NERD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclease-related domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IDX5_LEIIN

TriTrypDb:

LINF_360065900

Length:

541

Annotations

LeishMANIAdb annotations

A conserved signal-anchored protein family of obscure function also found in plants and bacteria.. Some of the Leishmaniid proteins might have 3 TM segments instead of 1

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4IDX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.523
CLV_NRD_NRD_1	150	152	PF00675	0.416
CLV_NRD_NRD_1	176	178	PF00675	0.321
CLV_NRD_NRD_1	188	190	PF00675	0.235
CLV_NRD_NRD_1	234	236	PF00675	0.355
CLV_NRD_NRD_1	258	260	PF00675	0.234
CLV_NRD_NRD_1	265	267	PF00675	0.234
CLV_NRD_NRD_1	435	437	PF00675	0.296
CLV_NRD_NRD_1	56	58	PF00675	0.599
CLV_PCSK_KEX2_1	150	152	PF00082	0.416
CLV_PCSK_KEX2_1	187	189	PF00082	0.235
CLV_PCSK_KEX2_1	236	238	PF00082	0.300
CLV_PCSK_KEX2_1	258	260	PF00082	0.234
CLV_PCSK_KEX2_1	265	267	PF00082	0.234
CLV_PCSK_KEX2_1	291	293	PF00082	0.316
CLV_PCSK_KEX2_1	473	475	PF00082	0.388
CLV_PCSK_KEX2_1	56	58	PF00082	0.558
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.307
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.349
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.409
CLV_PCSK_PC7_1	146	152	PF00082	0.456
CLV_PCSK_SKI1_1	23	27	PF00082	0.154
CLV_PCSK_SKI1_1	291	295	PF00082	0.372
CLV_PCSK_SKI1_1	331	335	PF00082	0.364
CLV_PCSK_SKI1_1	416	420	PF00082	0.402
CLV_PCSK_SKI1_1	437	441	PF00082	0.302
CLV_PCSK_SKI1_1	455	459	PF00082	0.463
CLV_PCSK_SKI1_1	474	478	PF00082	0.312
CLV_PCSK_SKI1_1	79	83	PF00082	0.489
DEG_APCC_DBOX_1	435	443	PF00400	0.540
DEG_APCC_KENBOX_2	500	504	PF00400	0.594
DEG_COP1_1	421	430	PF00400	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.526
DOC_CKS1_1	377	382	PF01111	0.616
DOC_CYCLIN_RxL_1	452	461	PF00134	0.556
DOC_MAPK_DCC_7	307	315	PF00069	0.537
DOC_MAPK_gen_1	2	12	PF00069	0.523
DOC_MAPK_gen_1	233	243	PF00069	0.537
DOC_MAPK_gen_1	436	444	PF00069	0.494
DOC_MAPK_gen_1	445	453	PF00069	0.546
DOC_MAPK_MEF2A_6	307	315	PF00069	0.469
DOC_MAPK_MEF2A_6	436	444	PF00069	0.482
DOC_MAPK_MEF2A_6	5	14	PF00069	0.521
DOC_MAPK_RevD_3	318	331	PF00069	0.602
DOC_PP1_RVXF_1	67	73	PF00149	0.277
DOC_PP2B_LxvP_1	81	84	PF13499	0.321
DOC_PP2B_PxIxI_1	207	213	PF00149	0.537
DOC_PP4_FxxP_1	315	318	PF00568	0.495
DOC_PP4_FxxP_1	82	85	PF00568	0.291
DOC_USP7_MATH_1	360	364	PF00917	0.652
DOC_USP7_MATH_1	90	94	PF00917	0.340
DOC_USP7_UBL2_3	299	303	PF12436	0.546
DOC_USP7_UBL2_3	473	477	PF12436	0.614
DOC_USP7_UBL2_3	478	482	PF12436	0.656
DOC_WW_Pin1_4	376	381	PF00397	0.685
DOC_WW_Pin1_4	38	43	PF00397	0.258
DOC_WW_Pin1_4	55	60	PF00397	0.402
LIG_14-3-3_CanoR_1	292	296	PF00244	0.539
LIG_CaM_IQ_9	163	179	PF13499	0.537
LIG_eIF4E_1	434	440	PF01652	0.539
LIG_FHA_1	111	117	PF00498	0.265
LIG_FHA_1	119	125	PF00498	0.276
LIG_FHA_1	336	342	PF00498	0.520
LIG_FHA_1	404	410	PF00498	0.555
LIG_FHA_1	41	47	PF00498	0.390
LIG_FHA_1	417	423	PF00498	0.574
LIG_FHA_1	457	463	PF00498	0.559
LIG_FHA_1	511	517	PF00498	0.539
LIG_GBD_Chelix_1	409	417	PF00786	0.383
LIG_LIR_Apic_2	60	65	PF02991	0.316
LIG_LIR_Gen_1	112	123	PF02991	0.331
LIG_LIR_Gen_1	240	251	PF02991	0.439
LIG_LIR_Gen_1	406	413	PF02991	0.466
LIG_LIR_Gen_1	502	511	PF02991	0.555
LIG_LIR_Nem_3	112	118	PF02991	0.331
LIG_LIR_Nem_3	240	246	PF02991	0.445
LIG_LIR_Nem_3	337	342	PF02991	0.486
LIG_LIR_Nem_3	366	371	PF02991	0.630
LIG_LIR_Nem_3	406	410	PF02991	0.463
LIG_LIR_Nem_3	429	434	PF02991	0.581
LIG_NRBOX	408	414	PF00104	0.570
LIG_Pex14_1	181	185	PF04695	0.445
LIG_Pex14_1	407	411	PF04695	0.475
LIG_REV1ctd_RIR_1	52	58	PF16727	0.337
LIG_RPA_C_Fungi	183	195	PF08784	0.414
LIG_SH2_CRK	62	66	PF00017	0.376
LIG_SH2_PTP2	115	118	PF00017	0.313
LIG_SH2_STAT5	115	118	PF00017	0.364
LIG_SH2_STAT5	260	263	PF00017	0.425
LIG_SH2_STAT5	332	335	PF00017	0.398
LIG_SH2_STAT5	411	414	PF00017	0.341
LIG_SH2_STAT5	505	508	PF00017	0.417
LIG_SH3_2	494	499	PF14604	0.554
LIG_SH3_3	264	270	PF00018	0.364
LIG_SH3_3	371	377	PF00018	0.653
LIG_SH3_3	491	497	PF00018	0.415
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.270
LIG_SUMO_SIM_anti_2	464	471	PF11976	0.474
LIG_SUMO_SIM_par_1	105	113	PF11976	0.547
LIG_SUMO_SIM_par_1	11	17	PF11976	0.385
LIG_SUMO_SIM_par_1	208	214	PF11976	0.274
LIG_SUMO_SIM_par_1	310	316	PF11976	0.285
LIG_SUMO_SIM_par_1	517	523	PF11976	0.356
LIG_WRC_WIRS_1	336	341	PF05994	0.360
MOD_CDK_SPxK_1	55	61	PF00069	0.444
MOD_CDK_SPxxK_3	38	45	PF00069	0.344
MOD_CK1_1	297	303	PF00069	0.406
MOD_CK1_1	363	369	PF00069	0.578
MOD_CK1_1	375	381	PF00069	0.510
MOD_CK1_1	461	467	PF00069	0.520
MOD_CK1_1	93	99	PF00069	0.401
MOD_CMANNOS	365	368	PF00535	0.603
MOD_Cter_Amidation	289	292	PF01082	0.469
MOD_DYRK1A_RPxSP_1	376	380	PF00069	0.651
MOD_GlcNHglycan	381	384	PF01048	0.609
MOD_GlcNHglycan	428	431	PF01048	0.440
MOD_GlcNHglycan	47	50	PF01048	0.442
MOD_GlcNHglycan	95	98	PF01048	0.561
MOD_GSK3_1	360	367	PF00069	0.536
MOD_GSK3_1	372	379	PF00069	0.550
MOD_GSK3_1	89	96	PF00069	0.461
MOD_NEK2_1	110	115	PF00069	0.512
MOD_NEK2_1	118	123	PF00069	0.364
MOD_NEK2_1	130	135	PF00069	0.371
MOD_NEK2_1	162	167	PF00069	0.451
MOD_NEK2_1	221	226	PF00069	0.443
MOD_NEK2_1	27	32	PF00069	0.181
MOD_NEK2_1	372	377	PF00069	0.518
MOD_NEK2_1	453	458	PF00069	0.421
MOD_NEK2_1	467	472	PF00069	0.362
MOD_NEK2_1	510	515	PF00069	0.483
MOD_NEK2_2	137	142	PF00069	0.572
MOD_PIKK_1	144	150	PF00454	0.613
MOD_PIKK_1	18	24	PF00454	0.316
MOD_PKA_1	291	297	PF00069	0.339
MOD_PKA_2	137	143	PF00069	0.416
MOD_PKA_2	283	289	PF00069	0.421
MOD_PKA_2	291	297	PF00069	0.409
MOD_PKA_2	372	378	PF00069	0.648
MOD_PKB_1	235	243	PF00069	0.339
MOD_Plk_1	110	116	PF00069	0.452
MOD_Plk_1	297	303	PF00069	0.223
MOD_Plk_1	90	96	PF00069	0.415
MOD_Plk_4	105	111	PF00069	0.487
MOD_Plk_4	119	125	PF00069	0.214
MOD_Plk_4	291	297	PF00069	0.285
MOD_Plk_4	360	366	PF00069	0.516
MOD_Plk_4	453	459	PF00069	0.492
MOD_Plk_4	515	521	PF00069	0.527
MOD_ProDKin_1	376	382	PF00069	0.621
MOD_ProDKin_1	38	44	PF00069	0.258
MOD_ProDKin_1	55	61	PF00069	0.504
MOD_SUMO_rev_2	165	172	PF00179	0.394
TRG_DiLeu_BaEn_1	502	507	PF01217	0.440
TRG_DiLeu_BaEn_2	157	163	PF01217	0.429
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.488
TRG_ENDOCYTIC_2	115	118	PF00928	0.364
TRG_ENDOCYTIC_2	505	508	PF00928	0.442
TRG_ENDOCYTIC_2	78	81	PF00928	0.365
TRG_ER_diArg_1	149	151	PF00400	0.516
TRG_ER_diArg_1	186	189	PF00400	0.311
TRG_ER_diArg_1	235	238	PF00400	0.401
TRG_ER_diArg_1	257	259	PF00400	0.270
TRG_ER_diArg_1	265	267	PF00400	0.270
TRG_ER_diArg_1	55	57	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN0	Leptomonas seymouri	73%	100%
A0A0S4J7E4	Bodo saltans	36%	100%
A0A1X0P0I4	Trypanosomatidae	42%	100%
A0A3R7R7J3	Trypanosoma rangeli	43%	100%
A0A3S7XC13	Leishmania donovani	99%	100%
A4HQ77	Leishmania braziliensis	86%	100%
D0A437	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0K0	Leishmania major	90%	100%
V5B3M2	Trypanosoma cruzi	41%	100%