Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase P1 - putative

Species:

Leishmania infantum

UniProt:

A4IDX0_LEIIN

TriTrypDb:

LINF_360065300

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0070006	metalloaminopeptidase activity	6	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.559
CLV_C14_Caspase3-7	368	372	PF00656	0.516
CLV_C14_Caspase3-7	470	474	PF00656	0.400
CLV_NRD_NRD_1	189	191	PF00675	0.546
CLV_NRD_NRD_1	3	5	PF00675	0.535
CLV_NRD_NRD_1	381	383	PF00675	0.360
CLV_NRD_NRD_1	49	51	PF00675	0.318
CLV_NRD_NRD_1	523	525	PF00675	0.336
CLV_NRD_NRD_1	559	561	PF00675	0.312
CLV_NRD_NRD_1	6	8	PF00675	0.530
CLV_NRD_NRD_1	96	98	PF00675	0.427
CLV_PCSK_FUR_1	4	8	PF00082	0.483
CLV_PCSK_FUR_1	47	51	PF00082	0.364
CLV_PCSK_KEX2_1	155	157	PF00082	0.440
CLV_PCSK_KEX2_1	189	191	PF00082	0.546
CLV_PCSK_KEX2_1	3	5	PF00082	0.536
CLV_PCSK_KEX2_1	342	344	PF00082	0.629
CLV_PCSK_KEX2_1	381	383	PF00082	0.360
CLV_PCSK_KEX2_1	47	49	PF00082	0.312
CLV_PCSK_KEX2_1	559	561	PF00082	0.328
CLV_PCSK_KEX2_1	6	8	PF00082	0.531
CLV_PCSK_KEX2_1	96	98	PF00082	0.427
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.440
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.615
CLV_PCSK_PC7_1	92	98	PF00082	0.431
CLV_PCSK_SKI1_1	119	123	PF00082	0.570
CLV_PCSK_SKI1_1	155	159	PF00082	0.432
CLV_PCSK_SKI1_1	190	194	PF00082	0.525
CLV_PCSK_SKI1_1	263	267	PF00082	0.534
CLV_PCSK_SKI1_1	391	395	PF00082	0.340
CLV_PCSK_SKI1_1	49	53	PF00082	0.464
CLV_PCSK_SKI1_1	524	528	PF00082	0.312
CLV_PCSK_SKI1_1	548	552	PF00082	0.300
CLV_PCSK_SKI1_1	658	662	PF00082	0.376
CLV_PCSK_SKI1_1	764	768	PF00082	0.398
DEG_APCC_DBOX_1	48	56	PF00400	0.340
DEG_APCC_DBOX_1	523	531	PF00400	0.312
DEG_APCC_DBOX_1	547	555	PF00400	0.291
DEG_APCC_DBOX_1	657	665	PF00400	0.312
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DEG_ODPH_VHL_1	99	112	PF01847	0.556
DEG_SPOP_SBC_1	271	275	PF00917	0.611
DEG_SPOP_SBC_1	561	565	PF00917	0.255
DOC_ANK_TNKS_1	498	505	PF00023	0.312
DOC_CYCLIN_RxL_1	152	161	PF00134	0.394
DOC_CYCLIN_RxL_1	296	305	PF00134	0.606
DOC_CYCLIN_yClb1_LxF_4	760	766	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.469
DOC_MAPK_MEF2A_6	16	23	PF00069	0.616
DOC_MAPK_MEF2A_6	666	673	PF00069	0.340
DOC_PP2B_LxvP_1	130	133	PF13499	0.387
DOC_PP2B_LxvP_1	376	379	PF13499	0.417
DOC_PP2B_LxvP_1	686	689	PF13499	0.359
DOC_PP2B_LxvP_1	99	102	PF13499	0.552
DOC_PP4_FxxP_1	277	280	PF00568	0.429
DOC_PP4_FxxP_1	393	396	PF00568	0.297
DOC_USP7_MATH_1	204	208	PF00917	0.524
DOC_USP7_MATH_1	258	262	PF00917	0.603
DOC_USP7_MATH_1	313	317	PF00917	0.385
DOC_USP7_MATH_1	360	364	PF00917	0.546
DOC_USP7_MATH_1	502	506	PF00917	0.344
DOC_USP7_MATH_1	532	536	PF00917	0.388
DOC_USP7_MATH_1	56	60	PF00917	0.388
DOC_USP7_MATH_1	561	565	PF00917	0.385
DOC_USP7_MATH_1	572	576	PF00917	0.277
DOC_USP7_MATH_1	66	70	PF00917	0.285
DOC_USP7_MATH_1	779	783	PF00917	0.392
DOC_USP7_MATH_1	810	814	PF00917	0.416
DOC_USP7_MATH_1	817	821	PF00917	0.365
DOC_WW_Pin1_4	165	170	PF00397	0.763
DOC_WW_Pin1_4	326	331	PF00397	0.527
DOC_WW_Pin1_4	352	357	PF00397	0.636
DOC_WW_Pin1_4	564	569	PF00397	0.295
DOC_WW_Pin1_4	578	583	PF00397	0.275
DOC_WW_Pin1_4	632	637	PF00397	0.291
DOC_WW_Pin1_4	687	692	PF00397	0.520
LIG_14-3-3_CanoR_1	16	20	PF00244	0.589
LIG_14-3-3_CanoR_1	381	389	PF00244	0.471
LIG_14-3-3_CanoR_1	407	414	PF00244	0.315
LIG_14-3-3_CanoR_1	419	425	PF00244	0.327
LIG_14-3-3_CanoR_1	507	513	PF00244	0.340
LIG_14-3-3_CanoR_1	559	568	PF00244	0.364
LIG_14-3-3_CanoR_1	7	13	PF00244	0.579
LIG_APCC_ABBA_1	606	611	PF00400	0.312
LIG_BIR_III_4	161	165	PF00653	0.507
LIG_BRCT_BRCA1_1	504	508	PF00533	0.340
LIG_CaM_IQ_9	756	772	PF13499	0.371
LIG_Clathr_ClatBox_1	553	557	PF01394	0.315
LIG_Clathr_ClatBox_1	661	665	PF01394	0.388
LIG_deltaCOP1_diTrp_1	82	89	PF00928	0.312
LIG_FHA_1	105	111	PF00498	0.510
LIG_FHA_1	124	130	PF00498	0.408
LIG_FHA_1	137	143	PF00498	0.531
LIG_FHA_1	176	182	PF00498	0.518
LIG_FHA_1	24	30	PF00498	0.651
LIG_FHA_1	312	318	PF00498	0.489
LIG_FHA_1	327	333	PF00498	0.493
LIG_FHA_1	371	377	PF00498	0.605
LIG_FHA_1	498	504	PF00498	0.307
LIG_FHA_1	545	551	PF00498	0.312
LIG_FHA_1	633	639	PF00498	0.454
LIG_FHA_1	757	763	PF00498	0.510
LIG_FHA_1	822	828	PF00498	0.333
LIG_FHA_2	175	181	PF00498	0.443
LIG_FHA_2	421	427	PF00498	0.390
LIG_FHA_2	468	474	PF00498	0.388
LIG_Integrin_RGD_1	712	714	PF01839	0.339
LIG_LIR_Apic_2	274	280	PF02991	0.472
LIG_LIR_Gen_1	282	293	PF02991	0.366
LIG_LIR_Gen_1	383	393	PF02991	0.560
LIG_LIR_Gen_1	410	421	PF02991	0.331
LIG_LIR_Gen_1	83	94	PF02991	0.312
LIG_LIR_Nem_3	152	157	PF02991	0.436
LIG_LIR_Nem_3	282	288	PF02991	0.378
LIG_LIR_Nem_3	383	389	PF02991	0.561
LIG_LIR_Nem_3	410	416	PF02991	0.312
LIG_LIR_Nem_3	510	515	PF02991	0.412
LIG_LIR_Nem_3	813	818	PF02991	0.408
LIG_LIR_Nem_3	82	88	PF02991	0.312
LIG_MYND_1	330	334	PF01753	0.615
LIG_NRBOX	549	555	PF00104	0.315
LIG_PCNA_TLS_4	278	285	PF02747	0.339
LIG_Pex14_1	85	89	PF04695	0.312
LIG_Pex14_2	600	604	PF04695	0.388
LIG_PTB_Apo_2	795	802	PF02174	0.501
LIG_PTB_Phospho_1	795	801	PF10480	0.492
LIG_SH2_CRK	154	158	PF00017	0.419
LIG_SH2_CRK	322	326	PF00017	0.451
LIG_SH2_CRK	418	422	PF00017	0.255
LIG_SH2_CRK	818	822	PF00017	0.335
LIG_SH2_GRB2like	801	804	PF00017	0.454
LIG_SH2_NCK_1	322	326	PF00017	0.499
LIG_SH2_PTP2	454	457	PF00017	0.312
LIG_SH2_PTP2	512	515	PF00017	0.388
LIG_SH2_SRC	454	457	PF00017	0.312
LIG_SH2_SRC	652	655	PF00017	0.388
LIG_SH2_STAP1	322	326	PF00017	0.390
LIG_SH2_STAP1	386	390	PF00017	0.455
LIG_SH2_STAP1	71	75	PF00017	0.312
LIG_SH2_STAP1	818	822	PF00017	0.335
LIG_SH2_STAT3	242	245	PF00017	0.450
LIG_SH2_STAT5	454	457	PF00017	0.339
LIG_SH2_STAT5	512	515	PF00017	0.388
LIG_SH2_STAT5	652	655	PF00017	0.388
LIG_SH2_STAT5	715	718	PF00017	0.352
LIG_SH3_3	292	298	PF00018	0.382
LIG_SH3_3	343	349	PF00018	0.798
LIG_SH3_3	472	478	PF00018	0.327
LIG_SH3_3	58	64	PF00018	0.388
LIG_SH3_3	612	618	PF00018	0.340
LIG_SH3_3	648	654	PF00018	0.388
LIG_SH3_3	703	709	PF00018	0.461
LIG_SH3_3	793	799	PF00018	0.412
LIG_SH3_3	802	808	PF00018	0.420
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.312
LIG_SUMO_SIM_anti_2	682	690	PF11976	0.312
LIG_SUMO_SIM_anti_2	830	835	PF11976	0.419
LIG_SUMO_SIM_par_1	18	26	PF11976	0.528
LIG_SUMO_SIM_par_1	682	690	PF11976	0.388
LIG_TRAF2_1	40	43	PF00917	0.496
LIG_TRAF2_1	624	627	PF00917	0.315
LIG_UBA3_1	519	525	PF00899	0.388
LIG_UBA3_1	526	531	PF00899	0.316
MOD_CDK_SPK_2	632	637	PF00069	0.340
MOD_CK1_1	104	110	PF00069	0.516
MOD_CK1_1	168	174	PF00069	0.493
MOD_CK1_1	212	218	PF00069	0.485
MOD_CK1_1	286	292	PF00069	0.530
MOD_CK1_1	365	371	PF00069	0.650
MOD_CK1_1	564	570	PF00069	0.245
MOD_CK1_1	613	619	PF00069	0.364
MOD_CK1_1	69	75	PF00069	0.388
MOD_CK1_1	782	788	PF00069	0.377
MOD_CK2_1	174	180	PF00069	0.450
MOD_CK2_1	204	210	PF00069	0.532
MOD_CK2_1	37	43	PF00069	0.432
MOD_CK2_1	420	426	PF00069	0.417
MOD_CK2_1	577	583	PF00069	0.397
MOD_GlcNHglycan	103	106	PF01048	0.572
MOD_GlcNHglycan	205	209	PF01048	0.493
MOD_GlcNHglycan	214	217	PF01048	0.466
MOD_GlcNHglycan	288	291	PF01048	0.470
MOD_GlcNHglycan	31	34	PF01048	0.569
MOD_GlcNHglycan	322	325	PF01048	0.445
MOD_GlcNHglycan	362	365	PF01048	0.629
MOD_GlcNHglycan	37	42	PF01048	0.445
MOD_GlcNHglycan	404	407	PF01048	0.325
MOD_GlcNHglycan	439	443	PF01048	0.380
MOD_GlcNHglycan	459	462	PF01048	0.255
MOD_GlcNHglycan	564	567	PF01048	0.304
MOD_GlcNHglycan	574	577	PF01048	0.319
MOD_GlcNHglycan	654	657	PF01048	0.424
MOD_GlcNHglycan	728	731	PF01048	0.576
MOD_GSK3_1	100	107	PF00069	0.518
MOD_GSK3_1	134	141	PF00069	0.637
MOD_GSK3_1	15	22	PF00069	0.662
MOD_GSK3_1	358	365	PF00069	0.630
MOD_GSK3_1	402	409	PF00069	0.315
MOD_GSK3_1	503	510	PF00069	0.340
MOD_GSK3_1	560	567	PF00069	0.345
MOD_GSK3_1	572	579	PF00069	0.366
MOD_GSK3_1	734	741	PF00069	0.542
MOD_GSK3_1	817	824	PF00069	0.495
MOD_NEK2_1	23	28	PF00069	0.589
MOD_NEK2_1	284	289	PF00069	0.396
MOD_NEK2_1	320	325	PF00069	0.482
MOD_NEK2_1	590	595	PF00069	0.388
MOD_NEK2_1	738	743	PF00069	0.437
MOD_NEK2_1	823	828	PF00069	0.338
MOD_NEK2_2	258	263	PF00069	0.524
MOD_NEK2_2	532	537	PF00069	0.340
MOD_NEK2_2	66	71	PF00069	0.388
MOD_PIKK_1	123	129	PF00454	0.420
MOD_PIKK_1	149	155	PF00454	0.391
MOD_PIKK_1	394	400	PF00454	0.362
MOD_PIKK_1	756	762	PF00454	0.390
MOD_PKA_2	110	116	PF00069	0.356
MOD_PKA_2	15	21	PF00069	0.600
MOD_PKA_2	320	326	PF00069	0.459
MOD_PKA_2	380	386	PF00069	0.496
MOD_PKA_2	406	412	PF00069	0.312
MOD_PKA_2	462	468	PF00069	0.312
MOD_Plk_1	209	215	PF00069	0.553
MOD_Plk_1	271	277	PF00069	0.636
MOD_Plk_1	370	376	PF00069	0.509
MOD_Plk_1	56	62	PF00069	0.365
MOD_Plk_1	610	616	PF00069	0.454
MOD_Plk_1	66	72	PF00069	0.265
MOD_Plk_4	125	131	PF00069	0.377
MOD_Plk_4	138	144	PF00069	0.561
MOD_Plk_4	272	278	PF00069	0.497
MOD_Plk_4	313	319	PF00069	0.485
MOD_Plk_4	508	514	PF00069	0.388
MOD_Plk_4	56	62	PF00069	0.388
MOD_Plk_4	66	72	PF00069	0.356
MOD_Plk_4	734	740	PF00069	0.467
MOD_Plk_4	746	752	PF00069	0.398
MOD_Plk_4	791	797	PF00069	0.451
MOD_Plk_4	80	86	PF00069	0.235
MOD_Plk_4	817	823	PF00069	0.375
MOD_ProDKin_1	165	171	PF00069	0.755
MOD_ProDKin_1	326	332	PF00069	0.530
MOD_ProDKin_1	352	358	PF00069	0.628
MOD_ProDKin_1	564	570	PF00069	0.295
MOD_ProDKin_1	578	584	PF00069	0.275
MOD_ProDKin_1	632	638	PF00069	0.291
MOD_ProDKin_1	687	693	PF00069	0.532
MOD_SUMO_for_1	624	627	PF00179	0.315
TRG_DiLeu_BaEn_1	546	551	PF01217	0.312
TRG_DiLeu_BaEn_1	682	687	PF01217	0.312
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.375
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.404
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.493
TRG_ENDOCYTIC_2	154	157	PF00928	0.427
TRG_ENDOCYTIC_2	322	325	PF00928	0.487
TRG_ENDOCYTIC_2	386	389	PF00928	0.391
TRG_ENDOCYTIC_2	390	393	PF00928	0.362
TRG_ENDOCYTIC_2	454	457	PF00928	0.312
TRG_ENDOCYTIC_2	512	515	PF00928	0.331
TRG_ENDOCYTIC_2	516	519	PF00928	0.294
TRG_ENDOCYTIC_2	818	821	PF00928	0.339
TRG_ENDOCYTIC_2	86	89	PF00928	0.312
TRG_ER_diArg_1	188	190	PF00400	0.544
TRG_ER_diArg_1	2	4	PF00400	0.545
TRG_ER_diArg_1	253	256	PF00400	0.731
TRG_ER_diArg_1	343	346	PF00400	0.667
TRG_ER_diArg_1	350	353	PF00400	0.634
TRG_ER_diArg_1	380	382	PF00400	0.365
TRG_ER_diArg_1	47	50	PF00400	0.312
TRG_ER_diArg_1	5	7	PF00400	0.534
TRG_ER_diArg_1	558	560	PF00400	0.312
TRG_ER_diArg_1	631	634	PF00400	0.337
TRG_ER_diArg_1	95	97	PF00400	0.385
TRG_NLS_MonoExtN_4	341	346	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	49%	98%
A0A3Q8IHX0	Leishmania donovani	99%	100%
A4HQ72	Leishmania braziliensis	75%	98%
E9ATZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4Q0K5	Leishmania major	93%	100%