LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Pyridine nucleotide-disulphide oxidoreductase/Thi4 family/FAD dependent oxidoreductase/NAD(P)-binding Rossmann-like domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IDY0_LEIIN
TriTrypDb:
LINF_360066400
Length:
717

Annotations

Annotations by Jardim et al.

Mitochondrial protein, FAD dependent oxidoreductase, putative (POMP20) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDY0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDY0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016491 oxidoreductase activity 2 11
GO:0000166 nucleotide binding 3 1
GO:0004497 monooxygenase activity 3 1
GO:0005488 binding 1 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.612
CLV_C14_Caspase3-7 682 686 PF00656 0.677
CLV_NRD_NRD_1 180 182 PF00675 0.417
CLV_NRD_NRD_1 209 211 PF00675 0.417
CLV_NRD_NRD_1 534 536 PF00675 0.532
CLV_NRD_NRD_1 555 557 PF00675 0.644
CLV_NRD_NRD_1 587 589 PF00675 0.596
CLV_NRD_NRD_1 619 621 PF00675 0.635
CLV_NRD_NRD_1 62 64 PF00675 0.411
CLV_NRD_NRD_1 657 659 PF00675 0.645
CLV_NRD_NRD_1 699 701 PF00675 0.692
CLV_NRD_NRD_1 707 709 PF00675 0.594
CLV_PCSK_KEX2_1 209 211 PF00082 0.417
CLV_PCSK_KEX2_1 534 536 PF00082 0.502
CLV_PCSK_KEX2_1 555 557 PF00082 0.584
CLV_PCSK_KEX2_1 618 620 PF00082 0.643
CLV_PCSK_KEX2_1 62 64 PF00082 0.411
CLV_PCSK_KEX2_1 699 701 PF00082 0.717
CLV_PCSK_KEX2_1 707 709 PF00082 0.570
CLV_PCSK_KEX2_1 715 717 PF00082 0.480
CLV_PCSK_PC1ET2_1 555 557 PF00082 0.592
CLV_PCSK_PC1ET2_1 699 701 PF00082 0.717
CLV_PCSK_PC1ET2_1 715 717 PF00082 0.480
CLV_PCSK_SKI1_1 461 465 PF00082 0.437
CLV_PCSK_SKI1_1 589 593 PF00082 0.651
CLV_PCSK_SKI1_1 710 714 PF00082 0.670
CLV_PCSK_SKI1_1 89 93 PF00082 0.364
CLV_PCSK_SKI1_1 98 102 PF00082 0.298
CLV_Separin_Metazoa 615 619 PF03568 0.588
CLV_Separin_Metazoa 95 99 PF03568 0.378
DEG_APCC_DBOX_1 71 79 PF00400 0.479
DEG_SPOP_SBC_1 317 321 PF00917 0.722
DEG_SPOP_SBC_1 437 441 PF00917 0.537
DOC_CKS1_1 673 678 PF01111 0.699
DOC_CKS1_1 691 696 PF01111 0.685
DOC_CYCLIN_yCln2_LP_2 119 125 PF00134 0.479
DOC_MAPK_DCC_7 72 80 PF00069 0.479
DOC_MAPK_gen_1 209 216 PF00069 0.445
DOC_MAPK_gen_1 429 438 PF00069 0.451
DOC_MAPK_MEF2A_6 72 80 PF00069 0.479
DOC_PP1_RVXF_1 50 56 PF00149 0.408
DOC_PP1_RVXF_1 637 644 PF00149 0.546
DOC_PP2B_LxvP_1 29 32 PF13499 0.567
DOC_PP4_FxxP_1 171 174 PF00568 0.447
DOC_PP4_FxxP_1 73 76 PF00568 0.417
DOC_USP7_MATH_1 13 17 PF00917 0.700
DOC_USP7_MATH_1 266 270 PF00917 0.411
DOC_USP7_MATH_1 316 320 PF00917 0.715
DOC_USP7_MATH_1 328 332 PF00917 0.770
DOC_USP7_MATH_1 376 380 PF00917 0.746
DOC_USP7_MATH_1 381 385 PF00917 0.744
DOC_USP7_MATH_1 415 419 PF00917 0.594
DOC_USP7_MATH_1 437 441 PF00917 0.611
DOC_USP7_MATH_1 695 699 PF00917 0.669
DOC_USP7_MATH_2 23 29 PF00917 0.668
DOC_USP7_UBL2_3 499 503 PF12436 0.405
DOC_USP7_UBL2_3 52 56 PF12436 0.393
DOC_WW_Pin1_4 17 22 PF00397 0.695
DOC_WW_Pin1_4 311 316 PF00397 0.742
DOC_WW_Pin1_4 320 325 PF00397 0.697
DOC_WW_Pin1_4 461 466 PF00397 0.396
DOC_WW_Pin1_4 528 533 PF00397 0.650
DOC_WW_Pin1_4 558 563 PF00397 0.658
DOC_WW_Pin1_4 593 598 PF00397 0.669
DOC_WW_Pin1_4 631 636 PF00397 0.578
DOC_WW_Pin1_4 672 677 PF00397 0.721
DOC_WW_Pin1_4 690 695 PF00397 0.705
LIG_14-3-3_CanoR_1 133 142 PF00244 0.473
LIG_14-3-3_CanoR_1 252 262 PF00244 0.437
LIG_14-3-3_CanoR_1 26 30 PF00244 0.675
LIG_14-3-3_CanoR_1 378 386 PF00244 0.742
LIG_14-3-3_CanoR_1 534 542 PF00244 0.557
LIG_14-3-3_CanoR_1 72 76 PF00244 0.439
LIG_Actin_WH2_2 284 302 PF00022 0.447
LIG_BRCT_BRCA1_1 363 367 PF00533 0.540
LIG_BRCT_BRCA1_1 73 77 PF00533 0.447
LIG_Clathr_ClatBox_1 402 406 PF01394 0.439
LIG_Clathr_ClatBox_1 570 574 PF01394 0.461
LIG_deltaCOP1_diTrp_1 301 307 PF00928 0.437
LIG_deltaCOP1_diTrp_1 636 643 PF00928 0.617
LIG_FHA_1 143 149 PF00498 0.368
LIG_FHA_1 199 205 PF00498 0.383
LIG_FHA_1 22 28 PF00498 0.666
LIG_FHA_1 234 240 PF00498 0.415
LIG_FHA_1 270 276 PF00498 0.361
LIG_FHA_1 344 350 PF00498 0.498
LIG_FHA_1 411 417 PF00498 0.621
LIG_FHA_1 520 526 PF00498 0.617
LIG_FHA_1 92 98 PF00498 0.417
LIG_FHA_2 441 447 PF00498 0.676
LIG_FHA_2 534 540 PF00498 0.496
LIG_FHA_2 559 565 PF00498 0.656
LIG_FHA_2 56 62 PF00498 0.335
LIG_FHA_2 610 616 PF00498 0.610
LIG_FHA_2 680 686 PF00498 0.751
LIG_FHA_2 691 697 PF00498 0.745
LIG_IBAR_NPY_1 576 578 PF08397 0.528
LIG_Integrin_RGD_1 63 65 PF01839 0.479
LIG_LIR_Apic_2 671 676 PF02991 0.693
LIG_LIR_Apic_2 70 76 PF02991 0.361
LIG_LIR_Gen_1 113 124 PF02991 0.354
LIG_LIR_Gen_1 256 266 PF02991 0.411
LIG_LIR_Gen_1 301 311 PF02991 0.437
LIG_LIR_Gen_1 477 486 PF02991 0.443
LIG_LIR_Gen_1 580 591 PF02991 0.597
LIG_LIR_Gen_1 640 647 PF02991 0.595
LIG_LIR_Nem_3 113 119 PF02991 0.373
LIG_LIR_Nem_3 227 231 PF02991 0.383
LIG_LIR_Nem_3 256 262 PF02991 0.381
LIG_LIR_Nem_3 301 307 PF02991 0.437
LIG_LIR_Nem_3 425 430 PF02991 0.446
LIG_LIR_Nem_3 477 481 PF02991 0.456
LIG_LIR_Nem_3 520 526 PF02991 0.623
LIG_LIR_Nem_3 74 80 PF02991 0.447
LIG_LYPXL_yS_3 163 166 PF13949 0.408
LIG_NRBOX 398 404 PF00104 0.469
LIG_PCNA_yPIPBox_3 121 133 PF02747 0.447
LIG_Pex14_2 73 77 PF04695 0.417
LIG_SH2_CRK 259 263 PF00017 0.426
LIG_SH2_GRB2like 144 147 PF00017 0.354
LIG_SH2_STAP1 144 148 PF00017 0.354
LIG_SH2_STAP1 212 216 PF00017 0.496
LIG_SH2_STAP1 259 263 PF00017 0.447
LIG_SH2_STAT3 212 215 PF00017 0.479
LIG_SH2_STAT5 144 147 PF00017 0.354
LIG_SH2_STAT5 228 231 PF00017 0.369
LIG_SH2_STAT5 359 362 PF00017 0.508
LIG_SH2_STAT5 427 430 PF00017 0.449
LIG_SH2_STAT5 459 462 PF00017 0.415
LIG_SH3_1 243 249 PF00018 0.447
LIG_SH3_3 238 244 PF00018 0.458
LIG_SH3_3 289 295 PF00018 0.447
LIG_SH3_3 688 694 PF00018 0.655
LIG_SUMO_SIM_anti_2 24 31 PF11976 0.642
LIG_SUMO_SIM_anti_2 260 265 PF11976 0.354
LIG_SUMO_SIM_anti_2 346 352 PF11976 0.455
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.622
LIG_SUMO_SIM_par_1 191 196 PF11976 0.355
LIG_SUMO_SIM_par_1 401 408 PF11976 0.505
LIG_TRAF2_1 537 540 PF00917 0.540
LIG_UBA3_1 402 410 PF00899 0.558
MOD_CDC14_SPxK_1 531 534 PF00782 0.620
MOD_CDK_SPxK_1 528 534 PF00069 0.643
MOD_CDK_SPxxK_3 528 535 PF00069 0.634
MOD_CK1_1 134 140 PF00069 0.400
MOD_CK1_1 149 155 PF00069 0.150
MOD_CK1_1 16 22 PF00069 0.665
MOD_CK1_1 235 241 PF00069 0.474
MOD_CK1_1 269 275 PF00069 0.440
MOD_CK1_1 286 292 PF00069 0.261
MOD_CK1_1 319 325 PF00069 0.688
MOD_CK1_1 352 358 PF00069 0.430
MOD_CK1_1 363 369 PF00069 0.584
MOD_CK1_1 377 383 PF00069 0.653
MOD_CK1_1 404 410 PF00069 0.497
MOD_CK1_1 439 445 PF00069 0.668
MOD_CK1_1 528 534 PF00069 0.643
MOD_CK1_1 563 569 PF00069 0.681
MOD_CK2_1 134 140 PF00069 0.408
MOD_CK2_1 319 325 PF00069 0.734
MOD_CK2_1 440 446 PF00069 0.666
MOD_CK2_1 533 539 PF00069 0.461
MOD_CK2_1 55 61 PF00069 0.354
MOD_CK2_1 558 564 PF00069 0.692
MOD_CK2_1 609 615 PF00069 0.583
MOD_CK2_1 668 674 PF00069 0.726
MOD_CK2_1 690 696 PF00069 0.743
MOD_DYRK1A_RPxSP_1 461 465 PF00069 0.413
MOD_GlcNHglycan 13 16 PF01048 0.718
MOD_GlcNHglycan 285 288 PF01048 0.408
MOD_GlcNHglycan 295 298 PF01048 0.408
MOD_GlcNHglycan 32 35 PF01048 0.488
MOD_GlcNHglycan 379 382 PF01048 0.749
MOD_GlcNHglycan 443 446 PF01048 0.755
MOD_GlcNHglycan 564 568 PF01048 0.672
MOD_GSK3_1 11 18 PF00069 0.698
MOD_GSK3_1 142 149 PF00069 0.403
MOD_GSK3_1 21 28 PF00069 0.601
MOD_GSK3_1 235 242 PF00069 0.382
MOD_GSK3_1 267 274 PF00069 0.338
MOD_GSK3_1 316 323 PF00069 0.731
MOD_GSK3_1 357 364 PF00069 0.511
MOD_GSK3_1 377 384 PF00069 0.428
MOD_GSK3_1 401 408 PF00069 0.436
MOD_GSK3_1 432 439 PF00069 0.536
MOD_GSK3_1 524 531 PF00069 0.636
MOD_GSK3_1 556 563 PF00069 0.710
MOD_GSK3_1 668 675 PF00069 0.641
MOD_GSK3_1 83 90 PF00069 0.454
MOD_N-GLC_1 146 151 PF02516 0.378
MOD_N-GLC_1 352 357 PF02516 0.493
MOD_NEK2_1 115 120 PF00069 0.390
MOD_NEK2_1 142 147 PF00069 0.354
MOD_NEK2_1 283 288 PF00069 0.410
MOD_NEK2_1 349 354 PF00069 0.499
MOD_NEK2_1 365 370 PF00069 0.723
MOD_NEK2_1 385 390 PF00069 0.638
MOD_NEK2_1 405 410 PF00069 0.283
MOD_NEK2_1 438 443 PF00069 0.593
MOD_NEK2_1 525 530 PF00069 0.649
MOD_NEK2_1 55 60 PF00069 0.335
MOD_NEK2_1 87 92 PF00069 0.479
MOD_NEK2_2 302 307 PF00069 0.447
MOD_NMyristoyl 1 7 PF02799 0.624
MOD_PIKK_1 391 397 PF00454 0.511
MOD_PIKK_1 410 416 PF00454 0.353
MOD_PIKK_1 668 674 PF00454 0.709
MOD_PKA_1 556 562 PF00069 0.714
MOD_PKA_2 239 245 PF00069 0.354
MOD_PKA_2 25 31 PF00069 0.667
MOD_PKA_2 3 9 PF00069 0.708
MOD_PKA_2 377 383 PF00069 0.740
MOD_PKA_2 533 539 PF00069 0.480
MOD_PKA_2 71 77 PF00069 0.449
MOD_Plk_1 146 152 PF00069 0.378
MOD_Plk_1 352 358 PF00069 0.318
MOD_Plk_1 405 411 PF00069 0.514
MOD_Plk_1 563 569 PF00069 0.661
MOD_Plk_2-3 191 197 PF00069 0.273
MOD_Plk_4 115 121 PF00069 0.415
MOD_Plk_4 151 157 PF00069 0.447
MOD_Plk_4 173 179 PF00069 0.395
MOD_Plk_4 224 230 PF00069 0.378
MOD_Plk_4 25 31 PF00069 0.637
MOD_Plk_4 352 358 PF00069 0.487
MOD_Plk_4 381 387 PF00069 0.704
MOD_Plk_4 423 429 PF00069 0.531
MOD_Plk_4 55 61 PF00069 0.335
MOD_ProDKin_1 17 23 PF00069 0.692
MOD_ProDKin_1 311 317 PF00069 0.746
MOD_ProDKin_1 320 326 PF00069 0.697
MOD_ProDKin_1 461 467 PF00069 0.400
MOD_ProDKin_1 528 534 PF00069 0.643
MOD_ProDKin_1 558 564 PF00069 0.659
MOD_ProDKin_1 593 599 PF00069 0.664
MOD_ProDKin_1 631 637 PF00069 0.578
MOD_ProDKin_1 672 678 PF00069 0.724
MOD_ProDKin_1 690 696 PF00069 0.701
MOD_SUMO_rev_2 674 683 PF00179 0.697
TRG_DiLeu_BaEn_1 25 30 PF01217 0.652
TRG_DiLeu_BaEn_1 540 545 PF01217 0.491
TRG_ENDOCYTIC_2 125 128 PF00928 0.428
TRG_ENDOCYTIC_2 163 166 PF00928 0.408
TRG_ENDOCYTIC_2 259 262 PF00928 0.447
TRG_ENDOCYTIC_2 427 430 PF00928 0.449
TRG_ER_diArg_1 454 457 PF00400 0.491
TRG_ER_diArg_1 617 620 PF00400 0.658
TRG_ER_diArg_1 707 710 PF00400 0.705
TRG_NES_CRM1_1 49 61 PF08389 0.335
TRG_NLS_MonoExtC_3 698 704 PF00514 0.672
TRG_Pf-PMV_PEXEL_1 202 206 PF00026 0.451

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I902 Leptomonas seymouri 60% 97%
A0A0S4IXS1 Bodo saltans 28% 100%
A0A1X0P069 Trypanosomatidae 34% 100%
A0A3Q8IK10 Leishmania donovani 100% 100%
A4HQ82 Leishmania braziliensis 82% 100%
D0A430 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AU00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q0J5 Leishmania major 95% 100%
V5DK61 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS