DiLeu_LyEn_5	212	217	PF01217	0.443
TRG_ENDOCYTIC_2	293	296	PF00928	0.423
TRG_ENDOCYTIC_2	405	408	PF00928	0.390
TRG_ER_diArg_1	248	251	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC61	Leptomonas seymouri	56%	67%
A0A0S4IPB1	Bodo saltans	33%	81%
A0A3S7XBY9	Leishmania donovani	100%	70%
A4HQB7	Leishmania braziliensis	77%	100%
E9AU33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0G2	Leishmania major	94%	100%