LeishMANIAdb
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A44l protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
A44l protein-like protein
Gene product:
a44l protein-like protein
Species:
Leishmania infantum
UniProt:
A4IDZ9_LEIIN
TriTrypDb:
LINF_360068500
Length:
719

Annotations

Annotations by Jardim et al.

Membrane associated proteins, A44l -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4IDZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDZ9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0005488 binding 1 19
GO:0005524 ATP binding 5 19
GO:0016462 pyrophosphatase activity 5 19
GO:0016787 hydrolase activity 2 19
GO:0016817 hydrolase activity, acting on acid anhydrides 3 19
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 19
GO:0016887 ATP hydrolysis activity 7 19
GO:0017076 purine nucleotide binding 4 19
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 19
GO:0030554 adenyl nucleotide binding 5 19
GO:0032553 ribonucleotide binding 3 19
GO:0032555 purine ribonucleotide binding 4 19
GO:0032559 adenyl ribonucleotide binding 5 19
GO:0035639 purine ribonucleoside triphosphate binding 4 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 180 184 PF00656 0.570
CLV_C14_Caspase3-7 460 464 PF00656 0.728
CLV_C14_Caspase3-7 628 632 PF00656 0.634
CLV_C14_Caspase3-7 695 699 PF00656 0.467
CLV_NRD_NRD_1 115 117 PF00675 0.298
CLV_NRD_NRD_1 204 206 PF00675 0.401
CLV_NRD_NRD_1 211 213 PF00675 0.382
CLV_NRD_NRD_1 228 230 PF00675 0.315
CLV_NRD_NRD_1 402 404 PF00675 0.436
CLV_NRD_NRD_1 467 469 PF00675 0.518
CLV_NRD_NRD_1 643 645 PF00675 0.446
CLV_PCSK_FUR_1 400 404 PF00082 0.479
CLV_PCSK_KEX2_1 204 206 PF00082 0.401
CLV_PCSK_KEX2_1 228 230 PF00082 0.326
CLV_PCSK_KEX2_1 322 324 PF00082 0.293
CLV_PCSK_KEX2_1 402 404 PF00082 0.453
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.309
CLV_PCSK_PC7_1 318 324 PF00082 0.329
CLV_PCSK_SKI1_1 122 126 PF00082 0.431
CLV_PCSK_SKI1_1 205 209 PF00082 0.364
CLV_PCSK_SKI1_1 288 292 PF00082 0.353
CLV_PCSK_SKI1_1 375 379 PF00082 0.329
CLV_PCSK_SKI1_1 446 450 PF00082 0.494
CLV_PCSK_SKI1_1 469 473 PF00082 0.532
DEG_APCC_DBOX_1 479 487 PF00400 0.536
DEG_Nend_Nbox_1 1 3 PF02207 0.753
DEG_SCF_SKP2-CKS1_1 557 564 PF00560 0.637
DEG_SPOP_SBC_1 360 364 PF00917 0.443
DOC_CKS1_1 677 682 PF01111 0.642
DOC_CKS1_1 96 101 PF01111 0.214
DOC_CYCLIN_yClb1_LxF_4 307 312 PF00134 0.529
DOC_CYCLIN_yCln2_LP_2 165 171 PF00134 0.611
DOC_MAPK_gen_1 130 138 PF00069 0.557
DOC_MAPK_gen_1 162 171 PF00069 0.599
DOC_MAPK_gen_1 204 211 PF00069 0.621
DOC_MAPK_gen_1 517 527 PF00069 0.565
DOC_MAPK_MEF2A_6 162 171 PF00069 0.602
DOC_MAPK_MEF2A_6 204 211 PF00069 0.606
DOC_MAPK_MEF2A_6 335 342 PF00069 0.494
DOC_PP1_RVXF_1 307 313 PF00149 0.516
DOC_PP1_RVXF_1 372 379 PF00149 0.529
DOC_PP1_RVXF_1 615 621 PF00149 0.633
DOC_PP2B_LxvP_1 165 168 PF13499 0.595
DOC_PP2B_LxvP_1 2 5 PF13499 0.590
DOC_USP7_MATH_1 13 17 PF00917 0.618
DOC_USP7_MATH_1 203 207 PF00917 0.646
DOC_USP7_MATH_1 341 345 PF00917 0.538
DOC_USP7_MATH_1 392 396 PF00917 0.633
DOC_USP7_MATH_1 464 468 PF00917 0.753
DOC_USP7_MATH_1 605 609 PF00917 0.750
DOC_USP7_MATH_1 91 95 PF00917 0.326
DOC_WW_Pin1_4 213 218 PF00397 0.564
DOC_WW_Pin1_4 45 50 PF00397 0.666
DOC_WW_Pin1_4 558 563 PF00397 0.675
DOC_WW_Pin1_4 676 681 PF00397 0.555
DOC_WW_Pin1_4 95 100 PF00397 0.214
LIG_14-3-3_CanoR_1 130 135 PF00244 0.587
LIG_14-3-3_CanoR_1 15 19 PF00244 0.558
LIG_14-3-3_CanoR_1 204 208 PF00244 0.627
LIG_14-3-3_CanoR_1 391 401 PF00244 0.613
LIG_14-3-3_CanoR_1 468 472 PF00244 0.784
LIG_14-3-3_CanoR_1 480 490 PF00244 0.485
LIG_14-3-3_CanoR_1 520 529 PF00244 0.561
LIG_14-3-3_CanoR_1 669 675 PF00244 0.550
LIG_14-3-3_CanoR_1 705 714 PF00244 0.621
LIG_14-3-3_CanoR_1 71 78 PF00244 0.371
LIG_Actin_WH2_2 2 17 PF00022 0.668
LIG_APCC_ABBA_1 158 163 PF00400 0.568
LIG_BIR_III_4 463 467 PF00653 0.659
LIG_BRCT_BRCA1_1 672 676 PF00533 0.578
LIG_FHA_1 106 112 PF00498 0.370
LIG_FHA_1 442 448 PF00498 0.631
LIG_FHA_1 520 526 PF00498 0.474
LIG_FHA_1 53 59 PF00498 0.402
LIG_FHA_1 96 102 PF00498 0.283
LIG_FHA_2 123 129 PF00498 0.614
LIG_FHA_2 178 184 PF00498 0.511
LIG_FHA_2 344 350 PF00498 0.458
LIG_FHA_2 383 389 PF00498 0.527
LIG_FHA_2 474 480 PF00498 0.699
LIG_FHA_2 609 615 PF00498 0.638
LIG_Integrin_RGD_1 347 349 PF01839 0.243
LIG_LIR_Apic_2 140 145 PF02991 0.636
LIG_LIR_Apic_2 93 99 PF02991 0.354
LIG_LIR_Gen_1 206 214 PF02991 0.516
LIG_LIR_Gen_1 365 376 PF02991 0.502
LIG_LIR_Gen_1 528 536 PF02991 0.534
LIG_LIR_Gen_1 673 680 PF02991 0.606
LIG_LIR_Nem_3 149 154 PF02991 0.749
LIG_LIR_Nem_3 206 211 PF02991 0.504
LIG_LIR_Nem_3 349 355 PF02991 0.433
LIG_LIR_Nem_3 365 371 PF02991 0.436
LIG_LIR_Nem_3 45 50 PF02991 0.636
LIG_LIR_Nem_3 528 532 PF02991 0.478
LIG_LIR_Nem_3 673 677 PF02991 0.579
LIG_LIR_Nem_3 94 100 PF02991 0.266
LIG_NRBOX 309 315 PF00104 0.434
LIG_NRBOX 482 488 PF00104 0.570
LIG_PCNA_PIPBox_1 135 144 PF02747 0.525
LIG_PTB_Apo_2 128 135 PF02174 0.613
LIG_RPA_C_Fungi 17 29 PF08784 0.408
LIG_SH2_CRK 142 146 PF00017 0.553
LIG_SH2_CRK 674 678 PF00017 0.501
LIG_SH2_NCK_1 142 146 PF00017 0.545
LIG_SH2_PTP2 529 532 PF00017 0.338
LIG_SH2_SRC 100 103 PF00017 0.359
LIG_SH2_STAP1 73 77 PF00017 0.530
LIG_SH2_STAT5 238 241 PF00017 0.388
LIG_SH2_STAT5 243 246 PF00017 0.404
LIG_SH2_STAT5 254 257 PF00017 0.350
LIG_SH2_STAT5 356 359 PF00017 0.274
LIG_SH2_STAT5 529 532 PF00017 0.322
LIG_SH2_STAT5 703 706 PF00017 0.387
LIG_SH2_STAT5 83 86 PF00017 0.441
LIG_SH2_STAT5 97 100 PF00017 0.323
LIG_SH3_1 96 102 PF00018 0.233
LIG_SH3_3 151 157 PF00018 0.527
LIG_SH3_3 166 172 PF00018 0.419
LIG_SH3_3 265 271 PF00018 0.540
LIG_SH3_3 276 282 PF00018 0.464
LIG_SH3_3 335 341 PF00018 0.463
LIG_SH3_3 398 404 PF00018 0.683
LIG_SH3_3 559 565 PF00018 0.693
LIG_SH3_3 96 102 PF00018 0.252
LIG_SH3_4 429 436 PF00018 0.562
LIG_SUMO_SIM_anti_2 495 504 PF11976 0.510
LIG_SUMO_SIM_anti_2 53 58 PF11976 0.322
LIG_SUMO_SIM_par_1 137 143 PF11976 0.449
LIG_SUMO_SIM_par_1 500 506 PF11976 0.428
LIG_SUMO_SIM_par_1 587 594 PF11976 0.526
LIG_TRAF2_1 364 367 PF00917 0.467
LIG_TRAF2_1 440 443 PF00917 0.752
LIG_TRAF2_1 656 659 PF00917 0.443
LIG_UBA3_1 110 117 PF00899 0.351
LIG_UBA3_1 135 144 PF00899 0.563
LIG_WRC_WIRS_1 342 347 PF05994 0.394
MOD_CDK_SPxK_1 558 564 PF00069 0.562
MOD_CK1_1 140 146 PF00069 0.549
MOD_CK1_1 343 349 PF00069 0.267
MOD_CK1_1 359 365 PF00069 0.193
MOD_CK1_1 419 425 PF00069 0.687
MOD_CK1_1 437 443 PF00069 0.664
MOD_CK1_1 45 51 PF00069 0.586
MOD_CK1_1 467 473 PF00069 0.744
MOD_CK1_1 482 488 PF00069 0.364
MOD_CK1_1 577 583 PF00069 0.693
MOD_CK1_1 608 614 PF00069 0.526
MOD_CK2_1 122 128 PF00069 0.443
MOD_CK2_1 13 19 PF00069 0.567
MOD_CK2_1 143 149 PF00069 0.484
MOD_CK2_1 360 366 PF00069 0.444
MOD_CK2_1 437 443 PF00069 0.735
MOD_Cter_Amidation 320 323 PF01082 0.394
MOD_GlcNHglycan 10 13 PF01048 0.514
MOD_GlcNHglycan 200 203 PF01048 0.477
MOD_GlcNHglycan 418 421 PF01048 0.681
MOD_GlcNHglycan 575 579 PF01048 0.703
MOD_GlcNHglycan 625 628 PF01048 0.651
MOD_GlcNHglycan 700 703 PF01048 0.453
MOD_GlcNHglycan 709 712 PF01048 0.564
MOD_GlcNHglycan 93 96 PF01048 0.526
MOD_GSK3_1 14 21 PF00069 0.628
MOD_GSK3_1 189 196 PF00069 0.535
MOD_GSK3_1 317 324 PF00069 0.249
MOD_GSK3_1 356 363 PF00069 0.335
MOD_GSK3_1 405 412 PF00069 0.518
MOD_GSK3_1 437 444 PF00069 0.748
MOD_GSK3_1 550 557 PF00069 0.729
MOD_GSK3_1 563 570 PF00069 0.675
MOD_GSK3_1 72 79 PF00069 0.538
MOD_GSK3_1 91 98 PF00069 0.547
MOD_N-GLC_1 130 135 PF02516 0.488
MOD_N-GLC_1 705 710 PF02516 0.538
MOD_NEK2_1 176 181 PF00069 0.342
MOD_NEK2_1 18 23 PF00069 0.543
MOD_NEK2_1 264 269 PF00069 0.534
MOD_NEK2_1 370 375 PF00069 0.353
MOD_NEK2_1 481 486 PF00069 0.498
MOD_NEK2_1 52 57 PF00069 0.339
MOD_NEK2_1 574 579 PF00069 0.562
MOD_NEK2_1 625 630 PF00069 0.542
MOD_NEK2_2 203 208 PF00069 0.393
MOD_PIKK_1 409 415 PF00454 0.695
MOD_PIKK_1 429 435 PF00454 0.562
MOD_PIKK_1 660 666 PF00454 0.437
MOD_PKA_2 14 20 PF00069 0.442
MOD_PKA_2 203 209 PF00069 0.496
MOD_PKA_2 317 323 PF00069 0.394
MOD_PKA_2 392 398 PF00069 0.564
MOD_PKA_2 467 473 PF00069 0.709
MOD_PKA_2 479 485 PF00069 0.486
MOD_PKA_2 519 525 PF00069 0.464
MOD_PKA_2 605 611 PF00069 0.543
MOD_PKA_2 670 676 PF00069 0.406
MOD_Plk_1 130 136 PF00069 0.494
MOD_Plk_1 52 58 PF00069 0.380
MOD_Plk_4 130 136 PF00069 0.433
MOD_Plk_4 137 143 PF00069 0.430
MOD_Plk_4 275 281 PF00069 0.422
MOD_Plk_4 286 292 PF00069 0.398
MOD_Plk_4 356 362 PF00069 0.270
MOD_Plk_4 467 473 PF00069 0.571
MOD_Plk_4 482 488 PF00069 0.336
MOD_Plk_4 52 58 PF00069 0.381
MOD_ProDKin_1 213 219 PF00069 0.433
MOD_ProDKin_1 45 51 PF00069 0.581
MOD_ProDKin_1 558 564 PF00069 0.599
MOD_ProDKin_1 676 682 PF00069 0.433
MOD_ProDKin_1 95 101 PF00069 0.233
TRG_DiLeu_BaEn_1 19 24 PF01217 0.410
TRG_DiLeu_BaEn_1 366 371 PF01217 0.274
TRG_DiLeu_BaEn_1 531 536 PF01217 0.490
TRG_DiLeu_BaEn_2 154 160 PF01217 0.450
TRG_DiLeu_BaEn_4 366 372 PF01217 0.274
TRG_DiLeu_LyEn_5 19 24 PF01217 0.410
TRG_ENDOCYTIC_2 151 154 PF00928 0.521
TRG_ENDOCYTIC_2 47 50 PF00928 0.591
TRG_ENDOCYTIC_2 529 532 PF00928 0.402
TRG_ENDOCYTIC_2 571 574 PF00928 0.565
TRG_ENDOCYTIC_2 674 677 PF00928 0.512
TRG_ENDOCYTIC_2 85 88 PF00928 0.508
TRG_ER_diArg_1 209 212 PF00400 0.469
TRG_ER_diArg_1 227 229 PF00400 0.393
TRG_ER_diArg_1 390 393 PF00400 0.458
TRG_ER_diArg_1 399 402 PF00400 0.533
TRG_Pf-PMV_PEXEL_1 116 120 PF00026 0.399

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P906 Leptomonas seymouri 46% 98%
A0A1X0NTT2 Trypanosomatidae 33% 100%
A0A3Q8IC80 Leishmania donovani 28% 97%
A0A3Q8IC95 Leishmania donovani 28% 100%
A0A3Q8IHZ0 Leishmania donovani 100% 100%
A0A422NUH1 Trypanosoma rangeli 30% 100%
A4HCE5 Leishmania braziliensis 27% 96%
A4HZW7 Leishmania infantum 28% 100%
C9ZSJ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AU21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AVS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AVS6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 98%
Q4Q0H4 Leishmania major 90% 100%
Q4QBQ3 Leishmania major 29% 100%
Q4QBQ4 Leishmania major 29% 100%
V5D9P2 Trypanosoma cruzi 27% 100%
V5DMJ8 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS