LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Pyridine nucleotide-disulphide oxidoreductase/Thi4 family/FAD dependent oxidoreductase/NAD(P)-binding Rossmann-like domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IDY0_LEIIN
TriTrypDb:
LINF_360066400
Length:
717

Annotations

Annotations by Jardim et al.

Mitochondrial protein, FAD dependent oxidoreductase, putative (POMP20) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4IDY0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY0

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 11
GO:0004497 monooxygenase activity 3 1
GO:0005488 binding 1 1
GO:0016491 oxidoreductase activity 2 11
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0097159 organic cyclic compound binding 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 14 18 PF00656 0.612
CLV_C14_Caspase3-7 682 686 PF00656 0.677
CLV_NRD_NRD_1 180 182 PF00675 0.417
CLV_NRD_NRD_1 209 211 PF00675 0.417
CLV_NRD_NRD_1 534 536 PF00675 0.532
CLV_NRD_NRD_1 555 557 PF00675 0.644
CLV_NRD_NRD_1 587 589 PF00675 0.596
CLV_NRD_NRD_1 619 621 PF00675 0.635
CLV_NRD_NRD_1 62 64 PF00675 0.411
CLV_NRD_NRD_1 657 659 PF00675 0.645
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I902 Leptomonas seymouri 60% 97%
A0A0S4IXS1 Bodo saltans 28% 100%
A0A1X0P069 Trypanosomatidae 34% 100%
A0A3Q8IK10 Leishmania donovani 100% 100%
A4HQ82 Leishmania braziliensis 82% 100%
D0A430 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AU00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q0J5 Leishmania major 95% 100%
V5DK61 Trypanosoma cruzi 36% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS