Integral membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDY2_LEIIN

TriTrypDb:

LINF_360066600

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4IDY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.595
CLV_PCSK_KEX2_1	112	114	PF00082	0.534
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.540
CLV_PCSK_SKI1_1	87	91	PF00082	0.434
DEG_APCC_DBOX_1	69	77	PF00400	0.504
DEG_ODPH_VHL_1	127	139	PF01847	0.481
DOC_MAPK_gen_1	150	159	PF00069	0.435
DOC_MAPK_gen_1	83	91	PF00069	0.429
DOC_MAPK_MEF2A_6	200	208	PF00069	0.428
DOC_MAPK_MEF2A_6	85	93	PF00069	0.394
DOC_PP4_FxxP_1	126	129	PF00568	0.523
DOC_PP4_FxxP_1	74	77	PF00568	0.603
DOC_USP7_MATH_1	46	50	PF00917	0.700
DOC_WW_Pin1_4	185	190	PF00397	0.453
LIG_14-3-3_CanoR_1	113	119	PF00244	0.500
LIG_14-3-3_CanoR_1	153	158	PF00244	0.566
LIG_APCC_ABBA_1	141	146	PF00400	0.574
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	116	120	PF00533	0.572
LIG_BRCT_BRCA1_1	212	216	PF00533	0.496
LIG_eIF4E_1	174	180	PF01652	0.417
LIG_eIF4E_1	214	220	PF01652	0.506
LIG_FHA_1	154	160	PF00498	0.481
LIG_FHA_1	21	27	PF00498	0.500
LIG_FHA_1	62	68	PF00498	0.514
LIG_FHA_2	106	112	PF00498	0.453
LIG_GBD_Chelix_1	26	34	PF00786	0.529
LIG_LIR_Gen_1	197	206	PF02991	0.403
LIG_LIR_Gen_1	213	224	PF02991	0.574
LIG_LIR_Gen_1	28	34	PF02991	0.480
LIG_LIR_Nem_3	117	123	PF02991	0.558
LIG_LIR_Nem_3	197	201	PF02991	0.397
LIG_LIR_Nem_3	205	211	PF02991	0.382
LIG_LIR_Nem_3	213	219	PF02991	0.427
LIG_LIR_Nem_3	28	32	PF02991	0.490
LIG_Pex14_2	140	144	PF04695	0.464
LIG_Pex14_2	216	220	PF04695	0.466
LIG_Pex14_2	25	29	PF04695	0.481
LIG_REV1ctd_RIR_1	138	146	PF16727	0.540
LIG_SH2_CRK	118	122	PF00017	0.544
LIG_SH2_CRK	69	73	PF00017	0.551
LIG_SH2_STAT3	214	217	PF00017	0.413
LIG_SH2_STAT5	138	141	PF00017	0.509
LIG_SH2_STAT5	209	212	PF00017	0.444
LIG_SH2_STAT5	227	230	PF00017	0.623
LIG_SH3_3	129	135	PF00018	0.529
LIG_SH3_3	50	56	PF00018	0.658
LIG_TRAF2_1	108	111	PF00917	0.427
LIG_WW_1	135	138	PF00397	0.449
MOD_CK1_1	20	26	PF00069	0.486
MOD_CK1_1	75	81	PF00069	0.537
MOD_CK2_1	105	111	PF00069	0.459
MOD_CK2_1	219	225	PF00069	0.528
MOD_DYRK1A_RPxSP_1	185	189	PF00069	0.548
MOD_GlcNHglycan	19	22	PF01048	0.489
MOD_GlcNHglycan	61	64	PF01048	0.641
MOD_GSK3_1	55	62	PF00069	0.553
MOD_GSK3_1	75	82	PF00069	0.272
MOD_NEK2_1	114	119	PF00069	0.551
MOD_NEK2_1	179	184	PF00069	0.377
MOD_NEK2_1	219	224	PF00069	0.540
MOD_NEK2_1	34	39	PF00069	0.534
MOD_PIKK_1	34	40	PF00454	0.539
MOD_PKA_2	79	85	PF00069	0.438
MOD_Plk_1	170	176	PF00069	0.408
MOD_Plk_1	196	202	PF00069	0.553
MOD_Plk_4	11	17	PF00069	0.524
MOD_ProDKin_1	185	191	PF00069	0.445
MOD_SUMO_rev_2	104	114	PF00179	0.505
TRG_ENDOCYTIC_2	118	121	PF00928	0.425
TRG_ENDOCYTIC_2	123	126	PF00928	0.441
TRG_ENDOCYTIC_2	138	141	PF00928	0.393
TRG_ER_diArg_1	152	155	PF00400	0.491
TRG_NES_CRM1_1	17	28	PF08389	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P911	Leptomonas seymouri	81%	100%
A0A0S4J1S1	Bodo saltans	49%	98%
A0A1X0P1B4	Trypanosomatidae	66%	100%
A0A3Q8IGN5	Leishmania donovani	100%	100%
A0A422NSE3	Trypanosoma rangeli	67%	100%
A4HQ84	Leishmania braziliensis	91%	100%
D0A428	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AU02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q0J3	Leishmania major	96%	100%
V5BJ65	Trypanosoma cruzi	66%	100%