Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase P1 - putative

Species:

Leishmania infantum

UniProt:

A4IDX0_LEIIN

TriTrypDb:

LINF_360065300

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IDX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDX0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.559
CLV_C14_Caspase3-7	368	372	PF00656	0.516
CLV_C14_Caspase3-7	470	474	PF00656	0.400
CLV_NRD_NRD_1	189	191	PF00675	0.546
CLV_NRD_NRD_1	3	5	PF00675	0.535
CLV_NRD_NRD_1	381	383	PF00675	0.360
CLV_NRD_NRD_1	49	51	PF00675	0.318
CLV_NRD_NRD_1	523	525	PF00675	0.336
CLV_NRD_NRD_1	559	561	PF00675	0.312
CLV_NRD_NRD_1	6	8	PF00675	0.530

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	49%	98%
A0A3Q8IHX0	Leishmania donovani	99%	100%
A4HQ72	Leishmania braziliensis	75%	98%
E9ATZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4Q0K5	Leishmania major	93%	100%

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