DUF3456 domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDX9_LEIIN

TriTrypDb:

LINF_360066300

Length:

327

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.496
CLV_C14_Caspase3-7	227	231	PF00656	0.475
CLV_NRD_NRD_1	212	214	PF00675	0.546
CLV_NRD_NRD_1	268	270	PF00675	0.485
CLV_NRD_NRD_1	308	310	PF00675	0.650
CLV_NRD_NRD_1	316	318	PF00675	0.699
CLV_NRD_NRD_1	37	39	PF00675	0.624
CLV_NRD_NRD_1	79	81	PF00675	0.497
CLV_PCSK_FUR_1	314	318	PF00082	0.627
CLV_PCSK_KEX2_1	122	124	PF00082	0.636
CLV_PCSK_KEX2_1	268	270	PF00082	0.491
CLV_PCSK_KEX2_1	316	318	PF00082	0.679
CLV_PCSK_KEX2_1	74	76	PF00082	0.401
CLV_PCSK_KEX2_1	81	83	PF00082	0.445
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.619
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.449
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.534
CLV_PCSK_PC7_1	264	270	PF00082	0.564
CLV_PCSK_SKI1_1	174	178	PF00082	0.431
CLV_PCSK_SKI1_1	207	211	PF00082	0.449
CLV_PCSK_SKI1_1	268	272	PF00082	0.532
DOC_CKS1_1	43	48	PF01111	0.472
DOC_CYCLIN_RxL_1	36	45	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.548
DOC_MAPK_gen_1	147	157	PF00069	0.468
DOC_MAPK_gen_1	213	219	PF00069	0.463
DOC_MAPK_MEF2A_6	134	141	PF00069	0.538
DOC_PP1_RVXF_1	189	196	PF00149	0.301
DOC_PP4_FxxP_1	198	201	PF00568	0.444
DOC_WW_Pin1_4	129	134	PF00397	0.625
DOC_WW_Pin1_4	2	7	PF00397	0.594
DOC_WW_Pin1_4	42	47	PF00397	0.490
LIG_14-3-3_CanoR_1	134	140	PF00244	0.499
LIG_14-3-3_CanoR_1	14	24	PF00244	0.557
LIG_Actin_WH2_2	212	228	PF00022	0.537
LIG_FHA_1	11	17	PF00498	0.612
LIG_FHA_1	152	158	PF00498	0.434
LIG_FHA_2	286	292	PF00498	0.566
LIG_FHA_2	297	303	PF00498	0.573
LIG_G3BP_FGDF_1	193	198	PF02136	0.291
LIG_GBD_Chelix_1	24	32	PF00786	0.461
LIG_LIR_Apic_2	197	201	PF02991	0.495
LIG_LIR_Gen_1	294	304	PF02991	0.480
LIG_LIR_Gen_1	61	69	PF02991	0.377
LIG_LIR_Nem_3	192	198	PF02991	0.511
LIG_LIR_Nem_3	294	300	PF02991	0.480
LIG_LIR_Nem_3	45	50	PF02991	0.442
LIG_LIR_Nem_3	61	65	PF02991	0.271
LIG_LYPXL_yS_3	47	50	PF13949	0.509
LIG_PDZ_Class_3	322	327	PF00595	0.695
LIG_PTAP_UEV_1	317	322	PF05743	0.650
LIG_PTB_Apo_2	63	70	PF02174	0.386
LIG_PTB_Phospho_1	63	69	PF10480	0.384
LIG_SH3_3	315	321	PF00018	0.640
LIG_SH3_3	43	49	PF00018	0.519
LIG_SH3_3	9	15	PF00018	0.617
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.470
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.486
LIG_TYR_ITSM	43	50	PF00017	0.464
LIG_WRC_WIRS_1	195	200	PF05994	0.421
LIG_WRC_WIRS_1	59	64	PF05994	0.387
MOD_CDK_SPK_2	129	134	PF00069	0.544
MOD_CK1_1	319	325	PF00069	0.735
MOD_CK1_1	5	11	PF00069	0.647
MOD_CK2_1	260	266	PF00069	0.484
MOD_CK2_1	290	296	PF00069	0.493
MOD_GlcNHglycan	164	167	PF01048	0.462
MOD_GlcNHglycan	18	21	PF01048	0.455
MOD_GlcNHglycan	257	260	PF01048	0.618
MOD_GlcNHglycan	318	321	PF01048	0.679
MOD_GlcNHglycan	35	38	PF01048	0.526
MOD_N-GLC_1	183	188	PF02516	0.450
MOD_N-GLC_2	96	98	PF02516	0.444
MOD_NEK2_1	16	21	PF00069	0.473
MOD_PKA_1	316	322	PF00069	0.646
MOD_PKA_2	225	231	PF00069	0.483
MOD_PKA_2	249	255	PF00069	0.552
MOD_PKA_2	316	322	PF00069	0.690
MOD_PKB_1	314	322	PF00069	0.637
MOD_Plk_1	295	301	PF00069	0.525
MOD_Plk_2-3	236	242	PF00069	0.556
MOD_Plk_2-3	296	302	PF00069	0.590
MOD_Plk_4	207	213	PF00069	0.314
MOD_Plk_4	243	249	PF00069	0.546
MOD_Plk_4	58	64	PF00069	0.363
MOD_ProDKin_1	129	135	PF00069	0.610
MOD_ProDKin_1	2	8	PF00069	0.593
MOD_ProDKin_1	42	48	PF00069	0.484
MOD_SUMO_for_1	73	76	PF00179	0.434
MOD_SUMO_rev_2	172	181	PF00179	0.307
TRG_ENDOCYTIC_2	47	50	PF00928	0.515
TRG_ER_diArg_1	267	269	PF00400	0.515
TRG_ER_diArg_1	314	317	PF00400	0.684
TRG_ER_diArg_1	80	83	PF00400	0.481
TRG_NES_CRM1_1	89	103	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P915	Leptomonas seymouri	51%	100%
A0A0S4IVP5	Bodo saltans	27%	100%
A0A1X0P0S9	Trypanosomatidae	31%	100%
A0A3R7NVI0	Trypanosoma rangeli	30%	100%
A0A3S7XC03	Leishmania donovani	100%	100%
A4HQ81	Leishmania braziliensis	65%	99%
D0A431	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0J6	Leishmania major	92%	100%
V5DK35	Trypanosoma cruzi	34%	99%