LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
tRNA pseudouridine synthase TruD - putative
Species:
Leishmania infantum
UniProt:
A4IDY9_LEIIN
TriTrypDb:
LINF_360067300
Length:
680

Annotations

Annotations by Jardim et al.

RNA Processing, pseudouridine synthase TruD Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4IDY9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY9

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 10
GO:0006399 tRNA metabolic process 7 10
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008033 tRNA processing 8 10
GO:0008152 metabolic process 1 11
GO:0009451 RNA modification 5 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0034470 ncRNA processing 7 10
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034660 ncRNA metabolic process 6 10
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0009982 pseudouridine synthase activity 4 11
GO:0016853 isomerase activity 2 11
GO:0016866 intramolecular transferase activity 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0106029 tRNA pseudouridine synthase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.276
CLV_NRD_NRD_1 15 17 PF00675 0.550
CLV_NRD_NRD_1 202 204 PF00675 0.465
CLV_NRD_NRD_1 207 209 PF00675 0.490
CLV_NRD_NRD_1 28 30 PF00675 0.436
CLV_NRD_NRD_1 512 514 PF00675 0.404
CLV_PCSK_KEX2_1 100 102 PF00082 0.575
CLV_PCSK_KEX2_1 15 17 PF00082 0.461
CLV_PCSK_KEX2_1 167 169 PF00082 0.535
CLV_PCSK_KEX2_1 202 204 PF00082 0.465
CLV_PCSK_KEX2_1 206 208 PF00082 0.503
CLV_PCSK_KEX2_1 256 258 PF00082 0.281
CLV_PCSK_KEX2_1 27 29 PF00082 0.394
CLV_PCSK_KEX2_1 512 514 PF00082 0.393
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.589
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.535
CLV_PCSK_PC1ET2_1 256 258 PF00082 0.276
CLV_PCSK_PC1ET2_1 27 29 PF00082 0.468
CLV_PCSK_PC7_1 202 208 PF00082 0.480
CLV_PCSK_SKI1_1 168 172 PF00082 0.455
CLV_PCSK_SKI1_1 173 177 PF00082 0.415
CLV_PCSK_SKI1_1 257 261 PF00082 0.311
CLV_PCSK_SKI1_1 273 277 PF00082 0.276
CLV_PCSK_SKI1_1 311 315 PF00082 0.406
CLV_PCSK_SKI1_1 384 388 PF00082 0.257
CLV_PCSK_SKI1_1 424 428 PF00082 0.276
CLV_PCSK_SKI1_1 512 516 PF00082 0.380
CLV_PCSK_SKI1_1 566 570 PF00082 0.380
DEG_APCC_DBOX_1 379 387 PF00400 0.401
DEG_APCC_DBOX_1 423 431 PF00400 0.276
DEG_APCC_DBOX_1 521 529 PF00400 0.394
DEG_APCC_KENBOX_2 224 228 PF00400 0.276
DEG_Nend_UBRbox_3 1 3 PF02207 0.556
DEG_SCF_FBW7_1 619 625 PF00400 0.560
DOC_CKS1_1 498 503 PF01111 0.298
DOC_CKS1_1 601 606 PF01111 0.481
DOC_CKS1_1 619 624 PF01111 0.572
DOC_MAPK_gen_1 254 261 PF00069 0.276
DOC_MAPK_gen_1 27 33 PF00069 0.424
DOC_MAPK_gen_1 378 387 PF00069 0.393
DOC_MAPK_HePTP_8 375 387 PF00069 0.314
DOC_MAPK_MEF2A_6 378 387 PF00069 0.334
DOC_MAPK_NFAT4_5 380 388 PF00069 0.325
DOC_PP1_RVXF_1 244 251 PF00149 0.276
DOC_PP2B_LxvP_1 530 533 PF13499 0.276
DOC_PP4_FxxP_1 647 650 PF00568 0.327
DOC_PP4_FxxP_1 662 665 PF00568 0.420
DOC_USP7_MATH_1 153 157 PF00917 0.592
DOC_USP7_MATH_1 158 162 PF00917 0.504
DOC_USP7_MATH_1 319 323 PF00917 0.329
DOC_USP7_MATH_1 47 51 PF00917 0.359
DOC_USP7_MATH_1 622 626 PF00917 0.607
DOC_USP7_MATH_1 86 90 PF00917 0.616
DOC_WW_Pin1_4 497 502 PF00397 0.441
DOC_WW_Pin1_4 600 605 PF00397 0.484
DOC_WW_Pin1_4 618 623 PF00397 0.574
LIG_14-3-3_CanoR_1 15 24 PF00244 0.536
LIG_14-3-3_CanoR_1 257 262 PF00244 0.276
LIG_Actin_WH2_2 368 386 PF00022 0.385
LIG_APCC_ABBA_1 221 226 PF00400 0.276
LIG_BIR_III_2 496 500 PF00653 0.330
LIG_BIR_III_4 304 308 PF00653 0.354
LIG_BIR_III_4 37 41 PF00653 0.484
LIG_BIR_III_4 615 619 PF00653 0.591
LIG_BRCT_BRCA1_1 278 282 PF00533 0.354
LIG_EH1_1 453 461 PF00400 0.276
LIG_FHA_1 138 144 PF00498 0.519
LIG_FHA_1 360 366 PF00498 0.288
LIG_FHA_1 601 607 PF00498 0.427
LIG_FHA_1 619 625 PF00498 0.395
LIG_FHA_1 635 641 PF00498 0.411
LIG_FHA_1 644 650 PF00498 0.456
LIG_FHA_1 654 660 PF00498 0.246
LIG_FHA_2 127 133 PF00498 0.576
LIG_FHA_2 16 22 PF00498 0.519
LIG_FHA_2 161 167 PF00498 0.527
LIG_FHA_2 267 273 PF00498 0.401
LIG_FHA_2 333 339 PF00498 0.330
LIG_FHA_2 485 491 PF00498 0.446
LIG_FHA_2 513 519 PF00498 0.290
LIG_FHA_2 54 60 PF00498 0.438
LIG_FHA_2 546 552 PF00498 0.401
LIG_Integrin_RGD_1 35 37 PF01839 0.438
LIG_LIR_Apic_2 646 650 PF02991 0.332
LIG_LIR_Apic_2 661 665 PF02991 0.395
LIG_LIR_Gen_1 215 224 PF02991 0.388
LIG_LIR_Gen_1 458 469 PF02991 0.276
LIG_LIR_Gen_1 53 63 PF02991 0.333
LIG_LIR_Gen_1 550 559 PF02991 0.393
LIG_LIR_Nem_3 215 221 PF02991 0.388
LIG_LIR_Nem_3 458 464 PF02991 0.393
LIG_LIR_Nem_3 53 58 PF02991 0.344
LIG_LIR_Nem_3 550 555 PF02991 0.364
LIG_LIR_Nem_3 580 584 PF02991 0.401
LIG_PCNA_PIPBox_1 397 406 PF02747 0.393
LIG_PCNA_yPIPBox_3 457 468 PF02747 0.375
LIG_Rb_pABgroove_1 398 406 PF01858 0.330
LIG_SH2_CRK 552 556 PF00017 0.401
LIG_SH2_CRK 581 585 PF00017 0.295
LIG_SH2_STAP1 552 556 PF00017 0.393
LIG_SH2_STAP1 654 658 PF00017 0.324
LIG_SH2_STAT3 419 422 PF00017 0.216
LIG_SH2_STAT5 354 357 PF00017 0.390
LIG_SH2_STAT5 409 412 PF00017 0.288
LIG_SH2_STAT5 419 422 PF00017 0.266
LIG_SH2_STAT5 437 440 PF00017 0.246
LIG_SH2_STAT5 452 455 PF00017 0.188
LIG_SH2_STAT5 55 58 PF00017 0.440
LIG_SH3_1 315 321 PF00018 0.318
LIG_SH3_3 110 116 PF00018 0.524
LIG_SH3_3 130 136 PF00018 0.565
LIG_SH3_3 315 321 PF00018 0.318
LIG_SH3_3 525 531 PF00018 0.295
LIG_SH3_3 630 636 PF00018 0.494
LIG_SUMO_SIM_anti_2 567 573 PF11976 0.361
LIG_SUMO_SIM_par_1 399 405 PF11976 0.330
LIG_SUMO_SIM_par_1 71 76 PF11976 0.344
LIG_TRAF2_1 129 132 PF00917 0.542
LIG_TRAF2_1 19 22 PF00917 0.429
LIG_TRAF2_1 487 490 PF00917 0.330
LIG_TRFH_1 647 651 PF08558 0.337
LIG_UBA3_1 95 100 PF00899 0.504
LIG_WRC_WIRS_1 644 649 PF05994 0.430
MOD_CDK_SPxxK_3 600 607 PF00069 0.477
MOD_CK1_1 364 370 PF00069 0.250
MOD_CK1_1 455 461 PF00069 0.368
MOD_CK1_1 467 473 PF00069 0.457
MOD_CK1_1 50 56 PF00069 0.336
MOD_CK1_1 653 659 PF00069 0.346
MOD_CK1_1 82 88 PF00069 0.673
MOD_CK2_1 125 131 PF00069 0.546
MOD_CK2_1 15 21 PF00069 0.521
MOD_CK2_1 160 166 PF00069 0.531
MOD_CK2_1 266 272 PF00069 0.406
MOD_CK2_1 319 325 PF00069 0.439
MOD_CK2_1 484 490 PF00069 0.427
MOD_CK2_1 53 59 PF00069 0.440
MOD_CK2_1 605 611 PF00069 0.349
MOD_CK2_1 629 635 PF00069 0.574
MOD_CK2_1 672 678 PF00069 0.702
MOD_GlcNHglycan 321 324 PF01048 0.418
MOD_GlcNHglycan 625 628 PF01048 0.631
MOD_GlcNHglycan 674 677 PF01048 0.698
MOD_GlcNHglycan 79 82 PF01048 0.687
MOD_GlcNHglycan 84 87 PF01048 0.663
MOD_GlcNHglycan 88 91 PF01048 0.747
MOD_GSK3_1 360 367 PF00069 0.287
MOD_GSK3_1 463 470 PF00069 0.403
MOD_GSK3_1 541 548 PF00069 0.438
MOD_GSK3_1 618 625 PF00069 0.546
MOD_GSK3_1 650 657 PF00069 0.392
MOD_GSK3_1 82 89 PF00069 0.634
MOD_GSK3_1 95 102 PF00069 0.691
MOD_LATS_1 240 246 PF00433 0.401
MOD_NEK2_1 179 184 PF00069 0.439
MOD_NEK2_1 241 246 PF00069 0.311
MOD_NEK2_1 360 365 PF00069 0.393
MOD_NEK2_1 444 449 PF00069 0.384
MOD_NEK2_1 463 468 PF00069 0.390
MOD_NEK2_1 484 489 PF00069 0.330
MOD_NEK2_1 503 508 PF00069 0.402
MOD_NEK2_1 577 582 PF00069 0.385
MOD_NEK2_1 77 82 PF00069 0.606
MOD_NEK2_1 9 14 PF00069 0.410
MOD_NEK2_2 190 195 PF00069 0.312
MOD_NEK2_2 47 52 PF00069 0.353
MOD_NEK2_2 79 84 PF00069 0.629
MOD_PIKK_1 4 10 PF00454 0.492
MOD_PK_1 20 26 PF00069 0.470
MOD_PKA_1 15 21 PF00069 0.432
MOD_PKA_1 206 212 PF00069 0.630
MOD_PKA_1 512 518 PF00069 0.401
MOD_PKA_2 15 21 PF00069 0.530
MOD_PKA_2 206 212 PF00069 0.514
MOD_PKA_2 266 272 PF00069 0.366
MOD_PKA_2 467 473 PF00069 0.393
MOD_PKA_2 512 518 PF00069 0.336
MOD_Plk_1 20 26 PF00069 0.441
MOD_Plk_1 267 273 PF00069 0.363
MOD_Plk_1 326 332 PF00069 0.330
MOD_Plk_1 484 490 PF00069 0.393
MOD_Plk_2-3 674 680 PF00069 0.667
MOD_Plk_4 109 115 PF00069 0.525
MOD_Plk_4 190 196 PF00069 0.486
MOD_Plk_4 361 367 PF00069 0.298
MOD_Plk_4 455 461 PF00069 0.309
MOD_Plk_4 50 56 PF00069 0.358
MOD_Plk_4 629 635 PF00069 0.455
MOD_Plk_4 654 660 PF00069 0.369
MOD_Plk_4 9 15 PF00069 0.428
MOD_ProDKin_1 497 503 PF00069 0.441
MOD_ProDKin_1 600 606 PF00069 0.480
MOD_ProDKin_1 618 624 PF00069 0.571
MOD_SUMO_rev_2 504 509 PF00179 0.349
TRG_DiLeu_BaEn_1 381 386 PF01217 0.325
TRG_DiLeu_BaEn_1 478 483 PF01217 0.401
TRG_DiLeu_BaEn_1 567 572 PF01217 0.385
TRG_DiLeu_BaEn_4 295 301 PF01217 0.393
TRG_DiLeu_BaLyEn_6 133 138 PF01217 0.501
TRG_DiLeu_LyEn_5 381 386 PF01217 0.314
TRG_ENDOCYTIC_2 218 221 PF00928 0.354
TRG_ENDOCYTIC_2 55 58 PF00928 0.323
TRG_ENDOCYTIC_2 552 555 PF00928 0.341
TRG_ENDOCYTIC_2 581 584 PF00928 0.276
TRG_ER_diArg_1 14 16 PF00400 0.559
TRG_ER_diArg_1 206 208 PF00400 0.521
TRG_ER_diArg_1 28 30 PF00400 0.427
TRG_ER_diArg_1 512 514 PF00400 0.389
TRG_NES_CRM1_1 373 388 PF08389 0.330
TRG_NLS_Bipartite_1 15 31 PF00514 0.420
TRG_Pf-PMV_PEXEL_1 384 388 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 512 517 PF00026 0.396

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4F4 Leptomonas seymouri 24% 71%
A0A0N0P912 Leptomonas seymouri 62% 95%
A0A1X0NMC1 Trypanosomatidae 38% 94%
A0A3Q8IJ87 Leishmania donovani 100% 100%
A0A3S7X658 Leishmania donovani 23% 95%
A0A422NSE9 Trypanosoma rangeli 42% 100%
A4HKY3 Leishmania braziliensis 24% 72%
A4HQ91 Leishmania braziliensis 76% 100%
A4I8G2 Leishmania infantum 22% 72%
D0A420 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 99%
E9AU09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O74343 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
Q08647 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
Q08DI8 Bos taurus 29% 100%
Q17426 Caenorhabditis elegans 26% 100%
Q4Q0I6 Leishmania major 93% 100%
Q4Q4T4 Leishmania major 23% 100%
Q5V1E6 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 26% 100%
Q91VU7 Mus musculus 29% 100%
Q96PZ0 Homo sapiens 29% 100%
Q9VSK9 Drosophila melanogaster 28% 93%
V5BT95 Trypanosoma cruzi 42% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS