CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDY4_LEIIN

TriTrypDb:

LINF_360066800

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.527
CLV_C14_Caspase3-7	4	8	PF00656	0.529
CLV_C14_Caspase3-7	550	554	PF00656	0.585
CLV_C14_Caspase3-7	587	591	PF00656	0.686
CLV_C14_Caspase3-7	663	667	PF00656	0.692
CLV_NRD_NRD_1	105	107	PF00675	0.550
CLV_NRD_NRD_1	254	256	PF00675	0.490
CLV_NRD_NRD_1	289	291	PF00675	0.626
CLV_NRD_NRD_1	677	679	PF00675	0.796
CLV_NRD_NRD_1	683	685	PF00675	0.656

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W0	Leptomonas seymouri	62%	99%
A0A1X0P037	Trypanosomatidae	37%	100%
A0A3S7XBW7	Leishmania donovani	99%	100%
A0A422NSD1	Trypanosoma rangeli	39%	100%
A4HQ86	Leishmania braziliensis	79%	100%
D0A425	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0J1	Leishmania major	92%	100%
V5BTA0	Trypanosoma cruzi	39%	100%

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