Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase TruD - putative

Species:

Leishmania infantum

UniProt:

A4IDY9_LEIIN

TriTrypDb:

LINF_360067300

Length:

680

Annotations

Annotations by Jardim et al.

RNA Processing, pseudouridine synthase TruD Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4IDY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY9

Function

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Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.276
CLV_NRD_NRD_1	15	17	PF00675	0.550
CLV_NRD_NRD_1	202	204	PF00675	0.465
CLV_NRD_NRD_1	207	209	PF00675	0.490
CLV_NRD_NRD_1	28	30	PF00675	0.436
CLV_NRD_NRD_1	512	514	PF00675	0.404
CLV_PCSK_KEX2_1	100	102	PF00082	0.575
CLV_PCSK_KEX2_1	15	17	PF00082	0.461
CLV_PCSK_KEX2_1	167	169	PF00082	0.535
CLV_PCSK_KEX2_1	202	204	PF00082	0.465

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F4	Leptomonas seymouri	24%	71%
A0A0N0P912	Leptomonas seymouri	62%	95%
A0A1X0NMC1	Trypanosomatidae	38%	94%
A0A3Q8IJ87	Leishmania donovani	100%	100%
A0A3S7X658	Leishmania donovani	23%	95%
A0A422NSE9	Trypanosoma rangeli	42%	100%
A4HKY3	Leishmania braziliensis	24%	72%
A4HQ91	Leishmania braziliensis	76%	100%
A4I8G2	Leishmania infantum	22%	72%
D0A420	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%

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