LeishMANIAdb
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Putative choline/ethanolamine phosphotransferase (CEPT)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative choline/ethanolamine phosphotransferase (CEPT)
Gene product:
choline/ethanolamine phosphotransferase - putative
Species:
Leishmania infantum
UniProt:
A4IE03_LEIIN
TriTrypDb:
LINF_360068900
Length:
417

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, choline/ethanolamine phosphotransferase (CEPT)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005635 nuclear envelope 4 1
GO:0005783 endoplasmic reticulum 5 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4IE03
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IE03

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006644 phospholipid metabolic process 4 9
GO:0006646 phosphatidylethanolamine biosynthetic process 6 1
GO:0006650 glycerophospholipid metabolic process 5 1
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0008152 metabolic process 1 9
GO:0008610 lipid biosynthetic process 4 9
GO:0008654 phospholipid biosynthetic process 5 9
GO:0009058 biosynthetic process 2 9
GO:0009987 cellular process 1 9
GO:0019637 organophosphate metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 9
GO:0045017 glycerolipid biosynthetic process 4 1
GO:0046337 phosphatidylethanolamine metabolic process 6 1
GO:0046474 glycerophospholipid biosynthetic process 5 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0071704 organic substance metabolic process 2 9
GO:0090407 organophosphate biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004142 diacylglycerol cholinephosphotransferase activity 6 4
GO:0004307 ethanolaminephosphotransferase activity 6 8
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 12
GO:0017169 CDP-alcohol phosphatidyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.447
CLV_NRD_NRD_1 119 121 PF00675 0.247
CLV_NRD_NRD_1 2 4 PF00675 0.452
CLV_NRD_NRD_1 28 30 PF00675 0.383
CLV_PCSK_KEX2_1 119 121 PF00082 0.247
CLV_PCSK_SKI1_1 245 249 PF00082 0.347
CLV_PCSK_SKI1_1 43 47 PF00082 0.364
DEG_APCC_DBOX_1 157 165 PF00400 0.369
DEG_APCC_DBOX_1 244 252 PF00400 0.415
DEG_APCC_DBOX_1 325 333 PF00400 0.467
DEG_ODPH_VHL_1 284 297 PF01847 0.330
DOC_CKS1_1 138 143 PF01111 0.300
DOC_CKS1_1 152 157 PF01111 0.300
DOC_MAPK_MEF2A_6 245 252 PF00069 0.385
DOC_MAPK_MEF2A_6 277 284 PF00069 0.497
DOC_PP1_RVXF_1 243 250 PF00149 0.300
DOC_PP1_RVXF_1 336 343 PF00149 0.514
DOC_PP4_FxxP_1 138 141 PF00568 0.315
DOC_USP7_MATH_1 2 6 PF00917 0.639
DOC_USP7_MATH_1 352 356 PF00917 0.446
DOC_USP7_MATH_1 363 367 PF00917 0.389
DOC_USP7_MATH_1 413 417 PF00917 0.688
DOC_WW_Pin1_4 122 127 PF00397 0.508
DOC_WW_Pin1_4 137 142 PF00397 0.300
DOC_WW_Pin1_4 151 156 PF00397 0.300
LIG_14-3-3_CanoR_1 158 167 PF00244 0.330
LIG_14-3-3_CanoR_1 3 12 PF00244 0.621
LIG_14-3-3_CanoR_1 326 330 PF00244 0.464
LIG_14-3-3_CanoR_1 331 337 PF00244 0.483
LIG_Actin_WH2_2 254 272 PF00022 0.436
LIG_BRCT_BRCA1_1 228 232 PF00533 0.373
LIG_BRCT_BRCA1_1 245 249 PF00533 0.235
LIG_BRCT_BRCA1_1 254 258 PF00533 0.334
LIG_eIF4E_1 99 105 PF01652 0.300
LIG_FHA_1 138 144 PF00498 0.300
LIG_FHA_1 179 185 PF00498 0.482
LIG_FHA_1 212 218 PF00498 0.373
LIG_FHA_1 236 242 PF00498 0.327
LIG_FHA_1 257 263 PF00498 0.330
LIG_FHA_1 67 73 PF00498 0.314
LIG_FHA_1 76 82 PF00498 0.288
LIG_FHA_2 152 158 PF00498 0.408
LIG_IRF3_LxIS_1 400 407 PF10401 0.547
LIG_LIR_Apic_2 136 141 PF02991 0.459
LIG_LIR_Apic_2 151 155 PF02991 0.349
LIG_LIR_Apic_2 16 22 PF02991 0.592
LIG_LIR_Gen_1 140 150 PF02991 0.352
LIG_LIR_Gen_1 168 177 PF02991 0.365
LIG_LIR_Gen_1 246 257 PF02991 0.345
LIG_LIR_Gen_1 339 350 PF02991 0.491
LIG_LIR_Gen_1 395 404 PF02991 0.464
LIG_LIR_Nem_3 140 145 PF02991 0.392
LIG_LIR_Nem_3 168 173 PF02991 0.372
LIG_LIR_Nem_3 221 227 PF02991 0.394
LIG_LIR_Nem_3 246 252 PF02991 0.308
LIG_LIR_Nem_3 255 261 PF02991 0.315
LIG_LIR_Nem_3 313 319 PF02991 0.300
LIG_LIR_Nem_3 339 345 PF02991 0.491
LIG_LIR_Nem_3 395 400 PF02991 0.456
LIG_LIR_Nem_3 67 71 PF02991 0.420
LIG_LIR_Nem_3 94 98 PF02991 0.410
LIG_LYPXL_yS_3 224 227 PF13949 0.336
LIG_MLH1_MIPbox_1 228 232 PF16413 0.409
LIG_PCNA_PIPBox_1 153 162 PF02747 0.352
LIG_PCNA_yPIPBox_3 146 158 PF02747 0.447
LIG_Pex14_1 342 346 PF04695 0.233
LIG_Pex14_1 95 99 PF04695 0.300
LIG_Pex14_2 138 142 PF04695 0.404
LIG_Pex14_2 170 174 PF04695 0.315
LIG_Rb_pABgroove_1 125 133 PF01858 0.447
LIG_SH2_CRK 152 156 PF00017 0.349
LIG_SH2_CRK 316 320 PF00017 0.395
LIG_SH2_CRK 337 341 PF00017 0.564
LIG_SH2_GRB2like 186 189 PF00017 0.539
LIG_SH2_GRB2like 49 52 PF00017 0.498
LIG_SH2_NCK_1 220 224 PF00017 0.394
LIG_SH2_PTP2 19 22 PF00017 0.570
LIG_SH2_SRC 186 189 PF00017 0.552
LIG_SH2_SRC 19 22 PF00017 0.570
LIG_SH2_STAP1 220 224 PF00017 0.369
LIG_SH2_STAP1 99 103 PF00017 0.311
LIG_SH2_STAT3 44 47 PF00017 0.505
LIG_SH2_STAT5 186 189 PF00017 0.520
LIG_SH2_STAT5 19 22 PF00017 0.520
LIG_SH2_STAT5 24 27 PF00017 0.499
LIG_SH2_STAT5 403 406 PF00017 0.504
LIG_SH2_STAT5 44 47 PF00017 0.362
LIG_SH2_STAT5 85 88 PF00017 0.271
LIG_SH3_3 184 190 PF00018 0.599
LIG_SH3_3 219 225 PF00018 0.331
LIG_SH3_3 251 257 PF00018 0.396
LIG_SH3_3 265 271 PF00018 0.526
LIG_SH3_3 296 302 PF00018 0.354
LIG_SH3_3 303 309 PF00018 0.384
LIG_SUMO_SIM_anti_2 34 42 PF11976 0.546
LIG_SUMO_SIM_anti_2 405 410 PF11976 0.599
LIG_TYR_ITIM 222 227 PF00017 0.336
LIG_TYR_ITIM 314 319 PF00017 0.408
LIG_UBA3_1 408 415 PF00899 0.569
LIG_WW_1 21 24 PF00397 0.542
MOD_CDK_SPxxK_3 151 158 PF00069 0.311
MOD_CK1_1 148 154 PF00069 0.407
MOD_CK1_1 162 168 PF00069 0.280
MOD_CK1_1 178 184 PF00069 0.427
MOD_CK1_1 243 249 PF00069 0.289
MOD_CK1_1 39 45 PF00069 0.513
MOD_CK1_1 395 401 PF00069 0.478
MOD_CK1_1 407 413 PF00069 0.532
MOD_CK2_1 151 157 PF00069 0.408
MOD_GlcNHglycan 203 206 PF01048 0.393
MOD_GlcNHglycan 213 217 PF01048 0.582
MOD_GlcNHglycan 332 335 PF01048 0.361
MOD_GlcNHglycan 354 357 PF01048 0.392
MOD_GlcNHglycan 394 397 PF01048 0.367
MOD_GSK3_1 118 125 PF00069 0.473
MOD_GSK3_1 159 166 PF00069 0.362
MOD_GSK3_1 207 214 PF00069 0.361
MOD_GSK3_1 252 259 PF00069 0.369
MOD_GSK3_1 269 276 PF00069 0.582
MOD_GSK3_1 318 325 PF00069 0.288
MOD_GSK3_1 32 39 PF00069 0.539
MOD_N-GLC_1 145 150 PF02516 0.385
MOD_N-GLC_1 235 240 PF02516 0.513
MOD_N-GLC_1 302 307 PF02516 0.534
MOD_NEK2_1 145 150 PF00069 0.435
MOD_NEK2_1 159 164 PF00069 0.230
MOD_NEK2_1 201 206 PF00069 0.309
MOD_NEK2_1 252 257 PF00069 0.297
MOD_NEK2_1 312 317 PF00069 0.299
MOD_NEK2_1 318 323 PF00069 0.293
MOD_NEK2_1 369 374 PF00069 0.364
MOD_NEK2_1 392 397 PF00069 0.277
MOD_NEK2_1 404 409 PF00069 0.510
MOD_NEK2_1 75 80 PF00069 0.318
MOD_NEK2_2 235 240 PF00069 0.355
MOD_NEK2_2 302 307 PF00069 0.334
MOD_PIKK_1 395 401 PF00454 0.470
MOD_PK_1 402 408 PF00069 0.543
MOD_PK_1 8 14 PF00069 0.626
MOD_PKA_1 3 9 PF00069 0.628
MOD_PKA_2 118 124 PF00069 0.447
MOD_PKA_2 2 8 PF00069 0.647
MOD_PKA_2 269 275 PF00069 0.570
MOD_PKA_2 325 331 PF00069 0.321
MOD_Plk_1 145 151 PF00069 0.420
MOD_Plk_1 212 218 PF00069 0.376
MOD_Plk_1 302 308 PF00069 0.389
MOD_Plk_1 312 318 PF00069 0.315
MOD_Plk_1 36 42 PF00069 0.504
MOD_Plk_4 148 154 PF00069 0.396
MOD_Plk_4 165 171 PF00069 0.156
MOD_Plk_4 207 213 PF00069 0.312
MOD_Plk_4 36 42 PF00069 0.495
MOD_Plk_4 369 375 PF00069 0.347
MOD_ProDKin_1 122 128 PF00069 0.508
MOD_ProDKin_1 137 143 PF00069 0.300
MOD_ProDKin_1 151 157 PF00069 0.300
MOD_SUMO_rev_2 111 118 PF00179 0.447
TRG_ENDOCYTIC_2 107 110 PF00928 0.282
TRG_ENDOCYTIC_2 224 227 PF00928 0.373
TRG_ENDOCYTIC_2 316 319 PF00928 0.365
TRG_ENDOCYTIC_2 337 340 PF00928 0.483
TRG_ENDOCYTIC_2 389 392 PF00928 0.300
TRG_ENDOCYTIC_2 403 406 PF00928 0.532
TRG_ENDOCYTIC_2 49 52 PF00928 0.495
TRG_ENDOCYTIC_2 83 86 PF00928 0.294
TRG_ENDOCYTIC_2 99 102 PF00928 0.312
TRG_NLS_MonoExtN_4 26 33 PF00514 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I260 Leptomonas seymouri 64% 100%
A0A0S4JA45 Bodo saltans 38% 95%
A0A1X0NLI0 Trypanosomatidae 49% 92%
A0A3Q8IRT0 Leishmania donovani 100% 100%
A0A3R7NAX1 Trypanosoma rangeli 48% 97%
A4HQA8 Leishmania braziliensis 80% 100%
D0A400 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 97%
E9AU25 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
O82567 Arabidopsis thaliana 31% 100%
O82568 Arabidopsis thaliana 32% 100%
P17898 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q4Q0H0 Leishmania major 94% 100%
Q550W1 Dictyostelium discoideum 29% 100%
Q55AQ3 Dictyostelium discoideum 31% 100%
V5B3K4 Trypanosoma cruzi 49% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS