LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IE08_LEIIN
TriTrypDb:
LINF_360069400
Length:
389

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IE08
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE08

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 239 243 PF00656 0.760
CLV_NRD_NRD_1 120 122 PF00675 0.607
CLV_NRD_NRD_1 303 305 PF00675 0.707
CLV_PCSK_KEX2_1 120 122 PF00082 0.606
CLV_PCSK_KEX2_1 303 305 PF00082 0.707
CLV_PCSK_PC7_1 299 305 PF00082 0.607
CLV_PCSK_SKI1_1 11 15 PF00082 0.658
DOC_CKS1_1 244 249 PF01111 0.821
DOC_CYCLIN_RxL_1 125 136 PF00134 0.460
DOC_MAPK_MEF2A_6 200 207 PF00069 0.664
DOC_USP7_MATH_1 232 236 PF00917 0.582
DOC_USP7_MATH_1 245 249 PF00917 0.742
DOC_USP7_MATH_1 284 288 PF00917 0.655
DOC_USP7_MATH_1 311 315 PF00917 0.786
DOC_USP7_MATH_1 385 389 PF00917 0.663
DOC_USP7_MATH_1 4 8 PF00917 0.560
DOC_USP7_MATH_1 43 47 PF00917 0.622
DOC_WW_Pin1_4 177 182 PF00397 0.812
DOC_WW_Pin1_4 225 230 PF00397 0.786
DOC_WW_Pin1_4 243 248 PF00397 0.628
DOC_WW_Pin1_4 307 312 PF00397 0.780
DOC_WW_Pin1_4 41 46 PF00397 0.729
DOC_WW_Pin1_4 73 78 PF00397 0.697
DOC_WW_Pin1_4 91 96 PF00397 0.581
LIG_14-3-3_CanoR_1 155 160 PF00244 0.699
LIG_14-3-3_CanoR_1 80 87 PF00244 0.718
LIG_BIR_III_4 186 190 PF00653 0.702
LIG_BRCT_BRCA1_1 215 219 PF00533 0.622
LIG_DLG_GKlike_1 155 163 PF00625 0.710
LIG_FHA_1 190 196 PF00498 0.693
LIG_FHA_1 199 205 PF00498 0.645
LIG_FHA_1 262 268 PF00498 0.632
LIG_FHA_1 287 293 PF00498 0.730
LIG_FHA_1 31 37 PF00498 0.744
LIG_FHA_1 310 316 PF00498 0.751
LIG_FHA_1 338 344 PF00498 0.688
LIG_FHA_2 112 118 PF00498 0.639
LIG_FHA_2 215 221 PF00498 0.651
LIG_FHA_2 74 80 PF00498 0.582
LIG_LIR_Gen_1 216 227 PF02991 0.665
LIG_LIR_Nem_3 148 152 PF02991 0.656
LIG_LIR_Nem_3 216 222 PF02991 0.661
LIG_MYND_3 320 324 PF01753 0.660
LIG_PCNA_yPIPBox_3 51 61 PF02747 0.521
LIG_Pex14_2 219 223 PF04695 0.670
LIG_Pex14_2 68 72 PF04695 0.689
LIG_PTAP_UEV_1 246 251 PF05743 0.734
LIG_Rb_pABgroove_1 363 371 PF01858 0.581
LIG_SH2_CRK 149 153 PF00017 0.612
LIG_SH2_STAP1 371 375 PF00017 0.705
LIG_SH2_STAT3 17 20 PF00017 0.602
LIG_SH3_3 226 232 PF00018 0.766
LIG_SH3_3 241 247 PF00018 0.690
LIG_SH3_3 264 270 PF00018 0.795
LIG_SH3_3 305 311 PF00018 0.769
LIG_SH3_3 315 321 PF00018 0.634
LIG_SH3_5 367 371 PF00018 0.587
LIG_SUMO_SIM_par_1 191 197 PF11976 0.666
LIG_TRAF2_1 60 63 PF00917 0.638
LIG_TRAF2_1 89 92 PF00917 0.562
LIG_TRFH_1 363 367 PF08558 0.627
LIG_UBA3_1 252 258 PF00899 0.559
MOD_CDC14_SPxK_1 180 183 PF00782 0.729
MOD_CDK_SPxK_1 177 183 PF00069 0.732
MOD_CDK_SPxxK_3 73 80 PF00069 0.608
MOD_CK1_1 151 157 PF00069 0.684
MOD_CK1_1 158 164 PF00069 0.765
MOD_CK1_1 179 185 PF00069 0.723
MOD_CK1_1 275 281 PF00069 0.743
MOD_CK1_1 309 315 PF00069 0.706
MOD_CK1_1 337 343 PF00069 0.643
MOD_CK1_1 41 47 PF00069 0.703
MOD_CK2_1 111 117 PF00069 0.649
MOD_CK2_1 299 305 PF00069 0.768
MOD_CK2_1 310 316 PF00069 0.672
MOD_CK2_1 57 63 PF00069 0.633
MOD_GlcNHglycan 138 141 PF01048 0.621
MOD_GlcNHglycan 160 163 PF01048 0.680
MOD_GlcNHglycan 167 173 PF01048 0.706
MOD_GlcNHglycan 234 237 PF01048 0.707
MOD_GlcNHglycan 247 250 PF01048 0.817
MOD_GlcNHglycan 27 30 PF01048 0.705
MOD_GlcNHglycan 274 277 PF01048 0.672
MOD_GlcNHglycan 40 43 PF01048 0.584
MOD_GlcNHglycan 45 48 PF01048 0.483
MOD_GSK3_1 151 158 PF00069 0.737
MOD_GSK3_1 210 217 PF00069 0.570
MOD_GSK3_1 268 275 PF00069 0.731
MOD_GSK3_1 280 287 PF00069 0.685
MOD_GSK3_1 306 313 PF00069 0.698
MOD_GSK3_1 75 82 PF00069 0.648
MOD_NEK2_1 105 110 PF00069 0.718
MOD_NEK2_1 207 212 PF00069 0.559
MOD_PIKK_1 278 284 PF00454 0.824
MOD_PKA_2 136 142 PF00069 0.608
MOD_PKA_2 337 343 PF00069 0.759
MOD_PKA_2 79 85 PF00069 0.706
MOD_PKB_1 304 312 PF00069 0.642
MOD_Plk_4 64 70 PF00069 0.707
MOD_ProDKin_1 177 183 PF00069 0.812
MOD_ProDKin_1 225 231 PF00069 0.786
MOD_ProDKin_1 243 249 PF00069 0.624
MOD_ProDKin_1 307 313 PF00069 0.776
MOD_ProDKin_1 41 47 PF00069 0.724
MOD_ProDKin_1 73 79 PF00069 0.696
MOD_ProDKin_1 91 97 PF00069 0.584
MOD_SUMO_for_1 85 88 PF00179 0.742
TRG_DiLeu_BaEn_2 340 346 PF01217 0.637
TRG_ENDOCYTIC_2 149 152 PF00928 0.611
TRG_ER_diArg_1 119 121 PF00400 0.577
TRG_Pf-PMV_PEXEL_1 120 124 PF00026 0.610
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.601

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P903 Leptomonas seymouri 34% 100%
A0A3Q8IGQ8 Leishmania donovani 99% 100%
A4HQB4 Leishmania braziliensis 52% 99%
E9AU30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q0G5 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS