Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDW8_LEIIN

TriTrypDb:

LINF_360065100

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDW8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.648
CLV_NRD_NRD_1	102	104	PF00675	0.484
CLV_NRD_NRD_1	332	334	PF00675	0.632
CLV_NRD_NRD_1	382	384	PF00675	0.519
CLV_NRD_NRD_1	89	91	PF00675	0.651
CLV_PCSK_FUR_1	330	334	PF00082	0.660
CLV_PCSK_KEX2_1	102	104	PF00082	0.473
CLV_PCSK_KEX2_1	332	334	PF00082	0.618
CLV_PCSK_KEX2_1	381	383	PF00082	0.486
CLV_PCSK_PC7_1	98	104	PF00082	0.508
CLV_PCSK_SKI1_1	186	190	PF00082	0.502
CLV_PCSK_SKI1_1	37	41	PF00082	0.540
CLV_PCSK_SKI1_1	98	102	PF00082	0.444
DEG_APCC_DBOX_1	175	183	PF00400	0.529
DEG_APCC_DBOX_1	312	320	PF00400	0.480
DOC_CKS1_1	187	192	PF01111	0.398
DOC_CYCLIN_RxL_1	98	110	PF00134	0.505
DOC_MAPK_JIP1_4	12	18	PF00069	0.312
DOC_MAPK_MEF2A_6	176	183	PF00069	0.417
DOC_MAPK_MEF2A_6	186	195	PF00069	0.402
DOC_PP2B_PxIxI_1	130	136	PF00149	0.385
DOC_PP4_FxxP_1	187	190	PF00568	0.475
DOC_USP7_MATH_1	11	15	PF00917	0.564
DOC_USP7_MATH_1	172	176	PF00917	0.613
DOC_USP7_MATH_1	213	217	PF00917	0.603
DOC_USP7_MATH_1	26	30	PF00917	0.411
DOC_USP7_MATH_1	281	285	PF00917	0.420
DOC_WW_Pin1_4	161	166	PF00397	0.541
DOC_WW_Pin1_4	186	191	PF00397	0.383
DOC_WW_Pin1_4	370	375	PF00397	0.636
DOC_WW_Pin1_4	4	9	PF00397	0.695
DOC_WW_Pin1_4	90	95	PF00397	0.459
LIG_14-3-3_CanoR_1	214	222	PF00244	0.524
LIG_14-3-3_CanoR_1	330	338	PF00244	0.509
LIG_14-3-3_CanoR_1	59	64	PF00244	0.404
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BIR_III_3	1	5	PF00653	0.667
LIG_CSL_BTD_1	217	220	PF09270	0.511
LIG_FHA_1	28	34	PF00498	0.314
LIG_FHA_1	340	346	PF00498	0.394
LIG_FHA_1	410	416	PF00498	0.642
LIG_FHA_1	99	105	PF00498	0.466
LIG_FHA_2	112	118	PF00498	0.392
LIG_FHA_2	408	414	PF00498	0.586
LIG_FHA_2	75	81	PF00498	0.543
LIG_HCF-1_HBM_1	232	235	PF13415	0.523
LIG_LIR_Apic_2	184	190	PF02991	0.459
LIG_LIR_Apic_2	216	221	PF02991	0.582
LIG_LIR_Nem_3	260	266	PF02991	0.426
LIG_LIR_Nem_3	439	444	PF02991	0.425
LIG_Pex14_2	183	187	PF04695	0.431
LIG_Rb_pABgroove_1	225	233	PF01858	0.494
LIG_SH2_NCK_1	235	239	PF00017	0.532
LIG_SH2_STAT3	160	163	PF00017	0.614
LIG_SH3_3	2	8	PF00018	0.715
LIG_SH3_3	216	222	PF00018	0.525
LIG_SUMO_SIM_anti_2	410	420	PF11976	0.509
LIG_SUMO_SIM_par_1	103	108	PF11976	0.495
LIG_SUMO_SIM_par_1	178	184	PF11976	0.508
LIG_SUMO_SIM_par_1	62	67	PF11976	0.412
LIG_SxIP_EBH_1	16	28	PF03271	0.460
MOD_CDK_SPK_2	7	12	PF00069	0.446
MOD_CDK_SPK_2	90	95	PF00069	0.505
MOD_CK1_1	161	167	PF00069	0.657
MOD_CK1_1	7	13	PF00069	0.617
MOD_CK2_1	111	117	PF00069	0.341
MOD_CK2_1	140	146	PF00069	0.483
MOD_CK2_1	161	167	PF00069	0.523
MOD_CK2_1	205	211	PF00069	0.627
MOD_CK2_1	59	65	PF00069	0.483
MOD_CK2_1	74	80	PF00069	0.484
MOD_CK2_1	83	89	PF00069	0.537
MOD_CMANNOS	251	254	PF00535	0.533
MOD_GlcNHglycan	109	112	PF01048	0.530
MOD_GlcNHglycan	13	16	PF01048	0.431
MOD_GlcNHglycan	206	210	PF01048	0.657
MOD_GlcNHglycan	215	218	PF01048	0.462
MOD_GlcNHglycan	419	422	PF01048	0.450
MOD_GlcNHglycan	45	48	PF01048	0.481
MOD_GlcNHglycan	85	88	PF01048	0.714
MOD_GSK3_1	107	114	PF00069	0.525
MOD_GSK3_1	3	10	PF00069	0.705
MOD_LATS_1	407	413	PF00433	0.565
MOD_LATS_1	57	63	PF00433	0.308
MOD_NEK2_1	105	110	PF00069	0.502
MOD_NEK2_1	18	23	PF00069	0.466
MOD_NEK2_1	283	288	PF00069	0.490
MOD_NEK2_1	417	422	PF00069	0.490
MOD_NEK2_1	425	430	PF00069	0.324
MOD_PIKK_1	105	111	PF00454	0.512
MOD_PIKK_1	257	263	PF00454	0.510
MOD_PIKK_1	267	273	PF00454	0.574
MOD_PK_1	59	65	PF00069	0.367
MOD_PKA_2	11	17	PF00069	0.325
MOD_PKA_2	213	219	PF00069	0.561
MOD_PKA_2	331	337	PF00069	0.430
MOD_PKA_2	41	47	PF00069	0.475
MOD_Plk_1	158	164	PF00069	0.583
MOD_Plk_1	326	332	PF00069	0.555
MOD_Plk_2-3	74	80	PF00069	0.524
MOD_Plk_4	27	33	PF00069	0.484
MOD_Plk_4	425	431	PF00069	0.485
MOD_Plk_4	59	65	PF00069	0.405
MOD_ProDKin_1	161	167	PF00069	0.549
MOD_ProDKin_1	186	192	PF00069	0.392
MOD_ProDKin_1	370	376	PF00069	0.629
MOD_ProDKin_1	4	10	PF00069	0.681
MOD_ProDKin_1	90	96	PF00069	0.452
MOD_SUMO_for_1	387	390	PF00179	0.532
MOD_SUMO_for_1	405	408	PF00179	0.561
MOD_SUMO_rev_2	86	93	PF00179	0.562
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.470
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.352
TRG_ENDOCYTIC_2	141	144	PF00928	0.381
TRG_ENDOCYTIC_2	148	151	PF00928	0.358
TRG_ER_diArg_1	102	104	PF00400	0.522
TRG_ER_diArg_1	313	316	PF00400	0.560
TRG_ER_diArg_1	330	333	PF00400	0.578
TRG_ER_diArg_1	380	383	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ4	Leptomonas seymouri	36%	96%
A0A1X0P061	Trypanosomatidae	24%	100%
A0A3Q8ILN7	Leishmania donovani	99%	100%
A0A422NKD5	Trypanosoma rangeli	26%	100%
A4HQ70	Leishmania braziliensis	73%	100%
E9ATY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0K7	Leishmania major	92%	100%
V5BNR2	Trypanosoma cruzi	27%	100%