LeishMANIAdb
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Mkiaa0324 protein-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mkiaa0324 protein-like protein
Gene product:
mkiaa0324 protein-like protein
Species:
Leishmania infantum
UniProt:
A4IDZ5_LEIIN
TriTrypDb:
LINF_360068000
Length:
500

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Mkiaa0324 -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDZ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.529
CLV_NRD_NRD_1 132 134 PF00675 0.466
CLV_NRD_NRD_1 175 177 PF00675 0.485
CLV_NRD_NRD_1 183 185 PF00675 0.536
CLV_NRD_NRD_1 193 195 PF00675 0.552
CLV_NRD_NRD_1 199 201 PF00675 0.471
CLV_NRD_NRD_1 211 213 PF00675 0.584
CLV_NRD_NRD_1 217 219 PF00675 0.545
CLV_NRD_NRD_1 248 250 PF00675 0.589
CLV_NRD_NRD_1 294 296 PF00675 0.675
CLV_NRD_NRD_1 302 304 PF00675 0.568
CLV_NRD_NRD_1 324 326 PF00675 0.700
CLV_NRD_NRD_1 33 35 PF00675 0.605
CLV_NRD_NRD_1 331 333 PF00675 0.529
CLV_NRD_NRD_1 376 378 PF00675 0.528
CLV_NRD_NRD_1 404 406 PF00675 0.602
CLV_NRD_NRD_1 67 69 PF00675 0.488
CLV_NRD_NRD_1 84 86 PF00675 0.513
CLV_PCSK_FUR_1 194 198 PF00082 0.601
CLV_PCSK_FUR_1 243 247 PF00082 0.494
CLV_PCSK_KEX2_1 103 105 PF00082 0.531
CLV_PCSK_KEX2_1 12 14 PF00082 0.504
CLV_PCSK_KEX2_1 132 134 PF00082 0.466
CLV_PCSK_KEX2_1 144 146 PF00082 0.322
CLV_PCSK_KEX2_1 163 165 PF00082 0.393
CLV_PCSK_KEX2_1 177 179 PF00082 0.562
CLV_PCSK_KEX2_1 192 194 PF00082 0.586
CLV_PCSK_KEX2_1 196 198 PF00082 0.414
CLV_PCSK_KEX2_1 228 230 PF00082 0.543
CLV_PCSK_KEX2_1 245 247 PF00082 0.521
CLV_PCSK_KEX2_1 248 250 PF00082 0.546
CLV_PCSK_KEX2_1 258 260 PF00082 0.492
CLV_PCSK_KEX2_1 274 276 PF00082 0.426
CLV_PCSK_KEX2_1 301 303 PF00082 0.595
CLV_PCSK_KEX2_1 323 325 PF00082 0.568
CLV_PCSK_KEX2_1 330 332 PF00082 0.529
CLV_PCSK_KEX2_1 376 378 PF00082 0.528
CLV_PCSK_KEX2_1 406 408 PF00082 0.658
CLV_PCSK_KEX2_1 484 486 PF00082 0.496
CLV_PCSK_KEX2_1 67 69 PF00082 0.465
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.531
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.371
CLV_PCSK_PC1ET2_1 144 146 PF00082 0.455
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.393
CLV_PCSK_PC1ET2_1 177 179 PF00082 0.562
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.541
CLV_PCSK_PC1ET2_1 228 230 PF00082 0.541
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.444
CLV_PCSK_PC1ET2_1 258 260 PF00082 0.495
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.636
CLV_PCSK_PC1ET2_1 301 303 PF00082 0.595
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.638
CLV_PCSK_PC1ET2_1 406 408 PF00082 0.622
CLV_PCSK_PC1ET2_1 484 486 PF00082 0.472
CLV_PCSK_PC7_1 140 146 PF00082 0.415
CLV_PCSK_PC7_1 192 198 PF00082 0.484
CLV_PCSK_PC7_1 254 260 PF00082 0.571
CLV_PCSK_SKI1_1 118 122 PF00082 0.637
CLV_PCSK_SKI1_1 144 148 PF00082 0.480
CLV_PCSK_SKI1_1 201 205 PF00082 0.716
CLV_PCSK_SKI1_1 213 217 PF00082 0.741
CLV_PCSK_SKI1_1 295 299 PF00082 0.509
CLV_PCSK_SKI1_1 359 363 PF00082 0.396
CLV_PCSK_SKI1_1 435 439 PF00082 0.388
CLV_PCSK_SKI1_1 485 489 PF00082 0.395
CLV_PCSK_SKI1_1 71 75 PF00082 0.409
CLV_PCSK_SKI1_1 79 83 PF00082 0.465
CLV_Separin_Metazoa 129 133 PF03568 0.448
DEG_APCC_DBOX_1 139 147 PF00400 0.418
DEG_Nend_Nbox_1 1 3 PF02207 0.485
DOC_CYCLIN_yClb5_NLxxxL_5 140 147 PF00134 0.391
DOC_MAPK_gen_1 103 109 PF00069 0.497
DOC_MAPK_gen_1 144 151 PF00069 0.506
DOC_MAPK_gen_1 163 171 PF00069 0.406
DOC_MAPK_gen_1 258 265 PF00069 0.529
DOC_MAPK_gen_1 330 339 PF00069 0.472
DOC_MAPK_MEF2A_6 163 171 PF00069 0.391
DOC_MAPK_MEF2A_6 258 267 PF00069 0.530
DOC_MAPK_MEF2A_6 330 339 PF00069 0.446
DOC_MAPK_RevD_3 261 275 PF00069 0.535
DOC_PP2B_LxvP_1 159 162 PF13499 0.493
DOC_PP4_FxxP_1 54 57 PF00568 0.366
DOC_USP7_MATH_1 15 19 PF00917 0.429
DOC_USP7_MATH_1 203 207 PF00917 0.605
DOC_USP7_MATH_1 208 212 PF00917 0.555
DOC_USP7_MATH_1 233 237 PF00917 0.526
DOC_USP7_MATH_1 273 277 PF00917 0.610
DOC_USP7_MATH_1 297 301 PF00917 0.603
DOC_USP7_MATH_1 424 428 PF00917 0.508
DOC_USP7_MATH_1 8 12 PF00917 0.500
DOC_USP7_MATH_1 89 93 PF00917 0.577
DOC_USP7_UBL2_3 185 189 PF12436 0.470
DOC_USP7_UBL2_3 484 488 PF12436 0.458
DOC_USP7_UBL2_3 71 75 PF12436 0.416
DOC_USP7_UBL2_3 82 86 PF12436 0.468
DOC_WW_Pin1_4 118 123 PF00397 0.451
DOC_WW_Pin1_4 22 27 PF00397 0.314
DOC_WW_Pin1_4 317 322 PF00397 0.502
DOC_WW_Pin1_4 411 416 PF00397 0.602
LIG_14-3-3_CanoR_1 155 160 PF00244 0.484
LIG_14-3-3_CanoR_1 212 220 PF00244 0.674
LIG_14-3-3_CanoR_1 234 244 PF00244 0.581
LIG_14-3-3_CanoR_1 259 264 PF00244 0.546
LIG_14-3-3_CanoR_1 28 36 PF00244 0.524
LIG_14-3-3_CanoR_1 303 312 PF00244 0.559
LIG_14-3-3_CanoR_1 477 481 PF00244 0.467
LIG_14-3-3_CanoR_1 53 57 PF00244 0.442
LIG_14-3-3_CanoR_1 98 102 PF00244 0.429
LIG_BRCT_BRCA1_1 444 448 PF00533 0.408
LIG_EH_1 445 449 PF12763 0.362
LIG_FHA_1 197 203 PF00498 0.502
LIG_FHA_1 344 350 PF00498 0.405
LIG_FHA_1 356 362 PF00498 0.457
LIG_FHA_1 36 42 PF00498 0.394
LIG_FHA_1 366 372 PF00498 0.383
LIG_FHA_1 380 386 PF00498 0.374
LIG_FHA_1 72 78 PF00498 0.431
LIG_IBAR_NPY_1 334 336 PF08397 0.410
LIG_LIR_Gen_1 121 131 PF02991 0.380
LIG_LIR_Gen_1 451 459 PF02991 0.350
LIG_LIR_Nem_3 121 126 PF02991 0.394
LIG_LIR_Nem_3 18 23 PF02991 0.426
LIG_LIR_Nem_3 451 455 PF02991 0.329
LIG_SH2_CRK 20 24 PF00017 0.367
LIG_SH2_CRK 452 456 PF00017 0.343
LIG_SH2_STAP1 452 456 PF00017 0.343
LIG_SH2_STAT5 336 339 PF00017 0.417
LIG_SH3_1 254 260 PF00018 0.571
LIG_SH3_3 20 26 PF00018 0.452
LIG_SH3_3 254 260 PF00018 0.571
LIG_SH3_3 309 315 PF00018 0.511
LIG_SH3_3 347 353 PF00018 0.443
LIG_SH3_3 392 398 PF00018 0.602
LIG_SH3_3 418 424 PF00018 0.635
LIG_SH3_4 82 89 PF00018 0.496
LIG_WRC_WIRS_1 16 21 PF05994 0.431
LIG_WW_1 440 443 PF00397 0.404
MOD_CDC14_SPxK_1 25 28 PF00782 0.346
MOD_CDK_SPxK_1 22 28 PF00069 0.325
MOD_CDK_SPxK_1 317 323 PF00069 0.503
MOD_CDK_SPxxK_3 317 324 PF00069 0.497
MOD_CK1_1 211 217 PF00069 0.693
MOD_Cter_Amidation 115 118 PF01082 0.504
MOD_GlcNHglycan 205 208 PF01048 0.590
MOD_GlcNHglycan 237 240 PF01048 0.523
MOD_GlcNHglycan 275 278 PF01048 0.563
MOD_GlcNHglycan 326 329 PF01048 0.558
MOD_GlcNHglycan 402 405 PF01048 0.624
MOD_GlcNHglycan 485 488 PF01048 0.422
MOD_GlcNHglycan 54 57 PF01048 0.538
MOD_GSK3_1 131 138 PF00069 0.483
MOD_GSK3_1 180 187 PF00069 0.511
MOD_GSK3_1 188 195 PF00069 0.521
MOD_GSK3_1 203 210 PF00069 0.467
MOD_GSK3_1 297 304 PF00069 0.530
MOD_GSK3_1 363 370 PF00069 0.430
MOD_GSK3_1 386 393 PF00069 0.587
MOD_GSK3_1 411 418 PF00069 0.550
MOD_GSK3_1 424 431 PF00069 0.520
MOD_NEK2_1 131 136 PF00069 0.413
MOD_NEK2_1 2 7 PF00069 0.478
MOD_NEK2_1 343 348 PF00069 0.409
MOD_NEK2_1 448 453 PF00069 0.327
MOD_NEK2_1 77 82 PF00069 0.563
MOD_NEK2_2 15 20 PF00069 0.429
MOD_PK_1 157 163 PF00069 0.442
MOD_PK_1 259 265 PF00069 0.551
MOD_PK_1 305 311 PF00069 0.514
MOD_PKA_1 184 190 PF00069 0.488
MOD_PKA_1 192 198 PF00069 0.504
MOD_PKA_1 295 301 PF00069 0.488
MOD_PKA_1 305 311 PF00069 0.470
MOD_PKA_1 324 330 PF00069 0.580
MOD_PKA_2 131 137 PF00069 0.579
MOD_PKA_2 192 198 PF00069 0.651
MOD_PKA_2 211 217 PF00069 0.581
MOD_PKA_2 220 226 PF00069 0.535
MOD_PKA_2 233 239 PF00069 0.548
MOD_PKA_2 27 33 PF00069 0.371
MOD_PKA_2 301 307 PF00069 0.553
MOD_PKA_2 324 330 PF00069 0.704
MOD_PKA_2 343 349 PF00069 0.355
MOD_PKA_2 379 385 PF00069 0.449
MOD_PKA_2 400 406 PF00069 0.589
MOD_PKA_2 476 482 PF00069 0.503
MOD_PKA_2 52 58 PF00069 0.437
MOD_PKA_2 97 103 PF00069 0.529
MOD_PKB_1 155 163 PF00069 0.447
MOD_PKB_1 303 311 PF00069 0.491
MOD_Plk_4 15 21 PF00069 0.435
MOD_ProDKin_1 118 124 PF00069 0.442
MOD_ProDKin_1 22 28 PF00069 0.325
MOD_ProDKin_1 317 323 PF00069 0.503
MOD_ProDKin_1 411 417 PF00069 0.604
MOD_SUMO_rev_2 479 486 PF00179 0.483
TRG_DiLeu_BaEn_4 386 392 PF01217 0.376
TRG_DiLeu_BaLyEn_6 167 172 PF01217 0.425
TRG_DiLeu_BaLyEn_6 454 459 PF01217 0.388
TRG_ENDOCYTIC_2 20 23 PF00928 0.337
TRG_ENDOCYTIC_2 336 339 PF00928 0.388
TRG_ENDOCYTIC_2 340 343 PF00928 0.380
TRG_ENDOCYTIC_2 452 455 PF00928 0.375
TRG_ER_diArg_1 131 133 PF00400 0.465
TRG_ER_diArg_1 192 194 PF00400 0.561
TRG_ER_diArg_1 246 249 PF00400 0.574
TRG_ER_diArg_1 302 305 PF00400 0.604
TRG_ER_diArg_1 315 318 PF00400 0.511
TRG_ER_diArg_1 330 332 PF00400 0.587
TRG_ER_diArg_1 376 378 PF00400 0.525
TRG_ER_diArg_1 66 68 PF00400 0.336
TRG_NLS_Bipartite_1 163 181 PF00514 0.397
TRG_NLS_Bipartite_1 200 222 PF00514 0.531
TRG_NLS_Bipartite_1 228 249 PF00514 0.523
TRG_NLS_Bipartite_1 305 327 PF00514 0.558
TRG_NLS_Bipartite_1 67 89 PF00514 0.398
TRG_NLS_MonoCore_2 217 222 PF00514 0.529
TRG_NLS_MonoExtC_3 244 249 PF00514 0.503
TRG_NLS_MonoExtC_3 300 305 PF00514 0.617
TRG_NLS_MonoExtN_4 102 107 PF00514 0.552
TRG_NLS_MonoExtN_4 174 181 PF00514 0.444
TRG_NLS_MonoExtN_4 216 222 PF00514 0.513
TRG_NLS_MonoExtN_4 243 249 PF00514 0.507
TRG_NLS_MonoExtN_4 321 327 PF00514 0.486
TRG_NLS_MonoExtN_4 82 89 PF00514 0.496
TRG_Pf-PMV_PEXEL_1 170 175 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V1 Leptomonas seymouri 41% 100%
A0A3Q8IK24 Leishmania donovani 100% 100%
A4HQ98 Leishmania braziliensis 63% 100%
E9AU16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q0H9 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS