LeishMANIAdb
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ULP_PROTEASE domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ULP_PROTEASE domain-containing protein
Gene product:
flagellum targeting protein kharon1 - putative
Species:
Leishmania infantum
UniProt:
A4IDZ8_LEIIN
TriTrypDb:
LINF_360068400
Length:
530

Annotations

Annotations by Jardim et al.

Flagella, flagellum targeting kharon1 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 163, 322, 401, 403, 406, 508
Promastigote: 311, 373, 377
Promastigote/Amastigote: 158, 17, 264, 294, 327, 364, 42, 44, 441

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDZ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDZ8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 121 123 PF00675 0.581
CLV_NRD_NRD_1 152 154 PF00675 0.541
CLV_NRD_NRD_1 22 24 PF00675 0.495
CLV_NRD_NRD_1 290 292 PF00675 0.572
CLV_NRD_NRD_1 300 302 PF00675 0.452
CLV_NRD_NRD_1 393 395 PF00675 0.574
CLV_NRD_NRD_1 47 49 PF00675 0.612
CLV_NRD_NRD_1 84 86 PF00675 0.540
CLV_PCSK_KEX2_1 121 123 PF00082 0.645
CLV_PCSK_KEX2_1 141 143 PF00082 0.590
CLV_PCSK_KEX2_1 154 156 PF00082 0.495
CLV_PCSK_KEX2_1 220 222 PF00082 0.613
CLV_PCSK_KEX2_1 393 395 PF00082 0.574
CLV_PCSK_KEX2_1 448 450 PF00082 0.608
CLV_PCSK_KEX2_1 47 49 PF00082 0.612
CLV_PCSK_KEX2_1 491 493 PF00082 0.600
CLV_PCSK_KEX2_1 84 86 PF00082 0.540
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.547
CLV_PCSK_PC1ET2_1 154 156 PF00082 0.479
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.613
CLV_PCSK_PC1ET2_1 448 450 PF00082 0.608
CLV_PCSK_PC1ET2_1 491 493 PF00082 0.578
CLV_PCSK_PC7_1 444 450 PF00082 0.485
CLV_PCSK_SKI1_1 228 232 PF00082 0.600
CLV_PCSK_SKI1_1 462 466 PF00082 0.580
CLV_PCSK_SKI1_1 67 71 PF00082 0.528
CLV_PCSK_SKI1_1 78 82 PF00082 0.469
DOC_CKS1_1 309 314 PF01111 0.526
DOC_CKS1_1 506 511 PF01111 0.509
DOC_MAPK_gen_1 521 529 PF00069 0.564
DOC_MAPK_MEF2A_6 33 40 PF00069 0.480
DOC_MAPK_NFAT4_5 33 41 PF00069 0.484
DOC_PP4_FxxP_1 63 66 PF00568 0.517
DOC_PP4_FxxP_1 70 73 PF00568 0.456
DOC_USP7_MATH_1 261 265 PF00917 0.484
DOC_USP7_MATH_1 367 371 PF00917 0.599
DOC_USP7_MATH_1 41 45 PF00917 0.497
DOC_USP7_MATH_1 428 432 PF00917 0.560
DOC_USP7_MATH_1 71 75 PF00917 0.448
DOC_USP7_UBL2_3 150 154 PF12436 0.590
DOC_USP7_UBL2_3 256 260 PF12436 0.565
DOC_WW_Pin1_4 14 19 PF00397 0.457
DOC_WW_Pin1_4 3 8 PF00397 0.614
DOC_WW_Pin1_4 308 313 PF00397 0.533
DOC_WW_Pin1_4 324 329 PF00397 0.415
DOC_WW_Pin1_4 418 423 PF00397 0.570
DOC_WW_Pin1_4 442 447 PF00397 0.551
DOC_WW_Pin1_4 505 510 PF00397 0.512
DOC_WW_Pin1_4 62 67 PF00397 0.530
LIG_14-3-3_CanoR_1 121 130 PF00244 0.525
LIG_14-3-3_CanoR_1 291 296 PF00244 0.493
LIG_14-3-3_CanoR_1 418 422 PF00244 0.568
LIG_14-3-3_CanoR_1 60 66 PF00244 0.518
LIG_14-3-3_CanoR_1 9 13 PF00244 0.558
LIG_BIR_III_2 213 217 PF00653 0.516
LIG_EVH1_2 76 80 PF00568 0.516
LIG_FHA_1 161 167 PF00498 0.459
LIG_FHA_1 345 351 PF00498 0.573
LIG_FHA_1 404 410 PF00498 0.501
LIG_FHA_1 506 512 PF00498 0.492
LIG_FHA_2 103 109 PF00498 0.498
LIG_FHA_2 177 183 PF00498 0.527
LIG_FHA_2 272 278 PF00498 0.499
LIG_LIR_Apic_2 322 328 PF02991 0.560
LIG_LIR_Apic_2 68 73 PF02991 0.506
LIG_MYND_1 296 300 PF01753 0.463
LIG_PCNA_yPIPBox_3 466 478 PF02747 0.485
LIG_SH2_STAT3 136 139 PF00017 0.499
LIG_SH2_STAT3 410 413 PF00017 0.536
LIG_SH2_STAT5 102 105 PF00017 0.502
LIG_SH2_STAT5 202 205 PF00017 0.603
LIG_SH2_STAT5 273 276 PF00017 0.496
LIG_SH2_STAT5 463 466 PF00017 0.458
LIG_SH3_2 181 186 PF14604 0.529
LIG_SH3_2 296 301 PF14604 0.464
LIG_SH3_2 73 78 PF14604 0.504
LIG_SH3_3 175 181 PF00018 0.538
LIG_SH3_3 205 211 PF00018 0.572
LIG_SH3_3 220 226 PF00018 0.455
LIG_SH3_3 233 239 PF00018 0.497
LIG_SH3_3 293 299 PF00018 0.530
LIG_SH3_3 302 308 PF00018 0.475
LIG_SH3_3 487 493 PF00018 0.541
LIG_SH3_3 70 76 PF00018 0.532
LIG_SUMO_SIM_anti_2 263 269 PF11976 0.510
LIG_TRAF2_1 238 241 PF00917 0.504
LIG_TRAF2_1 313 316 PF00917 0.473
LIG_WW_3 209 213 PF00397 0.573
LIG_WW_3 298 302 PF00397 0.495
LIG_WW_3 57 61 PF00397 0.525
LIG_WW_3 75 79 PF00397 0.404
MOD_CDC14_SPxK_1 327 330 PF00782 0.449
MOD_CDC14_SPxK_1 445 448 PF00782 0.557
MOD_CDC14_SPxK_1 6 9 PF00782 0.571
MOD_CDK_SPK_2 14 19 PF00069 0.439
MOD_CDK_SPK_2 442 447 PF00069 0.512
MOD_CDK_SPK_2 62 67 PF00069 0.530
MOD_CDK_SPxK_1 3 9 PF00069 0.571
MOD_CDK_SPxK_1 308 314 PF00069 0.529
MOD_CDK_SPxK_1 324 330 PF00069 0.417
MOD_CDK_SPxK_1 442 448 PF00069 0.551
MOD_CDK_SPxxK_3 14 21 PF00069 0.431
MOD_CDK_SPxxK_3 418 425 PF00069 0.573
MOD_CDK_SPxxK_3 442 449 PF00069 0.551
MOD_CK1_1 110 116 PF00069 0.478
MOD_CK1_1 124 130 PF00069 0.428
MOD_CK1_1 370 376 PF00069 0.558
MOD_CK1_1 379 385 PF00069 0.560
MOD_CK1_1 392 398 PF00069 0.548
MOD_CK1_1 403 409 PF00069 0.507
MOD_CK1_1 421 427 PF00069 0.552
MOD_CK1_1 523 529 PF00069 0.563
MOD_CK1_1 93 99 PF00069 0.374
MOD_CK2_1 176 182 PF00069 0.533
MOD_CK2_1 271 277 PF00069 0.503
MOD_CK2_1 291 297 PF00069 0.372
MOD_CK2_1 494 500 PF00069 0.608
MOD_CK2_1 62 68 PF00069 0.527
MOD_Cter_Amidation 218 221 PF01082 0.602
MOD_DYRK1A_RPxSP_1 418 422 PF00069 0.516
MOD_DYRK1A_RPxSP_1 442 446 PF00069 0.514
MOD_GlcNHglycan 115 118 PF01048 0.554
MOD_GlcNHglycan 132 135 PF01048 0.515
MOD_GlcNHglycan 26 29 PF01048 0.500
MOD_GlcNHglycan 293 296 PF01048 0.485
MOD_GlcNHglycan 378 381 PF01048 0.534
MOD_GlcNHglycan 398 401 PF01048 0.456
MOD_GlcNHglycan 402 405 PF01048 0.529
MOD_GlcNHglycan 43 46 PF01048 0.416
MOD_GSK3_1 103 110 PF00069 0.519
MOD_GSK3_1 370 377 PF00069 0.557
MOD_GSK3_1 392 399 PF00069 0.559
MOD_GSK3_1 417 424 PF00069 0.550
MOD_GSK3_1 438 445 PF00069 0.530
MOD_GSK3_1 494 501 PF00069 0.552
MOD_N-GLC_1 24 29 PF02516 0.484
MOD_N-GLC_1 261 266 PF02516 0.521
MOD_N-GLC_1 61 66 PF02516 0.489
MOD_N-GLC_2 174 176 PF02516 0.567
MOD_NEK2_1 246 251 PF00069 0.542
MOD_NEK2_1 454 459 PF00069 0.449
MOD_PIKK_1 135 141 PF00454 0.529
MOD_PK_1 155 161 PF00069 0.535
MOD_PK_1 398 404 PF00069 0.507
MOD_PKA_1 121 127 PF00069 0.548
MOD_PKA_1 291 297 PF00069 0.492
MOD_PKA_2 121 127 PF00069 0.548
MOD_PKA_2 392 398 PF00069 0.580
MOD_PKA_2 417 423 PF00069 0.557
MOD_PKA_2 428 434 PF00069 0.500
MOD_PKA_2 523 529 PF00069 0.563
MOD_PKA_2 8 14 PF00069 0.502
MOD_PKA_2 90 96 PF00069 0.488
MOD_PKB_1 153 161 PF00069 0.518
MOD_Plk_1 107 113 PF00069 0.522
MOD_Plk_1 261 267 PF00069 0.527
MOD_Plk_1 454 460 PF00069 0.448
MOD_Plk_4 93 99 PF00069 0.362
MOD_ProDKin_1 14 20 PF00069 0.453
MOD_ProDKin_1 3 9 PF00069 0.616
MOD_ProDKin_1 308 314 PF00069 0.529
MOD_ProDKin_1 324 330 PF00069 0.417
MOD_ProDKin_1 418 424 PF00069 0.570
MOD_ProDKin_1 442 448 PF00069 0.551
MOD_ProDKin_1 505 511 PF00069 0.510
MOD_ProDKin_1 62 68 PF00069 0.527
MOD_SUMO_for_1 313 316 PF00179 0.481
MOD_SUMO_rev_2 497 503 PF00179 0.546
TRG_ER_diArg_1 120 122 PF00400 0.538
TRG_ER_diArg_1 166 169 PF00400 0.483
TRG_ER_diArg_1 18 21 PF00400 0.422
TRG_ER_diArg_1 47 49 PF00400 0.568
TRG_ER_diArg_1 83 85 PF00400 0.536
TRG_NLS_Bipartite_1 141 157 PF00514 0.476
TRG_NLS_MonoExtC_3 149 154 PF00514 0.499
TRG_NLS_MonoExtN_4 148 154 PF00514 0.546
TRG_NLS_MonoExtN_4 21 27 PF00514 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IL75 Leishmania donovani 100% 100%
A4HQA3 Leishmania braziliensis 64% 96%
E9AU20 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 98%
Q4Q0H5 Leishmania major 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS