LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE10_LEIIN
TriTrypDb:
LINF_360069600
Length:
623

Annotations

LeishMANIAdb annotations

Very tentatively might be a transmembrane chaperone for some unknown protein secretion process. Not unique to kinetoplastids, also found in fungi and other Eukaryotes.

Annotations by Jardim et al.

Flagella, Flagellum attachment zone 5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0016020 membrane 2 7
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4IE10
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.697
CLV_C14_Caspase3-7 421 425 PF00656 0.617
CLV_C14_Caspase3-7 479 483 PF00656 0.696
CLV_NRD_NRD_1 221 223 PF00675 0.337
CLV_NRD_NRD_1 33 35 PF00675 0.334
CLV_NRD_NRD_1 373 375 PF00675 0.374
CLV_NRD_NRD_1 379 381 PF00675 0.429
CLV_NRD_NRD_1 464 466 PF00675 0.492
CLV_NRD_NRD_1 508 510 PF00675 0.584
CLV_NRD_NRD_1 517 519 PF00675 0.502
CLV_NRD_NRD_1 53 55 PF00675 0.197
CLV_NRD_NRD_1 557 559 PF00675 0.469
CLV_NRD_NRD_1 620 622 PF00675 0.432
CLV_NRD_NRD_1 7 9 PF00675 0.385
CLV_PCSK_KEX2_1 221 223 PF00082 0.337
CLV_PCSK_KEX2_1 372 374 PF00082 0.389
CLV_PCSK_KEX2_1 379 381 PF00082 0.435
CLV_PCSK_KEX2_1 464 466 PF00082 0.492
CLV_PCSK_KEX2_1 508 510 PF00082 0.584
CLV_PCSK_KEX2_1 517 519 PF00082 0.502
CLV_PCSK_KEX2_1 9 11 PF00082 0.353
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.353
CLV_PCSK_SKI1_1 27 31 PF00082 0.315
CLV_PCSK_SKI1_1 34 38 PF00082 0.336
CLV_PCSK_SKI1_1 411 415 PF00082 0.506
DEG_APCC_DBOX_1 281 289 PF00400 0.339
DEG_Nend_UBRbox_4 1 3 PF02207 0.630
DEG_SCF_FBW7_1 459 466 PF00400 0.681
DOC_CKS1_1 146 151 PF01111 0.546
DOC_CKS1_1 384 389 PF01111 0.616
DOC_CKS1_1 460 465 PF01111 0.750
DOC_MAPK_DCC_7 341 351 PF00069 0.342
DOC_MAPK_gen_1 221 229 PF00069 0.504
DOC_MAPK_gen_1 267 277 PF00069 0.266
DOC_MAPK_gen_1 332 342 PF00069 0.349
DOC_MAPK_gen_1 8 20 PF00069 0.575
DOC_MAPK_HePTP_8 215 227 PF00069 0.379
DOC_MAPK_MEF2A_6 218 227 PF00069 0.497
DOC_MAPK_MEF2A_6 270 279 PF00069 0.299
DOC_MAPK_MEF2A_6 303 310 PF00069 0.506
DOC_MAPK_RevD_3 358 373 PF00069 0.354
DOC_PP1_RVXF_1 25 32 PF00149 0.498
DOC_PP4_FxxP_1 175 178 PF00568 0.348
DOC_USP7_MATH_1 23 27 PF00917 0.548
DOC_USP7_MATH_1 463 467 PF00917 0.727
DOC_USP7_MATH_1 615 619 PF00917 0.650
DOC_USP7_MATH_1 83 87 PF00917 0.304
DOC_WW_Pin1_4 145 150 PF00397 0.649
DOC_WW_Pin1_4 160 165 PF00397 0.520
DOC_WW_Pin1_4 19 24 PF00397 0.538
DOC_WW_Pin1_4 232 237 PF00397 0.624
DOC_WW_Pin1_4 383 388 PF00397 0.653
DOC_WW_Pin1_4 459 464 PF00397 0.678
DOC_WW_Pin1_4 469 474 PF00397 0.659
DOC_WW_Pin1_4 483 488 PF00397 0.756
DOC_WW_Pin1_4 517 522 PF00397 0.723
LIG_14-3-3_CanoR_1 267 273 PF00244 0.333
LIG_14-3-3_CanoR_1 34 39 PF00244 0.556
LIG_14-3-3_CanoR_1 464 470 PF00244 0.731
LIG_14-3-3_CanoR_1 485 495 PF00244 0.643
LIG_14-3-3_CanoR_1 565 570 PF00244 0.724
LIG_14-3-3_CanoR_1 595 600 PF00244 0.704
LIG_BIR_III_4 64 68 PF00653 0.539
LIG_BRCT_BRCA1_1 324 328 PF00533 0.305
LIG_BRCT_BRCA1_1 426 430 PF00533 0.618
LIG_DLG_GKlike_1 595 602 PF00625 0.655
LIG_eIF4E_1 15 21 PF01652 0.568
LIG_eIF4E_1 210 216 PF01652 0.317
LIG_eIF4E_1 42 48 PF01652 0.572
LIG_eIF4E_1 90 96 PF01652 0.377
LIG_FHA_1 210 216 PF00498 0.380
LIG_FHA_1 297 303 PF00498 0.522
LIG_FHA_1 361 367 PF00498 0.406
LIG_FHA_1 573 579 PF00498 0.715
LIG_FHA_2 149 155 PF00498 0.571
LIG_FHA_2 449 455 PF00498 0.688
LIG_FHA_2 523 529 PF00498 0.724
LIG_FHA_2 574 580 PF00498 0.729
LIG_LIR_Apic_2 173 178 PF02991 0.304
LIG_LIR_Apic_2 214 220 PF02991 0.352
LIG_LIR_Gen_1 112 123 PF02991 0.325
LIG_LIR_Gen_1 198 205 PF02991 0.240
LIG_LIR_Gen_1 271 281 PF02991 0.285
LIG_LIR_Gen_1 352 362 PF02991 0.377
LIG_LIR_Gen_1 417 426 PF02991 0.609
LIG_LIR_Gen_1 427 437 PF02991 0.619
LIG_LIR_Gen_1 444 453 PF02991 0.647
LIG_LIR_Gen_1 540 550 PF02991 0.744
LIG_LIR_Gen_1 596 605 PF02991 0.718
LIG_LIR_Nem_3 112 118 PF02991 0.330
LIG_LIR_Nem_3 119 123 PF02991 0.287
LIG_LIR_Nem_3 173 177 PF02991 0.363
LIG_LIR_Nem_3 269 275 PF02991 0.264
LIG_LIR_Nem_3 352 358 PF02991 0.420
LIG_LIR_Nem_3 417 423 PF02991 0.652
LIG_LIR_Nem_3 427 433 PF02991 0.650
LIG_LIR_Nem_3 444 449 PF02991 0.648
LIG_LIR_Nem_3 540 546 PF02991 0.714
LIG_LIR_Nem_3 596 602 PF02991 0.721
LIG_LIR_Nem_3 63 69 PF02991 0.516
LIG_LIR_Nem_3 71 77 PF02991 0.525
LIG_MLH1_MIPbox_1 324 328 PF16413 0.305
LIG_NRBOX 13 19 PF00104 0.500
LIG_NRP_CendR_1 621 623 PF00754 0.511
LIG_Pex14_1 12 16 PF04695 0.537
LIG_Pex14_1 272 276 PF04695 0.283
LIG_Pex14_2 175 179 PF04695 0.348
LIG_Pex14_2 243 247 PF04695 0.320
LIG_PTB_Apo_2 237 244 PF02174 0.354
LIG_SH2_CRK 182 186 PF00017 0.409
LIG_SH2_CRK 239 243 PF00017 0.347
LIG_SH2_CRK 470 474 PF00017 0.700
LIG_SH2_CRK 58 62 PF00017 0.496
LIG_SH2_CRK 599 603 PF00017 0.719
LIG_SH2_CRK 66 70 PF00017 0.493
LIG_SH2_CRK 90 94 PF00017 0.377
LIG_SH2_GRB2like 549 552 PF00017 0.693
LIG_SH2_NCK_1 392 396 PF00017 0.583
LIG_SH2_NCK_1 543 547 PF00017 0.744
LIG_SH2_NCK_1 58 62 PF00017 0.533
LIG_SH2_PTP2 115 118 PF00017 0.318
LIG_SH2_SRC 152 155 PF00017 0.601
LIG_SH2_SRC 392 395 PF00017 0.581
LIG_SH2_STAP1 211 215 PF00017 0.377
LIG_SH2_STAP1 392 396 PF00017 0.599
LIG_SH2_STAP1 569 573 PF00017 0.668
LIG_SH2_STAP1 90 94 PF00017 0.348
LIG_SH2_STAT3 571 574 PF00017 0.808
LIG_SH2_STAT3 584 587 PF00017 0.685
LIG_SH2_STAT5 115 118 PF00017 0.350
LIG_SH2_STAT5 16 19 PF00017 0.558
LIG_SH2_STAT5 174 177 PF00017 0.362
LIG_SH2_STAT5 182 185 PF00017 0.337
LIG_SH2_STAT5 196 199 PF00017 0.281
LIG_SH2_STAT5 211 214 PF00017 0.225
LIG_SH2_STAT5 273 276 PF00017 0.315
LIG_SH2_STAT5 298 301 PF00017 0.562
LIG_SH2_STAT5 327 330 PF00017 0.354
LIG_SH2_STAT5 350 353 PF00017 0.335
LIG_SH2_STAT5 46 49 PF00017 0.486
LIG_SH2_STAT5 524 527 PF00017 0.695
LIG_SH2_STAT5 543 546 PF00017 0.690
LIG_SH2_STAT5 56 59 PF00017 0.478
LIG_SH2_STAT5 571 574 PF00017 0.732
LIG_SH2_STAT5 577 580 PF00017 0.733
LIG_SH2_STAT5 584 587 PF00017 0.710
LIG_SH3_3 453 459 PF00018 0.754
LIG_SH3_3 73 79 PF00018 0.558
LIG_SUMO_SIM_anti_2 363 369 PF11976 0.327
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.348
LIG_SUMO_SIM_par_1 16 22 PF11976 0.565
LIG_SUMO_SIM_par_1 91 97 PF11976 0.371
LIG_TRAF2_1 151 154 PF00917 0.570
LIG_TRAF2_1 375 378 PF00917 0.587
LIG_TRAF2_1 451 454 PF00917 0.719
LIG_TRAF2_1 525 528 PF00917 0.685
LIG_TYR_ITIM 172 177 PF00017 0.377
LIG_TYR_ITIM 180 185 PF00017 0.476
LIG_TYR_ITIM 237 242 PF00017 0.346
LIG_TYR_ITIM 88 93 PF00017 0.377
LIG_WRC_WIRS_1 313 318 PF05994 0.317
LIG_WW_3 5 9 PF00397 0.589
MOD_CDC14_SPxK_1 520 523 PF00782 0.695
MOD_CDK_SPK_2 145 150 PF00069 0.540
MOD_CDK_SPK_2 459 464 PF00069 0.724
MOD_CDK_SPK_2 469 474 PF00069 0.730
MOD_CDK_SPxK_1 459 465 PF00069 0.681
MOD_CDK_SPxK_1 517 523 PF00069 0.725
MOD_CK1_1 22 28 PF00069 0.518
MOD_CK1_1 315 321 PF00069 0.377
MOD_CK1_1 425 431 PF00069 0.661
MOD_CK1_1 512 518 PF00069 0.814
MOD_CK1_1 530 536 PF00069 0.629
MOD_CK1_1 567 573 PF00069 0.718
MOD_CK1_1 588 594 PF00069 0.674
MOD_CK1_1 597 603 PF00069 0.656
MOD_CK1_1 604 610 PF00069 0.612
MOD_CK2_1 148 154 PF00069 0.564
MOD_CK2_1 372 378 PF00069 0.549
MOD_CK2_1 448 454 PF00069 0.693
MOD_CK2_1 522 528 PF00069 0.690
MOD_CK2_1 57 63 PF00069 0.553
MOD_GlcNHglycan 406 409 PF01048 0.498
MOD_GlcNHglycan 511 514 PF01048 0.497
MOD_GlcNHglycan 527 532 PF01048 0.558
MOD_GlcNHglycan 603 606 PF01048 0.457
MOD_GlcNHglycan 613 616 PF01048 0.518
MOD_GlcNHglycan 617 620 PF01048 0.425
MOD_GlcNHglycan 70 73 PF01048 0.310
MOD_GSK3_1 180 187 PF00069 0.515
MOD_GSK3_1 19 26 PF00069 0.527
MOD_GSK3_1 422 429 PF00069 0.659
MOD_GSK3_1 459 466 PF00069 0.726
MOD_GSK3_1 486 493 PF00069 0.728
MOD_GSK3_1 509 516 PF00069 0.751
MOD_GSK3_1 541 548 PF00069 0.776
MOD_GSK3_1 561 568 PF00069 0.576
MOD_GSK3_1 569 576 PF00069 0.650
MOD_GSK3_1 587 594 PF00069 0.596
MOD_GSK3_1 597 604 PF00069 0.620
MOD_GSK3_1 611 618 PF00069 0.660
MOD_LATS_1 593 599 PF00433 0.690
MOD_N-GLC_1 50 55 PF02516 0.356
MOD_NEK2_1 195 200 PF00069 0.372
MOD_NEK2_1 209 214 PF00069 0.345
MOD_NEK2_1 268 273 PF00069 0.359
MOD_NEK2_1 296 301 PF00069 0.548
MOD_NEK2_1 321 326 PF00069 0.290
MOD_NEK2_1 360 365 PF00069 0.327
MOD_NEK2_1 563 568 PF00069 0.669
MOD_NEK2_1 57 62 PF00069 0.514
MOD_NEK2_1 68 73 PF00069 0.473
MOD_PIKK_1 180 186 PF00454 0.411
MOD_PIKK_1 463 469 PF00454 0.724
MOD_PIKK_1 585 591 PF00454 0.678
MOD_PKA_1 34 40 PF00069 0.554
MOD_PKA_1 372 378 PF00069 0.574
MOD_PKA_2 266 272 PF00069 0.273
MOD_PKA_2 372 378 PF00069 0.574
MOD_PKA_2 463 469 PF00069 0.718
MOD_PKA_2 497 503 PF00069 0.727
MOD_PKA_2 564 570 PF00069 0.748
MOD_PKA_2 594 600 PF00069 0.688
MOD_Plk_1 544 550 PF00069 0.745
MOD_Plk_2-3 154 160 PF00069 0.593
MOD_Plk_2-3 448 454 PF00069 0.680
MOD_Plk_4 154 160 PF00069 0.556
MOD_Plk_4 170 176 PF00069 0.225
MOD_Plk_4 195 201 PF00069 0.286
MOD_Plk_4 211 217 PF00069 0.282
MOD_Plk_4 312 318 PF00069 0.305
MOD_Plk_4 322 328 PF00069 0.231
MOD_Plk_4 349 355 PF00069 0.390
MOD_Plk_4 360 366 PF00069 0.433
MOD_Plk_4 545 551 PF00069 0.734
MOD_Plk_4 573 579 PF00069 0.703
MOD_Plk_4 83 89 PF00069 0.307
MOD_ProDKin_1 145 151 PF00069 0.648
MOD_ProDKin_1 160 166 PF00069 0.516
MOD_ProDKin_1 19 25 PF00069 0.532
MOD_ProDKin_1 232 238 PF00069 0.616
MOD_ProDKin_1 383 389 PF00069 0.656
MOD_ProDKin_1 459 465 PF00069 0.678
MOD_ProDKin_1 469 475 PF00069 0.658
MOD_ProDKin_1 483 489 PF00069 0.755
MOD_ProDKin_1 517 523 PF00069 0.725
TRG_DiLeu_BaEn_1 97 102 PF01217 0.377
TRG_DiLeu_BaEn_4 453 459 PF01217 0.634
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.558
TRG_ENDOCYTIC_2 115 118 PF00928 0.334
TRG_ENDOCYTIC_2 15 18 PF00928 0.495
TRG_ENDOCYTIC_2 174 177 PF00928 0.283
TRG_ENDOCYTIC_2 182 185 PF00928 0.320
TRG_ENDOCYTIC_2 199 202 PF00928 0.217
TRG_ENDOCYTIC_2 239 242 PF00928 0.280
TRG_ENDOCYTIC_2 273 276 PF00928 0.257
TRG_ENDOCYTIC_2 350 353 PF00928 0.328
TRG_ENDOCYTIC_2 446 449 PF00928 0.679
TRG_ENDOCYTIC_2 46 49 PF00928 0.486
TRG_ENDOCYTIC_2 543 546 PF00928 0.728
TRG_ENDOCYTIC_2 58 61 PF00928 0.489
TRG_ENDOCYTIC_2 599 602 PF00928 0.722
TRG_ENDOCYTIC_2 66 69 PF00928 0.416
TRG_ENDOCYTIC_2 90 93 PF00928 0.377
TRG_ER_diArg_1 220 222 PF00400 0.538
TRG_ER_diArg_1 339 342 PF00400 0.328
TRG_ER_diArg_1 371 374 PF00400 0.586
TRG_ER_diArg_1 379 381 PF00400 0.636
TRG_ER_diArg_1 463 465 PF00400 0.694
TRG_ER_diArg_1 507 509 PF00400 0.654
TRG_ER_diArg_1 7 10 PF00400 0.584
TRG_NLS_MonoExtN_4 6 12 PF00514 0.562

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAE8 Leptomonas seymouri 60% 99%
A0A3S7XC04 Leishmania donovani 100% 100%
A0A422NJ92 Trypanosoma rangeli 44% 100%
A4HQB6 Leishmania braziliensis 65% 100%
E9AU32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q0G3 Leishmania major 90% 100%
V5DK11 Trypanosoma cruzi 40% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS