Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDX4_LEIIN

TriTrypDb:

LINF_360065800

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.684
CLV_C14_Caspase3-7	238	242	PF00656	0.514
CLV_C14_Caspase3-7	401	405	PF00656	0.606
CLV_NRD_NRD_1	142	144	PF00675	0.531
CLV_NRD_NRD_1	229	231	PF00675	0.479
CLV_NRD_NRD_1	28	30	PF00675	0.634
CLV_NRD_NRD_1	318	320	PF00675	0.583
CLV_NRD_NRD_1	375	377	PF00675	0.596
CLV_NRD_NRD_1	447	449	PF00675	0.522
CLV_NRD_NRD_1	67	69	PF00675	0.753
CLV_PCSK_FUR_1	316	320	PF00082	0.568
CLV_PCSK_KEX2_1	142	144	PF00082	0.531
CLV_PCSK_KEX2_1	229	231	PF00082	0.440
CLV_PCSK_KEX2_1	27	29	PF00082	0.633
CLV_PCSK_KEX2_1	318	320	PF00082	0.583
CLV_PCSK_KEX2_1	375	377	PF00082	0.550
CLV_PCSK_KEX2_1	447	449	PF00082	0.522
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.702
CLV_PCSK_PC7_1	23	29	PF00082	0.649
CLV_PCSK_SKI1_1	143	147	PF00082	0.488
CLV_PCSK_SKI1_1	150	154	PF00082	0.521
CLV_PCSK_SKI1_1	230	234	PF00082	0.509
CLV_PCSK_SKI1_1	269	273	PF00082	0.775
CLV_PCSK_SKI1_1	319	323	PF00082	0.541
CLV_PCSK_SKI1_1	378	382	PF00082	0.535
CLV_PCSK_SKI1_1	503	507	PF00082	0.411
CLV_PCSK_SKI1_1	531	535	PF00082	0.678
DEG_APCC_DBOX_1	142	150	PF00400	0.538
DEG_APCC_DBOX_1	228	236	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.683
DEG_SPOP_SBC_1	523	527	PF00917	0.565
DOC_CKS1_1	9	14	PF01111	0.726
DOC_CYCLIN_RxL_1	227	237	PF00134	0.580
DOC_CYCLIN_yCln2_LP_2	152	155	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.543
DOC_MAPK_gen_1	170	178	PF00069	0.754
DOC_MAPK_gen_1	447	454	PF00069	0.428
DOC_MAPK_gen_1	503	513	PF00069	0.444
DOC_PP2B_LxvP_1	152	155	PF13499	0.593
DOC_PP2B_LxvP_1	283	286	PF13499	0.471
DOC_SPAK_OSR1_1	172	176	PF12202	0.718
DOC_USP7_MATH_1	157	161	PF00917	0.722
DOC_USP7_MATH_1	177	181	PF00917	0.666
DOC_USP7_MATH_1	385	389	PF00917	0.606
DOC_USP7_MATH_1	542	546	PF00917	0.679
DOC_USP7_UBL2_3	65	69	PF12436	0.734
DOC_WW_Pin1_4	126	131	PF00397	0.612
DOC_WW_Pin1_4	179	184	PF00397	0.698
DOC_WW_Pin1_4	2	7	PF00397	0.717
DOC_WW_Pin1_4	248	253	PF00397	0.612
DOC_WW_Pin1_4	278	283	PF00397	0.576
DOC_WW_Pin1_4	387	392	PF00397	0.713
DOC_WW_Pin1_4	476	481	PF00397	0.674
DOC_WW_Pin1_4	67	72	PF00397	0.772
DOC_WW_Pin1_4	75	80	PF00397	0.665
DOC_WW_Pin1_4	8	13	PF00397	0.652
DOC_WW_Pin1_4	92	97	PF00397	0.794
LIG_14-3-3_CanoR_1	16	25	PF00244	0.500
LIG_14-3-3_CanoR_1	191	198	PF00244	0.663
LIG_14-3-3_CanoR_1	327	332	PF00244	0.488
LIG_14-3-3_CanoR_1	360	364	PF00244	0.522
LIG_14-3-3_CanoR_1	375	381	PF00244	0.525
LIG_Actin_WH2_2	490	505	PF00022	0.492
LIG_BIR_III_2	34	38	PF00653	0.647
LIG_BRCT_BRCA1_1	518	522	PF00533	0.478
LIG_CSL_BTD_1	9	12	PF09270	0.724
LIG_EH1_1	328	336	PF00400	0.538
LIG_eIF4E_1	329	335	PF01652	0.462
LIG_FHA_1	249	255	PF00498	0.570
LIG_FHA_1	350	356	PF00498	0.521
LIG_FHA_1	405	411	PF00498	0.628
LIG_FHA_1	466	472	PF00498	0.526
LIG_FHA_1	48	54	PF00498	0.721
LIG_FHA_1	553	559	PF00498	0.566
LIG_FHA_2	236	242	PF00498	0.510
LIG_FHA_2	256	262	PF00498	0.785
LIG_FHA_2	399	405	PF00498	0.723
LIG_NRBOX	333	339	PF00104	0.452
LIG_Pex14_1	10	14	PF04695	0.648
LIG_RPA_C_Fungi	24	36	PF08784	0.690
LIG_SH2_CRK	323	327	PF00017	0.511
LIG_SH2_NCK_1	210	214	PF00017	0.487
LIG_SH2_NCK_1	329	333	PF00017	0.464
LIG_SH2_NCK_1	551	555	PF00017	0.577
LIG_SH2_SRC	551	554	PF00017	0.636
LIG_SH2_STAT5	14	17	PF00017	0.629
LIG_SH2_STAT5	24	27	PF00017	0.652
LIG_SH2_STAT5	290	293	PF00017	0.545
LIG_SH3_2	183	188	PF14604	0.709
LIG_SH3_2	63	68	PF14604	0.699
LIG_SH3_3	142	148	PF00018	0.613
LIG_SH3_3	180	186	PF00018	0.679
LIG_SH3_3	58	64	PF00018	0.710
LIG_SH3_3	73	79	PF00018	0.783
LIG_SH3_4	65	72	PF00018	0.651
LIG_SUMO_SIM_par_1	299	308	PF11976	0.454
LIG_SUMO_SIM_par_1	456	462	PF11976	0.429
LIG_TRAF2_1	416	419	PF00917	0.555
LIG_TYR_ITIM	321	326	PF00017	0.492
LIG_WW_3	185	189	PF00397	0.773
MOD_CDK_SPK_2	8	13	PF00069	0.728
MOD_CDK_SPxK_1	2	8	PF00069	0.658
MOD_CK1_1	124	130	PF00069	0.633
MOD_CK1_1	250	256	PF00069	0.727
MOD_CK1_1	362	368	PF00069	0.431
MOD_CK1_1	77	83	PF00069	0.718
MOD_CK2_1	67	73	PF00069	0.827
MOD_Cter_Amidation	25	28	PF01082	0.708
MOD_Cter_Amidation	316	319	PF01082	0.632
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.627
MOD_GlcNHglycan	138	142	PF01048	0.558
MOD_GlcNHglycan	159	162	PF01048	0.640
MOD_GlcNHglycan	163	166	PF01048	0.724
MOD_GlcNHglycan	179	182	PF01048	0.563
MOD_GlcNHglycan	19	22	PF01048	0.656
MOD_GlcNHglycan	211	214	PF01048	0.563
MOD_GlcNHglycan	278	281	PF01048	0.687
MOD_GlcNHglycan	392	395	PF01048	0.685
MOD_GlcNHglycan	528	531	PF01048	0.507
MOD_GlcNHglycan	562	565	PF01048	0.729
MOD_GlcNHglycan	90	93	PF01048	0.770
MOD_GSK3_1	117	124	PF00069	0.574
MOD_GSK3_1	157	164	PF00069	0.800
MOD_GSK3_1	246	253	PF00069	0.704
MOD_GSK3_1	272	279	PF00069	0.700
MOD_GSK3_1	349	356	PF00069	0.521
MOD_GSK3_1	359	366	PF00069	0.455
MOD_GSK3_1	436	443	PF00069	0.512
MOD_GSK3_1	522	529	PF00069	0.443
MOD_GSK3_1	88	95	PF00069	0.740
MOD_LATS_1	374	380	PF00433	0.515
MOD_NEK2_1	101	106	PF00069	0.650
MOD_NEK2_1	209	214	PF00069	0.464
MOD_NEK2_1	235	240	PF00069	0.576
MOD_NEK2_1	288	293	PF00069	0.418
MOD_NEK2_1	321	326	PF00069	0.566
MOD_NEK2_1	353	358	PF00069	0.522
MOD_NEK2_1	359	364	PF00069	0.508
MOD_NEK2_1	438	443	PF00069	0.441
MOD_NEK2_1	495	500	PF00069	0.565
MOD_NEK2_1	522	527	PF00069	0.491
MOD_PIKK_1	121	127	PF00454	0.642
MOD_PIKK_1	321	327	PF00454	0.574
MOD_PK_1	327	333	PF00069	0.479
MOD_PKA_2	190	196	PF00069	0.748
MOD_PKA_2	359	365	PF00069	0.518
MOD_PKA_2	88	94	PF00069	0.707
MOD_Plk_1	116	122	PF00069	0.433
MOD_Plk_1	418	424	PF00069	0.481
MOD_Plk_4	359	365	PF00069	0.514
MOD_ProDKin_1	126	132	PF00069	0.605
MOD_ProDKin_1	179	185	PF00069	0.698
MOD_ProDKin_1	2	8	PF00069	0.712
MOD_ProDKin_1	248	254	PF00069	0.613
MOD_ProDKin_1	278	284	PF00069	0.564
MOD_ProDKin_1	387	393	PF00069	0.721
MOD_ProDKin_1	476	482	PF00069	0.667
MOD_ProDKin_1	67	73	PF00069	0.772
MOD_ProDKin_1	75	81	PF00069	0.665
MOD_ProDKin_1	92	98	PF00069	0.793
TRG_DiLeu_BaEn_1	216	221	PF01217	0.533
TRG_DiLeu_BaEn_2	427	433	PF01217	0.446
TRG_DiLeu_BaEn_2	488	494	PF01217	0.539
TRG_DiLeu_BaEn_4	418	424	PF01217	0.559
TRG_ENDOCYTIC_2	323	326	PF00928	0.470
TRG_ENDOCYTIC_2	551	554	PF00928	0.583
TRG_ER_diArg_1	170	173	PF00400	0.611
TRG_ER_diArg_1	228	230	PF00400	0.470
TRG_ER_diArg_1	28	31	PF00400	0.708
TRG_ER_diArg_1	316	319	PF00400	0.593
TRG_ER_diArg_1	375	378	PF00400	0.600
TRG_NLS_MonoExtC_3	26	31	PF00514	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS8	Leptomonas seymouri	45%	95%
A0A1X0P1C1	Trypanosomatidae	28%	100%
A0A3Q8IJU5	Leishmania donovani	99%	100%
A4HQ76	Leishmania braziliensis	73%	98%
E9ATZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0K1	Leishmania major	90%	100%