Enolase-phosphatase E1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haloacid dehalogenase-like hydrolase - putative

Species:

Leishmania infantum

UniProt:

A4IE04_LEIIN

TriTrypDb:

LINF_360069000

Length:

374

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IE04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE04

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	4
GO:0000097	sulfur amino acid biosynthetic process	5	4
GO:0006082	organic acid metabolic process	3	4
GO:0006520	amino acid metabolic process	3	4
GO:0006555	methionine metabolic process	5	4
GO:0006790	sulfur compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008652	amino acid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009066	aspartate family amino acid metabolic process	5	4
GO:0009067	aspartate family amino acid biosynthetic process	6	4
GO:0009086	methionine biosynthetic process	6	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019509	L-methionine salvage from methylthioadenosine	6	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0043094	cellular metabolic compound salvage	3	4
GO:0043102	amino acid salvage	4	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044272	sulfur compound biosynthetic process	4	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0071265	L-methionine biosynthetic process	7	4
GO:0071267	L-methionine salvage	5	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901566	organonitrogen compound biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4
GO:1901605	alpha-amino acid metabolic process	4	4
GO:1901607	alpha-amino acid biosynthetic process	5	4

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	4
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0043874	acireductone synthase activity	6	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	180	182	PF00082	0.479
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.479
CLV_PCSK_SKI1_1	144	148	PF00082	0.481
CLV_PCSK_SKI1_1	230	234	PF00082	0.506
CLV_PCSK_SKI1_1	280	284	PF00082	0.501
CLV_PCSK_SKI1_1	3	7	PF00082	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CYCLIN_RxL_1	274	285	PF00134	0.523
DOC_PP2B_LxvP_1	287	290	PF13499	0.465
DOC_USP7_MATH_1	211	215	PF00917	0.301
DOC_USP7_MATH_1	290	294	PF00917	0.333
DOC_USP7_MATH_1	309	313	PF00917	0.458
DOC_USP7_MATH_1	314	318	PF00917	0.407
DOC_USP7_MATH_1	69	73	PF00917	0.579
DOC_USP7_UBL2_3	270	274	PF12436	0.429
DOC_USP7_UBL2_3	365	369	PF12436	0.507
DOC_WW_Pin1_4	130	135	PF00397	0.658
DOC_WW_Pin1_4	246	251	PF00397	0.395
DOC_WW_Pin1_4	86	91	PF00397	0.387
LIG_14-3-3_CanoR_1	3	13	PF00244	0.422
LIG_BRCT_BRCA1_1	142	146	PF00533	0.476
LIG_BRCT_BRCA1_1	206	210	PF00533	0.506
LIG_BRCT_BRCA1_1	213	217	PF00533	0.390
LIG_Clathr_ClatBox_1	81	85	PF01394	0.493
LIG_deltaCOP1_diTrp_1	327	331	PF00928	0.427
LIG_EH_1	254	258	PF12763	0.409
LIG_EH1_1	67	75	PF00400	0.365
LIG_eIF4E_1	261	267	PF01652	0.514
LIG_FHA_1	145	151	PF00498	0.468
LIG_FHA_1	17	23	PF00498	0.441
LIG_FHA_1	44	50	PF00498	0.537
LIG_FHA_1	76	82	PF00498	0.437
LIG_FHA_1	86	92	PF00498	0.334
LIG_LIR_Apic_2	259	264	PF02991	0.396
LIG_LIR_Gen_1	117	128	PF02991	0.491
LIG_LIR_Gen_1	169	179	PF02991	0.525
LIG_LIR_Gen_1	25	35	PF02991	0.545
LIG_LIR_Gen_1	275	284	PF02991	0.411
LIG_LIR_Gen_1	327	335	PF02991	0.529
LIG_LIR_Gen_1	344	349	PF02991	0.400
LIG_LIR_Nem_3	117	123	PF02991	0.466
LIG_LIR_Nem_3	169	174	PF02991	0.526
LIG_LIR_Nem_3	207	213	PF02991	0.381
LIG_LIR_Nem_3	214	219	PF02991	0.438
LIG_LIR_Nem_3	249	254	PF02991	0.393
LIG_LIR_Nem_3	25	31	PF02991	0.460
LIG_LIR_Nem_3	259	265	PF02991	0.317
LIG_LIR_Nem_3	275	279	PF02991	0.262
LIG_LIR_Nem_3	327	331	PF02991	0.529
LIG_LIR_Nem_3	344	348	PF02991	0.396
LIG_MLH1_MIPbox_1	213	217	PF16413	0.292
LIG_Pex14_1	196	200	PF04695	0.418
LIG_Pex14_2	171	175	PF04695	0.516
LIG_REV1ctd_RIR_1	214	222	PF16727	0.414
LIG_SH2_CRK	276	280	PF00017	0.413
LIG_SH2_NCK_1	142	146	PF00017	0.476
LIG_SH2_NCK_1	68	72	PF00017	0.568
LIG_SH2_STAP1	142	146	PF00017	0.476
LIG_SH2_STAP1	28	32	PF00017	0.551
LIG_SH2_STAT5	261	264	PF00017	0.421
LIG_SH2_STAT5	341	344	PF00017	0.493
LIG_SH3_3	124	130	PF00018	0.598
LIG_SH3_3	60	66	PF00018	0.568
LIG_SH3_3	94	100	PF00018	0.433
LIG_SUMO_SIM_par_1	263	269	PF11976	0.521
LIG_WRC_WIRS_1	213	218	PF05994	0.436
LIG_WRC_WIRS_1	342	347	PF05994	0.394
MOD_CDK_SPxxK_3	130	137	PF00069	0.653
MOD_CK1_1	235	241	PF00069	0.374
MOD_CK1_1	304	310	PF00069	0.443
MOD_CK2_1	101	107	PF00069	0.453
MOD_CK2_1	304	310	PF00069	0.545
MOD_GlcNHglycan	152	155	PF01048	0.484
MOD_GlcNHglycan	235	238	PF01048	0.494
MOD_GlcNHglycan	305	309	PF01048	0.431
MOD_GlcNHglycan	310	314	PF01048	0.457
MOD_GlcNHglycan	316	319	PF01048	0.401
MOD_GSK3_1	140	147	PF00069	0.544
MOD_GSK3_1	18	25	PF00069	0.494
MOD_GSK3_1	297	304	PF00069	0.429
MOD_N-GLC_1	301	306	PF02516	0.541
MOD_NEK2_1	101	106	PF00069	0.376
MOD_NEK2_1	150	155	PF00069	0.457
MOD_NEK2_1	18	23	PF00069	0.432
MOD_NEK2_1	233	238	PF00069	0.509
MOD_NEK2_1	266	271	PF00069	0.415
MOD_NEK2_1	343	348	PF00069	0.498
MOD_NEK2_2	290	295	PF00069	0.329
MOD_PIKK_1	204	210	PF00454	0.392
MOD_PIKK_1	343	349	PF00454	0.391
MOD_PKA_1	180	186	PF00069	0.441
MOD_PKA_2	16	22	PF00069	0.536
MOD_PKA_2	180	186	PF00069	0.402
MOD_Plk_1	211	217	PF00069	0.338
MOD_Plk_1	226	232	PF00069	0.403
MOD_Plk_2-3	327	333	PF00069	0.535
MOD_Plk_4	212	218	PF00069	0.434
MOD_Plk_4	272	278	PF00069	0.471
MOD_Plk_4	330	336	PF00069	0.357
MOD_Plk_4	69	75	PF00069	0.457
MOD_ProDKin_1	130	136	PF00069	0.652
MOD_ProDKin_1	246	252	PF00069	0.397
MOD_ProDKin_1	86	92	PF00069	0.390
MOD_SUMO_rev_2	198	205	PF00179	0.550
TRG_DiLeu_BaEn_3	29	35	PF01217	0.341
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.439
TRG_ENDOCYTIC_2	251	254	PF00928	0.373
TRG_ENDOCYTIC_2	276	279	PF00928	0.361
TRG_ENDOCYTIC_2	28	31	PF00928	0.457
TRG_ER_diArg_1	228	231	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN0	Leptomonas seymouri	47%	96%
A0A0S4JWP4	Bodo saltans	31%	100%
A0A1X0NM36	Trypanosomatidae	29%	100%
A0A3Q8IJW9	Leishmania donovani	99%	100%
A0A3R7M5E0	Trypanosoma rangeli	28%	100%
A4HQB3	Leishmania braziliensis	75%	100%
A6SRT0	Botryotinia fuckeliana (strain B05.10)	28%	100%
A7E3Z4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A9RBS1	Physcomitrium patens	31%	74%
A9V2Y9	Monosiga brevicollis	30%	100%
B3M173	Drosophila ananassae	33%	100%
B4G0F3	Zea mays	30%	72%
B4GFE6	Drosophila persimilis	32%	100%
B4I3X6	Drosophila sechellia	35%	100%
B4PV71	Drosophila yakuba	33%	100%
B4QW91	Drosophila simulans	33%	100%
B5X2D1	Salmo salar	32%	100%
B8BKI7	Oryza sativa subsp. indica	29%	72%
B9N1F9	Populus trichocarpa	30%	72%
B9SQI7	Ricinus communis	30%	71%
B9WAM8	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	100%
C3XR70	Branchiostoma floridae	26%	100%
C4YJE1	Candida albicans (strain WO-1)	24%	100%
C9SUS0	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	30%	100%
D2UYP1	Naegleria gruberi	27%	100%
E0CTF3	Vitis vinifera	29%	70%
E9AU26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q0VD27	Bos taurus	33%	100%
Q28C69	Xenopus tropicalis	29%	100%
Q296B0	Drosophila pseudoobscura pseudoobscura	31%	100%
Q2R483	Oryza sativa subsp. japonica	29%	72%
Q4Q0G9	Leishmania major	91%	100%
Q55FM6	Dictyostelium discoideum	27%	100%
Q5PPH0	Rattus norvegicus	32%	100%
Q6FLR5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	100%
Q6GMI7	Danio rerio	31%	100%
Q7Q9C0	Anopheles gambiae	28%	100%
Q8BGB7	Mus musculus	33%	100%
Q9FN41	Arabidopsis thaliana	32%	74%
Q9UHY7	Homo sapiens	32%	100%
Q9VN95	Drosophila melanogaster	34%	100%
V5BJ24	Trypanosoma cruzi	27%	100%